TAP and TAP-like — Brothers in arms?
Identifieur interne : 001175 ( Istex/Corpus ); précédent : 001174; suivant : 001176TAP and TAP-like — Brothers in arms?
Auteurs : Chenguang Zhao ; Robert Tampé ; Rupert AbeleSource :
- Naunyn-Schmiedeberg's Archives of Pharmacology [ 0028-1298 ] ; 2006-03-01.
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- KwdEn :
Abstract
Abstract: The transporter associated with antigen processing like (TAPL, ABCB9) is a member of the ATP-binding cassette (ABC) transporter family. Moreover, TAPL belongs to the TAP family due to its high sequence homology to TAP1 and TAP2. TAPL forms a homodimer which is localized in lysosomes with a minor fraction in the ER. It functions as an ATP-dependent peptide transporter which shows a broad peptide specificity ranging from 6-mer up to 59-mer peptides. In contrast to TAP, TAPL transports peptides with low affinity but high efficiency. This review will briefly summarize current knowledge about the structural organization and possible physiological function of TAPL in antigen processing and presentation.
Url:
DOI: 10.1007/s00210-005-0028-z
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ISTEX:D19D4A8965778A8A641C70D234C08919437A1713Le document en format XML
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Moreover, TAPL belongs to the TAP family due to its high sequence homology to TAP1 and TAP2. TAPL forms a homodimer which is localized in lysosomes with a minor fraction in the ER. It functions as an ATP-dependent peptide transporter which shows a broad peptide specificity ranging from 6-mer up to 59-mer peptides. In contrast to TAP, TAPL transports peptides with low affinity but high efficiency. This review will briefly summarize current knowledge about the structural organization and possible physiological function of TAPL in antigen processing and presentation.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>Chenguang Zhao</name><affiliations><json:string>Institute of Biochemistry, Biocenter, Goethe-University Frankfurt, Marie-Curie-Str. 9, 60439, Frankfurt am Main, Germany</json:string></affiliations></json:item><json:item><name>Robert Tampé</name><affiliations><json:string>Institute of Biochemistry, Biocenter, Goethe-University Frankfurt, Marie-Curie-Str. 9, 60439, Frankfurt am Main, Germany</json:string></affiliations></json:item><json:item><name>Rupert Abele</name><affiliations><json:string>Institute of Biochemistry, Biocenter, Goethe-University Frankfurt, Marie-Curie-Str. 9, 60439, Frankfurt am Main, Germany</json:string><json:string>E-mail: abele@em.uni-frankfurt.de</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>ABC transporter</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>ABCB9</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Adaptive immunity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Antigen processing</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Lysosome</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Peptide transporter</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>TAP family</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Transport assay</value></json:item></subject><articleId><json:string>28</json:string><json:string>s00210-005-0028-z</json:string></articleId><arkIstex>ark:/67375/VQC-R0D2S84W-M</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>ReviewPaper</json:string></originalGenre><abstract>Abstract: The transporter associated with antigen processing like (TAPL, ABCB9) is a member of the ATP-binding cassette (ABC) transporter family. Moreover, TAPL belongs to the TAP family due to its high sequence homology to TAP1 and TAP2. TAPL forms a homodimer which is localized in lysosomes with a minor fraction in the ER. It functions as an ATP-dependent peptide transporter which shows a broad peptide specificity ranging from 6-mer up to 59-mer peptides. In contrast to TAP, TAPL transports peptides with low affinity but high efficiency. This review will briefly summarize current knowledge about the structural organization and possible physiological function of TAPL in antigen processing and presentation.