Mice Chronically Infected with Chimeric HIV Resist Peripheral and Brain Superinfection: A Model of Protective Immunity to HIV
Identifieur interne : 001098 ( Istex/Curation ); précédent : 001097; suivant : 001099Mice Chronically Infected with Chimeric HIV Resist Peripheral and Brain Superinfection: A Model of Protective Immunity to HIV
Auteurs : Jennifer L. Kelschenbach [États-Unis] ; Manisha Saini [États-Unis] ; Eran Hadas [États-Unis] ; Chao-Jiang Gu [États-Unis] ; Wei Chao [États-Unis, Niger] ; Galina Bentsman [États-Unis] ; Jessie P. Hong [Royaume-Uni] ; Tomas Hanke [Royaume-Uni] ; Leroy R. Sharer [États-Unis] ; Mary Jane Potash [États-Unis] ; David J. Volsky [États-Unis]Source :
- Journal of Neuroimmune Pharmacology [ 1557-1890 ] ; 2012-06-01.
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Abstract
Abstract: Infection by some viruses induces immunity to reinfection, providing a means to identify protective epitopes. To investigate resistance to reinfection in an animal model of HIV disease and its control, we employed infection of mice with chimeric HIV, EcoHIV. When immunocompetent mice were infected by intraperitoneal (IP) injection of EcoHIV, they resisted subsequent secondary infection by IP injection, consistent with a systemic antiviral immune response. To investigate the potential role of these responses in restricting neurotropic HIV infection, we established a protocol for efficient EcoHIV expression in the brain following intracranial (IC) inoculation of virus. When mice were inoculated by IP injection and secondarily by IC injection, they also controlled EcoHIV replication in the brain. To investigate their role in EcoHIV antiviral responses, CD8+ T lymphocytes were isolated from spleens of EcoHIV infected and uninfected mice and adoptively transferred to isogenic recipients. Recipients of EcoHIV primed CD8+ cells resisted subsequent EcoHIV infection compared to recipients of cells from uninfected donors. CD8+ spleen cells from EcoHIV-infected mice also mounted modest but significant interferon-γ responses to two HIV Gag peptide pools. These findings suggest EcoHIV-infected mice may serve as a useful system to investigate the induction of anti-HIV protective immunity for eventual translation to human beings.
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DOI: 10.1007/s11481-011-9316-1
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code="no comma">E-mail: galina_bentsman@yahoo.com</wicri:noCountry></affiliation></author><author><name sortKey="Hong, Jessie P" sort="Hong, Jessie P" uniqKey="Hong J" first="Jessie P." last="Hong">Jessie P. Hong</name><affiliation wicri:level="1"><mods:affiliation>Weatherall Institute of Molecular Medicine, University of Oxford, The John Radcliffe, OX3 9DS, Oxford, UK</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Weatherall Institute of Molecular Medicine, University of Oxford, The John Radcliffe, OX3 9DS, Oxford</wicri:regionArea></affiliation><affiliation><mods:affiliation>E-mail: jessie.hong@gmail.com</mods:affiliation><wicri:noCountry code="no comma">E-mail: jessie.hong@gmail.com</wicri:noCountry></affiliation></author><author><name sortKey="Hanke, Tomas" sort="Hanke, Tomas" uniqKey="Hanke T" first="Tomas" last="Hanke">Tomas Hanke</name><affiliation wicri:level="1"><mods:affiliation>Weatherall Institute of Molecular Medicine, University of Oxford, The John Radcliffe, OX3 9DS, Oxford, UK</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Weatherall Institute of Molecular Medicine, University of Oxford, The John Radcliffe, OX3 9DS, Oxford</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: tomas.hanke@molecular-medicine.oxford.ac.uk</mods:affiliation><country wicri:rule="url">Royaume-Uni</country></affiliation></author><author><name sortKey="Sharer, Leroy R" sort="Sharer, Leroy R" uniqKey="Sharer L" first="Leroy R." last="Sharer">Leroy R. Sharer</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, New Jersey Medical School, 07103, Newark, NJ, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, New Jersey Medical School, 07103, Newark, NJ</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: sharer@umdnj.edu</mods:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Potash, Mary Jane" sort="Potash, Mary Jane" uniqKey="Potash M" first="Mary Jane" last="Potash">Mary Jane Potash</name><affiliation wicri:level="1"><mods:affiliation>Molecular Virology Division, St. Luke’s-Roosevelt Hospital Center, 432 West 58th Street, Antenucci Research Building, Room 709, 10019, New York, NY, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Virology Division, St. Luke’s-Roosevelt Hospital Center, 432 West 58th Street, Antenucci Research Building, Room 709, 10019, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology & Cell Biology, Columbia University, 10032, New York, NY, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology & Cell Biology, Columbia University, 10032, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Volsky, David J" sort="Volsky, David J" uniqKey="Volsky D" first="David J." last="Volsky">David J. Volsky</name><affiliation wicri:level="1"><mods:affiliation>Molecular Virology Division, St. Luke’s-Roosevelt Hospital Center, 432 West 58th Street, Antenucci Research Building, Room 709, 10019, New York, NY, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Virology Division, St. Luke’s-Roosevelt Hospital Center, 432 West 58th