SIV‐specific T lymphocyte responses in PBMC and lymphoid tissues of SIV‐infected pigtailed macaques during suppressive combination antiretroviral therapy
Identifieur interne : 001B02 ( Istex/Corpus ); précédent : 001B01; suivant : 001B03SIV‐specific T lymphocyte responses in PBMC and lymphoid tissues of SIV‐infected pigtailed macaques during suppressive combination antiretroviral therapy
Auteurs : Lucy M. Carruth ; M. Christine Zink ; Patrick M. Tarwater ; Michael D. Miller ; Ming Li ; Laurie A. Queen ; Joseph L. Mankowski ; Anding Shen ; Robert F. Siliciano ; Janice E. ClementsSource :
- Journal of Medical Primatology [ 0047-2565 ] ; 2005-06.
Abstract
Abstract: There is currently no SIV macaque model in which the effects of combination antiretroviral therapy on tissue immune responses and latent reservoirs have been measured. This study was performed to define the impact of combination therapy on the specificity and distribution of the T lymphocyte response in multiple tissue compartments. Pigtailed macaques (Macaca nemestrina) were infected with SIV/17E‐Fr and treated with combination antiretroviral therapy consisting of 9‐R‐(2‐phosphonomethoxypropyl)adenine (PMPA) and beta‐2′,3′‐dideoxy‐3′‐thia‐5‐fluorocytidine (FTC). The SIV‐specific T lymphocyte response was measured in peripheral blood, spleen and several lymph nodes at necropsy by IFN‐γ Elispot analysis. Two animals (one treated, one untreated) had high acute peak viremia, which was associated with lower SIV‐specific T lymphocyte responses in the peripheral blood and lymphoid tissues. In the treated animal, viremia was controlled to low or undetectable for the study duration, and virus‐specific responses remained low. The untreated animal remained viremic throughout the study and developed clinical symptoms of AIDS. In contrast, the two animals that had lower acute peak viremia (one treated, one untreated) had more robust T lymphocyte responses, and controlled viral replication. Virus‐specific responses were detected in the treated animal despite 6 months of suppressive therapy. These data suggest that in this model, in the context of acute peak viremia and weak T cell responses, combination therapy may be essential to control virus replication and disease progression. Conversely, in the setting of low initial viremia and robust T lymphocyte responses, treatment does not have a detrimental effect on the immune response.
Url:
DOI: 10.1111/j.1600-0684.2005.00103.x
Links to Exploration step
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<front><div type="abstract" xml:lang="en">Abstract: There is currently no SIV macaque model in which the effects of combination antiretroviral therapy on tissue immune responses and latent reservoirs have been measured. This study was performed to define the impact of combination therapy on the specificity and distribution of the T lymphocyte response in multiple tissue compartments. Pigtailed macaques (Macaca nemestrina) were infected with SIV/17E‐Fr and treated with combination antiretroviral therapy consisting of 9‐R‐(2‐phosphonomethoxypropyl)adenine (PMPA) and beta‐2′,3′‐dideoxy‐3′‐thia‐5‐fluorocytidine (FTC). The SIV‐specific T lymphocyte response was measured in peripheral blood, spleen and several lymph nodes at necropsy by IFN‐γ Elispot analysis. Two animals (one treated, one untreated) had high acute peak viremia, which was associated with lower SIV‐specific T lymphocyte responses in the peripheral blood and lymphoid tissues. In the treated animal, viremia was controlled to low or undetectable for the study duration, and virus‐specific responses remained low. The untreated animal remained viremic throughout the study and developed clinical symptoms of AIDS. In contrast, the two animals that had lower acute peak viremia (one treated, one untreated) had more robust T lymphocyte responses, and controlled viral replication. Virus‐specific responses were detected in the treated animal despite 6 months of suppressive therapy. These data suggest that in this model, in the context of acute peak viremia and weak T cell responses, combination therapy may be essential to control virus replication and disease progression. Conversely, in the setting of low initial viremia and robust T lymphocyte responses, treatment does not have a detrimental effect on the immune response.</div>
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<abstract>Abstract: There is currently no SIV macaque model in which the effects of combination antiretroviral therapy on tissue immune responses and latent reservoirs have been measured. This study was performed to define the impact of combination therapy on the specificity and distribution of the T lymphocyte response in multiple tissue compartments. Pigtailed macaques (Macaca nemestrina) were infected with SIV/17E‐Fr and treated with combination antiretroviral therapy consisting of 9‐R‐(2‐phosphonomethoxypropyl)adenine (PMPA) and beta‐2′,3′‐dideoxy‐3′‐thia‐5‐fluorocytidine (FTC). The SIV‐specific T lymphocyte response was measured in peripheral blood, spleen and several lymph nodes at necropsy by IFN‐γ Elispot analysis. Two animals (one treated, one untreated) had high acute peak viremia, which was associated with lower SIV‐specific T lymphocyte responses in the peripheral blood and lymphoid tissues. In the treated animal, viremia was controlled to low or undetectable for the study duration, and virus‐specific responses remained low. The untreated animal remained viremic throughout the study and developed clinical symptoms of AIDS. In contrast, the two animals that had lower acute peak viremia (one treated, one untreated) had more robust T lymphocyte responses, and controlled viral replication. Virus‐specific responses were detected in the treated animal despite 6 months of suppressive therapy. These data suggest that in this model, in the context of acute peak viremia and weak T cell responses, combination therapy may be essential to control virus replication and disease progression. Conversely, in the setting of low initial viremia and robust T lymphocyte responses, treatment does not have a detrimental effect on the immune response.</abstract>
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There is currently no SIV macaque model in which the effects of combination antiretroviral therapy on tissue immune responses and latent reservoirs have been measured. This study was performed to define the impact of combination therapy on the specificity and distribution of the T lymphocyte response in multiple tissue compartments. Pigtailed macaques (<hi rend="italic">Macaca nemestrina</hi>
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<abstract lang="en">Abstract: There is currently no SIV macaque model in which the effects of combination antiretroviral therapy on tissue immune responses and latent reservoirs have been measured. This study was performed to define the impact of combination therapy on the specificity and distribution of the T lymphocyte response in multiple tissue compartments. Pigtailed macaques (Macaca nemestrina) were infected with SIV/17E‐Fr and treated with combination antiretroviral therapy consisting of 9‐R‐(2‐phosphonomethoxypropyl)adenine (PMPA) and beta‐2′,3′‐dideoxy‐3′‐thia‐5‐fluorocytidine (FTC). The SIV‐specific T lymphocyte response was measured in peripheral blood, spleen and several lymph nodes at necropsy by IFN‐γ Elispot analysis. Two animals (one treated, one untreated) had high acute peak viremia, which was associated with lower SIV‐specific T lymphocyte responses in the peripheral blood and lymphoid tissues. In the treated animal, viremia was controlled to low or undetectable for the study duration, and virus‐specific responses remained low. The untreated animal remained viremic throughout the study and developed clinical symptoms of AIDS. In contrast, the two animals that had lower acute peak viremia (one treated, one untreated) had more robust T lymphocyte responses, and controlled viral replication. Virus‐specific responses were detected in the treated animal despite 6 months of suppressive therapy. These data suggest that in this model, in the context of acute peak viremia and weak T cell responses, combination therapy may be essential to control virus replication and disease progression. Conversely, in the setting of low initial viremia and robust T lymphocyte responses, treatment does not have a detrimental effect on the immune response.</abstract>
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<namePart type="family">Giovannetti</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Aiuti F, Giovannetti A: Structured interruptions of therapy: looking for the best protocol. AIDS 17: 2257–2258, 2003.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>17</number>
</detail>
<extent unit="pages"><start>2257</start>
<end>2258</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>AIDS</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>17</number>
</detail>
<extent unit="pages"><start>2257</start>
<end>2258</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit3"><titleInfo><title>Expansion of pre‐existing, lymph node‐localized CD8+ T cells during supervised treatment interruptions in chronic HIV‐1 infection</title>
</titleInfo>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Altfeld</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">van Lunzen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N</namePart>
<namePart type="family">Frahm</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">XG</namePart>
<namePart type="family">Yu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Schneider</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RL</namePart>
<namePart type="family">Eldridge</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">ME</namePart>
<namePart type="family">Feeney</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">D</namePart>
<namePart type="family">Meyer‐Olson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">HJ</namePart>
<namePart type="family">Stellbrink</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">BD</namePart>
<namePart type="family">Walker</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Altfeld M, van Lunzen J, Frahm N, Yu XG, Schneider C, Eldridge RL, Feeney ME, Meyer‐Olson D, Stellbrink HJ, Walker BD: Expansion of pre‐existing, lymph node‐localized CD8+ T cells during supervised treatment interruptions in chronic HIV‐1 infection. J Clin Invest 109: 837–843, 2002.</note>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>109</number>
</detail>
<extent unit="pages"><start>837</start>
<end>843</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Clin Invest</title>
</titleInfo>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>109</number>
</detail>
<extent unit="pages"><start>837</start>
<end>843</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit4"><titleInfo><title>Evidence for early local viral replication and local production of antiviral immunity upon mucosal simian‐human immunodeficiency virus SHIV(89.6) infection in Macaca nemestrina</title>
</titleInfo>
<name type="personal"><namePart type="given">Z</namePart>
<namePart type="family">Ambrose</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Larsen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Thompson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Stevens</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">E</namePart>
<namePart type="family">Finn</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SL</namePart>
<namePart type="family">Hu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">ML</namePart>
<namePart type="family">Bosch</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Ambrose Z, Larsen K, Thompson J, Stevens Y, Finn E, Hu SL, Bosch ML: Evidence for early local viral replication and local production of antiviral immunity upon mucosal simian‐human immunodeficiency virus SHIV(89.6) infection in Macaca nemestrina. J Virol 75: 8589–8596, 2001.</note>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>75</number>
</detail>
<extent unit="pages"><start>8589</start>
<end>8596</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>75</number>
</detail>
<extent unit="pages"><start>8589</start>
