Biogenesis and function of endogenous and exogenous siRNAs
Identifieur interne : 002445 ( Istex/Curation ); précédent : 002444; suivant : 002446Biogenesis and function of endogenous and exogenous siRNAs
Auteurs : Nicholas M. Snead [États-Unis] ; John J. Rossi [États-Unis]Source :
- Wiley Interdisciplinary Reviews ‐ RNA [ 1757-7004 ] ; 2010-07.
English descriptors
- Teeft :
- Ago2, Biogenesis, Biol, Biotechnol, Caenorhabditis elegans, Cell biol, Cleavage, Complementarity, Cullen, Degradation, Dicer, Dicer processing, Drosophila, Dsrna, Duplex, Duplex region, Embo, Endogenous, Exogenous, Exogenous sirnas, Exogenously, Gene, Gene expression, Guide strand, Hairpin, Helicase, Helicase domain, Human cells, Human dicer, Mammalian cells, Microrna, Microrna targets, Micrornas, Mirisc, Mirna, Mirnas, Mrna, Natl, Nucleic, Nucleic acids, Nucleotide, Overhang, Passenger strand, Pathway, Polya tail, Polymerase, Posttranscriptional gene, Proc natl acad, Risc, Risc loading, Rna, Rnai, Rnai triggers, Rnaibased therapeutics, Rnase, Sequence complementarity, Serum stability, Short hairpin rnas, Shrna, Shrnas, Sirna, Sirna sequences, Sirna variants, Sirnas, Slicer, Small rnas, Strand, Strand selection, Struct, Target mrna, Target mrnas, Therapeutics, Translation initiation, Translational, Translational repression, Trbp, Viral, Viral vectors, Wang.
Abstract
RNA interference (RNAi) is a sequence‐specific gene silencing, or ‘knockdown’, mechanism facilitated by short duplex strands of RNA with sequence complementarity to target mRNAs. RNAi has many different forms, including posttranscriptional gene silencing (PTGS), and transcriptional gene silencing (TGS). Here, we review the biogenesis and function of an endogenous set of small RNA gene regulators, called microRNAs, as well as the mechanism of exogenously delivered small interfering RNAs. The potential applications of RNAi‐based therapeutics are also highlighted. Copyright © 2010 John Wiley & Sons, Ltd. For further resources related to this article, please visit the WIREs website
Url:
DOI: 10.1002/wrna.14
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