Interaction between DEAE-dextran and nucleic acids
Identifieur interne : 001177 ( Istex/Corpus ); précédent : 001176; suivant : 001178Interaction between DEAE-dextran and nucleic acids
Auteurs : R. F. Maes ; M. V. FernandesSource :
- Archiv für die gesamte Virusforschung [ 0003-9012 ] ; 1970-06-01.
English descriptors
- Teeft :
- American disease center, American health organization, Animal host, Cationic polymer, Complex formation, Cumulative number, Dos, Dose response, Equal amount, Host resistance, Inducer, Inoculation, Interferon, Interferon production, Nucleic, Nucleic acid, Nucleic acids, Ooool, Polycationic polymer, Polymer, Polynucleotide, Polynucleotides, Synthetic polynucleotides, Time sequence, Virus challenge.
Abstract
Summary: The double-stranded polymer of poly-inosinic acid and poly-cytidylic acid protects mice during five days against foot-and-mouth disease infection. The peak protection is obtained one day after the inoculation of the interferon inducer. When one nucleic acid strand is coated with DEAE-Dextran before complex formation into a double-strand, the peak of protection against viral infection is delayed by two days. When the two nucleic acid strands are coated with DEAE-Dextran before complex formation into a double-strand, the induction of protection appears at its maximum only 5 to 9 days after inoculation of the inducer. An enhancement of the inducer effect is observed when the nucleic acid is coated in the double-strand form by the DEAE-Dextran. The peak of protection is obtained in this case one day after inoculation of the polymer.
Url:
DOI: 10.1007/BF01250182
Links to Exploration step
ISTEX:3CBC095204595E933124D4273F6CA2A47E9EDF91Le document en format XML
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Effect on interferon production in vivo</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><availability><licence><p>Springer-Verlag, 1970</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</p></availability><date>1969-08-26</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Interaction between DEAE-dextran and nucleic acids</title><title level="a" type="sub" xml:lang="en">II. Effect on interferon production in vivo</title><author xml:id="author-0000"><persName><forename type="first">R.</forename><surname>Maes</surname></persName><affiliation>Pan American Foot-and-Mouth Disease Center, Pan American Health Organization, P.O. Box 589-ZC-00, Rio de Janeiro, Brazil</affiliation></author><author xml:id="author-0001"><persName><forename type="first">M.</forename><surname>Fernandes</surname></persName><affiliation>Pan American Foot-and-Mouth Disease Center, Pan American Health Organization, P.O. 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The peak protection is obtained one day after the inoculation of the interferon inducer. When one nucleic acid strand is coated with DEAE-Dextran before complex formation into a double-strand, the peak of protection against viral infection is delayed by two days. When the two nucleic acid strands are coated with DEAE-Dextran before complex formation into a double-strand, the induction of protection appears at its maximum only 5 to 9 days after inoculation of the inducer. An enhancement of the inducer effect is observed when the nucleic acid is coated in the double-strand form by the DEAE-Dextran. The peak of protection is obtained in this case one day after inoculation of the polymer.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>Biomedicine</head><item><term>Medical Microbiology</term></item><item><term>Virology</term></item><item><term>Infectious Diseases</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1969-08-26">Created</change><change when="1970-06-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-PS6B2D05-K/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer-Verlag</PublisherName><PublisherLocation>Vienna</PublisherLocation></PublisherInfo><Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>705</JournalID><JournalPrintISSN>0003-9012</JournalPrintISSN><JournalElectronicISSN>1432-8798</JournalElectronicISSN><JournalTitle>Archiv für die gesamte Virusforschung</JournalTitle><JournalAbbreviatedTitle>Archiv f Virusforschung</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Biomedicine</JournalSubject><JournalSubject Type="Secondary">Medical Microbiology</JournalSubject><JournalSubject Type="Secondary">Virology</JournalSubject><JournalSubject Type="Secondary">Infectious Diseases</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>30</VolumeIDStart><VolumeIDEnd>30</VolumeIDEnd><VolumeIssueCount>4</VolumeIssueCount></VolumeInfo><Issue