<end>8596</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit5"><titleInfo><title>Levels of interleukin‐15 in plasma may predict a favorable outcome of structured treatment interruption in patients with chronic human immunodeficiency virus infection</title>
</titleInfo>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Amicosante</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">F</namePart>
<namePart type="family">Poccia</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Gioia</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Montesano</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Topino</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">F</namePart>
<namePart type="family">Martini</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">P</namePart>
<namePart type="family">Narciso</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">LP</namePart>
<namePart type="family">Pucillo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">D'Offizi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Amicosante M, Poccia F, Gioia C, Montesano C, Topino S, Martini F, Narciso P, Pucillo LP, D'Offizi G: Levels of interleukin‐15 in plasma may predict a favorable outcome of structured treatment interruption in patients with chronic human immunodeficiency virus infection. J Infect Dis 188: 661–665, 2003.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>188</number>
</detail>
<extent unit="pages"><start>661</start>
<end>665</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Infect Dis</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>188</number>
</detail>
<extent unit="pages"><start>661</start>
<end>665</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit6"><titleInfo><title>CD8+ cytotoxic T lymphocyte responses to lentiviruses and herpesviruses</title>
</titleInfo>
<name type="personal"><namePart type="given">DH</namePart>
<namePart type="family">Barouch</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">NL</namePart>
<namePart type="family">Letvin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Barouch DH, Letvin NL: CD8+ cytotoxic T lymphocyte responses to lentiviruses and herpesviruses. Curr Opin Immunol 13: 479–482, 2001.</note>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>13</number>
</detail>
<extent unit="pages"><start>479</start>
<end>482</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Curr Opin Immunol</title>
</titleInfo>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>13</number>
</detail>
<extent unit="pages"><start>479</start>
<end>482</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit7"><titleInfo><title>Kinetics of lymphocyte proliferation during primary immune response in macaques infected with pathogenic simian immunodeficiency virus SIVmac251: preliminary report of the effect of early antiviral therapy</title>
</titleInfo>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Benlhassan‐Chahour</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Penit</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">V</namePart>
<namePart type="family">Dioszeghy</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">F</namePart>
<namePart type="family">Vasseur</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">Janvier</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Riviere</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N</namePart>
<namePart type="family">Dereuddre‐Bosquet</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">D</namePart>
<namePart type="family">Dormont</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">Le Grand</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Vaslin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Benlhassan‐Chahour K, Penit C, Dioszeghy V, Vasseur F, Janvier G, Riviere Y, Dereuddre‐Bosquet N, Dormont D, Le Grand R, Vaslin B: Kinetics of lymphocyte proliferation during primary immune response in macaques infected with pathogenic simian immunodeficiency virus SIVmac251: preliminary report of the effect of early antiviral therapy. J Virol 77: 12479–12493, 2003.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>77</number>
</detail>
<extent unit="pages"><start>12479</start>
<end>12493</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>77</number>
</detail>
<extent unit="pages"><start>12479</start>
<end>12493</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit8"><titleInfo><title>Virus‐specific CD8+ cytotoxic T‐lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection</title>
</titleInfo>
<name type="personal"><namePart type="given">P</namePart>
<namePart type="family">Borrow</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Lewicki</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">BH</namePart>
<namePart type="family">Hahn</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">GM</namePart>
<namePart type="family">Shaw</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MB</namePart>
<namePart type="family">Oldstone</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Borrow P, Lewicki H, Hahn BH, Shaw GM, Oldstone MB: Virus‐specific CD8+ cytotoxic T‐lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J Virol 68: 6103–6110, 1994.</note>
<part><date>1994</date>
<detail type="volume"><caption>vol.</caption>
<number>68</number>
</detail>
<extent unit="pages"><start>6103</start>
<end>6110</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>1994</date>
<detail type="volume"><caption>vol.</caption>
<number>68</number>
</detail>
<extent unit="pages"><start>6103</start>
<end>6110</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit9"><titleInfo><title>Relationship between the size of the human immunodeficiency virus type 1 (HIV‐1) reservoir in peripheral blood CD4+ T cells and CD4+: CD8+ T cell ratios in aviremic HIV‐1‐infected individuals receiving long‐term highly active antiretroviral therapy</title>
</titleInfo>
<name type="personal"><namePart type="given">TW</namePart>
<namePart type="family">Chun</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JS</namePart>
<namePart type="family">Justement</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">P</namePart>
<namePart type="family">Pandya</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CW</namePart>
<namePart type="family">Hallahan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">McLaughlin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Liu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">LA</namePart>
<namePart type="family">Ehler</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Kovacs</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AS</namePart>
<namePart type="family">Fauci</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Chun TW, Justement JS, Pandya P, Hallahan CW, McLaughlin M, Liu S, Ehler LA, Kovacs C, Fauci AS: Relationship between the size of the human immunodeficiency virus type 1 (HIV‐1) reservoir in peripheral blood CD4+ T cells and CD4+: CD8+ T cell ratios in aviremic HIV‐1‐infected individuals receiving long‐term highly active antiretroviral therapy. J Infect Dis 185: 1672–1676, 2002.</note>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>185</number>
</detail>
<extent unit="pages"><start>1672</start>
<end>1676</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Infect Dis</title>
</titleInfo>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>185</number>
</detail>
<extent unit="pages"><start>1672</start>
<end>1676</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit10"><titleInfo><title>Interleukin‐15 in HIV infection: immunological and virological interactions in antiretroviral‐naive and ‐treated patients</title>
</titleInfo>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">D'Ettorre</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">Forcina</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Lichtner</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">F</namePart>
<namePart type="family">Mengoni</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">D'Agostino</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AP</namePart>
<namePart type="family">Massetti</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CM</namePart>
<namePart type="family">Mastroianni</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">V</namePart>
<namePart type="family">Vullo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">D'Ettorre G, Forcina G, Lichtner M, Mengoni F, D'Agostino C, Massetti AP, Mastroianni CM, Vullo V: Interleukin‐15 in HIV infection: immunological and virological interactions in antiretroviral‐naive and ‐treated patients. AIDS 16: 181–188, 2002.</note>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>16</number>
</detail>
<extent unit="pages"><start>181</start>
<end>188</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>AIDS</title>
</titleInfo>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>16</number>
</detail>
<extent unit="pages"><start>181</start>
<end>188</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit11"><titleInfo><title>Molecular and biological characterization of a neurovirulent molecular clone of simian immunodeficiency virus</title>
</titleInfo>
<name type="personal"><namePart type="given">MT</namePart>
<namePart type="family">Flaherty</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DA</namePart>
<namePart type="family">Hauer</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JL</namePart>
<namePart type="family">Mankowski</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MC</namePart>
<namePart type="family">Zink</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JE</namePart>
<namePart type="family">Clements</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Flaherty MT, Hauer DA, Mankowski JL, Zink MC, Clements JE: Molecular and biological characterization of a neurovirulent molecular clone of simian immunodeficiency virus. J Virol 71: 5790–5798, 1997.</note>
<part><date>1997</date>
<detail type="volume"><caption>vol.</caption>
<number>71</number>
</detail>
<extent unit="pages"><start>5790</start>
<end>5798</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>1997</date>
<detail type="volume"><caption>vol.</caption>
<number>71</number>
</detail>
<extent unit="pages"><start>5790</start>
<end>5798</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit12"><titleInfo><title>Microanatomic relationships between CD8+ cells and HIV‐1‐producing cells in human lymphoid tissue in vivo</title>
</titleInfo>
<name type="personal"><namePart type="given">JM</namePart>
<namePart type="family">Folkvord</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DM</namePart>
<namePart type="family">Anderson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Arya</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">MaWhinney</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">E</namePart>
<namePart type="family">Connick</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Folkvord JM, Anderson DM, Arya J, MaWhinney S, Connick E: Microanatomic relationships between CD8+ cells and HIV‐1‐producing cells in human lymphoid tissue in vivo. J Acquir Immune Defic Syndr 32: 469–476, 2003.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>32</number>
</detail>
<extent unit="pages"><start>469</start>
<end>476</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Acquir Immune Defic Syndr</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>32</number>
</detail>
<extent unit="pages"><start>469</start>
<end>476</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit13"><titleInfo><title>The virological and immunological consequences of structured treatment interruptions in chronic HIV‐1 infection</title>
</titleInfo>
<name type="personal"><namePart type="given">F</namePart>
<namePart type="family">Garcia</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Plana</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">GM</namePart>
<namePart type="family">Ortiz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Bonhoeffer</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Soriano</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Vidal</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Cruceta</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Arnedo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Gil</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">Pantaleo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Pumarola</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Gallart</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DF</namePart>
