Cell Type-Specific Expression of Fasciclin II Isoforms Reveals Neuronal–Glial Interactions during Peripheral Nerve Growth
Identifieur interne : 001851 ( Istex/Curation ); précédent : 001850; suivant : 001852Cell Type-Specific Expression of Fasciclin II Isoforms Reveals Neuronal–Glial Interactions during Peripheral Nerve Growth
Auteurs : Jay W. Wright ; Philip F. CopenhaverSource :
- Developmental Biology [ 0012-1606 ] ; 2001.
English descriptors
- KwdEn :
- Teeft :
- Academic press, Adhesion, Antisense, Antisense odns, Arrowhead, Axon, Axon fascicles, Axon outgrowth, Axon pathways, Axonal, Axonal guidance, Bastiani, Biol, Black arrowhead, Black arrowheads, Black arrows, Bridge formation, Bridge glia, Cellular motility, Copenhaver, Copyright, Cultured embryos, Developmental expression, Dorsal, Dorsal nerve, Drosophila, Embryo, Embryogenesis, Embryonic, Embryonic development, Ensheathed, Extracellular, Extracellular domain, Fascicle, Fasciclin, Ganglion, Genetic analysis, Glia, Glial, Glial bridge, Glial cells, Glial interactions, Glial processes, Goodman, Gpimfas, Grasshopper, Grenningloh, Growth cone guidance, Growth cones, Harrelson, Hybridization, Hybridization histochemistry, Immunohistochemical staining, Immunoreactivity, Immunostained, Initial outgrowth, Isoform, Isoforms, Kinase, Large number, Lateral branch, Localized, Manduca, Manduca sexta, Mesodermal, Mfa, Motility, Motor axons, Motor terminals, Mrna, Ncam, Nerve, Nerve branch, Nervous system, Neuromuscular junction, Neuron, Neuronal, Neuronal migration, Neuronal motility, Neurosci, Nomarski optics, Nonneural cells, Odns, Other insects, Outgrowth, Pathway, Peripheral glia, Peripheral glial cells, Peripheral nerves, Phenotype, Precursor, Previous work, Receptor, Schwann, Schwann cells, Short processes, Soma, Spiracle, Subsequent trajectories, Subset, Synapse formation, Synaptic, Taghert, Target muscles, Trajectory, Transmembrane, Transmembrane isoform, Transverse nerve, Vertebrate, White arrowhead, White arrows.
Abstract
Abstract: During the formation of the insect peripheral nervous system (PNS), the cell adhesion receptor fasciclin II has been shown to play a prominent role in axonal fasciculation and synapse formation during motor neuron outgrowth. In the moth Manduca, fasciclin II (MFas II) is expressed both as a transmembrane isoform (TM-MFas II) and a glycosyl phosphatidylinositol-linked isoform (GPI-MFas II). By using RNA and antibody probes, we have shown that these two isoforms are expressed in nonoverlapping patterns: TM-MFas II is expressed exclusively by neurons and becomes localized to their most motile regions, while GPI-MFas II is expressed primarily by the glial cells that ensheath the peripheral nerves. This cell-type specificity of expression allowed us to monitor the nature of neuronal–glial interactions during PNS development. The outgrowth of TM-MFas II-positive axons in many regions preceded the arrival of GPI-MFas II-expressing glial processes that enwrapped them. In a few key locations, however, GPI-MFas II-positive glial cells differentiated before the arrival of the first axons and prefigured their subsequent trajectories. Prior inhibition of GPI-MFas II expression disrupted the subsequent outgrowth of axons at these locations but not elsewhere in the PNS. Our results suggest that the two isoforms of MFas II play distinct roles with respect to cellular motility and nerve formation.
