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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The COMET Initiative database: progress and activities update (2015)</title><author><name sortKey="Gargon, E" sort="Gargon, E" uniqKey="Gargon E" first="E." last="Gargon">E. Gargon</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8470</institution-id><institution-id institution-id-type="GRID">grid.10025.36</institution-id><institution>Department of Biostatistics,</institution><institution>University of Liverpool,</institution></institution-wrap>1st floor Duncan Building, Daulby Street, Liverpool, L69 3GA UK</nlm:aff></affiliation></author><author><name sortKey="Williamson, P R" sort="Williamson, P R" uniqKey="Williamson P" first="P. R." last="Williamson">P. R. Williamson</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8470</institution-id><institution-id institution-id-type="GRID">grid.10025.36</institution-id><institution>Department of Biostatistics,</institution><institution>University of Liverpool,</institution></institution-wrap>1st floor Duncan Building, Daulby Street, Liverpool, L69 3GA UK</nlm:aff></affiliation></author><author><name sortKey="Altman, D G" sort="Altman, D G" uniqKey="Altman D" first="D. G." last="Altman">D. G. Altman</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution></institution><institution>University of Oxford, Centre for Statistics in Medicine, Botnar Research Centre,</institution></institution-wrap>Windmill Road, Oxford, OX3 7LD UK</nlm:aff></affiliation></author><author><name sortKey="Blazeby, J M" sort="Blazeby, J M" uniqKey="Blazeby J" first="J. M." last="Blazeby">J. M. Blazeby</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7603</institution-id><institution-id institution-id-type="GRID">grid.5337.2</institution-id><institution>School of Social and Community Medicine,</institution><institution>University of Bristol,</institution></institution-wrap>Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS UK</nlm:aff></affiliation></author><author><name sortKey="Tunis, S" sort="Tunis, S" uniqKey="Tunis S" first="S." last="Tunis">S. Tunis</name><affiliation><nlm:aff id="Aff4">Center for Medical Technology Policy (CMTP), World Trade Center Baltimore, 401 East Pratt Street, Suite 631, Baltimore, MD 21202 USA</nlm:aff></affiliation></author><author><name sortKey="Clarke, M" sort="Clarke, M" uniqKey="Clarke M" first="M." last="Clarke">M. Clarke</name><affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 7521</institution-id><institution-id institution-id-type="GRID">grid.4777.3</institution-id><institution></institution><institution>Queen’s University Belfast, Institute of Clinical Sciences, Block B, Royal Hospitals,</institution></institution-wrap>Grosvenor Road, Belfast, BT12 6BJ UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28159003</idno><idno type="pmc">5291989</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291989</idno><idno type="RBID">PMC:5291989</idno><idno type="doi">10.1186/s13063-017-1788-8</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000019</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000019</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The COMET Initiative database: progress and activities update (2015)</title><author><name sortKey="Gargon, E" sort="Gargon, E" uniqKey="Gargon E" first="E." last="Gargon">E. Gargon</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8470</institution-id><institution-id institution-id-type="GRID">grid.10025.36</institution-id><institution>Department of Biostatistics,</institution><institution>University of Liverpool,</institution></institution-wrap>1st floor Duncan Building, Daulby Street, Liverpool, L69 3GA UK</nlm:aff></affiliation></author><author><name sortKey="Williamson, P R" sort="Williamson, P R" uniqKey="Williamson P" first="P. R." last="Williamson">P. R. Williamson</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8470</institution-id><institution-id institution-id-type="GRID">grid.10025.36</institution-id><institution>Department of Biostatistics,</institution><institution>University of Liverpool,</institution></institution-wrap>1st floor Duncan Building, Daulby Street, Liverpool, L69 3GA UK</nlm:aff></affiliation></author><author><name sortKey="Altman, D G" sort="Altman, D G" uniqKey="Altman D" first="D. G." last="Altman">D. G. Altman</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution></institution><institution>University of Oxford, Centre for Statistics in Medicine, Botnar Research Centre,</institution></institution-wrap>Windmill Road, Oxford, OX3 7LD UK</nlm:aff></affiliation></author><author><name sortKey="Blazeby, J