<namePart type="family">Nixon</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JM</namePart>
<namePart type="family">Miro</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JM</namePart>
<namePart type="family">Gatell</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Garcia F, Plana M, Ortiz GM, Bonhoeffer S, Soriano A, Vidal C, Cruceta A, Arnedo M, Gil C, Pantaleo G, Pumarola T, Gallart T, Nixon DF, Miro JM, Gatell JM: The virological and immunological consequences of structured treatment interruptions in chronic HIV‐1 infection. AIDS 15: F29‐F40, 2001.</note>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>15</number>
</detail>
<extent unit="pages"><start>F29</start>
<end>F40</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>AIDS</title>
</titleInfo>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>15</number>
</detail>
<extent unit="pages"><start>F29</start>
<end>F40</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit14"><titleInfo><title>Substantial differences in specificity of HIV‐specific cytotoxic T cells in acute and chronic HIV infection</title>
</titleInfo>
<name type="personal"><namePart type="given">PJ</namePart>
<namePart type="family">Goulder</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MA</namePart>
<namePart type="family">Altfeld</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">ES</namePart>
<namePart type="family">Rosenberg</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Nguyen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Tang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RL</namePart>
<namePart type="family">Eldridge</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MM</namePart>
<namePart type="family">Addo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">He</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JS</namePart>
<namePart type="family">Mukherjee</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MN</namePart>
<namePart type="family">Phillips</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Bunce</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SA</namePart>
<namePart type="family">Kalams</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RP</namePart>
<namePart type="family">Sekaly</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">BD</namePart>
<namePart type="family">Walker</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Brander</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Goulder PJ, Altfeld MA, Rosenberg ES, Nguyen T, Tang Y, Eldridge RL, Addo MM, He S, Mukherjee JS, Phillips MN, Bunce M, Kalams SA, Sekaly RP, Walker BD, Brander C: Substantial differences in specificity of HIV‐specific cytotoxic T cells in acute and chronic HIV infection. J Exp Med 193: 181–194, 2001.</note>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>193</number>
</detail>
<extent unit="pages"><start>181</start>
<end>194</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Exp Med</title>
</titleInfo>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>193</number>
</detail>
<extent unit="pages"><start>181</start>
<end>194</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit15"><titleInfo><title>Impairment of Gag‐specific CD8(+) T‐cell function in mucosal and systemic compartments of simian immunodeficiency virus mac251‐ and simian‐human immunodeficiency virus KU2‐infected macaques</title>
</titleInfo>
<name type="personal"><namePart type="given">Z</namePart>
<namePart type="family">Hel</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Nacsa</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Kelsall</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">WP</namePart>
<namePart type="family">Tsai</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N</namePart>
<namePart type="family">Letvin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RW</namePart>
<namePart type="family">Parks</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">E</namePart>
<namePart type="family">Tryniszewska</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Picker</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MG</namePart>
<namePart type="family">Lewis</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Edghill‐Smith</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Moniuszko</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">Pal</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Stevceva</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JD</namePart>
<namePart type="family">Altman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">TM</namePart>
<namePart type="family">Allen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">D</namePart>
<namePart type="family">Watkins</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JV</namePart>
<namePart type="family">Torres</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JA</namePart>
<namePart type="family">Berzofsky</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">IM</namePart>
<namePart type="family">Belyakov</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">W</namePart>
<namePart type="family">Strober</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">Franchini</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Hel Z, Nacsa J, Kelsall B, Tsai WP, Letvin N, Parks RW, Tryniszewska E, Picker L, Lewis MG, Edghill‐Smith Y, Moniuszko M, Pal R, Stevceva L, Altman JD, Allen TM, Watkins D, Torres JV, Berzofsky JA, Belyakov IM, Strober W, Franchini G: Impairment of Gag‐specific CD8(+) T‐cell function in mucosal and systemic compartments of simian immunodeficiency virus mac251‐ and simian‐human immunodeficiency virus KU2‐infected macaques. J Virol 75: 11483–11495, 2001.</note>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>75</number>
</detail>
<extent unit="pages"><start>11483</start>
<end>11495</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>75</number>
</detail>
<extent unit="pages"><start>11483</start>
<end>11495</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit16"><titleInfo><title>Patterns of viral replication correlate with outcome in simian immunodeficiency virus (SIV)‐infected macaques: effect of prior immunization with a trivalent SIV vaccine in modified vaccinia virus Ankara</title>
</titleInfo>
<name type="personal"><namePart type="given">VM</namePart>
<namePart type="family">Hirsch</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">TR</namePart>
<namePart type="family">Fuerst</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">Sutter</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MW</namePart>
<namePart type="family">Carroll</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">LC</namePart>
<namePart type="family">Yang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Goldstein</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Piatak Jr</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">WR</namePart>
<namePart type="family">Elkins</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">WG</namePart>
<namePart type="family">Alvord</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DC</namePart>
<namePart type="family">Montefiori</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Moss</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JD</namePart>
<namePart type="family">Lifson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Hirsch VM, Fuerst TR, Sutter G, Carroll MW, Yang LC, Goldstein S, Piatak M Jr, Elkins WR, Alvord WG, Montefiori DC, Moss B, Lifson JD: Patterns of viral replication correlate with outcome in simian immunodeficiency virus (SIV)‐infected macaques: effect of prior immunization with a trivalent SIV vaccine in modified vaccinia virus Ankara. J Virol 70: 3741–3752, 1996.</note>
<part><date>1996</date>
<detail type="volume"><caption>vol.</caption>
<number>70</number>
</detail>
<extent unit="pages"><start>3741</start>
<end>3752</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>1996</date>
<detail type="volume"><caption>vol.</caption>
<number>70</number>
</detail>
<extent unit="pages"><start>3741</start>
<end>3752</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit17"><titleInfo><title>Levels of human immunodeficiency virus type 1‐specific cytotoxic T‐lymphocyte effector and memory responses decline after suppression of viremia with highly active antiretroviral therapy</title>
</titleInfo>
<name type="personal"><namePart type="given">SA</namePart>
<namePart type="family">Kalams</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">PJ</namePart>
<namePart type="family">Goulder</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AK</namePart>
<namePart type="family">Shea</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">NG</namePart>
<namePart type="family">Jones</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AK</namePart>
<namePart type="family">Trocha</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">GS</namePart>
<namePart type="family">Ogg</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">BD</namePart>
<namePart type="family">Walker</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Kalams SA, Goulder PJ, Shea AK, Jones NG, Trocha AK, Ogg GS, Walker BD: Levels of human immunodeficiency virus type 1‐specific cytotoxic T‐lymphocyte effector and memory responses decline after suppression of viremia with highly active antiretroviral therapy. J Virol 73: 6721–6728, 1999.</note>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>73</number>
</detail>
<extent unit="pages"><start>6721</start>
<end>6728</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>73</number>
</detail>
<extent unit="pages"><start>6721</start>
<end>6728</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit18"><titleInfo><title>When to begin highly active antiretroviral therapy? Evidence supporting initiation of therapy at CD4+ lymphocyte counts <350 cells/microL</title>
</titleInfo>
<name type="personal"><namePart type="given">JE</namePart>
<namePart type="family">Kaplan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DL</namePart>
<namePart type="family">Hanson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DL</namePart>
<namePart type="family">Cohn</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Karon</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Buskin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Thompson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">P</namePart>
<namePart type="family">Fleming</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MS</namePart>
<namePart type="family">Dworkin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Kaplan JE, Hanson DL, Cohn DL, Karon J, Buskin S, Thompson M, Fleming P, Dworkin MS: When to begin highly active antiretroviral therapy? Evidence supporting initiation of therapy at CD4+ lymphocyte counts <350 cells/microL. Clin Infect Dis 37: 951–958, 2003.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>37</number>
</detail>
<extent unit="pages"><start>951</start>
<end>958</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Clin Infect Dis</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>37</number>
</detail>
<extent unit="pages"><start>951</start>
<end>958</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit19"><titleInfo><title>Cytotoxic and proliferative T cell responses in HIV‐1‐infected Macaca nemestrina</title>
</titleInfo>
<name type="personal"><namePart type="given">SJ</namePart>
<namePart type="family">Kent</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Corey</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MB</namePart>
<namePart type="family">Agy</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">WR</namePart>
<namePart type="family">Morton</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MJ</namePart>
<namePart type="family">McElrath</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">PD</namePart>
<namePart type="family">Greenberg</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Kent SJ, Corey L, Agy MB, Morton WR, McElrath MJ, Greenberg PD: Cytotoxic and proliferative T cell responses in HIV‐1‐infected Macaca nemestrina. J Clin Invest 95: 248–256, 1995.</note>
<part><date>1995</date>
<detail type="volume"><caption>vol.</caption>
<number>95</number>
</detail>
<extent unit="pages"><start>248</start>
