Condylomata acuminata in children: Frequent association with human papillomaviruses responsible for cutaneous warts
Identifieur interne : 001653 ( Istex/Corpus ); précédent : 001652; suivant : 001654Condylomata acuminata in children: Frequent association with human papillomaviruses responsible for cutaneous warts
Auteurs : Slavomir Obalek ; Stéfania Jablonska ; Michel Favre ; Leszek Walczak ; Gérard OrthSource :
- Journal of the American Academy of Dermatology [ 0190-9622 ] ; 1990.
English descriptors
- Teeft :
- Acuminata, American academy, Anal, Anal condylomata, Anal wart, Anogenital, Anogenital area, Anogenital condylomata, Anogenital warts, Blot hybridization, Cervical, Cervical condylomata, Cervix, Common hand warts, Common warts, Condyloma, Condylomata acuminata, Cutaneous, Cutaneous warts, External condylomata, First week, Genital, Genital papillomaviruses, Genital warts, Histologic, Histologic features, Human papillomavirus, Hybridization, Lesion, Obstet gynecol, Papillomavirus, Papillomaviruses, Penis, Perianal, Sexual abuse, Skin warts, Viral, Virologic, Virologic studies, Vulva, Vulvar, Vulvar anal, Vulvar condylomata, Wart.
Abstract
To identify the papillomavirus types associated with condylomata acuminata in children and to evaluate their mode of transmission, we studied 32 children with anogenital warts. External condylomata were found in 12 of their mothers and in 10 of their fathers. Ten mothers, including two without external lesions, had cervical condylomata. Blot hybridization studies disclosed a genital human papillomavirus (HPV) in 14 of 27 children (HPV-6 in 12 and HPV-11 in two) and in 8 of 14 patients (HPV-6 in all). HPV-6 was found in another child by the polymerase chain reaction technique. Infection occurred most likely at birth or from nonsexual contact, but sexual abuse could not be excluded in one 11 -year-old girl. Cutaneous HPV-2 was found in seven children and as yet uncharacterized papillomaviruses were found in two children. Three mothers of HPV-2-infected children had common hand warts, and two children had subungual warts. This study shows the frequent nonsexual transmission of genital papillomaviruses in children and the unexpectedly high association of children's condylomata with papillomaviruses responsible for skin warts, possibly transmitted by heteroinoculation or autoinoculation.
Url:
DOI: 10.1016/0190-9622(90)70200-2
Links to Exploration step
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<abstract><p>To identify the papillomavirus types associated with condylomata acuminata in children and to evaluate their mode of transmission, we studied 32 children with anogenital warts. External condylomata were found in 12 of their mothers and in 10 of their fathers. Ten mothers, including two without external lesions, had cervical condylomata. Blot hybridization studies disclosed a genital human papillomavirus (HPV) in 14 of 27 children (HPV-6 in 12 and HPV-11 in two) and in 8 of 14 patients (HPV-6 in all). HPV-6 was found in another child by the polymerase chain reaction technique. Infection occurred most likely at birth or from nonsexual contact, but sexual abuse could not be excluded in one 11 -year-old girl. Cutaneous HPV-2 was found in seven children and as yet uncharacterized papillomaviruses were found in two children. Three mothers of HPV-2-infected children had common hand warts, and two children had subungual warts. This study shows the frequent nonsexual transmission of genital papillomaviruses in children and the unexpectedly high association of children's condylomata with papillomaviruses responsible for skin warts, possibly transmitted by heteroinoculation or autoinoculation.</p>
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<ce:pii>0190-9622(90)70200-2</ce:pii>
<ce:doi>10.1016/0190-9622(90)70200-2</ce:doi>
<ce:copyright type="unknown" year="1990">American Academy of Dermatology, Inc.</ce:copyright>
</item-info>
<head><ce:article-footnote><ce:label>‡</ce:label>
<ce:note-para>Supported in part by a grant from the Collaborative Joint Program of the Institut National de la Santé et de la Recherche Médicale and from the Caisse Nationale d’Assurance Maladie des Travailleurs Salariés, and by the Polish National Cancer Program.</ce:note-para>
</ce:article-footnote>