Street, Antenucci Research Building, Room 709, 10019, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology & Cell Biology, Columbia University, 10032, New York, NY, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology & Cell Biology, Columbia University, 10032, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: djv4@columbia.edu</mods:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:4965E275D19BC1D93D36047D12435B604366B022</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1007/s11481-011-9316-1</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-VNSFD39P-R/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001098</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001098</idno><idno type="wicri:Area/Istex/Curation">001098</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Mice Chronically Infected with Chimeric HIV Resist Peripheral and Brain Superinfection: A Model of Protective Immunity to HIV</title><author><name sortKey="Kelschenbach, Jennifer L" sort="Kelschenbach, Jennifer L" uniqKey="Kelschenbach J" first="Jennifer L." last="Kelschenbach">Jennifer L. Kelschenbach</name><affiliation wicri:level="1"><mods:affiliation>Molecular Virology Division, St. Luke’s-Roosevelt Hospital Center, 432 West 58th Street, Antenucci Research Building, Room 709, 10019, New York, NY, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Virology Division, St. Luke’s-Roosevelt Hospital Center, 432 West 58th Street, Antenucci Research Building, Room 709, 10019, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology & Cell Biology, Columbia University, 10032, New York, NY, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology & Cell Biology, Columbia University, 10032, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: jlk2152@columbia.edu</mods:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Saini, Manisha" sort="Saini, Manisha" uniqKey="Saini M" first="Manisha" last="Saini">Manisha Saini</name><affiliation wicri:level="1"><mods:affiliation>Molecular Virology Division, St. Luke’s-Roosevelt Hospital Center, 432 West 58th Street, Antenucci Research Building, Room 709, 10019, New York, NY, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Virology Division, St. Luke’s-Roosevelt Hospital Center, 432 West 58th Street, Antenucci Research Building, Room 709, 10019, New York, NY</wicri:regionArea></affiliation><affiliation><mods:affiliation>E-mail: manisaini@gmail.com</mods:affiliation></affiliation></author><author><name sortKey="Hadas, Eran" sort="Hadas, Eran" uniqKey="Hadas E" first="Eran" last="Hadas">Eran Hadas</name><affiliation wicri:level="1"><mods:affiliation>Molecular Virology Division, St. Luke’s-Roosevelt Hospital Center, 432 West 58th Street, Antenucci Research Building, Room 709, 10019, New York, NY, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Virology Division, St. Luke’s-Roosevelt Hospital Center, 432 West 58th Street, Antenucci Research Building, Room 709, 10019, New York, NY</wicri:regionArea></affiliation><affiliation><mods:affiliation>E-mail: eran.hadas@gmail.com</mods:affiliation></affiliation></author><author><name sortKey="Gu, Chao Jiang" sort="Gu, Chao Jiang" uniqKey="Gu C" first="Chao-Jiang" last="Gu">Chao-Jiang Gu</name><affiliation wicri:level="1"><mods:affiliation>Molecular Virology Division, St. Luke’s-Roosevelt Hospital Center, 432 West 58th Street, Antenucci Research Building, Room 709, 10019, New York, NY, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Virology Division, St. Luke’s-Roosevelt Hospital Center, 432 West 58th Street, Antenucci Research Building, Room 709, 10019, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology & Cell Biology, Columbia University, 10032, New York, NY, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology & Cell Biology, Columbia University, 10032, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: cg2447@columbia.edu</mods:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Chao, Wei" sort="Chao, Wei" uniqKey="Chao W" first="Wei" last="Chao">Wei Chao</name><affiliation wicri:level="1"><mods:affiliation>Molecular Virology Division, St. Luke’s-Roosevelt Hospital Center, 432 West 58th Street, Antenucci Research Building, Room 709, 10019, New York, NY, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Virology Division, St. Luke’s-Roosevelt Hospital Center, 432 West 58th Street, Antenucci Research Building, Room 709, 10019, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: wei616@verizon.net</mods:affiliation><country wicri:rule="url">Niger</country></affiliation></author><author><name sortKey="Bentsman, Galina" sort="Bentsman, Galina" uniqKey="Bentsman G" first="Galina" last="Bentsman">Galina Bentsman</name><affiliation wicri:level="1"><mods:affiliation>Molecular Virology Division, St. Luke’s-Roosevelt Hospital Center, 432 West 58th Street, Antenucci Research Building, Room 709, 10019, New York, NY, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Virology Division, St. Luke’s-Roosevelt Hospital Center, 432 West 58th Street, Antenucci Research Building, Room 709, 10019, New York, NY</wicri:regionArea></affiliation><affiliation><mods:affiliation>E-mail: galina_bentsman@yahoo.com</mods:affiliation></affiliation></author><author><name sortKey="Hong, Jessie P" sort="Hong, Jessie P" uniqKey="Hong J" first="Jessie P." last="Hong">Jessie P. Hong</name><affiliation wicri:level="1"><mods:affiliation>Weatherall Institute