Systematic, active surveillance for Middle East respiratory syndrome coronavirus in camels in Egypt
Identifieur interne : 000B67 ( Main/Curation ); précédent : 000B66; suivant : 000B68Systematic, active surveillance for Middle East respiratory syndrome coronavirus in camels in Egypt
Auteurs : Mohamed A. Ali [Égypte] ; Mahmoud M. Shehata [Égypte] ; Mokhtar R. Gomaa [Égypte] ; Ahmed Kandeil [Égypte] ; Rabeh El-Shesheny [Égypte] ; Ahmed S. Kayed [Égypte] ; Ahmed N. El-Taweel [Égypte] ; Mohamed Atea [Égypte] ; Nagla Hassan [Égypte] ; Ola Bagato [Égypte] ; Yassmin Moatasim [Égypte] ; Sara H. Mahmoud [Égypte] ; Omnia Kutkat [Égypte] ; Asmaa M. Maatouq [Égypte] ; Ahmed Osman [Égypte] ; Pamela P. Mckenzie [États-Unis] ; Richard J. Webby [États-Unis] ; Ghazi Kayali [États-Unis, Liban]Source :
- Emerging Microbes & Infections [ 2222-1751 ] ; 2017.
Descripteurs français
- KwdFr :
- ARN viral (analyse), Animaux, Anticorps antiviraux (sang), Bovins, Chameaux (virologie), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Femelle, Flambées de maladies, Infections à coronavirus (diagnostic), Infections à coronavirus (médecine vétérinaire), Infections à coronavirus (épidémiologie), Liquides biologiques (virologie), Muqueuse nasale (virologie), Mâle, RT-PCR, Rectum (virologie), Techniques de diagnostic moléculaire, Tests sérologiques, Égypte (épidémiologie), Épidémiosurveillance, Études séroépidémiologiques.
- MESH :
- analyse : ARN viral.
- diagnostic : Infections à coronavirus.
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient.
- immunologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- médecine vétérinaire : Infections à coronavirus.
- sang : Anticorps antiviraux.
- virologie : Chameaux, Liquides biologiques, Muqueuse nasale, Rectum.
- épidémiologie : Infections à coronavirus, Égypte.
- Animaux, Bovins, Femelle, Flambées de maladies, Mâle, RT-PCR, Techniques de diagnostic moléculaire, Tests sérologiques, Épidémiosurveillance, Études séroépidémiologiques.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (blood), Body Fluids (virology), Camelus (virology), Cattle, Coronavirus Infections (diagnosis), Coronavirus Infections (epidemiology), Coronavirus Infections (veterinary), Disease Outbreaks, Egypt (epidemiology), Epidemiological Monitoring, Female, Male, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (immunology), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Molecular Diagnostic Techniques, Nasal Mucosa (virology), RNA, Viral (analysis), Rectum (virology), Reverse Transcriptase Polymerase Chain Reaction, Seroepidemiologic Studies, Serologic Tests.
- MESH :
- chemical , analysis : RNA, Viral.
- chemical , blood : Antibodies, Viral.
- diagnosis : Coronavirus Infections.
- epidemiology : Coronavirus Infections, Egypt.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- immunology : Middle East Respiratory Syndrome Coronavirus.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- veterinary : Coronavirus Infections.
- virology : Body Fluids, Camelus, Nasal Mucosa, Rectum.
- Animals, Cattle, Disease Outbreaks, Epidemiological Monitoring, Female, Male, Molecular Diagnostic Techniques, Reverse Transcriptase Polymerase Chain Reaction, Seroepidemiologic Studies, Serologic Tests.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe human infections and dromedary camels are considered an intermediary host. The dynamics of natural infection in camels are not well understood. Through systematic surveillance in Egypt, nasal, rectal, milk, urine and serum samples were collected from camels between June 2014 and February 2016. Locations included quarantines, markets, abattoirs, free-roaming herds and farmed breeding herds. The overall seroprevalence was 71% and RNA detection rate was 15%. Imported camels had higher seroprevalence (90% vs 61%) and higher RT-PCR detection rates (21% vs 12%) than locally raised camels. Juveniles had lower seroprevalence than adults (37% vs 82%) but similar RT-PCR detection rates (16% vs 15%). An outbreak in a breeding herd, showed that antibodies rapidly wane, that camels become re-infected, and that outbreaks in a herd are sustained for an extended time. Maternal antibodies titers were very low in calves regardless of the antibody titers of the mothers. Our results support the hypothesis that camels are a reservoir for MERS-CoV and that camel trade is an important route of introducing the virus into importing countries. Findings related to waning antibodies and re-infection have implications for camel vaccine development, disease management and zoonotic threat.