<end>256</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Clin Invest</title>
</titleInfo>
<part><date>1995</date>
<detail type="volume"><caption>vol.</caption>
<number>95</number>
</detail>
<extent unit="pages"><start>248</start>
<end>256</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit20"><titleInfo><title>Human immunodeficiency virus type 1 (HIV‐1)‐specific T cell responses correlate with control of acute HIV‐1 infection in macaques</title>
</titleInfo>
<name type="personal"><namePart type="given">SJ</namePart>
<namePart type="family">Kent</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Woodward</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Zhao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Kent SJ, Woodward A, Zhao A: Human immunodeficiency virus type 1 (HIV‐1)‐specific T cell responses correlate with control of acute HIV‐1 infection in macaques. J Infect Dis 176: 1188–1197, 1997.</note>
<part><date>1997</date>
<detail type="volume"><caption>vol.</caption>
<number>176</number>
</detail>
<extent unit="pages"><start>1188</start>
<end>1197</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Infect Dis</title>
</titleInfo>
<part><date>1997</date>
<detail type="volume"><caption>vol.</caption>
<number>176</number>
</detail>
<extent unit="pages"><start>1188</start>
<end>1197</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit21"><titleInfo><title>Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome</title>
</titleInfo>
<name type="personal"><namePart type="given">RA</namePart>
<namePart type="family">Koup</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JT</namePart>
<namePart type="family">Safrit</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Cao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CA</namePart>
<namePart type="family">Andrews</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">McLeod</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">W</namePart>
<namePart type="family">Borkowsky</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Farthing</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DD</namePart>
<namePart type="family">Ho</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Koup RA, Safrit JT, Cao Y, Andrews CA, McLeod G, Borkowsky W, Farthing C, Ho DD: Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol 68: 4650–4655, 1994.</note>
<part><date>1994</date>
<detail type="volume"><caption>vol.</caption>
<number>68</number>
</detail>
<extent unit="pages"><start>4650</start>
<end>4655</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>1994</date>
<detail type="volume"><caption>vol.</caption>
<number>68</number>
</detail>
<extent unit="pages"><start>4650</start>
<end>4655</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit22"><titleInfo><title>Development of virus‐specific immune responses in SHIV(KU)‐infected macaques treated with PMPA</title>
</titleInfo>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Kumar</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Buch</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Foresman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N</namePart>
<namePart type="family">Bischofberger</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JD</namePart>
<namePart type="family">Lifson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">O</namePart>
<namePart type="family">Narayan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Kumar A, Buch S, Foresman L, Bischofberger N, Lifson JD, Narayan O: Development of virus‐specific immune responses in SHIV(KU)‐infected macaques treated with PMPA. Virology 279: 97–108, 2001.</note>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>279</number>
</detail>
<extent unit="pages"><start>97</start>
<end>108</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Virology</title>
</titleInfo>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>279</number>
</detail>
<extent unit="pages"><start>97</start>
<end>108</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit23"><titleInfo><title>Emergence of CTL coincides with clearance of virus during primary simian immunodeficiency virus infection in rhesus monkeys</title>
</titleInfo>
<name type="personal"><namePart type="given">MJ</namePart>
<namePart type="family">Kuroda</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JE</namePart>
<namePart type="family">Schmitz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">WA</namePart>
<namePart type="family">Charini</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CE</namePart>
<namePart type="family">Nickerson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MA</namePart>
<namePart type="family">Lifton</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CI</namePart>
<namePart type="family">Lord</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MA</namePart>
<namePart type="family">Forman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">NL</namePart>
<namePart type="family">Letvin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Kuroda MJ, Schmitz JE, Charini WA, Nickerson CE, Lifton MA, Lord CI, Forman MA, Letvin NL: Emergence of CTL coincides with clearance of virus during primary simian immunodeficiency virus infection in rhesus monkeys. J Immunol 162: 5127–5133, 1999.</note>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>162</number>
</detail>
<extent unit="pages"><start>5127</start>
<end>5133</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Immunol</title>
</titleInfo>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>162</number>
</detail>
<extent unit="pages"><start>5127</start>
<end>5133</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit24"><titleInfo><title>Simian immunodeficiency virus‐specific cytotoxic T lymphocytes and cell‐associated viral RNA levels in distinct lymphoid compartments of SIVmac‐infected rhesus monkeys</title>
</titleInfo>
<name type="personal"><namePart type="given">MJ</namePart>
<namePart type="family">Kuroda</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JE</namePart>
<namePart type="family">Schmitz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Seth</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RS</namePart>
<namePart type="family">Veazey</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CE</namePart>
<namePart type="family">Nickerson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MA</namePart>
<namePart type="family">Lifton</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">PJ</namePart>
<namePart type="family">Dailey</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MA</namePart>
<namePart type="family">Forman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">P</namePart>
<namePart type="family">Racz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Tenner‐Racz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">NL</namePart>
<namePart type="family">Letvin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Kuroda MJ, Schmitz JE, Seth A, Veazey RS, Nickerson CE, Lifton MA, Dailey PJ, Forman MA, Racz P, Tenner‐Racz K, Letvin NL: Simian immunodeficiency virus‐specific cytotoxic T lymphocytes and cell‐associated viral RNA levels in distinct lymphoid compartments of SIVmac‐infected rhesus monkeys. Blood 96: 1474–1479, 2000.</note>
<part><date>2000</date>
<detail type="volume"><caption>vol.</caption>
<number>96</number>
</detail>
<extent unit="pages"><start>1474</start>
<end>1479</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Blood</title>
</titleInfo>
<part><date>2000</date>
<detail type="volume"><caption>vol.</caption>
<number>96</number>
</detail>
<extent unit="pages"><start>1474</start>
<end>1479</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit25"><titleInfo><title>Impact of suppression of viral replication by highly active antiretroviral therapy on immune function and phenotype in chronic HIV‐1 infection</title>
</titleInfo>
<name type="personal"><namePart type="given">CG</namePart>
<namePart type="family">Lange</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MM</namePart>
<namePart type="family">Lederman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JS</namePart>
<namePart type="family">Madero</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Medvik</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">Asaad</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Pacheko</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Carranza</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Valdez</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Lange CG, Lederman MM, Madero JS, Medvik K, Asaad R, Pacheko C, Carranza C, Valdez H: Impact of suppression of viral replication by highly active antiretroviral therapy on immune function and phenotype in chronic HIV‐1 infection. J Acquir Immune Defic Syndr 30: 33–40, 2002.</note>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>30</number>
</detail>
<extent unit="pages"><start>33</start>
<end>40</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Acquir Immune Defic Syndr</title>
</titleInfo>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>30</number>
</detail>
<extent unit="pages"><start>33</start>
<end>40</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit26"><titleInfo><title>Titration and characterization of two rhesus‐derived SIVmac challenge stocks</title>
</titleInfo>
<name type="personal"><namePart type="given">MG</namePart>
<namePart type="family">Lewis</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Bellah</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">McKinnon</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Yalley‐Ogunro</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">PM</namePart>
<namePart type="family">Zack</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">WR</namePart>
<namePart type="family">Elkins</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RC</namePart>
<namePart type="family">Desrosiers</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">GA</namePart>
<namePart type="family">Eddy</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Lewis MG, Bellah S, McKinnon K, Yalley‐Ogunro J, Zack PM, Elkins WR, Desrosiers RC, Eddy GA: Titration and characterization of two rhesus‐derived SIVmac challenge stocks. AIDS Res Hum Retroviruses 10: 213–220, 1994.</note>
<part><date>1994</date>
<detail type="volume"><caption>vol.</caption>
<number>10</number>
</detail>
<extent unit="pages"><start>213</start>
<end>220</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>AIDS Res Hum Retroviruses</title>
</titleInfo>
<part><date>1994</date>
<detail type="volume"><caption>vol.</caption>
<number>10</number>
</detail>
<extent unit="pages"><start>213</start>
<end>220</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit27"><titleInfo><title>Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment</title>
</titleInfo>
<name type="personal"><namePart type="given">JD</namePart>
<namePart type="family">Lifson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JL</namePart>
<namePart type="family">Rossio</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Piatak Jr</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Parks</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Li</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">Kiser</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">V</namePart>
<namePart type="family">Coalter</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Fisher</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">BM</namePart>
<namePart type="family">Flynn</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Czajak</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">VM</namePart>
<namePart type="family">Hirsch</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">KA</namePart>
<namePart type="family">Reimann</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JE</namePart>
<namePart type="family">Schmitz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Ghrayeb</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N</namePart>
<namePart type="family">Bischofberger</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MA</namePart>
<namePart type="family">Nowak</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RC</namePart>
<namePart type="family">Desrosiers</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">D</namePart>
