MersV1, Ncbi, Merge, bibRecord, 002C19

Efficient replication and shedding of MERS CoV from the upper respiratory tract of experimentally infected dromedary camels

Identifieur interne : 002C19 ( Ncbi/Merge ); précédent : 002C18; suivant : 002C20

Efficient replication and shedding of MERS CoV from the upper respiratory tract of experimentally infected dromedary camels

Auteurs : Dr Adney ; Vr Brown ; N. Van Doremalen ; T. Bushmaker ; D. Scott ; E. De Wit ; Va Munster ; Ra Bowen

Source :

New Horizons in Translational Medicine [ 2352-7536 ] ; 2015.

RBID : PMC:7129280

Abstract

The Middle East respiratory syndrome coronavirus (MERS CoV) is a novel coronavirus first recognized in 2012 and is associated with severe respiratory disease in humans. Virus has been isolated from dromedary camels in endemic areas, and many camels also have neutralizing antibodies against the virus, suggesting that they are likely a reservoir host. In order to better understand the role of camels in virus transmission we experimentally infected 3 adult, male dromedary camels with a human isolate of MERS CoV. All animals developed a transient, upper respiratory tract infection associated with very minor clinical disease. Large quantities of infectious virus were isolated from nasal secretions from each animal through 7 days post-inoculation, and viral RNA was detected much longer. Although our study design was limited to 3 animals, these data indicate that MERS CoV readily infects camels, which shed large amounts of virus and likely can efficiently transmit virus to other camels and humans.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129280

DOI: 10.1016/j.nhtm.2015.07.056
PubMed: NONE
PubMed Central: 7129280

Links toward previous steps (curation, corpus...)

to stream Pmc, to step Corpus: 000623
to stream Pmc, to step Curation: 000623
to stream Pmc, to step Checkpoint: 000E61

