lncRNAs regulate the innate immune response to viral infection
Identifieur interne : 001B05 ( Istex/Corpus ); précédent : 001B04; suivant : 001B06lncRNAs regulate the innate immune response to viral infection
Auteurs : Jing Ouyang ; Jiayue Hu ; Ji-Long ChenSource :
- Wiley Interdisciplinary Reviews: RNA [ 1757-7004 ] ; 2016-01.
Abstract
Long noncoding RNAs (lncRNAs) are extensively expressed in mammalian cells and play a crucial role as RNA regulators in various cellular processes. Increasing data reveal that they function in innate antiviral immunity through complex mechanisms. Thousands of lncRNAs are regulated by RNA virus or DNA virus infection. The significant differential expression of lncRNAs is induced by virus or host antiviral signaling mediated by interferons (IFNs) and tumor necrosis factor‐α. In turn, these lncRNAs modulate the host immune response including the pathogen recognition receptor (PRR)‐related signaling, the translocation and activation of transcription factors, the production of IFNs and cytokines, the IFN‐activated JAK‐STAT signaling and the transcription of antiviral IFN‐stimulated genes (ISGs). Using gain‐ or loss‐of‐function analysis, the effect of lncRNAs on viral replication has been investigated to elucidate the essential role of lncRNA in the host–virus interaction. lncRNAs have shown specifically elevated or decreased levels in patients with viral diseases, suggesting the possibility of clinical application as biomarkers. Here we review the current advances of viral infection‐associated host lncRNAs, their functional significance in different aspects of antiviral immune response, the specific mechanisms and unsolved issues. We also summarize the regulation of lncRNAs by viruses, PRR agonists and cytokines. In addition, virus‐encoded lncRNAs and their functional involvement in host–virus interaction are addressed. WIREs RNA 2016, 7:129–143. doi: 10.1002/wrna.1321 For further resources related to this article, please visit the WIREs website.
Url:
DOI: 10.1002/wrna.1321
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Increasing data reveal that they function in innate antiviral immunity through complex mechanisms. Thousands of lncRNAs are regulated by RNA virus or DNA virus infection. The significant differential expression of lncRNAs is induced by virus or host antiviral signaling mediated by interferons (IFNs) and tumor necrosis factor‐α. In turn, these lncRNAs modulate the host immune response including the pathogen recognition receptor (PRR)‐related signaling, the translocation and activation of transcription factors, the production of IFNs and cytokines, the IFN‐activated JAK‐STAT signaling and the transcription of antiviral IFN‐stimulated genes (ISGs). Using gain‐ or loss‐of‐function analysis, the effect of lncRNAs on viral replication has been investigated to elucidate the essential role of lncRNA in the host–virus interaction. lncRNAs have shown specifically elevated or decreased levels in patients with viral diseases, suggesting the possibility of clinical application as biomarkers. Here we review the current advances of viral infection‐associated host lncRNAs, their functional significance in different aspects of antiviral immune response, the specific mechanisms and unsolved issues. We also summarize the regulation of lncRNAs by viruses, PRR agonists and cytokines. In addition, virus‐encoded lncRNAs and their functional involvement in host–virus interaction are addressed. 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Microbiology</orgName><orgName type="institution">Chinese Academy of Sciences</orgName><address><settlement>Beijing</settlement><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Jiayue</forename><surname>Hu</surname></persName><affiliation><orgName type="division">CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology</orgName><orgName type="institution">Chinese Academy of Sciences</orgName><address><settlement>Beijing</settlement><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><author xml:id="author-0002" role="corresp"><persName><forename type="first">Ji‐Long</forename><surname>Chen</surname></persName><affiliation><orgName type="division">CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology</orgName><orgName type="institution">Chinese Academy of 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In turn, these <hi rend="fc">lncRNAs</hi> modulate the host immune response including the pathogen recognition receptor (<hi rend="fc">PRR</hi>)‐related signaling, the translocation and activation of transcription factors, the production of <hi rend="fc">IFNs</hi> and cytokines, the <hi rend="fc">IFN</hi>‐activated <hi rend="fc">JAK‐STAT</hi> signaling and the transcription of antiviral <hi rend="fc">IFN</hi>‐stimulated genes (<hi rend="fc">ISGs</hi>). Using gain‐ or loss‐of‐function analysis, the effect of <hi rend="fc">lncRNAs</hi> on viral replication has been investigated to elucidate the essential role of <hi rend="fc">lncRNA</hi> in the host–virus interaction. <hi rend="fc">lncRNAs</hi> have shown specifically elevated or decreased levels in patients with viral diseases, suggesting the possibility of clinical application as biomarkers. Here we review the current advances of viral infection‐associated host <hi rend="fc">lncRNAs</hi>, their functional significance in different aspects of antiviral immune response, the specific mechanisms and unsolved issues. We also summarize the regulation of <hi rend="fc">lncRNAs</hi> by viruses, <hi rend="fc">PRR</hi> agonists and cytokines. In addition, virus‐encoded <hi rend="fc">lncRNAs</hi> and their functional involvement in host–virus interaction are addressed. <hi rend="italic">WIREs RNA</hi> 2016, 7:129–143. doi: 10.1002/wrna.1321</p><p>For further resources related to this article, please visit the <ref type="url">http://wires.wiley.com/remdoi.cgi?doi=10.1002/wrna.1321</ref>.