<ce:title>Condylomata acuminata in children: Frequent association with human papillomaviruses responsible for cutaneous warts</ce:title>
<ce:author-group><ce:author><ce:given-name>Slavomir</ce:given-name>
<ce:surname>Obalek</ce:surname>
<ce:degrees>MD</ce:degrees>
<ce:cross-ref refid="aff1"><ce:sup>a</ce:sup>
</ce:cross-ref>
<ce:cross-ref refid="aff2"><ce:sup>b</ce:sup>
</ce:cross-ref>
<ce:cross-ref refid="fn1"><ce:sup>*</ce:sup>
</ce:cross-ref>
</ce:author>
<ce:author><ce:given-name>Stéfania</ce:given-name>
<ce:surname>Jablonska</ce:surname>
<ce:degrees>MD</ce:degrees>
<ce:cross-ref refid="aff1"><ce:sup>a</ce:sup>
</ce:cross-ref>
</ce:author>
<ce:author><ce:given-name>Michel</ce:given-name>
<ce:surname>Favre</ce:surname>
<ce:degrees>PhD</ce:degrees>
<ce:cross-ref refid="aff2"><ce:sup>b</ce:sup>
</ce:cross-ref>
</ce:author>
<ce:author><ce:given-name>Leszek</ce:given-name>
<ce:surname>Walczak</ce:surname>
<ce:degrees>MD</ce:degrees>
<ce:cross-ref refid="aff1"><ce:sup>a</ce:sup>
</ce:cross-ref>
</ce:author>
<ce:author><ce:given-name>Gérard</ce:given-name>
<ce:surname>Orth</ce:surname>
<ce:degrees>DVM</ce:degrees>
<ce:cross-ref refid="aff2"><ce:sup>b</ce:sup>
</ce:cross-ref>
<ce:cross-ref refid="cor1"><ce:sup>†</ce:sup>
</ce:cross-ref>
</ce:author>
<ce:affiliation id="aff1"><ce:label>a</ce:label>
<ce:textfn>From the Department of Dermatology, Warsaw School of Medicine, Warsaw, Poland</ce:textfn>
</ce:affiliation>
<ce:affiliation id="aff2"><ce:label>b</ce:label>
<ce:textfn>From the Unité des Papillomavirus, Unité INSERM 190, Institut Pasteur, Paris, France</ce:textfn>
</ce:affiliation>
<ce:correspondence id="cor1"><ce:label>†</ce:label>
<ce:text>Reprint requests: Gérard Orth, DVM, Unité des Papillomavirus, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France.</ce:text>
</ce:correspondence>
<ce:footnote id="fn1"><ce:label>*</ce:label>
<ce:note-para>Recipient of a fellowship from the Fondation pour la Recherche Médicale.</ce:note-para>
</ce:footnote>
</ce:author-group>
<ce:date-accepted day="29" month="10" year="1989"></ce:date-accepted>
<ce:abstract id="ab1"><ce:abstract-sec><ce:simple-para>To identify the papillomavirus types associated with condylomata acuminata in children and to evaluate their mode of transmission, we studied 32 children with anogenital warts. External condylomata were found in 12 of their mothers and in 10 of their fathers. Ten mothers, including two without external lesions, had cervical condylomata. Blot hybridization studies disclosed a genital human papillomavirus (HPV) in 14 of 27 children (HPV-6 in 12 and HPV-11 in two) and in 8 of 14 patients (HPV-6 in all). HPV-6 was found in another child by the polymerase chain reaction technique. Infection occurred most likely at birth or from nonsexual contact, but sexual abuse could not be excluded in one 11 -year-old girl. Cutaneous HPV-2 was found in seven children and as yet uncharacterized papillomaviruses were found in two children. Three mothers of HPV-2-infected children had common hand warts, and two children had subungual warts. This study shows the frequent nonsexual transmission of genital papillomaviruses in children and the unexpectedly high association of children's condylomata with papillomaviruses responsible for skin warts, possibly transmitted by heteroinoculation or autoinoculation.</ce:simple-para>
</ce:abstract-sec>
</ce:abstract>
</head>
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<mods version="3.6"><titleInfo lang="en"><title>Condylomata acuminata in children: Frequent association with human papillomaviruses responsible for cutaneous warts</title>
</titleInfo>
<titleInfo type="alternative" lang="en" contentType="CDATA"><title>Condylomata acuminata in children: Frequent association with human papillomaviruses responsible for cutaneous warts</title>
</titleInfo>
<name type="personal"><namePart type="given">Slavomir</namePart>
<namePart type="family">Obalek</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>From the Department of Dermatology, Warsaw School of Medicine, Warsaw, Poland</affiliation>
<affiliation>From the Unité des Papillomavirus, Unité INSERM 190, Institut Pasteur, Paris, France</affiliation>
<affiliation>*Recipient of a fellowship from the Fondation pour la Recherche Médicale.</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Stéfania</namePart>
