The influence of base sequence on the immunostimulatory properties of DNA
Identifieur interne : 001102 ( Istex/Corpus ); précédent : 001101; suivant : 001103The influence of base sequence on the immunostimulatory properties of DNA
Auteurs : David S. PisetskySource :
- Immunologic Research [ 0257-277X ] ; 1999-02-01.
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Abstract
Abstract: DNA is a complex macromolecule whose immunological properties vary with base sequences. As shown with synthetic oligonucleotides, potent immune stimulation results from six base motifs called CpG motifs or immunostimulatory sequences (ISS). These sequences center on an unmethylated CpG dinucleotide and occur much more commonly in bacterial DNA than mammalian DNA. As such, CpG motifs may function as a danger signal to stimulate B cell activation and cytokine production. In addition to CpG motifs, runs of deoxyguanosine (dG) residues in DNA can induce B cell activation and promote macrophage cytokine expression by adjacent CpG motifs. The array of these sequences may determine the overall immune activity of a DNA molecule and affect such processes as host defense against infection as well as the use of plasmids and synthetic oligonucleotides to treat disease.
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DOI: 10.1007/BF02786475
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Pisetsky</name><affiliation><mods:affiliation>Medical Service Durham VA Medical Center and Division of Rheumatology, Allergy and Clinical Immunology, Duke University Medical Center, Box 15IG, 508 Fulton St., 27705, Durham, NC</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: dpiset@acpub.duke.edu</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:851D18CABBDD15BCF7E6CA82E19A717712D71AD9</idno><date when="1999" year="1999">1999</date><idno type="doi">10.1007/BF02786475</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-NPX7D9TB-9/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001102</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001102</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The influence of base sequence on the immunostimulatory properties of DNA</title><author><name sortKey="Pisetsky, David S" sort="Pisetsky, David S" uniqKey="Pisetsky D" first="David S." last="Pisetsky">David S. Pisetsky</name><affiliation><mods:affiliation>Medical Service Durham VA Medical Center and Division of Rheumatology, Allergy and Clinical Immunology, Duke University Medical Center, Box 15IG, 508 Fulton St., 27705, Durham, NC</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: dpiset@acpub.duke.edu</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Immunologic Research</title><title level="j" type="abbrev">Immunol Res</title><idno type="ISSN">0257-277X</idno><idno type="eISSN">1559-0755</idno><imprint><publisher>Humana Press</publisher><pubPlace>Totowa</pubPlace><date type="published" when="1999-02-01">1999-02-01</date><biblScope unit="volume">19</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="35">35</biblScope><biblScope unit="page" to="46">46</biblScope></imprint><idno type="ISSN">0257-277X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0257-277X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antisense</term><term>Cytokines</term><term>DNA</term><term>Host defense</term><term>Immunostimulation</term><term>Phosphorothioates</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: DNA is a complex macromolecule whose immunological properties vary with base sequences. As shown with synthetic oligonucleotides, potent immune stimulation results from six base motifs called CpG motifs or immunostimulatory sequences (ISS). These sequences center on an unmethylated CpG dinucleotide and occur much more commonly in bacterial DNA than mammalian DNA. As such, CpG motifs may function as a danger signal to stimulate B cell activation and cytokine production. In addition to CpG motifs, runs of deoxyguanosine (dG) residues in DNA can induce B cell activation and promote macrophage cytokine expression by adjacent CpG motifs. The array of these sequences may determine the overall immune activity of a DNA molecule and affect such processes as host defense against infection as well as the use of plasmids and synthetic oligonucleotides to treat disease.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>David S. 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Inc.</CopyrightHolderName><CopyrightYear>1999</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>12026</JournalID><VolumeIDStart>19</VolumeIDStart><VolumeIDEnd>19</VolumeIDEnd><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>David</GivenName><GivenName>S.</GivenName><FamilyName>Pisetsky</FamilyName></AuthorName><Contact><Email>dpiset@acpub.duke.edu</Email></Contact></Author><Affiliation ID="Aff1"><OrgDivision>Medical Service Durham VA Medical Center and Division of Rheumatology, Allergy and Clinical Immunology</OrgDivision><OrgName>Duke University Medical Center</OrgName><OrgAddress><Street>Box 15IG, 508 Fulton St.