M" sort="Blazeby, J M" uniqKey="Blazeby J" first="J. M." last="Blazeby">J. M. Blazeby</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7603</institution-id><institution-id institution-id-type="GRID">grid.5337.2</institution-id><institution>School of Social and Community Medicine,</institution><institution>University of Bristol,</institution></institution-wrap>Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS UK</nlm:aff></affiliation></author><author><name sortKey="Tunis, S" sort="Tunis, S" uniqKey="Tunis S" first="S." last="Tunis">S. Tunis</name><affiliation><nlm:aff id="Aff4">Center for Medical Technology Policy (CMTP), World Trade Center Baltimore, 401 East Pratt Street, Suite 631, Baltimore, MD 21202 USA</nlm:aff></affiliation></author><author><name sortKey="Clarke, M" sort="Clarke, M" uniqKey="Clarke M" first="M." last="Clarke">M. Clarke</name><affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 7521</institution-id><institution-id institution-id-type="GRID">grid.4777.3</institution-id><institution></institution><institution>Queen’s University Belfast, Institute of Clinical Sciences, Block B, Royal Hospitals,</institution></institution-wrap>Grosvenor Road, Belfast, BT12 6BJ UK</nlm:aff></affiliation></author></analytic><series><title level="j">Trials</title><idno type="eISSN">1745-6215</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>This letter describes the substantial activity on the Core Outcome Measure in Effectiveness Trials (COMET) website in 2015, updating our earlier progress reports for the period from the launch of the COMET website and database in August 2011 to December 2014. As in previous years, 2015 saw further increases in the annual number of visits to the website, the number of pages viewed and the number of searches undertaken. The sustained growth in use of the website and database suggests that COMET is continuing to gain interest and prominence, and that the resources are useful to people interested in the development of core outcome sets.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Gargon, E" uniqKey="Gargon E">E Gargon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gorst, Sl" uniqKey="Gorst S">SL Gorst</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Gargon, E" uniqKey="Gargon E">E Gargon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gargon, E" uniqKey="Gargon E">E Gargon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khan, K" uniqKey="Khan K">K Khan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Williamson, Pr" uniqKey="Williamson P">PR Williamson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Treweek, S" uniqKey="Treweek S">S Treweek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ioannidis, Jpa" uniqKey="Ioannidis J">JPA Ioannidis</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="letter"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Trials</journal-id><journal-id journal-id-type="iso-abbrev">Trials</journal-id><journal-title-group><journal-title>Trials</journal-title></journal-title-group><issn pub-type="epub">1745-6215</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28159003</article-id><article-id pub-id-type="pmc">5291989</article-id><article-id pub-id-type="publisher-id">1788</article-id><article-id pub-id-type="doi">10.1186/s13063-017-1788-8</article-id><article-categories><subj-group subj-group-type="heading"><subject>Letter</subject></subj-group></article-categories><title-group><article-title>The COMET Initiative database: progress and activities update (2015)</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Gargon</surname><given-names>E.</given-names></name><address><email>e.gargon@liv.ac.uk</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Williamson</surname><given-names>P. R.</given-names></name><address><email>prw@liverpool.ac.uk</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Altman</surname><given-names>D. G.</given-names></name><address><email>doug.altman@csm.ox.ac.uk</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Blazeby</surname><given-names>J. M.</given-names></name><address><email>J.M.Blazeby@bristol.ac.uk</email></address><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Tunis</surname><given-names>S.</given-names></name><address><email>Sean.tunis@cmtpnet.org</email></address><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Clarke</surname><given-names>M.