Biogenesis and function of endogenous and exogenous siRNAs
Identifieur interne : 002445 ( Istex/Corpus ); précédent : 002444; suivant : 002446Biogenesis and function of endogenous and exogenous siRNAs
Auteurs : Nicholas M. Snead ; John J. RossiSource :
- Wiley Interdisciplinary Reviews ‐ RNA [ 1757-7004 ] ; 2010-07.
English descriptors
- Teeft :
- Ago2, Biogenesis, Biol, Biotechnol, Caenorhabditis elegans, Cell biol, Cleavage, Complementarity, Cullen, Degradation, Dicer, Dicer processing, Drosophila, Dsrna, Duplex, Duplex region, Embo, Endogenous, Exogenous, Exogenous sirnas, Exogenously, Gene, Gene expression, Guide strand, Hairpin, Helicase, Helicase domain, Human cells, Human dicer, Mammalian cells, Microrna, Microrna targets, Micrornas, Mirisc, Mirna, Mirnas, Mrna, Natl, Nucleic, Nucleic acids, Nucleotide, Overhang, Passenger strand, Pathway, Polya tail, Polymerase, Posttranscriptional gene, Proc natl acad, Risc, Risc loading, Rna, Rnai, Rnai triggers, Rnaibased therapeutics, Rnase, Sequence complementarity, Serum stability, Short hairpin rnas, Shrna, Shrnas, Sirna, Sirna sequences, Sirna variants, Sirnas, Slicer, Small rnas, Strand, Strand selection, Struct, Target mrna, Target mrnas, Therapeutics, Translation initiation, Translational, Translational repression, Trbp, Viral, Viral vectors, Wang.
Abstract
RNA interference (RNAi) is a sequence‐specific gene silencing, or ‘knockdown’, mechanism facilitated by short duplex strands of RNA with sequence complementarity to target mRNAs. RNAi has many different forms, including posttranscriptional gene silencing (PTGS), and transcriptional gene silencing (TGS). Here, we review the biogenesis and function of an endogenous set of small RNA gene regulators, called microRNAs, as well as the mechanism of exogenously delivered small interfering RNAs. The potential applications of RNAi‐based therapeutics are also highlighted. Copyright © 2010 John Wiley & Sons, Ltd. For further resources related to this article, please visit the WIREs website
Url:
DOI: 10.1002/wrna.14
Links to Exploration step
ISTEX:93897BB487467E7C390766BE1FCE4AA61270F200Le document en format XML
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Copyright © 2010 John Wiley & Sons, Ltd.</p><p>For further resources related to this article, please visit the <ref type="url">http://wires.wiley.com/remdoi.cgi?doi=10.1002/wrna.14</ref></p></abstract><textClass><keywords rend="articleCategory"><term>Advanced Review</term></keywords><keywords rend="tocHeading1"><term>Advanced Reviews</term></keywords></textClass><textClass><keywords ana="subject"><term ref="psi.wiley.com/subject/17577004/RIAB">Biogenesis of Effector Small RNAs</term><term ref="psi.wiley.com/subject/17577004/RIAC">RNAi‐Mechanisms of Action</term><term ref="psi.wiley.com/subject/17577004/RJAB">RNA in Disease</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-XB0C46B0-6/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Inc.</publisherName><publisherLoc>Hoboken, USA</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1757-7012</doi><issn type="print">1757-7004</issn><issn type="electronic">1757-7012</issn><idGroup><id type="product" value="WRNA"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="WILEY INTERDISCIPLINARY REVIEWS - RNA">Wiley Interdisciplinary Reviews ‐ RNA</title><title type="short">WIREs RNA</title></titleGroup></publicationMeta><publicationMeta level="part" position="10"><doi origin="wiley" registered="yes">10.1002/wrna.v1:1</doi><numberingGroup><numbering type="journalVolume" number="1">1</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="2010-07">July/August 2010</coverDate></publicationMeta><publicationMeta level="unit" type="miscellaneous" position="100" status="forIssue"><doi origin="wiley" registered="yes">10.1002/wrna.14</doi><idGroup><id type="unit" value="WRNA14"></id></idGroup><countGroup><count type="pageTotal" number="15"></count></countGroup><titleGroup><title type="articleCategory">Advanced Review</title><title type="tocHeading1">Advanced Reviews</title></titleGroup><copyright ownership="publisher">Copyright © 2010 John Wiley & Sons, Ltd.</copyright><eventGroup><event type="publishedOnlineEarlyUnpaginated" date="2010-05-06"></event><event type="firstOnline" date="2010-05-06"></event><event type="publishedOnlineFinalForm" date="2010-06-22"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.15 mode:FullText source:FullText result:FullText" date="2010-07-15"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-10"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-11-04"></event></eventGroup><numberingGroup><numbering type="pageFirst">117</numbering><numbering type="pageLast">131</numbering></numberingGroup><correspondenceTo>Department of Molecular and Cellular Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA</correspondenceTo><subjectInfo><subject href="psi.wiley.com/subject/17577004/RIAB">Biogenesis of Effector Small RNAs</subject><subject href="psi.wiley.com/subject/17577004/RIAC">RNAi‐Mechanisms of Action</subject><subject href="psi.wiley.com/subject/17577004/RJAB">RNA in Disease</subject></subjectInfo><linkGroup><link type="toTypesetVersion" href="file:WRNA.WRNA14.