Links to Exploration step

PMC:7129280

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Efficient replication and shedding of MERS CoV from the upper respiratory tract of experimentally infected dromedary camels</title>
<author><name sortKey="Adney, Dr" sort="Adney, Dr" uniqKey="Adney D" first="Dr" last="Adney">Dr Adney</name>
<affiliation><nlm:aff id="aff0265">Department of Microbiology, Immunology, and Pathology, Colorado State University</nlm:aff>
<wicri:noCountry code="subfield">Colorado State University</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Brown, Vr" sort="Brown, Vr" uniqKey="Brown V" first="Vr" last="Brown">Vr Brown</name>
<affiliation><nlm:aff id="aff0265">Department of Microbiology, Immunology, and Pathology, Colorado State University</nlm:aff>
<wicri:noCountry code="subfield">Colorado State University</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Van Doremalen, N" sort="Van Doremalen, N" uniqKey="Van Doremalen N" first="N" last="Van Doremalen">N. Van Doremalen</name>
<affiliation><nlm:aff id="aff0170">Laboratory of Virology, Rocky Mountain Laboratories, NIAID</nlm:aff>
<wicri:noCountry code="subfield">NIAID</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bushmaker, T" sort="Bushmaker, T" uniqKey="Bushmaker T" first="T" last="Bushmaker">T. Bushmaker</name>
<affiliation><nlm:aff id="aff0170">Laboratory of Virology, Rocky Mountain Laboratories, NIAID</nlm:aff>
<wicri:noCountry code="subfield">NIAID</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Scott, D" sort="Scott, D" uniqKey="Scott D" first="D" last="Scott">D. Scott</name>
<affiliation><nlm:aff id="aff0175">Rocky Mountain Veterinary Branch, Division of Intramural Research NIAID</nlm:aff>
<wicri:noCountry code="subfield">Division of Intramural Research NIAID</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="De Wit, E" sort="De Wit, E" uniqKey="De Wit E" first="E" last="De Wit">E. De Wit</name>
<affiliation><nlm:aff id="aff0170">Laboratory of Virology, Rocky Mountain Laboratories, NIAID</nlm:aff>
<wicri:noCountry code="subfield">NIAID</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Munster, Va" sort="Munster, Va" uniqKey="Munster V" first="Va" last="Munster">Va Munster</name>
<affiliation><nlm:aff id="aff0170">Laboratory of Virology, Rocky Mountain Laboratories, NIAID</nlm:aff>
<wicri:noCountry code="subfield">NIAID</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bowen, Ra" sort="Bowen, Ra" uniqKey="Bowen R" first="Ra" last="Bowen">Ra Bowen</name>
<affiliation><nlm:aff id="aff0265">Department of Microbiology, Immunology, and Pathology, Colorado State University</nlm:aff>
<wicri:noCountry code="subfield">Colorado State University</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmc">7129280</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129280</idno>
<idno type="RBID">PMC:7129280</idno>
<idno type="doi">10.1016/j.nhtm.2015.07.056</idno>
<idno type="pmid">NONE</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000623</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000623</idno>
<idno type="wicri:Area/Pmc/Curation">000623</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000623</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000E61</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000E61</idno>
<idno type="wicri:Area/Ncbi/Merge">002C19</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Efficient replication and shedding of MERS CoV from the upper respiratory tract of experimentally infected dromedary camels</title>
<author><name sortKey="Adney, Dr" sort="Adney, Dr" uniqKey="Adney D" first="Dr" last="Adney">Dr Adney</name>
<affiliation><nlm:aff id="aff0265">Department of Microbiology, Immunology, and Pathology, Colorado State University</nlm:aff>
<wicri:noCountry code="subfield">Colorado State University</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Brown, Vr" sort="Brown, Vr" uniqKey="Brown V" first="Vr" last="Brown">Vr Brown</name>
<affiliation><nlm:aff id="aff0265">Department of Microbiology, Immunology, and Pathology, Colorado State University</nlm:aff>
<wicri:noCountry code="subfield">Colorado State University</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Van Doremalen, N" sort="Van Doremalen, N" uniqKey="Van Doremalen N" first="N" last="Van Doremalen">N. Van Doremalen</name>
<affiliation><nlm:aff id="aff0170">Laboratory of Virology, Rocky Mountain Laboratories, NIAID</nlm:aff>
<wicri:noCountry code="subfield">NIAID</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bushmaker, T" sort="Bushmaker, T" uniqKey="Bushmaker T" first="T" last="Bushmaker">T. Bushmaker</name>
<affiliation><nlm:aff id="aff0170">Laboratory of Virology, Rocky Mountain Laboratories, NIAID</nlm:aff>
<wicri:noCountry code="subfield">NIAID</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Scott, D" sort="Scott, D" uniqKey="Scott D" first="D" last="Scott">D. Scott</name>
<affiliation><nlm:aff id="aff0175">Rocky Mountain Veterinary Branch, Division of Intramural Research NIAID</nlm:aff>
<wicri:noCountry code="subfield">Division of Intramural Research NIAID</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="De Wit, E" sort="De Wit, E" uniqKey="De Wit E" first="E" last="De Wit">E. De Wit</name>
<affiliation><nlm:aff id="aff0170">Laboratory of Virology, Rocky Mountain Laboratories, NIAID</nlm:aff>
<wicri:noCountry code="subfield">NIAID</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Munster, Va" sort="Munster, Va" uniqKey="Munster V" first="Va" last="Munster">Va Munster</name>
<affiliation><nlm:aff id="aff0170">Laboratory of Virology, Rocky Mountain Laboratories, NIAID</nlm:aff>
<wicri:noCountry code="subfield">NIAID</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bowen, Ra" sort="Bowen, Ra" uniqKey="Bowen R" first="Ra" last="Bowen">Ra Bowen</name>
<affiliation><nlm:aff id="aff0265">Department of Microbiology, Immunology, and Pathology, Colorado State University</nlm:aff>
<wicri:noCountry code="subfield">Colorado State University</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">New Horizons in Translational Medicine</title>
<idno type="ISSN">2352-7536</idno>