<namePart type="family">Wodarz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Lifson JD, Rossio JL, Piatak M Jr, Parks T, Li L, Kiser R, Coalter V, Fisher B, Flynn BM, Czajak S, Hirsch VM, Reimann KA, Schmitz JE, Ghrayeb J, Bischofberger N, Nowak MA, Desrosiers RC, Wodarz D: Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment. J Virol 75: 10187–10199, 2001.</note>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>75</number>
</detail>
<extent unit="pages"><start>10187</start>
<end>10199</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>75</number>
</detail>
<extent unit="pages"><start>10187</start>
<end>10199</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit28"><titleInfo><title>Control of SIV rebound through structured treatment interruptions during early infection</title>
</titleInfo>
<name type="personal"><namePart type="given">F</namePart>
<namePart type="family">Lori</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MG</namePart>
<namePart type="family">Lewis</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Xu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">Varga</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DE</namePart>
<namePart type="family">Zinn Jr</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Crabbs</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">W</namePart>
<namePart type="family">Wagner</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Greenhouse</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">P</namePart>
<namePart type="family">Silvera</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Yalley‐Ogunro</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Tinelli</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Lisziewicz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Lori F, Lewis MG, Xu J, Varga G, Zinn DE Jr, Crabbs C, Wagner W, Greenhouse J, Silvera P, Yalley‐Ogunro J, Tinelli C, Lisziewicz J: Control of SIV rebound through structured treatment interruptions during early infection. Science 290: 1591–1593, 2000.</note>
<part><date>2000</date>
<detail type="volume"><caption>vol.</caption>
<number>290</number>
</detail>
<extent unit="pages"><start>1591</start>
<end>1593</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Science</title>
</titleInfo>
<part><date>2000</date>
<detail type="volume"><caption>vol.</caption>
<number>290</number>
</detail>
<extent unit="pages"><start>1591</start>
<end>1593</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit29"><titleInfo><title>Characterization of a polyclonal cytolytic T lymphocyte response to human immunodeficiency virus in persons without clinical progression</title>
</titleInfo>
<name type="personal"><namePart type="given">NM</namePart>
<namePart type="family">Lubaki</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SC</namePart>
<namePart type="family">Ray</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Dhruva</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">TC</namePart>
<namePart type="family">Quinn</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RF</namePart>
<namePart type="family">Siliciano</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RC</namePart>
<namePart type="family">Bollinger</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Lubaki NM, Ray SC, Dhruva B, Quinn TC, Siliciano RF, Bollinger RC: Characterization of a polyclonal cytolytic T lymphocyte response to human immunodeficiency virus in persons without clinical progression. J Infect Dis 175: 1360–1367, 1997.</note>
<part><date>1997</date>
<detail type="volume"><caption>vol.</caption>
<number>175</number>
</detail>
<extent unit="pages"><start>1360</start>
<end>1367</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Infect Dis</title>
</titleInfo>
<part><date>1997</date>
<detail type="volume"><caption>vol.</caption>
<number>175</number>
</detail>
<extent unit="pages"><start>1360</start>
<end>1367</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit30"><titleInfo><title>Pathogenesis of simian immunodeficiency virus encephalitis: viral determinants of neurovirulence</title>
</titleInfo>
<name type="personal"><namePart type="given">JL</namePart>
<namePart type="family">Mankowski</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MT</namePart>
<namePart type="family">Flaherty</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JP</namePart>
<namePart type="family">Spelman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DA</namePart>
<namePart type="family">Hauer</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">PJ</namePart>
<namePart type="family">Didier</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AM</namePart>
<namePart type="family">Amedee</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Murphey‐Corb</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">LM</namePart>
<namePart type="family">Kirstein</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Munoz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JE</namePart>
<namePart type="family">Clements</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MC</namePart>
<namePart type="family">Zink</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Mankowski JL, Flaherty MT, Spelman JP, Hauer DA, Didier PJ, Amedee AM, Murphey‐Corb M, Kirstein LM, Munoz A, Clements JE, Zink MC: Pathogenesis of simian immunodeficiency virus encephalitis: viral determinants of neurovirulence. J Virol 71: 6055–6060, 1997.</note>
<part><date>1997</date>
<detail type="volume"><caption>vol.</caption>
<number>71</number>
</detail>
<extent unit="pages"><start>6055</start>
<end>6060</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>1997</date>
<detail type="volume"><caption>vol.</caption>
<number>71</number>
</detail>
<extent unit="pages"><start>6055</start>
<end>6060</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit31"><titleInfo><title>Derivation and characterization of a highly pathogenic isolate of human immunodeficiency virus type 2 that causes rapid CD4+ cell depletion in Macaca nemestrina</title>
</titleInfo>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">McClure</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AM</namePart>
<namePart type="family">Schmidt</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MA</namePart>
<namePart type="family">Rey‐Cuille</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Bannink</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Misher</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CC</namePart>
<namePart type="family">Tsai</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DM</namePart>
<namePart type="family">Anderson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">WR</namePart>
<namePart type="family">Morton</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SL</namePart>
<namePart type="family">Hu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">McClure J, Schmidt AM, Rey‐Cuille MA, Bannink J, Misher L, Tsai CC, Anderson DM, Morton WR, Hu SL: Derivation and characterization of a highly pathogenic isolate of human immunodeficiency virus type 2 that causes rapid CD4+ cell depletion in Macaca nemestrina. J Med Primatol 29: 114–126, 2000.</note>
<part><date>2000</date>
<detail type="volume"><caption>vol.</caption>
<number>29</number>
</detail>
<extent unit="pages"><start>114</start>
<end>126</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Med Primatol</title>
</titleInfo>
<part><date>2000</date>
<detail type="volume"><caption>vol.</caption>
<number>29</number>
</detail>
<extent unit="pages"><start>114</start>
<end>126</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit32"><titleInfo><title>Antigen‐specific cytokine responses in vaccinated Macaca nemestrina</title>
</titleInfo>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Mulvania</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JB</namePart>
<namePart type="family">Lynch</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MN</namePart>
<namePart type="family">Robertson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">PD</namePart>
<namePart type="family">Greenberg</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">WR</namePart>
<namePart type="family">Morton</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JI</namePart>
<namePart type="family">Mullins</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Mulvania T, Lynch JB, Robertson MN, Greenberg PD, Morton WR, Mullins JI: Antigen‐specific cytokine responses in vaccinated Macaca nemestrina. J Med Primatol 28: 181–189, 1999.</note>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>28</number>
</detail>
<extent unit="pages"><start>181</start>
<end>189</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Med Primatol</title>
</titleInfo>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>28</number>
</detail>
<extent unit="pages"><start>181</start>
<end>189</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit33"><titleInfo><title>HIV‐1 gag‐specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides</title>
</titleInfo>
<name type="personal"><namePart type="given">DF</namePart>
<namePart type="family">Nixon</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AR</namePart>
<namePart type="family">Townsend</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JG</namePart>
<namePart type="family">Elvin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CR</namePart>
<namePart type="family">Rizza</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Gallwey</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AJ</namePart>
<namePart type="family">McMichael</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Nixon DF, Townsend AR, Elvin JG, Rizza CR, Gallwey J, McMichael AJ: HIV‐1 gag‐specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides. Nature 336: 484–487, 1988.</note>
<part><date>1988</date>
<detail type="volume"><caption>vol.</caption>
<number>336</number>
</detail>
<extent unit="pages"><start>484</start>
<end>487</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Nature</title>
</titleInfo>
<part><date>1988</date>
<detail type="volume"><caption>vol.</caption>
<number>336</number>
</detail>
<extent unit="pages"><start>484</start>
<end>487</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit34"><titleInfo><title>Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection</title>
</titleInfo>
<name type="personal"><namePart type="given">DH</namePart>
<namePart type="family">O'Connor</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">TM</namePart>
<namePart type="family">Allen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">TU</namePart>
<namePart type="family">Vogel</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">P</namePart>
<namePart type="family">Jing</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">IP</namePart>
<namePart type="family">DeSouza</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">E</namePart>
<namePart type="family">Dodds</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">EJ</namePart>
<namePart type="family">Dunphy</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Melsaether</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Mothe</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Yamamoto</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Horton</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N</namePart>
<namePart type="family">Wilson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AL</namePart>
<namePart type="family">Hughes</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DI</namePart>
<namePart type="family">Watkins</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">O'Connor DH, Allen TM, Vogel TU, Jing P, DeSouza IP, Dodds E, Dunphy EJ, Melsaether C, Mothe B, Yamamoto H, Horton H, Wilson N, Hughes AL, Watkins DI: Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection. Nat Med 8: 493–499, 2002.</note>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>8</number>
</detail>
<extent unit="pages"><start>493</start>
<end>499</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Nat Med</title>
</titleInfo>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>8</number>
</detail>
<extent unit="pages"><start>493</start>
<end>499</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit35"><titleInfo><title>Quantitation of HIV‐1‐specific cytotoxic T lymphocytes and plasma load of viral RNA</title>