</p></abstract><textClass><keywords rend="articleCategory"><term>Advanced Review</term></keywords><keywords rend="tocHeading1"><term>Advanced Reviews</term></keywords></textClass><textClass><keywords ana="subject"><term ref="http://psi.wiley.com/subject/17577004/RJAB">RNA in Disease</term><term ref="http://psi.wiley.com/subject/17577004/RDAE">Protein–RNA Interactions—Functional Implications</term><term ref="http://psi.wiley.com/subject/17577004/RDAA">RNA Interactions with Proteins and Other Molecules</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" 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Interactions with Proteins and Other Molecules</subject></subjectInfo><linkGroup><link type="toTypesetVersion" href="file:WRNA.WRNA1321.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main"><fc>lncRNAs</fc> regulate the innate immune response to viral infection</title><title type="short"><fc>lncRNAs</fc> regulate the innate immune response</title></titleGroup><creators><creator creatorRole="author" xml:id="wrna1321-cr-0001" affiliationRef="#wrna1321-aff-0001"><personName><givenNames>Jing</givenNames><familyName>Ouyang</familyName></personName></creator><creator creatorRole="author" xml:id="wrna1321-cr-0002" affiliationRef="#wrna1321-aff-0001"><personName><givenNames>Jiayue</givenNames><familyName>Hu</familyName></personName></creator><creator creatorRole="author" xml:id="wrna1321-cr-0003" affiliationRef="#wrna1321-aff-0001 #wrna1321-aff-0002" corresponding="yes"><personName><givenNames>Ji‐Long</givenNames><familyName>Chen</familyName></personName></creator></creators><affiliationGroup xml:id="wrna1321-affgp-0001"><affiliation countryCode="CN" type="organization" xml:id="wrna1321-aff-0001"><orgDiv>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology</orgDiv><orgName>Chinese Academy of Sciences</orgName><address><city>Beijing</city><country>China</country></address></affiliation><affiliation countryCode="CN" type="organization" xml:id="wrna1321-aff-0002"><orgDiv>College of Animal Sciences</orgDiv><orgName>Fujian Agriculture and Forestry University</orgName><address><city>Fuzhou</city><country>China</country></address></affiliation></affiliationGroup><fundingInfo><fundingAgency>National Basic Research Program (973) of China</fundingAgency><fundingNumber>2015CB910502</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Natural Science Foundation of China</fundingAgency><fundingNumber>U1305212</fundingNumber></fundingInfo><fundingInfo><fundingAgency>National Key Technologies Research and Development Program of China</fundingAgency><fundingNumber>2013ZX10004‐611</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Natural Science Foundation of China</fundingAgency><fundingNumber>81590765</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:id="wrna1321-abs-0001"><p xml:id="wrna1321-para-0001">Long noncoding <fc>RNAs</fc> (<fc>lncRNAs</fc>) are extensively expressed in mammalian cells and play a crucial role as <fc>RNA</fc> regulators in various cellular processes. Increasing data reveal that they function in innate antiviral immunity through complex mechanisms. Thousands of <fc>lncRNAs</fc> are regulated by <fc>RNA</fc> virus or <fc>DNA</fc> virus infection. The significant differential expression of <fc>lncRNAs</fc> is induced by virus or host antiviral signaling mediated by interferons (<fc>IFNs</fc>) and tumor necrosis factor‐α. In turn, these <fc>lncRNAs</fc> modulate the host immune response including the pathogen recognition receptor (<fc>PRR</fc>)‐related signaling, the translocation and activation of transcription factors, the production of <fc>IFNs</fc> and cytokines, the <fc>IFN</fc>‐activated <fc>JAK‐STAT</fc> signaling and the transcription of antiviral <fc>IFN</fc>‐stimulated genes (<fc>ISGs</fc>). Using gain‐ or loss‐of‐function analysis, the effect of <fc>lncRNAs</fc> on viral replication has been investigated to elucidate the essential role of <fc>lncRNA</fc> in the host–virus interaction. <fc>lncRNAs</fc> have shown specifically elevated or decreased levels in patients with viral diseases, suggesting the possibility of clinical application as biomarkers. Here we review the current advances of viral infection‐associated host <fc>lncRNAs</fc>, their functional significance in different aspects of antiviral immune response, the specific mechanisms and unsolved issues. We also summarize the regulation of <fc>lncRNAs</fc> by viruses, <fc>PRR</fc> agonists and cytokines. In addition, virus‐encoded <fc>lncRNAs</fc> and their functional involvement in host–virus interaction are addressed. <i>WIREs RNA</i> 2016, 7:129–143. doi: 10.1002/wrna.1321</p><p>For further resources related to this article, please visit the <url href="http://wires.wiley.com/remdoi.cgi?doi=10.1002/wrna.1321">WIREs website</url>.