</abstract><qualityIndicators><score>7.94</score><pdfWordCount>4644</pdfWordCount><pdfCharCount>29339</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>7</pdfPageCount><pdfPageSize>595.276 x 785.197 pts</pdfPageSize><refBibsNative>false</refBibsNative><abstractWordCount>108</abstractWordCount><abstractCharCount>716</abstractCharCount><keywordCount>8</keywordCount></qualityIndicators><title>TAP and TAP-like — Brothers in arms?</title><genre><json:string>review-article</json:string></genre><host><title>Naunyn-Schmiedeberg's Archives of Pharmacology</title><language><json:string>unknown</json:string></language><publicationDate>2006</publicationDate><copyrightDate>2006</copyrightDate><issn><json:string>0028-1298</json:string></issn><eissn><json:string>1432-1912</json:string></eissn><journalId><json:string>210</json:string></journalId><volume>372</volume><issue>6</issue><pages><first>444</first><last>450</last></pages><genre><json:string>journal</json:string></genre></host><ark><json:string>ark:/67375/VQC-R0D2S84W-M</json:string></ark><publicationDate>2006</publicationDate><copyrightDate>2006</copyrightDate><doi><json:string>10.1007/s00210-005-0028-z</json:string></doi><id>D19D4A8965778A8A641C70D234C08919437A1713</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-R0D2S84W-M/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-R0D2S84W-M/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/VQC-R0D2S84W-M/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">TAP and TAP-like — Brothers in arms?</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><availability><licence><p>Springer-Verlag, 2006</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</p></availability><date>2005-10-27</date></publicationStmt><notesStmt><note type="review-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note>Review</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">TAP and TAP-like — Brothers in arms?</title><author xml:id="author-0000"><persName><forename type="first">Chenguang</forename><surname>Zhao</surname></persName><affiliation>Institute of Biochemistry, Biocenter, Goethe-University Frankfurt, Marie-Curie-Str. 9, 60439, Frankfurt am Main, Germany</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Robert</forename><surname>Tampé</surname></persName><affiliation>Institute of Biochemistry, Biocenter, Goethe-University Frankfurt, Marie-Curie-Str. 9, 60439, Frankfurt am Main, Germany</affiliation></author><author xml:id="author-0002" corresp="yes"><persName><forename type="first">Rupert</forename><surname>Abele</surname></persName><email>abele@em.uni-frankfurt.de</email><affiliation>Institute of Biochemistry, Biocenter, Goethe-University Frankfurt, Marie-Curie-Str. 9, 60439, Frankfurt am Main, Germany</affiliation></author><idno type="istex">D19D4A8965778A8A641C70D234C08919437A1713</idno><idno type="ark">ark:/67375/VQC-R0D2S84W-M</idno><idno type="DOI">10.1007/s00210-005-0028-z</idno><idno type="article-id">28</idno><idno type="article-id">s00210-005-0028-z</idno></analytic><monogr><title level="j">Naunyn-Schmiedeberg's Archives of Pharmacology</title><title level="j" type="abbrev">Naunyn-Schmied Arch Pharmacol</title><idno type="pISSN">0028-1298</idno><idno type="eISSN">1432-1912</idno><idno type="journal-ID">true</idno><idno type="issue-article-count">8</idno><idno type="volume-issue-count">6</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="2006-03-01"></date><biblScope unit="volume">372</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="444">444</biblScope><biblScope unit="page" to="450">450</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2005-10-27</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: The transporter associated with antigen processing like (TAPL, ABCB9) is a member of the ATP-binding cassette (ABC) transporter family. Moreover, TAPL belongs to the TAP family due to its high sequence homology to TAP1 and TAP2. TAPL forms a homodimer which is localized in lysosomes with a minor fraction in the ER. It functions as an ATP-dependent peptide transporter which shows a broad peptide specificity ranging from 6-mer up to 59-mer peptides. In contrast to TAP, TAPL transports peptides with low affinity but high efficiency. This review will briefly summarize current knowledge about the structural organization and possible physiological function of TAPL in antigen processing and presentation.