<idno type="eISSN">2307-5023</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The Middle East respiratory syndrome coronavirus (MERS CoV) is a novel coronavirus first recognized in 2012 and is associated with severe respiratory disease in humans. Virus has been isolated from dromedary camels in endemic areas, and many camels also have neutralizing antibodies against the virus, suggesting that they are likely a reservoir host. In order to better understand the role of camels in virus transmission we experimentally infected 3 adult, male dromedary camels with a human isolate of MERS CoV. All animals developed a transient, upper respiratory tract infection associated with very minor clinical disease. Large quantities of infectious virus were isolated from nasal secretions from each animal through 7 days post-inoculation, and viral RNA was detected much longer. Although our study design was limited to 3 animals, these data indicate that MERS CoV readily infects camels, which shed large amounts of virus and likely can efficiently transmit virus to other camels and humans.</p>
</div>
</front>
</TEI>
<pmc article-type="abstract"><pmc-dir>properties open_access</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">New Horiz Transl Med</journal-id>
<journal-id journal-id-type="iso-abbrev">New Horiz Transl Med</journal-id>
<journal-title-group><journal-title>New Horizons in Translational Medicine</journal-title>
</journal-title-group>
<issn pub-type="ppub">2352-7536</issn>
<issn pub-type="epub">2307-5023</issn>
<publisher><publisher-name>Published by Elsevier Ltd.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmc">7129280</article-id>
<article-id pub-id-type="publisher-id">S2307-5023(15)00084-3</article-id>
<article-id pub-id-type="doi">10.1016/j.nhtm.2015.07.056</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Efficient replication and shedding of MERS CoV from the upper respiratory tract of experimentally infected dromedary camels</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" id="au0445"><name><surname>Adney</surname>
<given-names>DR</given-names>
</name>
<xref rid="aff0265" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author" id="au0450"><name><surname>Brown</surname>
<given-names>VR</given-names>
</name>
<xref rid="aff0265" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author" id="au0455"><name><surname>van Doremalen</surname>
<given-names>N</given-names>
</name>
<xref rid="aff0170" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author" id="au0460"><name><surname>Bushmaker</surname>
<given-names>T</given-names>
</name>
<xref rid="aff0170" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author" id="au0465"><name><surname>Scott</surname>
<given-names>D</given-names>
</name>
<xref rid="aff0175" ref-type="aff">c</xref>
</contrib>
<contrib contrib-type="author" id="au0470"><name><surname>de Wit</surname>
<given-names>E</given-names>
</name>
<xref rid="aff0170" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author" id="au0475"><name><surname>Munster</surname>
<given-names>VA</given-names>
</name>
<xref rid="aff0170" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author" id="au0480"><name><surname>Bowen</surname>
<given-names>RA</given-names>
</name>
<xref rid="aff0265" ref-type="aff">a</xref>
</contrib>
</contrib-group>
<aff id="aff0265"><label>a</label>
Department of Microbiology, Immunology, and Pathology, Colorado State University</aff>
<aff id="aff0170"><label>b</label>
Laboratory of Virology, Rocky Mountain Laboratories, NIAID</aff>
<aff id="aff0175"><label>c</label>
Rocky Mountain Veterinary Branch, Division of Intramural Research NIAID</aff>
<pub-date pub-type="pmc-release"><day>11</day>
<month>9</month>
<year>2015</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
      <pub-date pub-type="ppub" iso-8601-date="2015-07-01"><season>May-July</season>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>11</day>
<month>9</month>
<year>2015</year>
</pub-date>
<volume>2</volume>
<issue>4</issue>
<fpage>131</fpage>
<lpage>131</lpage>
<permissions><copyright-statement>Copyright © 2015 Published by Elsevier Ltd.</copyright-statement>
<copyright-year>2015</copyright-year>
<copyright-holder></copyright-holder>
<license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract id="ab0090"><p>The Middle East respiratory syndrome coronavirus (MERS CoV) is a novel coronavirus first recognized in 2012 and is associated with severe respiratory disease in humans. Virus has been isolated from dromedary camels in endemic areas, and many camels also have neutralizing antibodies against the virus, suggesting that they are likely a reservoir host. In order to better understand the role of camels in virus transmission we experimentally infected 3 adult, male dromedary camels with a human isolate of MERS CoV. All animals developed a transient, upper respiratory tract infection associated with very minor clinical disease. Large quantities of infectious virus were isolated from nasal secretions from each animal through 7 days post-inoculation, and viral RNA was detected much longer. Although our study design was limited to 3 animals, these data indicate that MERS CoV readily infects camels, which shed large amounts of virus and likely can efficiently transmit virus to other camels and humans.</p>
</abstract>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Adney, Dr" sort="Adney, Dr" uniqKey="Adney D" first="Dr" last="Adney">Dr Adney</name>
<name sortKey="Bowen, Ra" sort="Bowen, Ra" uniqKey="Bowen R" first="Ra" last="Bowen">Ra Bowen</name>
<name sortKey="Brown, Vr" sort="Brown, Vr" uniqKey="Brown V" first="Vr" last="Brown">Vr Brown</name>
<name sortKey="Bushmaker, T" sort="Bushmaker, T" uniqKey="Bushmaker T" first="T" last="Bushmaker">T. Bushmaker</name>
<name sortKey="De Wit, E" sort="De Wit, E" uniqKey="De Wit E" first="E" last="De Wit">E. De Wit</name>
<name sortKey="Munster, Va" sort="Munster, Va" uniqKey="Munster V" first="Va" last="Munster">Va Munster</name>
<name sortKey="Scott, D" sort="Scott, D" uniqKey="Scott D" first="D" last="Scott">D. Scott</name>
<name sortKey="Van Doremalen, N" sort="Van Doremalen, N" uniqKey="Van Doremalen N" first="N" last="Van Doremalen">N. Van Doremalen</name>
</noCountry>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Ncbi/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002C19 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 002C19 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    Ncbi
   |étape=   Merge
   |type=    RBID
   |clé=     PMC:7129280
   |texte=   Efficient replication and shedding of MERS CoV from the upper respiratory tract of experimentally infected dromedary camels
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i   -Sk "pubmed:NONE" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration MERS

Efficient replication and shedding of MERS CoV from the upper respiratory tract of experimentally infected dromedary camels

Efficient replication and shedding of MERS CoV from the upper respiratory tract of experimentally infected dromedary camels

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki