Glucocorticosteroid inhibition of cytokine production: Relevance to antiallergic actions
Identifieur interne : 002621 ( Istex/Curation ); précédent : 002620; suivant : 002622Glucocorticosteroid inhibition of cytokine production: Relevance to antiallergic actions
Auteurs : Lisa A. Schwiebert [États-Unis] ; Lisa A. Beck [États-Unis] ; Cristiana Stellato [États-Unis] ; Carol A. Bickel [États-Unis] ; Bruce S. Bochner [États-Unis] ; Robert P. Schleimer [États-Unis]Source :
- The Journal of Allergy and Clinical Immunology [ 0091-6749 ] ; 1996.
English descriptors
- Teeft :
- Activator, Acute response, Adhesion, Airway, Airway epithelial cells, Airway inflammation, Allergic, Allergic reactions, Allergy, Allergy clin immunol january, Allergy clin immunol volume, Antiinflammatory, Asthma, Basophil, Bochner, Cell types, Chemokine, Chemokine rantes, Chemokines, Clin, Cytokine, Differential display, Endothelial, Endothelial activation, Endothelial cells, Endothelium, Eosinophil, Eosinophil migration, Eosinophil survival, Epithelial, Epithelial cells, Gene expression, Glucocorticoid, Glucocorticoid receptor, Human eosinophils, Immunol, Inflammation, Inflammatory, Inflammatory cells, Inflammatory mediators, Inflammatory response, Inhaled, Interleukin, Leukocyte, Lichtenstein, Lymphocyte, Macrophage, Mast cells, Mediator, Monocyte, Mrna, Neutrophil, Original magnification, Proc natl acad, Rantes, Rantes expression, Receptor, Respir, Respir cell, Schleimer, Schwiebert, Steroid, Vascular cell adhesion, Ying.
Abstract
Summary: We believe that there are the following four classes of glucocorticoid-sensitive cytokines that are involved in cell recruitment: (1) those that activate endothelium nonspecifically; (2) those that activate endothelium specifically; (3) those that activate, prime, and prolong the survival of eosinophils; and (4) those that stimulate movement of cells up into the epithelium. Glucocorticoids inhibit the generation of these cytokines and thereby prevent several different aspects of inflamation, including the activation and recruitment of inflammatory cells (eosinophils, basophils, and lymphocytes) and the release of inflammatory mediators. We believe such pleiotropic actions account for the efficacy and widespread use of glucocorticoids in the treatment of asthma.
Url:
DOI: 10.1016/S0091-6749(96)80214-4
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Glucocorticoids inhibit the generation of these cytokines and thereby prevent several different aspects of inflamation, including the activation and recruitment of inflammatory cells (eosinophils, basophils, and lymphocytes) and the release of inflammatory mediators. We believe such pleiotropic actions account for the efficacy and widespread use of glucocorticoids in the treatment of asthma.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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