Url:
DOI: 10.1038/emi.2016.130
PubMed: 28050021
PubMed Central: 5285495
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PMC:5285495Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Systematic, active surveillance for Middle East respiratory syndrome coronavirus in camels in Egypt</title>
<author><name sortKey="Ali, Mohamed A" sort="Ali, Mohamed A" uniqKey="Ali M" first="Mohamed A" last="Ali">Mohamed A. Ali</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Center of Scientific Excellence for Influenza Viruses, National Research Centre</institution>
, Giza 12311,<country>Egypt</country>
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<country xml:lang="fr">Égypte</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Shehata, Mahmoud M" sort="Shehata, Mahmoud M" uniqKey="Shehata M" first="Mahmoud M" last="Shehata">Mahmoud M. Shehata</name>
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<author><name sortKey="Gomaa, Mokhtar R" sort="Gomaa, Mokhtar R" uniqKey="Gomaa M" first="Mokhtar R" last="Gomaa">Mokhtar R. Gomaa</name>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Kandeil, Ahmed" sort="Kandeil, Ahmed" uniqKey="Kandeil A" first="Ahmed" last="Kandeil">Ahmed Kandeil</name>
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, Giza 12311,<country>Egypt</country>
</nlm:aff>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="El Shesheny, Rabeh" sort="El Shesheny, Rabeh" uniqKey="El Shesheny R" first="Rabeh" last="El-Shesheny">Rabeh El-Shesheny</name>
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<author><name sortKey="Kayed, Ahmed S" sort="Kayed, Ahmed S" uniqKey="Kayed A" first="Ahmed S" last="Kayed">Ahmed S. Kayed</name>
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</nlm:aff>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="El Taweel, Ahmed N" sort="El Taweel, Ahmed N" uniqKey="El Taweel A" first="Ahmed N" last="El-Taweel">Ahmed N. El-Taweel</name>
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, Giza 12311,<country>Egypt</country>
</nlm:aff>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Atea, Mohamed" sort="Atea, Mohamed" uniqKey="Atea M" first="Mohamed" last="Atea">Mohamed Atea</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>General Organization of Veterinary Services, Ministry of Agriculture and Land Reclamation</institution>
, Giza 11772,<country>Egypt</country>
</nlm:aff>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Hassan, Nagla" sort="Hassan, Nagla" uniqKey="Hassan N" first="Nagla" last="Hassan">Nagla Hassan</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>General Organization of Veterinary Services, Ministry of Agriculture and Land Reclamation</institution>
, Giza 11772,<country>Egypt</country>
</nlm:aff>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Bagato, Ola" sort="Bagato, Ola" uniqKey="Bagato O" first="Ola" last="Bagato">Ola Bagato</name>
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, Giza 12311,<country>Egypt</country>
</nlm:aff>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Moatasim, Yassmin" sort="Moatasim, Yassmin" uniqKey="Moatasim Y" first="Yassmin" last="Moatasim">Yassmin Moatasim</name>
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, Giza 12311,<country>Egypt</country>
</nlm:aff>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Mahmoud, Sara H" sort="Mahmoud, Sara H" uniqKey="Mahmoud S" first="Sara H" last="Mahmoud">Sara H. Mahmoud</name>
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</nlm:aff>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Kutkat, Omnia" sort="Kutkat, Omnia" uniqKey="Kutkat O" first="Omnia" last="Kutkat">Omnia Kutkat</name>
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, Giza 12311,<country>Egypt</country>
</nlm:aff>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Maatouq, Asmaa M" sort="Maatouq, Asmaa M" uniqKey="Maatouq A" first="Asmaa M" last="Maatouq">Asmaa M. Maatouq</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Center of Scientific Excellence for Influenza Viruses, National Research Centre</institution>
, Giza 12311,<country>Egypt</country>
</nlm:aff>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Osman, Ahmed" sort="Osman, Ahmed" uniqKey="Osman A" first="Ahmed" last="Osman">Ahmed Osman</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Biochemistry, Faculty of Science, Ain Shams University</institution>
, Cairo 38105,<country>Egypt</country>
</nlm:aff>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mckenzie, Pamela P" sort="Mckenzie, Pamela P" uniqKey="Mckenzie P" first="Pamela P" last="Mckenzie">Pamela P. Mckenzie</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Infectious Diseases, St Jude Children's Research Hospital</institution>
, Memphis, TN 77030,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Webby, Richard J" sort="Webby, Richard J" uniqKey="Webby R" first="Richard J" last="Webby">Richard J. Webby</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Infectious Diseases, St Jude Children's Research Hospital</institution>
