Clinically mild encephalitis/encephalopathy with a reversible splenial lesion associated with Mycoplasma pneumoniae infection
Identifieur interne : 000165 ( Pmc/Curation ); précédent : 000164; suivant : 000166Clinically mild encephalitis/encephalopathy with a reversible splenial lesion associated with Mycoplasma pneumoniae infection
Auteurs : Zhe-Feng Yuan ; Jue Shen ; Shan-Shan Mao ; Yong-Lin Yu ; Lu Xu ; Pei-Fang Jiang ; Feng Gao ; Zhe-Zhi XiaSource :
- BMC Infectious Diseases [ 1471-2334 ] ; 2016.
Abstract
Clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a clinico-radiological syndrome characterized by transient mild symptoms of encephalopathy and a reversible lesion in the splenium of the corpus callosum on magnetic resonance imaging (MRI). It is often triggered by infection. The common pathogens of MERS are viruses, especially influenza virus. However,
Here we report two paediatric cases of
Our study enriches the available information on the pathogens of MERS and provides valuable data for better understanding of this syndrome.
Url:
DOI: 10.1186/s12879-016-1556-5
PubMed: 27230114
PubMed Central: 4880818
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Zhe-Feng Yuan<affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinically mild encephalitis/encephalopathy with a reversible splenial lesion associated with <italic>Mycoplasma pneumoniae</italic> infection</title><author><name sortKey="Yuan, Zhe Feng" sort="Yuan, Zhe Feng" uniqKey="Yuan Z" first="Zhe-Feng" last="Yuan">Zhe-Feng Yuan</name><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation></author><author><name sortKey="Shen, Jue" sort="Shen, Jue" uniqKey="Shen J" first="Jue" last="Shen">Jue Shen</name><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation></author><author><name sortKey="Mao, Shan Shan" sort="Mao, Shan Shan" uniqKey="Mao S" first="Shan-Shan" last="Mao">Shan-Shan Mao</name><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation></author><author><name sortKey="Yu, Yong Lin" sort="Yu, Yong Lin" uniqKey="Yu Y" first="Yong-Lin" last="Yu">Yong-Lin Yu</name><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation></author><author><name sortKey="Xu, Lu" sort="Xu, Lu" uniqKey="Xu L" first="Lu" last="Xu">Lu Xu</name><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation></author><author><name sortKey="Jiang, Pei Fang" sort="Jiang, Pei Fang" uniqKey="Jiang P" first="Pei-Fang" last="Jiang">Pei-Fang Jiang</name><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation></author><author><name sortKey="Gao, Feng" sort="Gao, Feng" uniqKey="Gao F" first="Feng" last="Gao">Feng Gao</name><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation></author><author><name sortKey="Xia, Zhe Zhi" sort="Xia, Zhe Zhi" uniqKey="Xia Z" first="Zhe-Zhi" last="Xia">Zhe-Zhi Xia</name><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27230114</idno><idno type="pmc">4880818</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880818</idno><idno type="RBID">PMC:4880818</idno><idno type="doi">10.1186/s12879-016-1556-5</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000165</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000165</idno><idno type="wicri:Area/Pmc/Curation">000165</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000165</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinically mild encephalitis/encephalopathy with a reversible splenial lesion associated with <italic>Mycoplasma pneumoniae</italic> infection</title><author><name sortKey="Yuan, Zhe Feng" sort="Yuan, Zhe Feng" uniqKey="Yuan Z" first="Zhe-Feng" last="Yuan">Zhe-Feng Yuan</name><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation></author><author><name sortKey="Shen, Jue" sort="Shen, Jue" uniqKey="Shen J" first="Jue" last="Shen">Jue Shen</name><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation></author><author><name sortKey="Mao, Shan Shan" sort="Mao, Shan Shan" uniqKey="Mao S" first="Shan-Shan" last="Mao">Shan-Shan Mao</name><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation></author><author><name sortKey="Yu, Yong Lin" sort="Yu, Yong Lin" uniqKey="Yu Y" first="Yong-Lin" last="Yu">Yong-Lin Yu</name><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation></author><author><name sortKey="Xu, Lu" sort="Xu, Lu" uniqKey="Xu L" first="Lu" last="Xu">Lu Xu</name><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation></author><author><name sortKey="Jiang, Pei Fang" sort="Jiang, Pei Fang" uniqKey="Jiang P" first="Pei-Fang" last="Jiang">Pei-Fang Jiang</name><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation></author><author><name sortKey="Gao, Feng" sort="Gao, Feng" uniqKey="Gao F" first="Feng" last="Gao">Feng Gao</name><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation></author><author><name sortKey="Xia, Zhe Zhi" sort="Xia, Zhe Zhi" uniqKey="Xia Z" first="Zhe-Zhi" last="Xia">Zhe-Zhi Xia</name><affiliation><nlm:aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</nlm:aff><wicri:noCountry code="subfield">310003 Zhejiang Province China</wicri:noCountry></affiliation></author></analytic><series><title level="j">BMC Infectious Diseases</title><idno type="eISSN">1471-2334</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a clinico-radiological syndrome characterized by transient mild symptoms of encephalopathy and a reversible lesion in the splenium of the corpus callosum on magnetic resonance imaging (MRI). It is often triggered by infection. The common pathogens of MERS are viruses, especially influenza virus. However, <italic>Mycoplasma pneumoniae</italic> (<italic>M.pneumoniae</italic>) are relatively rare pathogens for MERS.