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>ABC transporter</term></item><item><term>ABCB9</term></item><item><term>Adaptive immunity</term></item><item><term>Antigen processing</term></item><item><term>Lysosome</term></item><item><term>Peptide transporter</term></item><item><term>TAP family</term></item><item><term>Transport assay</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list></list></keywords></textClass></profileDesc><revisionDesc><change when="2005-10-27">Created</change><change 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Transporters</IssueTitle><IssueArticleCount>8</IssueArticleCount><IssueHistory><OnlineDate><Year>2006</Year><Month>3</Month><Day>20</Day></OnlineDate><PrintDate><Year>2006</Year><Month>3</Month><Day>20</Day></PrintDate><CoverDate><Year>2006</Year><Month>3</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>2006</CopyrightYear></IssueCopyright></IssueInfo><Article ID="s00210-005-0028-z" OutputMedium="All"><ArticleInfo ArticleType="ReviewPaper" ContainsESM="No" Language="En" NumberingStyle="Unnumbered" TocLevels="0"><ArticleID>28</ArticleID><ArticleDOI>10.1007/s00210-005-0028-z</ArticleDOI><ArticleSequenceNumber>6</ArticleSequenceNumber><ArticleTitle Language="En">TAP and TAP-like — Brothers in arms?</ArticleTitle><ArticleCategory>Review</ArticleCategory><ArticleFirstPage>444</ArticleFirstPage><ArticleLastPage>450</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2005</Year><Month>12</Month><Day>13</Day></RegistrationDate><Received><Year>2005</Year><Month>10</Month><Day>27</Day></Received><Accepted><Year>2005</Year><Month>12</Month><Day>7</Day></Accepted><OnlineDate><Year>2006</Year><Month>3</Month><Day>9</Day></OnlineDate></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>2006</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="OpenAccess"></BodyPDFGrant><BodyHTMLGrant Grant="OpenAccess"></BodyHTMLGrant><BibliographyGrant Grant="OpenAccess"></BibliographyGrant><ESMGrant Grant="OpenAccess"></ESMGrant></ArticleGrants></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Chenguang</GivenName><FamilyName>Zhao</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Robert</GivenName><FamilyName>Tampé</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Rupert</GivenName><FamilyName>Abele</FamilyName></AuthorName><Contact><Phone>+49-69-79829437</Phone><Fax>+49-69-79829495</Fax><Email>abele@em.uni-frankfurt.de</Email></Contact></Author><Affiliation ID="Aff1"><OrgDivision>Institute of Biochemistry, Biocenter</OrgDivision><OrgName>Goethe-University Frankfurt</OrgName><OrgAddress><Street>Marie-Curie-Str. 9</Street><Postcode>60439</Postcode><City>Frankfurt am Main</City><Country Code="DE">Germany</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>The transporter associated with antigen processing like (TAPL, ABCB9) is a member of the ATP-binding cassette (ABC) transporter family. Moreover, TAPL belongs to the TAP family due to its high sequence homology to TAP1 and TAP2. TAPL forms a homodimer which is localized in lysosomes with a minor fraction in the ER. It functions as an ATP-dependent peptide transporter which shows a broad peptide specificity ranging from 6-mer up to 59-mer peptides. In contrast to TAP, TAPL transports peptides with low affinity but high efficiency. This review will briefly summarize current knowledge about the structural organization and possible physiological function of TAPL in antigen processing and presentation.</Para></Abstract><KeywordGroup Language="En"><Heading>Keywords</Heading><Keyword>ABC transporter</Keyword><Keyword>ABCB9</Keyword><Keyword>Adaptive immunity</Keyword><Keyword>Antigen processing</Keyword><Keyword>Lysosome</Keyword><Keyword>Peptide transporter</Keyword><Keyword>TAP family</Keyword><Keyword>Transport assay</Keyword></KeywordGroup><AbbreviationGroup><AbbreviationGroupSection ID="AGS1"><Heading>Abbreviations</Heading><DefinitionList><DefinitionListEntry><Term>ABC</Term><Description><Para>ATP-binding cassette</Para></Description></DefinitionListEntry><DefinitionListEntry><Term>ER</Term><Description><Para>endoplasmic reticulum</Para></Description></DefinitionListEntry><DefinitionListEntry><Term>MHC</Term><Description><Para>major histocompatibility complex</Para></Description></DefinitionListEntry><DefinitionListEntry><Term>NBD</Term><Description><Para>nucleotide binding domain</Para></Description></DefinitionListEntry><DefinitionListEntry><Term>TAP</Term><Description><Para>transporter associated with antigen processing</Para></Description></DefinitionListEntry><DefinitionListEntry><Term>TAPL</Term><Description><Para>transporter associated with antigen processing like</Para></Description></DefinitionListEntry><DefinitionListEntry><Term>TMD</Term><Description><Para>transmembrane domain</Para></Description></DefinitionListEntry></DefinitionList></AbbreviationGroupSection></AbbreviationGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>TAP and TAP-like — Brothers in arms?