</titleInfo>
<name type="personal"><namePart type="given">GS</namePart>
<namePart type="family">Ogg</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">X</namePart>
<namePart type="family">Jin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Bonhoeffer</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">PR</namePart>
<namePart type="family">Dunbar</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MA</namePart>
<namePart type="family">Nowak</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Monard</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JP</namePart>
<namePart type="family">Segal</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Cao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SL</namePart>
<namePart type="family">Rowland‐Jones</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">V</namePart>
<namePart type="family">Cerundolo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Hurley</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Markowitz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DD</namePart>
<namePart type="family">Ho</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DF</namePart>
<namePart type="family">Nixon</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AJ</namePart>
<namePart type="family">McMichael</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Ogg GS, Jin X, Bonhoeffer S, Dunbar PR, Nowak MA, Monard S, Segal JP, Cao Y, Rowland‐Jones SL, Cerundolo V, Hurley A, Markowitz M, Ho DD, Nixon DF, McMichael AJ: Quantitation of HIV‐1‐specific cytotoxic T lymphocytes and plasma load of viral RNA. Science 279: 2103–2106, 1998.</note>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>279</number>
</detail>
<extent unit="pages"><start>2103</start>
<end>2106</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Science</title>
</titleInfo>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>279</number>
</detail>
<extent unit="pages"><start>2103</start>
<end>2106</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit36"><titleInfo><title>Structured antiretroviral treatment interruptions in chronically HIV‐1‐infected subjects</title>
</titleInfo>
<name type="personal"><namePart type="given">GM</namePart>
<namePart type="family">Ortiz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Wellons</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Brancato</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">HT</namePart>
<namePart type="family">Vo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RL</namePart>
<namePart type="family">Zinn</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DE</namePart>
<namePart type="family">Clarkson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Van Loon</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Bonhoeffer</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">GD</namePart>
<namePart type="family">Miralles</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">D</namePart>
<namePart type="family">Montefiori</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JA</namePart>
<namePart type="family">Bartlett</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DF</namePart>
<namePart type="family">Nixon</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Ortiz GM, Wellons M, Brancato J, Vo HT, Zinn RL, Clarkson DE, Van Loon K, Bonhoeffer S, Miralles GD, Montefiori D, Bartlett JA, Nixon DF: Structured antiretroviral treatment interruptions in chronically HIV‐1‐infected subjects. Proc Natl Acad Sci U S A 98: 13288–13293, 2001.</note>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>98</number>
</detail>
<extent unit="pages"><start>13288</start>
<end>13293</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Proc Natl Acad Sci U S A</title>
</titleInfo>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>98</number>
</detail>
<extent unit="pages"><start>13288</start>
<end>13293</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit37"><titleInfo><title>Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV</title>
</titleInfo>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">Pantaleo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JF</namePart>
<namePart type="family">Demarest</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Soudeyns</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Graziosi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">F</namePart>
<namePart type="family">Denis</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JW</namePart>
<namePart type="family">Adelsberger</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">P</namePart>
<namePart type="family">Borrow</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MS</namePart>
<namePart type="family">Saag</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">GM</namePart>
<namePart type="family">Shaw</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RP</namePart>
<namePart type="family">Sekaly</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Pantaleo G, Demarest JF, Soudeyns H, Graziosi C, Denis F, Adelsberger JW, Borrow P, Saag MS, Shaw GM, Sekaly RP: Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV. Nature 370: 463–467, 1994.</note>
<part><date>1994</date>
<detail type="volume"><caption>vol.</caption>
<number>370</number>
</detail>
<extent unit="pages"><start>463</start>
<end>467</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Nature</title>
</titleInfo>
<part><date>1994</date>
<detail type="volume"><caption>vol.</caption>
<number>370</number>
</detail>
<extent unit="pages"><start>463</start>
<end>467</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit38"><titleInfo><title>Association of Gag‐specific T lymphocyte responses during the early phase of human immunodeficiency virus type 1 infection and lower virus load set point</title>
</titleInfo>
<name type="personal"><namePart type="given">DS</namePart>
<namePart type="family">Patke</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SJ</namePart>
<namePart type="family">Langan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">LM</namePart>
<namePart type="family">Carruth</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SM</namePart>
<namePart type="family">Keating</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">BP</namePart>
<namePart type="family">Sabundayo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JB</namePart>
<namePart type="family">Margolick</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">TC</namePart>
<namePart type="family">Quinn</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RC</namePart>
<namePart type="family">Bollinger</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Patke DS, Langan SJ, Carruth LM, Keating SM, Sabundayo BP, Margolick JB, Quinn TC, Bollinger RC: Association of Gag‐specific T lymphocyte responses during the early phase of human immunodeficiency virus type 1 infection and lower virus load set point. J Infect Dis 186: 1177–1180, 2002.</note>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>186</number>
</detail>
<extent unit="pages"><start>1177</start>
<end>1180</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Infect Dis</title>
</titleInfo>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>186</number>
</detail>
<extent unit="pages"><start>1177</start>
<end>1180</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit39"><titleInfo><title>Functional T cell reconstitution and human immunodeficiency virus‐1‐specific cell‐mediated immunity during highly active antiretroviral therapy</title>
</titleInfo>
<name type="personal"><namePart type="given">O</namePart>
<namePart type="family">Pontesilli</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Kerkhof‐Garde</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DW</namePart>
<namePart type="family">Notermans</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">NA</namePart>
<namePart type="family">Foudraine</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MT</namePart>
<namePart type="family">Roos</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MR</namePart>
<namePart type="family">Klein</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SA</namePart>
<namePart type="family">Danner</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JM</namePart>
<namePart type="family">Lange</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">F</namePart>
<namePart type="family">Miedema</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Pontesilli O, Kerkhof‐Garde S, Notermans DW, Foudraine NA, Roos MT, Klein MR, Danner SA, Lange JM, Miedema F: Functional T cell reconstitution and human immunodeficiency virus‐1‐specific cell‐mediated immunity during highly active antiretroviral therapy. J Infect Dis 180: 76–86, 1999.</note>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>180</number>
</detail>
<extent unit="pages"><start>76</start>
<end>86</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Infect Dis</title>
</titleInfo>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>180</number>
</detail>
<extent unit="pages"><start>76</start>
<end>86</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit40"><titleInfo><title>High levels of anti‐human immunodeficiency virus type 1 (HIV‐1) memory cytotoxic T‐lymphocyte activity and low viral load are associated with lack of disease in HIV‐1‐infected long‐term nonprogressors</title>
</titleInfo>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Rinaldo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">XL</namePart>
<namePart type="family">Huang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">ZF</namePart>
<namePart type="family">Fan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Ding</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Beltz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Logar</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">D</namePart>
<namePart type="family">Panicali</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">Mazzara</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Liebmann</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Cottrill</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Rinaldo C, Huang XL, Fan ZF, Ding M, Beltz L, Logar A, Panicali D, Mazzara G, Liebmann J, Cottrill M: High levels of anti‐human immunodeficiency virus type 1 (HIV‐1) memory cytotoxic T‐lymphocyte activity and low viral load are associated with lack of disease in HIV‐1‐infected long‐term nonprogressors. J Virol 69: 5838–5842, 1995.</note>
<part><date>1995</date>
<detail type="volume"><caption>vol.</caption>
<number>69</number>
</detail>
<extent unit="pages"><start>5838</start>
<end>5842</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>1995</date>
<detail type="volume"><caption>vol.</caption>
<number>69</number>
</detail>
<extent unit="pages"><start>5838</start>
<end>5842</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit41"><titleInfo><title>Antiretroviral therapy during primary immunodeficiency virus infection can induce persistent suppression of virus load and protection from heterologous challenge in rhesus macaques</title>
</titleInfo>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Rosenwirth</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">P</namePart>
<namePart type="family">ten Haaft</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">WM</namePart>
<namePart type="family">Bogers</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">IG</namePart>
<namePart type="family">Nieuwenhuis</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Niphuis</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">EM</namePart>
<namePart type="family">Kuhn</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N</namePart>
<namePart type="family">Bischofberger</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JL</namePart>
<namePart type="family">Heeney</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Uberla</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Rosenwirth B, ten Haaft P, Bogers WM, Nieuwenhuis IG, Niphuis H, Kuhn EM, Bischofberger N, Heeney JL, Uberla K: Antiretroviral therapy during primary immunodeficiency virus infection can induce persistent suppression of virus load and protection from heterologous challenge in rhesus macaques. J Virol 74: 1704–1711, 2000.</note>
<part><date>2000</date>
<detail type="volume"><caption>vol.</caption>