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="0"></count><count type="referenceTotal" number="140"></count></countGroup><titleGroup><title type="main" xml:lang="en">Biogenesis and function of endogenous and exogenous siRNAs</title><title type="short" xml:lang="en">Endogenous and exogenous siRNAs</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Nicholas M.</givenNames><familyName>Snead</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><givenNames>John J.</givenNames><familyName>Rossi</familyName></personName><contactDetails><email>jrossi@coh.org</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Department of Molecular and Cellular Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>RNA interference (RNAi) is a sequence‐specific gene silencing, or ‘knockdown’, mechanism facilitated by short duplex strands of RNA with sequence complementarity to target mRNAs. RNAi has many different forms, including posttranscriptional gene silencing (PTGS), and transcriptional gene silencing (TGS). Here, we review the biogenesis and function of an endogenous set of small RNA gene regulators, called microRNAs, as well as the mechanism of exogenously delivered small interfering RNAs. The potential applications of RNAi‐based therapeutics are also highlighted. Copyright © 2010 John Wiley & Sons, Ltd.</p><p>For further resources related to this article, please visit the <url href="http://wires.wiley.com/remdoi.cgi?doi=10.1002/wrna.14">WIREs website</url></p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Biogenesis and function of endogenous and exogenous siRNAs</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Endogenous and exogenous siRNAs</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Biogenesis and function of endogenous and exogenous siRNAs</title></titleInfo><name type="personal"><namePart type="given">Nicholas M.</namePart><namePart type="family">Snead</namePart><affiliation>Department of Molecular and Cellular Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA</affiliation><affiliation>Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John J.</namePart><namePart type="family">Rossi</namePart><affiliation>Department of Molecular and Cellular Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA</affiliation><affiliation>Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA</affiliation><affiliation>E-mail: jrossi@coh.org</affiliation><affiliation>Correspondence address: Department of Molecular and Cellular Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="miscellaneous" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>John Wiley & Sons, Inc.</publisher><place><placeTerm type="text">Hoboken, USA</placeTerm></place><dateIssued encoding="w3cdtf">2010-07</dateIssued><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">2</extent><extent unit="tables">0</extent><extent unit="references">140</extent></physicalDescription><abstract lang="en">RNA interference (RNAi) is a sequence‐specific gene silencing, or ‘knockdown’, mechanism facilitated by short duplex strands of RNA with sequence complementarity to target mRNAs. RNAi has many different forms, including posttranscriptional gene silencing (PTGS), and transcriptional gene silencing (TGS). Here, we review the biogenesis and function of an endogenous set of small RNA gene regulators, called microRNAs, as well as the mechanism of exogenously delivered small interfering RNAs. The potential applications of RNAi‐based therapeutics are also highlighted. Copyright © 2010 John Wiley & Sons, Ltd. For further resources related to this article, please visit the WIREs website</abstract><relatedItem type="host"><titleInfo><title>Wiley Interdisciplinary Reviews ‐ RNA</title></titleInfo><titleInfo type="abbreviated"><title>WIREs RNA</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>index-terms</genre><topic authorityURI="psi.wiley.com/subject/17577004/RIAB">Biogenesis of Effector Small RNAs</topic><topic authorityURI="psi.wiley.com/subject/17577004/RIAC">RNAi‐Mechanisms of Action</topic><topic authorityURI="psi.wiley.com/subject/17577004/RJAB">RNA in Disease</topic></subject><subject><genre>article-category</genre><topic>Advanced Review</topic><topic>Advanced Reviews</topic></subject><identifier type="ISSN">1757-7004</identifier><identifier type="eISSN">1757-7012</identifier><identifier type="DOI">10.1002/(ISSN)1757-7012</identifier><identifier type="PublisherID">WRNA</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>117</start><end>131</end><total>15</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Introduction of a chimeric chalcone synthase gene into petunia results in reversible co‐suppression of homologous genes in trans</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Napoli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Lemieux</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Jorgensen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Napoli C, Lemieux C, Jorgensen R. 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