of Molecular Medicine, University of Oxford, The John Radcliffe, OX3 9DS, Oxford, UK</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Weatherall Institute of Molecular Medicine, University of Oxford, The John Radcliffe, OX3 9DS, Oxford</wicri:regionArea></affiliation><affiliation><mods:affiliation>E-mail: jessie.hong@gmail.com</mods:affiliation></affiliation></author><author><name sortKey="Hanke, Tomas" sort="Hanke, Tomas" uniqKey="Hanke T" first="Tomas" last="Hanke">Tomas Hanke</name><affiliation wicri:level="1"><mods:affiliation>Weatherall Institute of Molecular Medicine, University of Oxford, The John Radcliffe, OX3 9DS, Oxford, UK</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Weatherall Institute of Molecular Medicine, University of Oxford, The John Radcliffe, OX3 9DS, Oxford</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: tomas.hanke@molecular-medicine.oxford.ac.uk</mods:affiliation><country wicri:rule="url">Royaume-Uni</country></affiliation></author><author><name sortKey="Sharer, Leroy R" sort="Sharer, Leroy R" uniqKey="Sharer L" first="Leroy R." last="Sharer">Leroy R. Sharer</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, New Jersey Medical School, 07103, Newark, NJ, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, New Jersey Medical School, 07103, Newark, NJ</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: sharer@umdnj.edu</mods:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Potash, Mary Jane" sort="Potash, Mary Jane" uniqKey="Potash M" first="Mary Jane" last="Potash">Mary Jane Potash</name><affiliation wicri:level="1"><mods:affiliation>Molecular Virology Division, St. Luke’s-Roosevelt Hospital Center, 432 West 58th Street, Antenucci Research Building, Room 709, 10019, New York, NY, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Virology Division, St. Luke’s-Roosevelt Hospital Center, 432 West 58th Street, Antenucci Research Building, Room 709, 10019, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology & Cell Biology, Columbia University, 10032, New York, NY, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology & Cell Biology, Columbia University, 10032, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Volsky, David J" sort="Volsky, David J" uniqKey="Volsky D" first="David J." last="Volsky">David J. Volsky</name><affiliation wicri:level="1"><mods:affiliation>Molecular Virology Division, St. Luke’s-Roosevelt Hospital Center, 432 West 58th Street, Antenucci Research Building, Room 709, 10019, New York, NY, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Virology Division, St. Luke’s-Roosevelt Hospital Center, 432 West 58th Street, Antenucci Research Building, Room 709, 10019, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology & Cell Biology, Columbia University, 10032, New York, NY, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology & Cell Biology, Columbia University, 10032, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: djv4@columbia.edu</mods:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neuroimmune Pharmacology</title><title level="j" type="abbrev">J Neuroimmune Pharmacol</title><idno type="ISSN">1557-1890</idno><idno type="eISSN">1557-1904</idno><imprint><publisher>Springer US; http://www.springer-ny.com</publisher><pubPlace>Boston</pubPlace><date type="published" when="2012-06-01">2012-06-01</date><biblScope unit="volume">7</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="380">380</biblScope><biblScope unit="page" to="387">387</biblScope></imprint><idno type="ISSN">1557-1890</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1557-1890</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptive immune responses</term><term>Brain</term><term>Chimeric HIV</term><term>HIV neuropathogenesis</term><term>Mouse model</term><term>Superinfection</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Infection by some viruses induces immunity to reinfection, providing a means to identify protective epitopes. To investigate resistance to reinfection in an animal model of HIV disease and its control, we employed infection of mice with chimeric HIV, EcoHIV. When immunocompetent mice were infected by intraperitoneal (IP) injection of EcoHIV, they resisted subsequent secondary infection by IP injection, consistent with a systemic antiviral immune response. To investigate the potential role of these responses in restricting neurotropic HIV infection, we established a protocol for efficient EcoHIV expression in the brain following intracranial (IC) inoculation of virus. When mice were inoculated by IP injection and secondarily by IC injection, they also controlled EcoHIV replication in the brain. To investigate their role in EcoHIV antiviral responses, CD8+ T lymphocytes were isolated from spleens of EcoHIV infected and uninfected mice and adoptively transferred to isogenic recipients. Recipients of EcoHIV primed CD8+ cells resisted subsequent EcoHIV infection compared to recipients of cells from uninfected donors. CD8+ spleen cells from EcoHIV-infected mice also mounted modest but significant interferon-γ responses to two HIV Gag peptide pools. These findings suggest EcoHIV-infected mice may serve as a useful system to investigate the induction of anti-HIV protective immunity for eventual translation to human beings.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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