<number>74</number>
</detail>
<extent unit="pages"><start>1704</start>
<end>1711</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2000</date>
<detail type="volume"><caption>vol.</caption>
<number>74</number>
</detail>
<extent unit="pages"><start>1704</start>
<end>1711</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit42"><titleInfo><title>HIV dynamics and T‐cell immunity after three structured treatment interruptions in chronic HIV‐1 infection</title>
</titleInfo>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Ruiz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">Carcelain</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Martinez‐Picado</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Frost</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Marfil</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">Paredes</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Romeu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">E</namePart>
<namePart type="family">Ferrer</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Morales‐Lopetegi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Autran</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Clotet</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Ruiz L, Carcelain G, Martinez‐Picado J, Frost S, Marfil S, Paredes R, Romeu J, Ferrer E, Morales‐Lopetegi K, Autran B, Clotet B: HIV dynamics and T‐cell immunity after three structured treatment interruptions in chronic HIV‐1 infection. AIDS 15: F19–F27, 2001.</note>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>15</number>
</detail>
<extent unit="pages"><start>F19</start>
<end>F27</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>AIDS</title>
</titleInfo>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>15</number>
</detail>
<extent unit="pages"><start>F19</start>
<end>F27</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit43"><titleInfo><title>Low blood CD8+ T‐lymphocytes and high circulating monocytes are predictors of HIV‐1‐associated progressive encephalopathy in children</title>
</titleInfo>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Sanchez‐Ramon</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JM</namePart>
<namePart type="family">Bellon</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Resino</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Canto‐Nogues</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">D</namePart>
<namePart type="family">Gurbindo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JT</namePart>
<namePart type="family">Ramos</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MA</namePart>
<namePart type="family">Munoz‐Fernandez</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Sanchez‐Ramon S, Bellon JM, Resino S, Canto‐Nogues C, Gurbindo D, Ramos JT, Munoz‐Fernandez MA: Low blood CD8+ T‐lymphocytes and high circulating monocytes are predictors of HIV‐1‐associated progressive encephalopathy in children. Pediatrics 111: E168–E175, 2003.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>111</number>
</detail>
<extent unit="pages"><start>E168</start>
<end>E175</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Pediatrics</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>111</number>
</detail>
<extent unit="pages"><start>E168</start>
<end>E175</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit44"><titleInfo><title>Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes</title>
</titleInfo>
<name type="personal"><namePart type="given">JE</namePart>
<namePart type="family">Schmitz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MJ</namePart>
<namePart type="family">Kuroda</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Santra</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">VG</namePart>
<namePart type="family">Sasseville</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MA</namePart>
<namePart type="family">Simon</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MA</namePart>
<namePart type="family">Lifton</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">P</namePart>
<namePart type="family">Racz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Tenner‐Racz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Dalesandro</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">BJ</namePart>
<namePart type="family">Scallon</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Ghrayeb</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MA</namePart>
<namePart type="family">Forman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DC</namePart>
<namePart type="family">Montefiori</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">EP</namePart>
<namePart type="family">Rieber</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">NL</namePart>
<namePart type="family">Letvin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">KA</namePart>
<namePart type="family">Reimann</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Schmitz JE, Kuroda MJ, Santra S, Sasseville VG, Simon MA, Lifton MA, Racz P, Tenner‐Racz K, Dalesandro M, Scallon BJ, Ghrayeb J, Forman MA, Montefiori DC, Rieber EP, Letvin NL, Reimann KA: Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. Science 283: 857–860, 1999.</note>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>283</number>
</detail>
<extent unit="pages"><start>857</start>
<end>860</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Science</title>
</titleInfo>
<part><date>1999</date>
<detail type="volume"><caption>vol.</caption>
<number>283</number>
</detail>
<extent unit="pages"><start>857</start>
<end>860</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit45"><titleInfo><title>Derivation of neurotropic simian immunodeficiency virus from exclusively lymphocytetropic parental virus: pathogenesis of infection in macaques</title>
</titleInfo>
<name type="personal"><namePart type="given">DP</namePart>
<namePart type="family">Sharma</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MC</namePart>
<namePart type="family">Zink</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Anderson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">Adams</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JE</namePart>
<namePart type="family">Clements</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SV</namePart>
<namePart type="family">Joag</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">O</namePart>
<namePart type="family">Narayan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Sharma DP, Zink MC, Anderson M, Adams R, Clements JE, Joag SV, Narayan O: Derivation of neurotropic simian immunodeficiency virus from exclusively lymphocytetropic parental virus: pathogenesis of infection in macaques. J Virol 66: 3550–3556, 1992.</note>
<part><date>1992</date>
<detail type="volume"><caption>vol.</caption>
<number>66</number>
</detail>
<extent unit="pages"><start>3550</start>
<end>3556</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>1992</date>
<detail type="volume"><caption>vol.</caption>
<number>66</number>
</detail>
<extent unit="pages"><start>3550</start>
<end>3556</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit46"><titleInfo><title>Resting CD4(+) T lymphocytes but not thymocytes provide a latent viral reservoir in a simian immunodeficiency virus –Macaca nemestrina model of human immunodeficiency virus type 1‐infected patients on highly active antiretroviral therapy</title>
</titleInfo>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Shen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MC</namePart>
<namePart type="family">Zink</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JL</namePart>
<namePart type="family">Mankowski</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Chadwick</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JB</namePart>
<namePart type="family">Margolick</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">LM</namePart>
<namePart type="family">Carruth</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Li</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JE</namePart>
<namePart type="family">Clements</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RF</namePart>
<namePart type="family">Siliciano</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Shen A, Zink MC, Mankowski JL, Chadwick K, Margolick JB, Carruth LM, Li M, Clements JE, Siliciano RF: Resting CD4(+) T lymphocytes but not thymocytes provide a latent viral reservoir in a simian immunodeficiency virus –Macaca nemestrina model of human immunodeficiency virus type 1‐infected patients on highly active antiretroviral therapy. J Virol 77: 4938–4949, 2003.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>77</number>
</detail>
<extent unit="pages"><start>4938</start>
<end>4949</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>77</number>
</detail>
<extent unit="pages"><start>4938</start>
<end>4949</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit47"><titleInfo><title>Impact of simian immunodeficiency virus (SIV) infection on lymphocyte numbers and T‐cell turnover in different organs of rhesus monkeys</title>
</titleInfo>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Sopper</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">D</namePart>
<namePart type="family">Nierwetberg</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Halbach</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">U</namePart>
<namePart type="family">Sauer</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Scheller</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Stahl‐Hennig</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Matz‐Rensing</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">F</namePart>
<namePart type="family">Schafer</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Schneider</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">V</namePart>
<namePart type="family">Ter Meulen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JG</namePart>
<namePart type="family">Muller</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Sopper S, Nierwetberg D, Halbach A, Sauer U, Scheller C, Stahl‐Hennig C, Matz‐Rensing K, Schafer F, Schneider T, Ter Meulen V, Muller JG: Impact of simian immunodeficiency virus (SIV) infection on lymphocyte numbers and T‐cell turnover in different organs of rhesus monkeys. Blood 101: 1213–1219, 2003.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>101</number>
</detail>
<extent unit="pages"><start>1213</start>
<end>1219</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Blood</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>101</number>
</detail>
<extent unit="pages"><start>1213</start>
<end>1219</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit48"><titleInfo><title>Lymphocyte subsets and expression of differentiation markers in blood and lymphoid organs of rhesus monkeys</title>
</titleInfo>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Sopper</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Stahl‐Hennig</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Demuth</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">IC</namePart>
<namePart type="family">Johnston</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">Dorries</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">V</namePart>
<namePart type="family">Ter Meulen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Sopper S, Stahl‐Hennig C, Demuth M, Johnston IC, Dorries R, Ter Meulen V: Lymphocyte subsets and expression of differentiation markers in blood and lymphoid organs of rhesus monkeys. Cytometry 29: 351–362, 1997.</note>
<part><date>1997</date>
<detail type="volume"><caption>vol.</caption>
<number>29</number>
</detail>
<extent unit="pages"><start>351</start>
<end>362</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Cytometry</title>
</titleInfo>
<part><date>1997</date>
<detail type="volume"><caption>vol.</caption>
<number>29</number>
</detail>
<extent unit="pages"><start>351</start>
<end>362</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit49"><titleInfo><title>Lymph nodes during antiretroviral therapy</title>
</titleInfo>
<name type="personal"><namePart type="given">HJ</namePart>