</p></abstract></abstractGroup></contentMeta><noteGroup xml:id="wrna1321-ntgp-0001"><note xml:id="wrna1321-note-0001" numbered="no">Conflict of interest: The authors have declared no conflicts of interest for this article.</note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>lncRNAs regulate the innate immune response to viral infection</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>lncRNAs regulate the innate immune response</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>lncRNAs regulate the innate immune response to viral infection</title></titleInfo><name type="personal"><namePart type="given">Jing</namePart><namePart type="family">Ouyang</namePart><affiliation>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jiayue</namePart><namePart type="family">Hu</namePart><affiliation>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ji‐Long</namePart><namePart type="family">Chen</namePart><affiliation>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China</affiliation><affiliation>College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou, China</affiliation><affiliation>E-mail: chenjl@im.ac.cn</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="reviewArticle" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>John Wiley & Sons, Inc.</publisher><place><placeTerm type="text">Hoboken, USA</placeTerm></place><dateIssued encoding="w3cdtf">2016-01</dateIssued><dateCreated encoding="w3cdtf">2015-11-21</dateCreated><dateCaptured encoding="w3cdtf">2015-08-08</dateCaptured><dateValid encoding="w3cdtf">2015-11-04</dateValid><copyrightDate encoding="w3cdtf">2016</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>Long noncoding RNAs (lncRNAs) are extensively expressed in mammalian cells and play a crucial role as RNA regulators in various cellular processes. Increasing data reveal that they function in innate antiviral immunity through complex mechanisms. Thousands of lncRNAs are regulated by RNA virus or DNA virus infection. The significant differential expression of lncRNAs is induced by virus or host antiviral signaling mediated by interferons (IFNs) and tumor necrosis factor‐α. In turn, these lncRNAs modulate the host immune response including the pathogen recognition receptor (PRR)‐related signaling, the translocation and activation of transcription factors, the production of IFNs and cytokines, the IFN‐activated JAK‐STAT signaling and the transcription of antiviral IFN‐stimulated genes (ISGs). Using gain‐ or loss‐of‐function analysis, the effect of lncRNAs on viral replication has been investigated to elucidate the essential role of lncRNA in the host–virus interaction. lncRNAs have shown specifically elevated or decreased levels in patients with viral diseases, suggesting the possibility of clinical application as biomarkers. Here we review the current advances of viral infection‐associated host lncRNAs, their functional significance in different aspects of antiviral immune response, the specific mechanisms and unsolved issues. We also summarize the regulation of lncRNAs by viruses, PRR agonists and cytokines. In addition, virus‐encoded lncRNAs and their functional involvement in host–virus interaction are addressed. WIREs RNA 2016, 7:129–143. doi: 10.1002/wrna.1321 For further resources related to this article, please visit the WIREs website.</abstract><note type="funding">National Basic Research Program (973) of China - No. 2015CB910502; </note><note type="funding">Natural Science Foundation of China - No. U1305212; </note><note type="funding">National Key Technologies Research and Development Program of China - No. 2013ZX10004‐611; </note><note type="funding">Natural Science Foundation of China - No. 81590765; </note><relatedItem type="host"><titleInfo><title>Wiley Interdisciplinary Reviews: RNA</title></titleInfo><titleInfo type="abbreviated"><title>WIREs RNA</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>index-terms</genre><topic authorityURI="http://psi.wiley.com/subject/17577004/RJAB">RNA in Disease</topic><topic authorityURI="http://psi.wiley.com/subject/17577004/RDAE">Protein–RNA Interactions—Functional Implications</topic><topic authorityURI="http://psi.wiley.com/subject/17577004/RDAA">RNA Interactions with Proteins and Other Molecules</topic></subject><subject><genre>article-category</genre><topic>Advanced Review</topic><topic>Advanced Reviews</topic></subject><identifier type="ISSN">1757-7004</identifier><identifier type="eISSN">1757-7012</identifier><identifier type="DOI">10.1002/(ISSN)1757-7012</identifier><identifier type="PublisherID">WRNA</identifier><part><date>2016</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>129</start><end>143</end><total>15</total></extent></part></relatedItem><identifier type="istex">5C9C5D13A8FAD9E767ABCC6AFB2AAF5F652341AD</identifier><identifier type="ark">ark:/67375/WNG-R36XDM13-0</identifier><identifier type="DOI">10.1002/wrna.1321</identifier><identifier type="ArticleID">WRNA1321</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2016 Wiley Periodicals, Inc.© 2015 Wiley Periodicals, Inc.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-16</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-R36XDM13-0/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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