Systematic characterization of protein-DNA interactions
Identifieur interne : 001980 ( Istex/Corpus ); précédent : 001979; suivant : 001981Systematic characterization of protein-DNA interactions
Auteurs : Zhi Xie ; Shaohui Hu ; Jiang Qian ; Seth Blackshaw ; Heng ZhuSource :
- Cellular and Molecular Life Sciences [ 1420-682X ] ; 2011-05-01.
English descriptors
- KwdEn :
Abstract
Abstract: Sequence-specific protein-DNA interactions (PDIs) are critical for regulating many cellular processes, including transcription, DNA replication, repair, and rearrangement. We review recent experimental advances in high-throughput technologies designed to characterize PDIs and discuss recent studies that use these tools, including ChIP-chip/seq, SELEX-based approaches, yeast one-hybrid, bacterial one-hybrid, protein binding microarray, and protein microarray. The results of these studies have challenged some long-standing concepts of PDI and provide valuable insights into the complex transcriptional regulatory networks.
Url:
DOI: 10.1007/s00018-010-0617-y
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<Para>Sequence-specific protein-DNA interactions (PDIs) are critical for regulating many cellular processes, including transcription, DNA replication, repair, and rearrangement. We review recent experimental advances in high-throughput technologies designed to characterize PDIs and discuss recent studies that use these tools, including ChIP-chip/seq, SELEX-based approaches, yeast one-hybrid, bacterial one-hybrid, protein binding microarray, and protein microarray. The results of these studies have challenged some long-standing concepts of PDI and provide valuable insights into the complex transcriptional regulatory networks.</Para>
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<Keyword>Protein DNA interactions</Keyword>
<Keyword>Transcription factors</Keyword>
<Keyword>Unconventional DNA-binding proteins</Keyword>
<Keyword>Protein microarray</Keyword>
<Keyword>DNA-binding specificity</Keyword>
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<name type="personal"><namePart type="given">Zhi</namePart>
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<affiliation>Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA</affiliation>
<affiliation>The Center for Human Immunology, National Institutes of Health, Bethesda, MD, USA</affiliation>
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<affiliation>Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA</affiliation>
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<name type="personal"><namePart type="given">Jiang</namePart>
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<affiliation>Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA</affiliation>
<affiliation>The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA</affiliation>
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<name type="personal"><namePart type="given">Seth</namePart>
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<abstract lang="en">Abstract: Sequence-specific protein-DNA interactions (PDIs) are critical for regulating many cellular processes, including transcription, DNA replication, repair, and rearrangement. We review recent experimental advances in high-throughput technologies designed to characterize PDIs and discuss recent studies that use these tools, including ChIP-chip/seq, SELEX-based approaches, yeast one-hybrid, bacterial one-hybrid, protein binding microarray, and protein microarray. The results of these studies have challenged some long-standing concepts of PDI and provide valuable insights into the complex transcriptional regulatory networks.</abstract>
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<topic>Protein DNA interactions</topic>
<topic>Transcription factors</topic>
<topic>Unconventional DNA-binding proteins</topic>
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<topic>DNA-binding specificity</topic>
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