MersV1, Main, Curation, bibRecord, 000A00

Distribution and absence of generalized lesions in mice following single dose intramuscular inoculation of the vaccine candidate MVA-MERS-S

Identifieur interne : 000A00 ( Main/Curation ); précédent : 000999; suivant : 000A01

Distribution and absence of generalized lesions in mice following single dose intramuscular inoculation of the vaccine candidate MVA-MERS-S

Auteurs : Martin C. Langenmayer [Allemagne] ; Anna-Theresa Lülf-Averhoff [Allemagne] ; Silvia Adam-Neumair [Allemagne] ; Robert Fux [Allemagne] ; Gerd Sutter [Allemagne] ; Asisa Volz [Allemagne]

Source :

Biologicals [ 1045-1056 ] ; 2018.

RBID : PMC:7128986

Descripteurs français

KwdFr :
- Animaux, Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Infections à coronavirus (), Infections à coronavirus (immunologie), Injections musculaires, Souris, Vaccination, Vaccins antiviraux (immunologie), Vaccins antiviraux (pharmacologie), Virus de la vaccine (immunologie).
MESH :
- immunologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Infections à coronavirus, Vaccins antiviraux, Virus de la vaccine.
- pharmacologie : Vaccins antiviraux.
- Animaux, Infections à coronavirus, Injections musculaires, Souris, Vaccination.

English descriptors

KwdEn :
- Animals, Coronavirus Infections (immunology), Coronavirus Infections (prevention & control), Injections, Intramuscular, Mice, Middle East Respiratory Syndrome Coronavirus (immunology), Vaccination, Vaccinia virus (immunology), Viral Vaccines (immunology), Viral Vaccines (pharmacology).
MESH :
- chemical , immunology : Viral Vaccines.
- immunology : Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus, Vaccinia virus.
- chemical , pharmacology : Viral Vaccines.
- prevention & control : Coronavirus Infections.
- Animals, Injections, Intramuscular, Mice, Vaccination.

Abstract

Modified Vaccinia Virus Ankara (MVA) is a highly attenuated and replication-deficient virus serving as vaccine against infectious diseases. Here, we assessed the in vivo distribution of a recombinant MVA candidate vaccine against the Middle Eastern Respiratory Syndrome (MVA-MERS-S) in mice. Intramuscularly inoculated mice were necropsied at different time points and examined by histology, immunohistochemistry and real-time PCR. We detected inflammation and myonecrosis at the parenteral site and hyperplasia of the draining lymph nodes. MVA-MERS-S did not result in detectable lesions in tissues peripheral to the parenteral site and draining lymph nodes. Real-time PCR analysis of >240 tissue samples detected MVA-DNA predominantly at the injection site and in the draining lymph nodes, and suggested continuous clearance of the candidate vaccine during the observation period. Levels of parenteral site inflammation and hyperplasia of draining lymph nodes were considered in line with immunological responses to vaccine inoculation.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128986

DOI: 10.1016/j.biologicals.2018.05.004
PubMed: 29759890
PubMed Central: 7128986

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PMC:7128986

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Modified Vaccinia Virus Ankara (MVA) is a highly attenuated and replication-deficient virus serving as vaccine against infectious diseases. Here, we assessed the <italic>in vivo</italic>
 distribution of a recombinant MVA candidate vaccine against the Middle Eastern Respiratory Syndrome (MVA-MERS-S) in mice. Intramuscularly inoculated mice were necropsied at different time points and examined by histology, immunohistochemistry and real-time PCR. We detected inflammation and myonecrosis at the parenteral site and hyperplasia of the draining lymph nodes. MVA-MERS-S did not result in detectable lesions in tissues peripheral to the parenteral site and draining lymph nodes. Real-time PCR analysis of >240 tissue samples detected MVA-DNA predominantly at the injection site and in the draining lymph nodes, and suggested continuous clearance of the candidate vaccine during the observation period. Levels of parenteral site inflammation and hyperplasia of draining lymph nodes were considered in line with immunological responses to vaccine inoculation.</p>
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</author>
<author><name sortKey="Hochstein Mintzel, V" uniqKey="Hochstein Mintzel V">V. Hochstein-Mintzel</name>
</author>
<author><name sortKey="Stickl, H" uniqKey="Stickl H">H. Stickl</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Volz, A" uniqKey="Volz A">A. Volz</name>
</author>
<author><name sortKey="Sutter, G" uniqKey="Sutter G">G. Sutter</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Verheust, C" uniqKey="Verheust C">C. Verheust</name>
</author>
<author><name sortKey="Goossens, M" uniqKey="Goossens M">M. Goossens</name>
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</author>
</analytic>
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</author>
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</author>
</analytic>
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</author>
<author><name sortKey="Mcmichael, A J" uniqKey="Mcmichael A">A.J. McMichael</name>
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<biblStruct><analytic><author><name sortKey="Hanke, T" uniqKey="Hanke T">T. Hanke</name>
</author>
<author><name sortKey="Mcmichael, A J" uniqKey="Mcmichael A">A.J. McMichael</name>
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<author><name sortKey="Crome, S J" uniqKey="Crome S">S.J. Crome</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ondondo, B" uniqKey="Ondondo B">B. Ondondo</name>
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<author><name sortKey="Brennan, C" uniqKey="Brennan C">C. Brennan</name>
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<author><name sortKey="Hanke, T" uniqKey="Hanke T">T. Hanke</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stittelaar, K J" uniqKey="Stittelaar K">K.J. Stittelaar</name>
</author>
<author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T. Kuiken</name>
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<author><name sortKey="De Swart, R L" uniqKey="De Swart R">R.L. de Swart</name>
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<author><name sortKey="Van Amerongen, G" uniqKey="Van Amerongen G">G. van Amerongen</name>
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<author><name sortKey="Vos, H W" uniqKey="Vos H">H.W. Vos</name>
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<author><name sortKey="Niesters, H G" uniqKey="Niesters H">H.G. Niesters</name>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Sanchez Sampedro, L" uniqKey="Sanchez Sampedro L">L. Sanchez-Sampedro</name>
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<author><name sortKey="Perdiguero, B" uniqKey="Perdiguero B">B. Perdiguero</name>
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</biblStruct>
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</div1>
</back>
</TEI>
</record>

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   |texte=   Distribution and absence of generalized lesions in mice following single dose intramuscular inoculation of the vaccine candidate MVA-MERS-S
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	Serveur d'exploration MERS
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Serveur d'exploration MERS

Distribution and absence of generalized lesions in mice following single dose intramuscular inoculation of the vaccine candidate MVA-MERS-S

Distribution and absence of generalized lesions in mice following single dose intramuscular inoculation of the vaccine candidate MVA-MERS-S

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