, Memphis, TN 77030,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kayali, Ghazi" sort="Kayali, Ghazi" uniqKey="Kayali G" first="Ghazi" last="Kayali">Ghazi Kayali</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas</institution>
, Houston, TX 77030,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Human Link</institution>
, Baabda 1107-2090,<country>Lebanon</country>
</nlm:aff>
<country xml:lang="fr">Liban</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Emerging Microbes & Infections</title>
<idno type="eISSN">2222-1751</idno>
<imprint><date when="2017">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antibodies, Viral (blood)</term>
<term>Body Fluids (virology)</term>
<term>Camelus (virology)</term>
<term>Cattle</term>
<term>Coronavirus Infections (diagnosis)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Coronavirus Infections (veterinary)</term>
<term>Disease Outbreaks</term>
<term>Egypt (epidemiology)</term>
<term>Epidemiological Monitoring</term>
<term>Female</term>
<term>Male</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
<term>Middle East Respiratory Syndrome Coronavirus (immunology)</term>
<term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term>
<term>Molecular Diagnostic Techniques</term>
<term>Nasal Mucosa (virology)</term>
<term>RNA, Viral (analysis)</term>
<term>Rectum (virology)</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Seroepidemiologic Studies</term>
<term>Serologic Tests</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (analyse)</term>
<term>Animaux</term>
<term>Anticorps antiviraux (sang)</term>
<term>Bovins</term>
<term>Chameaux (virologie)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term>
<term>Femelle</term>
<term>Flambées de maladies</term>
<term>Infections à coronavirus (diagnostic)</term>
<term>Infections à coronavirus (médecine vétérinaire)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Liquides biologiques (virologie)</term>
<term>Muqueuse nasale (virologie)</term>
<term>Mâle</term>
<term>RT-PCR</term>
<term>Rectum (virologie)</term>
<term>Techniques de diagnostic moléculaire</term>
<term>Tests sérologiques</term>
<term>Égypte (épidémiologie)</term>
<term>Épidémiosurveillance</term>
<term>Études séroépidémiologiques</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term>
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</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ARN viral</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Egypt</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chameaux</term>
<term>Liquides biologiques</term>
<term>Muqueuse nasale</term>
<term>Rectum</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Body Fluids</term>
<term>Camelus</term>
<term>Nasal Mucosa</term>
<term>Rectum</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Égypte</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cattle</term>
<term>Disease Outbreaks</term>
<term>Epidemiological Monitoring</term>
<term>Female</term>
<term>Male</term>
<term>Molecular Diagnostic Techniques</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Seroepidemiologic Studies</term>
<term>Serologic Tests</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Bovins</term>
<term>Femelle</term>
<term>Flambées de maladies</term>
<term>Mâle</term>
<term>RT-PCR</term>
<term>Techniques de diagnostic moléculaire</term>
<term>Tests sérologiques</term>
<term>Épidémiosurveillance</term>
<term>Études séroépidémiologiques</term>
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<front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe human infections and dromedary camels are considered an intermediary host. The dynamics of natural infection in camels are not well understood. Through systematic surveillance in Egypt, nasal, rectal, milk, urine and serum samples were collected from camels between June 2014 and February 2016. Locations included quarantines, markets, abattoirs, free-roaming herds and farmed breeding herds. The overall seroprevalence was 71% and RNA detection rate was 15%. Imported camels had higher seroprevalence (90% vs 61%) and higher RT-PCR detection rates (21% vs 12%) than locally raised camels. Juveniles had lower seroprevalence than adults (37% vs 82%) but similar RT-PCR detection rates (16% vs 15%). An outbreak in a breeding herd, showed that antibodies rapidly wane, that camels become re-infected, and that outbreaks in a herd are sustained for an extended time. Maternal antibodies titers were very low in calves regardless of the antibody titers of the mothers. Our results support the hypothesis that camels are a reservoir for MERS-CoV and that camel trade is an important route of introducing the virus into importing countries. Findings related to waning antibodies and re-infection have implications for camel vaccine development, disease management and zoonotic threat.</p>
</div>
</front>
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