<namePart type="family">Jablonska</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>From the Department of Dermatology, Warsaw School of Medicine, Warsaw, Poland</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Michel</namePart>
<namePart type="family">Favre</namePart>
<namePart type="termsOfAddress">PhD</namePart>
<affiliation>From the Unité des Papillomavirus, Unité INSERM 190, Institut Pasteur, Paris, France</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Leszek</namePart>
<namePart type="family">Walczak</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>From the Department of Dermatology, Warsaw School of Medicine, Warsaw, Poland</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Gérard</namePart>
<namePart type="family">Orth</namePart>
<namePart type="termsOfAddress">DVM</namePart>
<affiliation>From the Unité des Papillomavirus, Unité INSERM 190, Institut Pasteur, Paris, France</affiliation>
<affiliation>Reprint requests: Gérard Orth, DVM, Unité des Papillomavirus, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France.</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<typeOfResource>text</typeOfResource>
<genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre>
<originInfo><publisher>ELSEVIER</publisher>
<dateIssued encoding="w3cdtf">1990</dateIssued>
<copyrightDate encoding="w3cdtf">1990</copyrightDate>
</originInfo>
<language><languageTerm type="code" authority="iso639-2b">eng</languageTerm>
<languageTerm type="code" authority="rfc3066">en</languageTerm>
</language>
<abstract>To identify the papillomavirus types associated with condylomata acuminata in children and to evaluate their mode of transmission, we studied 32 children with anogenital warts. External condylomata were found in 12 of their mothers and in 10 of their fathers. Ten mothers, including two without external lesions, had cervical condylomata. Blot hybridization studies disclosed a genital human papillomavirus (HPV) in 14 of 27 children (HPV-6 in 12 and HPV-11 in two) and in 8 of 14 patients (HPV-6 in all). HPV-6 was found in another child by the polymerase chain reaction technique. Infection occurred most likely at birth or from nonsexual contact, but sexual abuse could not be excluded in one 11 -year-old girl. Cutaneous HPV-2 was found in seven children and as yet uncharacterized papillomaviruses were found in two children. Three mothers of HPV-2-infected children had common hand warts, and two children had subungual warts. This study shows the frequent nonsexual transmission of genital papillomaviruses in children and the unexpectedly high association of children's condylomata with papillomaviruses responsible for skin warts, possibly transmitted by heteroinoculation or autoinoculation.</abstract>
<note>Supported in part by a grant from the Collaborative Joint Program of the Institut National de la Santé et de la Recherche Médicale and from the Caisse Nationale d’Assurance Maladie des Travailleurs Salariés, and by the Polish National Cancer Program.</note>
<relatedItem type="host"><titleInfo><title>Journal of the American Academy of Dermatology</title>
</titleInfo>
<titleInfo type="abbreviated"><title>YMJD</title>
</titleInfo>
<genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre>
<originInfo><publisher>ELSEVIER</publisher>
<dateIssued encoding="w3cdtf">1990</dateIssued>
</originInfo>
<identifier type="ISSN">0190-9622</identifier>
<identifier type="PII">S0190-9622(05)X7134-1</identifier>
<part><date>1990</date>
<detail type="volume"><number>23</number>
<caption>vol.</caption>
</detail>
<detail type="issue"><number>2</number>
<caption>no.</caption>
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<detail type="supplement"><number>P1</number>
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<extent unit="issue-pages"><start>167</start>
<end>330</end>
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<extent unit="pages"><start>205</start>
<end>213</end>
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<identifier type="istex">A151382182153FE88A682DAAECB76D4645617F67</identifier>
<identifier type="ark">ark:/67375/6H6-0WPZMNCK-G</identifier>
<identifier type="DOI">10.1016/0190-9622(90)70200-2</identifier>
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