Clinically mild encephalitis/encephalopathy with a reversible splenial lesion associated with Mycoplasma pneumoniae infection
Identifieur interne : 001339 ( Main/Curation ); précédent : 001338; suivant : 001340Clinically mild encephalitis/encephalopathy with a reversible splenial lesion associated with Mycoplasma pneumoniae infection
Auteurs : Zhe-Feng Yuan ; Jue Shen ; Shan-Shan Mao ; Yong-Lin Yu ; Lu Xu ; Pei-Fang Jiang ; Feng Gao ; Zhe-Zhi XiaSource :
- BMC Infectious Diseases [ 1471-2334 ] ; 2016.
Descripteurs français
- KwdFr :
- Anti-infectieux (usage thérapeutique), Azithromycine (usage thérapeutique), Corps calleux (imagerie diagnostique), Céphalée (étiologie), Diagnostic différentiel, Encéphalite (), Encéphalite (diagnostic), Encéphalite (imagerie diagnostique), Encéphalite (sang), Enfant, Humains, Infections à Mycoplasma (), Infections à Mycoplasma (diagnostic), Infections à Mycoplasma (imagerie diagnostique), Infections à Mycoplasma (sang), Mycoplasma pneumoniae (isolement et purification), Mâle.
- MESH :
- diagnostic : Encéphalite, Infections à Mycoplasma.
- imagerie diagnostique : Corps calleux, Encéphalite, Infections à Mycoplasma.
- isolement et purification : Mycoplasma pneumoniae.
- sang : Encéphalite, Infections à Mycoplasma.
- usage thérapeutique : Anti-infectieux, Azithromycine.
- étiologie : Céphalée.
- Diagnostic différentiel, Encéphalite, Enfant, Humains, Infections à Mycoplasma, Mâle.
English descriptors
- KwdEn :
- Anti-Infective Agents (therapeutic use), Azithromycin (therapeutic use), Child, Corpus Callosum (diagnostic imaging), Diagnosis, Differential, Encephalitis (blood), Encephalitis (complications), Encephalitis (diagnosis), Encephalitis (diagnostic imaging), Headache (etiology), Humans, Male, Mycoplasma Infections (blood), Mycoplasma Infections (complications), Mycoplasma Infections (diagnosis), Mycoplasma Infections (diagnostic imaging), Mycoplasma pneumoniae (isolation & purification).
- MESH :
- chemical , therapeutic use : Anti-Infective Agents, Azithromycin.
- blood : Encephalitis, Mycoplasma Infections.
- complications : Encephalitis, Mycoplasma Infections.
- diagnosis : Encephalitis, Mycoplasma Infections.
- diagnostic imaging : Corpus Callosum, Encephalitis, Mycoplasma Infections.
- etiology : Headache.
- isolation & purification : Mycoplasma pneumoniae.
- Child, Diagnosis, Differential, Humans, Male.
Abstract
Clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a clinico-radiological syndrome characterized by transient mild symptoms of encephalopathy and a reversible lesion in the splenium of the corpus callosum on magnetic resonance imaging (MRI). It is often triggered by infection. The common pathogens of MERS are viruses, especially influenza virus. However,
Here we report two paediatric cases of
Our study enriches the available information on the pathogens of MERS and provides valuable data for better understanding of this syndrome.
Url:
DOI: 10.1186/s12879-016-1556-5
PubMed: 27230114
PubMed Central: 4880818
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Zhe-Feng Yuan<affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff>
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<series><title level="j">BMC Infectious Diseases</title>
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<term>Azithromycin (therapeutic use)</term>
<term>Child</term>
<term>Corpus Callosum (diagnostic imaging)</term>
<term>Diagnosis, Differential</term>
<term>Encephalitis (blood)</term>
<term>Encephalitis (complications)</term>
<term>Encephalitis (diagnosis)</term>
<term>Encephalitis (diagnostic imaging)</term>
<term>Headache (etiology)</term>
<term>Humans</term>
<term>Male</term>
<term>Mycoplasma Infections (blood)</term>
<term>Mycoplasma Infections (complications)</term>
<term>Mycoplasma Infections (diagnosis)</term>
<term>Mycoplasma Infections (diagnostic imaging)</term>
<term>Mycoplasma pneumoniae (isolation & purification)</term>
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<term>Azithromycine (usage thérapeutique)</term>
<term>Corps calleux (imagerie diagnostique)</term>
<term>Céphalée (étiologie)</term>
<term>Diagnostic différentiel</term>
<term>Encéphalite ()</term>
<term>Encéphalite (diagnostic)</term>
<term>Encéphalite (imagerie diagnostique)</term>
<term>Encéphalite (sang)</term>
<term>Enfant</term>
<term>Humains</term>
<term>Infections à Mycoplasma ()</term>
<term>Infections à Mycoplasma (diagnostic)</term>
<term>Infections à Mycoplasma (imagerie diagnostique)</term>
<term>Infections à Mycoplasma (sang)</term>
<term>Mycoplasma pneumoniae (isolement et purification)</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Encephalitis</term>
<term>Mycoplasma Infections</term>
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<term>Mycoplasma Infections</term>
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<term>Infections à Mycoplasma</term>
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<term>Encephalitis</term>
<term>Mycoplasma Infections</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Headache</term>
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<keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Corps calleux</term>
<term>Encéphalite</term>
<term>Infections à Mycoplasma</term>
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<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Mycoplasma pneumoniae</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a clinico-radiological syndrome characterized by transient mild symptoms of encephalopathy and a reversible lesion in the splenium of the corpus callosum on magnetic resonance imaging (MRI). It is often triggered by infection. The common pathogens of MERS are viruses, especially influenza virus. However, <italic>Mycoplasma pneumoniae</italic>
(<italic>M.pneumoniae</italic>
) are relatively rare pathogens for MERS.</p>
</sec>
<sec><title>Case presentation</title>
<p>Here we report two paediatric cases of <italic>M.pneumoniae</italic>
infection-induced MERS. The diagnosis of <italic>M.pneumoniae</italic>
infection was established based on polymerase chain reaction (PCR) and specific serum antibodies (IgM). Both of the two patients presented with mild encephalopathy manifestations and recovered completely within a few days. The initial MRI showed a lesion in the central portion of the splenium of the corpus callosum, which completely resolved on the seventh and eighth day after admission for case 1 and case 2. Lumbar puncture was performed in both patients, which revealed no pleocytosis. In case 1, the patient had hyponatremia, peripheral facial nerve paralysis, and rash. To the best of our knowledge, it is the first MERS case associated with peripheral nerve damage. In case 2, interleukin-6(IL-6) was moderately increased in the cerebrospinal fluid (CSF). It suggested that IL-6 may play a role in the pathogenesis of <italic>M.pneumoniae</italic>
-induced MERS.</p>
</sec>
<sec><title>Conclusion</title>
<p>Our study enriches the available information on the pathogens of MERS and provides valuable data for better understanding of this syndrome.</p>
</sec>
</div>
</front>
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</listBibl>
</div1>
</back>
</TEI>
</record>
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