<namePart type="family">Stellbrink</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">van Lunzen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Stellbrink HJ, van Lunzen J: Lymph nodes during antiretroviral therapy. Curr Opin Infect Dis 14: 17–22, 2001.</note>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>14</number>
</detail>
<extent unit="pages"><start>17</start>
<end>22</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Curr Opin Infect Dis</title>
</titleInfo>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>14</number>
</detail>
<extent unit="pages"><start>17</start>
<end>22</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit50"><titleInfo><title>Initiation of highly active antiretroviral therapy at CD4+ T lymphocyte counts of >350 cells/mm3: disease progression, treatment durability, and drug toxicity</title>
</titleInfo>
<name type="personal"><namePart type="given">TR</namePart>
<namePart type="family">Sterling</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RE</namePart>
<namePart type="family">Chaisson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RD</namePart>
<namePart type="family">Moore</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Sterling TR, Chaisson RE, Moore RD: Initiation of highly active antiretroviral therapy at CD4+ T lymphocyte counts of >350 cells/mm3: disease progression, treatment durability, and drug toxicity. Clin Infect Dis 36: 812–815, 2003.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>36</number>
</detail>
<extent unit="pages"><start>812</start>
<end>815</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Clin Infect Dis</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>36</number>
</detail>
<extent unit="pages"><start>812</start>
<end>815</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit51"><titleInfo><title>Plasma SIV RNA viral load determination by real‐time quantification of product generation in reverse transcriptase‐polymerase chain reaction</title>
</titleInfo>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Suryanarayana</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">TA</namePart>
<namePart type="family">Wiltrout</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">GM</namePart>
<namePart type="family">Vasquez</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">VM</namePart>
<namePart type="family">Hirsch</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JD</namePart>
<namePart type="family">Lifson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Suryanarayana K, Wiltrout TA, Vasquez GM, Hirsch VM, Lifson JD: Plasma SIV RNA viral load determination by real‐time quantification of product generation in reverse transcriptase‐polymerase chain reaction. AIDS Res Hum Retroviruses 14: 183–189, 1998.</note>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>14</number>
</detail>
<extent unit="pages"><start>183</start>
<end>189</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>AIDS Res Hum Retroviruses</title>
</titleInfo>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>14</number>
</detail>
<extent unit="pages"><start>183</start>
<end>189</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit52"><titleInfo><title>Emergence and kinetics of simian immunodeficiency virus‐specific CD8(+) T cells in the intestines of macaques during primary infection</title>
</titleInfo>
<name type="personal"><namePart type="given">RS</namePart>
<namePart type="family">Veazey</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MC</namePart>
<namePart type="family">Gauduin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">KG</namePart>
<namePart type="family">Mansfield</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">IC</namePart>
<namePart type="family">Tham</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JD</namePart>
<namePart type="family">Altman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JD</namePart>
<namePart type="family">Lifson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AA</namePart>
<namePart type="family">Lackner</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RP</namePart>
<namePart type="family">Johnson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Veazey RS, Gauduin MC, Mansfield KG, Tham IC, Altman JD, Lifson JD, Lackner AA, Johnson RP: Emergence and kinetics of simian immunodeficiency virus‐specific CD8(+) T cells in the intestines of macaques during primary infection. J Virol 75: 10515–10519, 2001.</note>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>75</number>
</detail>
<extent unit="pages"><start>10515</start>
<end>10519</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>75</number>
</detail>
<extent unit="pages"><start>10515</start>
<end>10519</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit53"><titleInfo><title>Dynamics of Simian immunodeficiency virus‐specific cytotoxic T‐cell responses in tissues</title>
</titleInfo>
<name type="personal"><namePart type="given">RS</namePart>
<namePart type="family">Veazey</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JD</namePart>
<namePart type="family">Lifson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JE</namePart>
<namePart type="family">Schmitz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MJ</namePart>
<namePart type="family">Kuroda</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Piatak Jr</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">I</namePart>
<namePart type="family">Pandrea</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Purcell</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">Bohm</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Blanchard</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">KC</namePart>
<namePart type="family">Williams</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AA</namePart>
<namePart type="family">Lackner</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Veazey RS, Lifson JD, Schmitz JE, Kuroda MJ, Piatak M Jr, Pandrea I, Purcell J, Bohm R, Blanchard J, Williams KC, Lackner AA: Dynamics of Simian immunodeficiency virus‐specific cytotoxic T‐cell responses in tissues. J Med Primatol 32: 194–200, 2003.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>32</number>
</detail>
<extent unit="pages"><start>194</start>
<end>200</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Med Primatol</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>32</number>
</detail>
<extent unit="pages"><start>194</start>
<end>200</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit54"><titleInfo><title>Early postinfection antiviral treatment reduces viral load and prevents CD4+ cell decline in HIV type 2‐infected macaques</title>
</titleInfo>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Watson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">McClure</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Ranchalis</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Scheibel</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Schmidt</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Kennedy</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">WR</namePart>
<namePart type="family">Morton</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">NL</namePart>
<namePart type="family">Haigwood</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SL</namePart>
<namePart type="family">Hu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Watson A, McClure J, Ranchalis J, Scheibel M, Schmidt A, Kennedy B, Morton WR, Haigwood NL, Hu SL: Early postinfection antiviral treatment reduces viral load and prevents CD4+ cell decline in HIV type 2‐infected macaques. AIDS Res Hum Retroviruses 13: 1375–1381, 1997.</note>
<part><date>1997</date>
<detail type="volume"><caption>vol.</caption>
<number>13</number>
</detail>
<extent unit="pages"><start>1375</start>
<end>1381</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>AIDS Res Hum Retroviruses</title>
</titleInfo>
<part><date>1997</date>
<detail type="volume"><caption>vol.</caption>
<number>13</number>
</detail>
<extent unit="pages"><start>1375</start>
<end>1381</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit55"><titleInfo><title>Simian immunodeficiency virus‐specific CD8+ lymphocyte response in acutely infected rhesus monkeys</title>
</titleInfo>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Yasutomi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">KA</namePart>
<namePart type="family">Reimann</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CI</namePart>
<namePart type="family">Lord</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MD</namePart>
<namePart type="family">Miller</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">NL</namePart>
<namePart type="family">Letvin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Yasutomi Y, Reimann KA, Lord CI, Miller MD, Letvin NL: Simian immunodeficiency virus‐specific CD8+ lymphocyte response in acutely infected rhesus monkeys. J Virol 67: 1707–1711, 1993.</note>
<part><date>1993</date>
<detail type="volume"><caption>vol.</caption>
<number>67</number>
</detail>
<extent unit="pages"><start>1707</start>
<end>1711</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>1993</date>
<detail type="volume"><caption>vol.</caption>
<number>67</number>
</detail>
<extent unit="pages"><start>1707</start>
<end>1711</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit56"><titleInfo><title>Consistent patterns in the development and immunodominance of human immunodeficiency virus type 1 (HIV‐1)‐specific CD8+ T‐cell responses following acute HIV‐1 infection</title>
</titleInfo>
<name type="personal"><namePart type="given">XG</namePart>
<namePart type="family">Yu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MM</namePart>
<namePart type="family">Addo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">ES</namePart>
<namePart type="family">Rosenberg</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">WR</namePart>
<namePart type="family">Rodriguez</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">PK</namePart>
<namePart type="family">Lee</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CA</namePart>
<namePart type="family">Fitzpatrick</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MN</namePart>
<namePart type="family">Johnston</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">D</namePart>
<namePart type="family">Strick</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">PJ</namePart>
<namePart type="family">Goulder</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">BD</namePart>
<namePart type="family">Walker</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Altfeld</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Yu XG, Addo MM, Rosenberg ES, Rodriguez WR, Lee PK, Fitzpatrick CA, Johnston MN, Strick D, Goulder PJ, Walker BD, Altfeld M: Consistent patterns in the development and immunodominance of human immunodeficiency virus type 1 (HIV‐1)‐specific CD8+ T‐cell responses following acute HIV‐1 infection. J Virol 76: 8690–8701, 2002.</note>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>76</number>
</detail>
<extent unit="pages"><start>8690</start>
<end>8701</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>76</number>
</detail>
<extent unit="pages"><start>8690</start>
<end>8701</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit57"><titleInfo><title>High viral load in the cerebrospinal fluid and brain correlates with severity of simian immunodeficiency virus encephalitis</title>
</titleInfo>
<name type="personal"><namePart type="given">MC</namePart>
<namePart type="family">Zink</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Suryanarayana</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JL</namePart>
<namePart type="family">Mankowski</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Shen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Piatak Jr</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JP</namePart>
<namePart type="family">Spelman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DL</namePart>
<namePart type="family">Carter</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RJ</namePart>
<namePart type="family">Adams</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JD</namePart>
<namePart type="family">Lifson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JE</namePart>
<namePart type="family">Clements</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
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