</given-names></name><address><email>m.clarke@qub.ac.uk</email></address><xref ref-type="aff" rid="Aff5">5</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8470</institution-id><institution-id institution-id-type="GRID">grid.10025.36</institution-id><institution>Department of Biostatistics,</institution><institution>University of Liverpool,</institution></institution-wrap>1st floor Duncan Building, Daulby Street, Liverpool, L69 3GA UK</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution></institution><institution>University of Oxford, Centre for Statistics in Medicine, Botnar Research Centre,</institution></institution-wrap>Windmill Road, Oxford, OX3 7LD UK</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7603</institution-id><institution-id institution-id-type="GRID">grid.5337.2</institution-id><institution>School of Social and Community Medicine,</institution><institution>University of Bristol,</institution></institution-wrap>Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS UK</aff><aff id="Aff4"><label>4</label>Center for Medical Technology Policy (CMTP), World Trade Center Baltimore, 401 East Pratt Street, Suite 631, Baltimore, MD 21202 USA</aff><aff id="Aff5"><label>5</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0374 7521</institution-id><institution-id institution-id-type="GRID">grid.4777.3</institution-id><institution></institution><institution>Queen’s University Belfast, Institute of Clinical Sciences, Block B, Royal Hospitals,</institution></institution-wrap>Grosvenor Road, Belfast, BT12 6BJ UK</aff></contrib-group><pub-date pub-type="epub"><day>3</day><month>2</month><year>2017</year></pub-date><pub-date pub-type="pmc-release"><day>3</day><month>2</month><year>2017</year></pub-date><pub-date pub-type="collection"><year>2017</year></pub-date><volume>18</volume><elocation-id>54</elocation-id><history><date date-type="received"><day>25</day><month>5</month><year>2016</year></date><date date-type="accepted"><day>9</day><month>1</month><year>2017</year></date></history><permissions><copyright-statement>© The Author(s). 2017</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><p>This letter describes the substantial activity on the Core Outcome Measure in Effectiveness Trials (COMET) website in 2015, updating our earlier progress reports for the period from the launch of the COMET website and database in August 2011 to December 2014. As in previous years, 2015 saw further increases in the annual number of visits to the website, the number of pages viewed and the number of searches undertaken. The sustained growth in use of the website and database suggests that COMET is continuing to gain interest and prominence, and that the resources are useful to people interested in the development of core outcome sets.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Core outcome set</kwd><kwd>Database</kwd><kwd>Resources</kwd></kwd-group><funding-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100000265</institution-id><institution>Medical Research Council</institution></institution-wrap></funding-source><award-id>MRC North West Hub for Trials Methodology Research (MR/K025635/1)</award-id></award-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100000272</institution-id><institution>National Institute for Health Research</institution></institution-wrap></funding-source><award-id>Senior Investigators Award (NF-SI_0513-10025)</award-id></award-group></funding-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2017</meta-value></custom-meta></custom-meta-group></article-meta></front><body><sec id="Sec1"><title>Correspondence/findings</title><sec id="Sec2"><title>Background</title><p>As the New Year bells were ringing and the fireworks were exploding to welcome 2016 in cities such as Fray Bentos in South America, an Internet user in Tianjin, China ran the 10,000th search of the Core Outcome Measures in Effectiveness Trials (COMET) database. They were looking for information about non-small-cell lung cancer (NSCLC), and will have been shown details of two core outcome sets (COS) recently added to the database [<xref ref-type="bibr" rid="CR1">1</xref>, <xref ref-type="bibr" rid="CR2">2</xref>]. This letter describes the substantial activity on the COMET website [<xref ref-type="bibr" rid="CR3">3</xref>] in the 365 days before that search. We update our earlier progress since the launch of the COMET website and database in August 2011 to December 2014 [<xref ref-type="bibr" rid="CR4">4</xref>, <xref ref-type="bibr" rid="CR5">5</xref>].</p></sec><sec id="Sec3"><title>Activity and content</title><p>A total of 720 studies relevant to the development of COS were included in the COMET database at the end of December 2015, with 147 added during the year. This included 32 reports relating to 29 COS identified in the most recent update to the systematic review of COS [<xref ref-type="bibr" rid="CR2">2</xref>], which had originally been performed in 2013 [<xref ref-type="bibr" rid="CR1">1</xref>].