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Efficient replication and shedding of MERS CoV from the upper respiratory tract of experimentally infected dromedary camels

Identifieur interne : 001815 ( Main/Curation ); précédent : 001814; suivant : 001816

Efficient replication and shedding of MERS CoV from the upper respiratory tract of experimentally infected dromedary camels

Auteurs : Dr Adney ; Vr Brown ; N. Van Doremalen ; T. Bushmaker ; D. Scott ; E. De Wit ; Va Munster ; Ra Bowen

Source :

New Horizons in Translational Medicine [ 2352-7536 ] ; 2015.

RBID : PMC:7129280

Abstract

The Middle East respiratory syndrome coronavirus (MERS CoV) is a novel coronavirus first recognized in 2012 and is associated with severe respiratory disease in humans. Virus has been isolated from dromedary camels in endemic areas, and many camels also have neutralizing antibodies against the virus, suggesting that they are likely a reservoir host. In order to better understand the role of camels in virus transmission we experimentally infected 3 adult, male dromedary camels with a human isolate of MERS CoV. All animals developed a transient, upper respiratory tract infection associated with very minor clinical disease. Large quantities of infectious virus were isolated from nasal secretions from each animal through 7 days post-inoculation, and viral RNA was detected much longer. Although our study design was limited to 3 animals, these data indicate that MERS CoV readily infects camels, which shed large amounts of virus and likely can efficiently transmit virus to other camels and humans.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129280

DOI: 10.1016/j.nhtm.2015.07.056
PubMed: NONE
PubMed Central: 7129280

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Dr Adney

<affiliation><nlm:aff id="aff0265">Department of Microbiology, Immunology, and Pathology, Colorado State University</nlm:aff>
<wicri:noCountry code="subfield">Colorado State University</wicri:noCountry>
</affiliation>

Vr Brown

<affiliation><nlm:aff id="aff0265">Department of Microbiology, Immunology, and Pathology, Colorado State University</nlm:aff>
<wicri:noCountry code="subfield">Colorado State University</wicri:noCountry>
</affiliation>

N. Van Doremalen

<affiliation><nlm:aff id="aff0170">Laboratory of Virology, Rocky Mountain Laboratories, NIAID</nlm:aff>
<wicri:noCountry code="subfield">NIAID</wicri:noCountry>
</affiliation>

T. Bushmaker

<affiliation><nlm:aff id="aff0170">Laboratory of Virology, Rocky Mountain Laboratories, NIAID</nlm:aff>
<wicri:noCountry code="subfield">NIAID</wicri:noCountry>
</affiliation>

D. Scott

<affiliation><nlm:aff id="aff0175">Rocky Mountain Veterinary Branch, Division of Intramural Research NIAID</nlm:aff>
<wicri:noCountry code="subfield">Division of Intramural Research NIAID</wicri:noCountry>
</affiliation>

E. De Wit

<affiliation><nlm:aff id="aff0170">Laboratory of Virology, Rocky Mountain Laboratories, NIAID</nlm:aff>
<wicri:noCountry code="subfield">NIAID</wicri:noCountry>
</affiliation>

Va Munster

<affiliation><nlm:aff id="aff0170">Laboratory of Virology, Rocky Mountain Laboratories, NIAID</nlm:aff>
<wicri:noCountry code="subfield">NIAID</wicri:noCountry>
</affiliation>

Ra Bowen

<affiliation><nlm:aff id="aff0265">Department of Microbiology, Immunology, and Pathology, Colorado State University</nlm:aff>
<wicri:noCountry code="subfield">Colorado State University</wicri:noCountry>
</affiliation>

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<wicri:noCountry code="subfield">NIAID</wicri:noCountry>
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<front><div type="abstract" xml:lang="en"><p>The Middle East respiratory syndrome coronavirus (MERS CoV) is a novel coronavirus first recognized in 2012 and is associated with severe respiratory disease in humans. Virus has been isolated from dromedary camels in endemic areas, and many camels also have neutralizing antibodies against the virus, suggesting that they are likely a reservoir host. In order to better understand the role of camels in virus transmission we experimentally infected 3 adult, male dromedary camels with a human isolate of MERS CoV. All animals developed a transient, upper respiratory tract infection associated with very minor clinical disease. Large quantities of infectious virus were isolated from nasal secretions from each animal through 7 days post-inoculation, and viral RNA was detected much longer. Although our study design was limited to 3 animals, these data indicate that MERS CoV readily infects camels, which shed large amounts of virus and likely can efficiently transmit virus to other camels and humans.</p>
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Efficient replication and shedding of MERS CoV from the upper respiratory tract of experimentally infected dromedary camels

Efficient replication and shedding of MERS CoV from the upper respiratory tract of experimentally infected dromedary camels

Source :

Abstract

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