</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>TAP and TAP-like — Brothers in arms?</title></titleInfo><name type="personal"><namePart type="given">Chenguang</namePart><namePart type="family">Zhao</namePart><affiliation>Institute of Biochemistry, Biocenter, Goethe-University Frankfurt, Marie-Curie-Str. 9, 60439, Frankfurt am Main, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robert</namePart><namePart type="family">Tampé</namePart><affiliation>Institute of Biochemistry, Biocenter, Goethe-University Frankfurt, Marie-Curie-Str. 9, 60439, Frankfurt am Main, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">Rupert</namePart><namePart type="family">Abele</namePart><affiliation>Institute of Biochemistry, Biocenter, Goethe-University Frankfurt, Marie-Curie-Str. 9, 60439, Frankfurt am Main, Germany</affiliation><affiliation>E-mail: abele@em.uni-frankfurt.de</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="ReviewPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">2005-10-27</dateCreated><dateIssued encoding="w3cdtf">2006-03-01</dateIssued><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: The transporter associated with antigen processing like (TAPL, ABCB9) is a member of the ATP-binding cassette (ABC) transporter family. Moreover, TAPL belongs to the TAP family due to its high sequence homology to TAP1 and TAP2. TAPL forms a homodimer which is localized in lysosomes with a minor fraction in the ER. It functions as an ATP-dependent peptide transporter which shows a broad peptide specificity ranging from 6-mer up to 59-mer peptides. In contrast to TAP, TAPL transports peptides with low affinity but high efficiency. This review will briefly summarize current knowledge about the structural organization and possible physiological function of TAPL in antigen processing and presentation.</abstract><note>Review</note><subject lang="en"><genre>Keywords</genre><topic>ABC transporter</topic><topic>ABCB9</topic><topic>Adaptive immunity</topic><topic>Antigen processing</topic><topic>Lysosome</topic><topic>Peptide transporter</topic><topic>TAP family</topic><topic>Transport assay</topic></subject><subject></subject><relatedItem type="host"><titleInfo><title>Naunyn-Schmiedeberg's Archives of Pharmacology</title></titleInfo><titleInfo type="abbreviated"><title>Naunyn-Schmied Arch Pharmacol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2006-03-20</dateIssued><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><identifier type="ISSN">0028-1298</identifier><identifier type="eISSN">1432-1912</identifier><identifier type="JournalID">210</identifier><identifier type="IssueArticleCount">8</identifier><identifier type="VolumeIssueCount">6</identifier><part><date>2006</date><detail type="issue"><title>Special Issue: Transporters</title></detail><detail type="volume"><number>372</number><caption>vol.</caption></detail><detail type="issue"><number>6</number><caption>no.</caption></detail><extent unit="pages"><start>444</start><end>450</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 2006</recordOrigin></recordInfo></relatedItem><identifier type="istex">D19D4A8965778A8A641C70D234C08919437A1713</identifier><identifier type="ark">ark:/67375/VQC-R0D2S84W-M</identifier><identifier type="DOI">10.1007/s00210-005-0028-z</identifier><identifier type="ArticleID">28</identifier><identifier type="ArticleID">s00210-005-0028-z</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 2006</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer-Verlag, 2006</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-R0D2S84W-M/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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