</p></sec><sec><title>Case presentation</title><p>Here we report two paediatric cases of <italic>M.pneumoniae</italic> infection-induced MERS. The diagnosis of <italic>M.pneumoniae</italic> infection was established based on polymerase chain reaction (PCR) and specific serum antibodies (IgM). Both of the two patients presented with mild encephalopathy manifestations and recovered completely within a few days. The initial MRI showed a lesion in the central portion of the splenium of the corpus callosum, which completely resolved on the seventh and eighth day after admission for case 1 and case 2. Lumbar puncture was performed in both patients, which revealed no pleocytosis. In case 1, the patient had hyponatremia, peripheral facial nerve paralysis, and rash. To the best of our knowledge, it is the first MERS case associated with peripheral nerve damage. In case 2, interleukin-6(IL-6) was moderately increased in the cerebrospinal fluid (CSF). It suggested that IL-6 may play a role in the pathogenesis of <italic>M.pneumoniae</italic>-induced MERS.</p></sec><sec><title>Conclusion</title><p>Our study enriches the available information on the pathogens of MERS and provides valuable data for better understanding of this syndrome.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Tada, H" uniqKey="Tada H">H Tada</name></author><author><name sortKey="Takanashi, J" uniqKey="Takanashi J">J Takanashi</name></author><author><name sortKey="Barkovich, Aj" uniqKey="Barkovich A">AJ Barkovich</name></author><author><name sortKey="Oba, H" uniqKey="Oba H">H Oba</name></author><author><name sortKey="Maeda, M" uniqKey="Maeda M">M Maeda</name></author><author><name sortKey="Tsukahara, H" uniqKey="Tsukahara H">H Tsukahara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takanashi, J" uniqKey="Takanashi J">J 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<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">BMC Infect. Dis</journal-id><journal-title-group><journal-title>BMC Infectious Diseases</journal-title></journal-title-group><issn pub-type="epub">1471-2334</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27230114</article-id><article-id pub-id-type="pmc">4880818</article-id><article-id pub-id-type="publisher-id">1556</article-id><article-id pub-id-type="doi">10.1186/s12879-016-1556-5</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Clinically mild encephalitis/encephalopathy with a reversible splenial lesion associated with <italic>Mycoplasma pneumoniae</italic> infection</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Yuan</surname><given-names>Zhe-Feng</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Shen</surname><given-names>Jue</given-names></name><address><phone>+86-571-86670902</phone><fax>+86-571-87074655</fax><email>shenjue1982@163.com</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Mao</surname><given-names>Shan-Shan</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Yu</surname><given-names>Yong-Lin</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Lu</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Jiang</surname><given-names>Pei-Fang</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Gao</surname><given-names>Feng</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Xia</surname><given-names>Zhe-Zhi</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><aff id="Aff1">Department of neurology, The Children’s Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003 Zhejiang Province China</aff></contrib-group><pub-date pub-type="epub"><day>26</day><month>5</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>26</day><month>5</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>16</volume><elocation-id>230</elocation-id><history><date date-type="received"><day>9</day><month>12</month><year>2015</year></date><date date-type="accepted"><day>10</day><month>5</month><year>2016</year></date></history><permissions><copyright-statement>© Yuan et al. 2016</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><sec><title>Background</title><p>Clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a clinico-radiological syndrome characterized by transient mild symptoms of encephalopathy and a reversible lesion in the splenium of the corpus callosum on magnetic resonance imaging (MRI). It is often triggered by infection. The common pathogens of MERS are viruses, especially influenza virus. However, <italic>Mycoplasma pneumoniae</italic> (<italic>M.pneumoniae</italic>) are relatively rare pathogens for MERS.</p></sec><sec><title>Case presentation</title><p>Here we report two paediatric cases of <italic>M.pneumoniae</italic> infection-induced MERS. The diagnosis of <italic>M.pneumoniae</italic> infection was established based on polymerase chain reaction (PCR) and specific serum antibodies (IgM). Both of the two patients presented with mild encephalopathy manifestations and recovered completely within a few days. The initial MRI showed a lesion in the central portion of the splenium of the corpus callosum, which completely resolved on the seventh and eighth day after admission for case 1 and case 2. Lumbar puncture was performed in both patients, which revealed no pleocytosis. In case 1, the patient had hyponatremia, peripheral facial nerve paralysis, and rash. To the best of our knowledge, it is the first MERS case associated with peripheral nerve damage. In case 2, interleukin-6(IL-6) was moderately increased in the cerebrospinal fluid (CSF). It suggested that IL-6 may play a role in the pathogenesis of <italic>M.pneumoniae</italic>-induced MERS.</p></sec><sec><title>Conclusion</title><p>Our study enriches the available information on the pathogens of MERS and provides valuable data for better understanding of this syndrome.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>MERS</kwd><kwd>Mycoplasma pneumoniae</kwd><kwd>Corpus callosum</kwd><kwd>Encephalopathy</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2016</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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