Url:
DOI: 10.1006/dbio.2001.0247
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Jay W. Wright<affiliation><mods:affiliation>Department of Cell and Developmental Biology L-215, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, Oregon, 97201</mods:affiliation><wicri:noCountry code="subField">97201</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Cell and Developmental Biology L-215, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, Oregon, 97201</mods:affiliation><wicri:noCountry code="subField">97201</wicri:noCountry></affiliation>Le document en format XML
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Copenhaver</name><affiliation><mods:affiliation>Department of Cell and Developmental Biology L-215, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, Oregon, 97201</mods:affiliation><wicri:noCountry code="subField">97201</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9B1FEFC0F55C6A9A8B8EC252133E4F39349D1959</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1006/dbio.2001.0247</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-1LWFF0V5-Q/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001851</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001851</idno><idno type="wicri:Area/Istex/Curation">001851</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cell Type-Specific Expression of Fasciclin II Isoforms Reveals Neuronal–Glial Interactions during Peripheral Nerve Growth</title><author><name sortKey="Wright, Jay W" sort="Wright, Jay W" uniqKey="Wright J" first="Jay W." last="Wright">Jay W. 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Copenhaver</name><affiliation><mods:affiliation>Department of Cell and Developmental Biology L-215, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, Oregon, 97201</mods:affiliation><wicri:noCountry code="subField">97201</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Developmental Biology</title><title level="j" type="abbrev">YDBIO</title><idno type="ISSN">0012-1606</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001">2001</date><biblScope unit="volume">234</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="24">24</biblScope><biblScope unit="page" to="41">41</biblScope></imprint><idno type="ISSN">0012-1606</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0012-1606</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Manduca sexta.</term><term>adhesion</term><term>fasciculation</term><term>growth cone</term><term>insect</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Academic press</term><term>Adhesion</term><term>Antisense</term><term>Antisense odns</term><term>Arrowhead</term><term>Axon</term><term>Axon fascicles</term><term>Axon outgrowth</term><term>Axon pathways</term><term>Axonal</term><term>Axonal guidance</term><term>Bastiani</term><term>Biol</term><term>Black arrowhead</term><term>Black arrowheads</term><term>Black arrows</term><term>Bridge formation</term><term>Bridge glia</term><term>Cellular motility</term><term>Copenhaver</term><term>Copyright</term><term>Cultured embryos</term><term>Developmental expression</term><term>Dorsal</term><term>Dorsal nerve</term><term>Drosophila</term><term>Embryo</term><term>Embryogenesis</term><term>Embryonic</term><term>Embryonic development</term><term>Ensheathed</term><term>Extracellular</term><term>Extracellular domain</term><term>Fascicle</term><term>Fasciclin</term><term>Ganglion</term><term>Genetic analysis</term><term>Glia</term><term>Glial</term><term>Glial bridge</term><term>Glial cells</term><term>Glial interactions</term><term>Glial processes</term><term>Goodman</term><term>Gpimfas</term><term>Grasshopper</term><term>Grenningloh</term><term>Growth cone guidance</term><term>Growth cones</term><term>Harrelson</term><term>Hybridization</term><term>Hybridization histochemistry</term><term>Immunohistochemical staining</term><term>Immunoreactivity</term><term>Immunostained</term><term>Initial outgrowth</term><term>Isoform</term><term>Isoforms</term><term>Kinase</term><term>Large number</term><term>Lateral branch</term><term>Localized</term><term>Manduca</term><term>Manduca sexta</term><term>Mesodermal</term><term>Mfa</term><term>Motility</term><term>Motor axons</term><term>Motor terminals</term><term>Mrna</term><term>Ncam</term><term>Nerve</term><term>Nerve branch</term><term>Nervous system</term><term>Neuromuscular junction</term><term>Neuron</term><term>Neuronal</term><term>Neuronal migration</term><term>Neuronal motility</term><term>Neurosci</term><term>Nomarski optics</term><term>Nonneural cells</term><term>Odns</term><term>Other insects</term><term>Outgrowth</term><term>Pathway</term><term>Peripheral glia</term><term>Peripheral glial cells</term><term>Peripheral nerves</term><term>Phenotype</term><term>Precursor</term><term>Previous work</term><term>Receptor</term><term>Schwann</term><term>Schwann cells</term><term>Short processes</term><term>Soma</term><term>Spiracle</term><term>Subsequent trajectories</term><term>Subset</term><term>Synapse formation</term><term>Synaptic</term><term>Taghert</term><term>Target muscles</term><term>Trajectory</term><term>Transmembrane</term><term>Transmembrane isoform</term><term>Transverse nerve</term><term>Vertebrate</term><term>White arrowhead</term><term>White arrows</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: During the formation of the insect peripheral nervous system (PNS), the cell adhesion receptor fasciclin II has been shown to play a prominent role in axonal fasciculation and synapse formation during motor neuron outgrowth. In the moth Manduca, fasciclin II (MFas II) is expressed both as a transmembrane isoform (TM-MFas II) and a glycosyl phosphatidylinositol-linked isoform (GPI-MFas II). By using RNA and antibody probes, we have shown that these two isoforms are expressed in nonoverlapping patterns: TM-MFas II is expressed exclusively by neurons and becomes localized to their most motile regions, while GPI-MFas II is expressed primarily by the glial cells that ensheath the peripheral nerves. This cell-type specificity of expression allowed us to monitor the nature of neuronal–glial interactions during PNS development. The outgrowth of TM-MFas II-positive axons in many regions preceded the arrival of GPI-MFas II-expressing glial processes that enwrapped them. In a few key locations, however, GPI-MFas II-positive glial cells differentiated before the arrival of the first axons and prefigured their subsequent trajectories. Prior inhibition of GPI-MFas II expression disrupted the subsequent outgrowth of axons at these locations but not elsewhere in the PNS. Our results suggest that the two isoforms of MFas II play distinct roles with respect to cellular motility and nerve formation.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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