IssueType="Combined"><IssueInfo TocLevels="0"><IssueIDStart>2</IssueIDStart><IssueIDEnd>3</IssueIDEnd><IssueArticleCount>26</IssueArticleCount><IssueHistory><CoverDate><DateString>1970</DateString><Year>1970</Year><Month>6</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1970</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art7"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF01250182</ArticleID><ArticleDOI>10.1007/BF01250182</ArticleDOI><ArticleSequenceNumber>7</ArticleSequenceNumber><ArticleTitle Language="En">Interaction between DEAE-dextran and nucleic acids</ArticleTitle><ArticleSubTitle Language="En">II. Effect on interferon production in vivo</ArticleSubTitle><ArticleFirstPage>147</ArticleFirstPage><ArticleLastPage>154</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2005</Year><Month>2</Month><Day>17</Day></RegistrationDate><Received><Year>1969</Year><Month>8</Month><Day>26</Day></Received></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1970</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>705</JournalID><VolumeIDStart>30</VolumeIDStart><VolumeIDEnd>30</VolumeIDEnd><IssueIDStart>2</IssueIDStart><IssueIDEnd>3</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1" PresentAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>R.</GivenName><GivenName>F.</GivenName><FamilyName>Maes</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>M.</GivenName><GivenName>V.</GivenName><FamilyName>Fernandes</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Pan American Foot-and-Mouth Disease Center</OrgDivision><OrgName>Pan American Health Organization</OrgName><OrgAddress><Postbox>P.O. Box 589-ZC-00</Postbox><City>Rio de Janeiro</City><Country>Brazil</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>The double-stranded polymer of poly-inosinic acid and poly-cytidylic acid protects mice during five days against foot-and-mouth disease infection. The peak protection is obtained one day after the inoculation of the interferon inducer.</Para><Para>When one nucleic acid strand is coated with DEAE-Dextran before complex formation into a double-strand, the peak of protection against viral infection is delayed by two days. When the two nucleic acid strands are coated with DEAE-Dextran before complex formation into a double-strand, the induction of protection appears at its maximum only 5 to 9 days after inoculation of the inducer.</Para><Para>An enhancement of the inducer effect is observed when the nucleic acid is coated in the double-strand form by the DEAE-Dextran. The peak of protection is obtained in this case one day after inoculation of the polymer.</Para></Abstract></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Interaction between DEAE-dextran and nucleic acids</title><subTitle>II. Effect on interferon production in vivo</subTitle></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Interaction between DEAE-dextran and nucleic acids</title></titleInfo><name type="personal"><namePart type="given">R.</namePart><namePart type="given">F.</namePart><namePart type="family">Maes</namePart><affiliation>Pan American Foot-and-Mouth Disease Center, Pan American Health Organization, P.O. Box 589-ZC-00, Rio de Janeiro, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="given">V.</namePart><namePart type="family">Fernandes</namePart><affiliation>Pan American Foot-and-Mouth Disease Center, Pan American Health Organization, P.O. Box 589-ZC-00, Rio de Janeiro, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Vienna</placeTerm></place><dateCreated encoding="w3cdtf">1969-08-26</dateCreated><dateIssued encoding="w3cdtf">1970-06-01</dateIssued><copyrightDate encoding="w3cdtf">1970</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Summary: The double-stranded polymer of poly-inosinic acid and poly-cytidylic acid protects mice during five days against foot-and-mouth disease infection. The peak protection is obtained one day after the inoculation of the interferon inducer. When one nucleic acid strand is coated with DEAE-Dextran before complex formation into a double-strand, the peak of protection against viral infection is delayed by two days. When the two nucleic acid strands are coated with DEAE-Dextran before complex formation into a double-strand, the induction of protection appears at its maximum only 5 to 9 days after inoculation of the inducer. An enhancement of the inducer effect is observed when the nucleic acid is coated in the double-strand form by the DEAE-Dextran. 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