</Street><Postcode>27705</Postcode><City>Durham</City><State>NC</State></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>DNA is a complex macromolecule whose immunological properties vary with base sequences. As shown with synthetic oligonucleotides, potent immune stimulation results from six base motifs called CpG motifs or immunostimulatory sequences (ISS). These sequences center on an unmethylated CpG dinucleotide and occur much more commonly in bacterial DNA than mammalian DNA. As such, CpG motifs may function as a danger signal to stimulate B cell activation and cytokine production. In addition to CpG motifs, runs of deoxyguanosine (dG) residues in DNA can induce B cell activation and promote macrophage cytokine expression by adjacent CpG motifs. The array of these sequences may determine the overall immune activity of a DNA molecule and affect such processes as host defense against infection as well as the use of plasmids and synthetic oligonucleotides to treat disease.</Para></Abstract><KeywordGroup Language="En"><Heading>Key Words</Heading><Keyword>DNA</Keyword><Keyword>Immunostimulation</Keyword><Keyword>Antisense</Keyword><Keyword>Phosphorothioates</Keyword><Keyword>Cytokines</Keyword><Keyword>Host defense</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The influence of base sequence on the immunostimulatory properties of DNA</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>The influence of base sequence on the immunostimulatory properties of DNA</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">David</namePart><namePart type="given">S.</namePart><namePart type="family">Pisetsky</namePart><affiliation>Medical Service Durham VA Medical Center and Division of Rheumatology, Allergy and Clinical Immunology, Duke University Medical Center, Box 15IG, 508 Fulton St., 27705, Durham, NC</affiliation><affiliation>E-mail: dpiset@acpub.duke.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Humana Press</publisher><place><placeTerm type="text">Totowa</placeTerm></place><dateIssued encoding="w3cdtf">1999-02-01</dateIssued><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: DNA is a complex macromolecule whose immunological properties vary with base sequences. As shown with synthetic oligonucleotides, potent immune stimulation results from six base motifs called CpG motifs or immunostimulatory sequences (ISS). These sequences center on an unmethylated CpG dinucleotide and occur much more commonly in bacterial DNA than mammalian DNA. As such, CpG motifs may function as a danger signal to stimulate B cell activation and cytokine production. In addition to CpG motifs, runs of deoxyguanosine (dG) residues in DNA can induce B cell activation and promote macrophage cytokine expression by adjacent CpG motifs. The array of these sequences may determine the overall immune activity of a DNA molecule and affect such processes as host defense against infection as well as the use of plasmids and synthetic oligonucleotides to treat disease.</abstract><subject lang="en"><genre>Key Words</genre><topic>DNA</topic><topic>Immunostimulation</topic><topic>Antisense</topic><topic>Phosphorothioates</topic><topic>Cytokines</topic><topic>Host defense</topic></subject><relatedItem type="host"><titleInfo><title>Immunologic Research</title></titleInfo><titleInfo type="abbreviated"><title>Immunol Res</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">1999-02-01</dateIssued><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><subject><genre>Journal-Subject-Group</genre><topic authority="SpringerSubjectCodes" authorityURI="H">Medicine & Public Health</topic><topic authority="SpringerSubjectCodes" authorityURI="H11009">Allergology</topic><topic authority="SpringerSubjectCodes" authorityURI="B14000">Immunology</topic><topic authority="SpringerSubjectCodes" authorityURI="H00007">Medicine/Public Health, general</topic><topic authority="SpringerSubjectCodes" authorityURI="H33002">Internal Medicine</topic></subject><identifier type="ISSN">0257-277X</identifier><identifier type="eISSN">1559-0755</identifier><identifier type="JournalID">12026</identifier><identifier type="IssueArticleCount">6</identifier><identifier type="VolumeIssueCount">3</identifier><part><date>1999</date><detail type="volume"><number>19</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="pages"><start>35</start><end>46</end></extent></part><recordInfo><recordOrigin>Humana Press Inc., 1999</recordOrigin></recordInfo></relatedItem><identifier type="istex">851D18CABBDD15BCF7E6CA82E19A717712D71AD9</identifier><identifier type="ark">ark:/67375/VQC-NPX7D9TB-9</identifier><identifier type="DOI">10.1007/BF02786475</identifier><identifier type="ArticleID">BF02786475</identifier><identifier type="ArticleID">Art3</identifier><accessCondition type="use and reproduction" contentType="copyright">Humana Press Inc., 1999</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Humana Press Inc., 1999</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-NPX7D9TB-9/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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