</p><p>As in previous years, 2015 saw further increases in the annual number of visits to the website (Table <xref rid="Tab1" ref-type="table">1</xref>) and although the proportional change declined in 2015, the absolute numbers continue to increase. For instance, the proportional increase in new visitors from 2014 to 2015 was 33%, compared to 43% for 2013 to 2014; but the absolute increase from 2014 to 2015 was 3269 compared to 2936 for 2013 to 2014. Most visitors to the website arrived either via links following an organic search using a search engine, such as Google (68%), or direct (20%) (Fig. <xref rid="Fig1" ref-type="fig">1</xref>). However, new for 2015, were arrivals from links in emails, which is in large part attributable to the move of the COMET newsletter from a PDF format to an email format.<table-wrap id="Tab1"><label>Table 1</label><caption><p>Core Outcome Measures in Effectiveness Trials (COMET) website usage statistics 2012 to 2015</p></caption><table frame="hsides" rules="groups"><thead><tr><th></th><th colspan="4">Number of visits</th><th colspan="4">Number of unique visitors</th><th colspan="4">Number of new visitors</th><th colspan="4">Number of searches</th></tr></thead><tbody><tr><td>Year</td><td align="center">2012</td><td align="center">2013</td><td align="center">2014</td><td align="center">2015</td><td align="center">2012</td><td align="center">2013</td><td align="center">2014</td><td align="center">2015</td><td align="center">2012</td><td align="center">2013</td><td align="center">2014</td><td align="center">2015</td><td align="center">2012</td><td align="center">2013</td><td align="center">2014</td><td align="center">2015</td></tr><tr><td>Total</td><td align="center">7982</td><td align="center">12332</td><td align="center">16768</td><td align="center">20952</td><td align="center">5471</td><td align="center">8369</td><td align="center">12257</td><td align="center">15366</td><td align="center">4611</td><td align="center">6844</td><td align="center">9780</td><td align="center">13049</td><td align="center">1597</td><td align="center">2139</td><td align="center">2383</td><td align="center">3411</td></tr><tr><td>Increase per year (%)</td><td align="center">n/a</td><td align="center">55%</td><td align="center">36%</td><td align="center">25%</td><td align="center">n/a</td><td align="center">53%</td><td align="center">47%</td><td align="center">25%</td><td align="center">n/a</td><td align="center">48%</td><td align="center">43%</td><td align="center">33%</td><td align="center">n/a</td><td align="center">34%</td><td align="center">11%</td><td align="center">43%</td></tr><tr><td>Overall increase from 2012 to 2015 (%)</td><td align="center" colspan="4">163%</td><td align="center" colspan="4">181%</td><td align="center" colspan="4">183%</td><td align="center" colspan="4">114%</td></tr></tbody></table></table-wrap><fig id="Fig1"><label>Fig. 1</label><caption><p>Core Outcome Measures in Effectiveness Trials (COMET) website acquisition overview</p></caption><graphic xlink:href="13063_2017_1788_Fig1_HTML" id="MO1"></graphic></fig></p><p>Social media also leads many people to the website and Twitter accounted for 89% of social referrals to the COMET website in 2015 (Table <xref rid="Tab2" ref-type="table">2</xref>). The COMET Twitter account is monitored by the research team and tweets are sent when new COS papers are published, to announce relevant presentations at conferences and to retweet COS-related tweets from others that we follow. The COMET account has more than 1300 followers and the Twitter page links to the COMET website.<table-wrap id="Tab2"><label>Table 2</label><caption><p>Examples of Twitter referrals</p></caption><graphic xlink:href="13063_2017_1788_Tab2_HTML" id="MO2"></graphic></table-wrap></p><p>The highest proportions of referrals were from the Core Outcomes in Women’s Health (CROWN) Initiative (10%), the University of Liverpool (6%), <italic>Trials</italic> journal (5%), MRC Hubs for Trials Methodology Research (5%), Cochrane Canada (5%) and the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) initiative (4%). CROWN is an international initiative to harmonise outcome reporting in women’s health research. More than 70 journals have committed to encouraging the development and reporting of COS in this area and CROWN advises all COS developers to register with COMET [<xref ref-type="bibr" rid="CR6">6</xref>]. <italic>Trials</italic> has published several COS papers which generated referrals to the COMET website, including ‘Developing core outcome sets for clinical trials: issues to consider’ [<xref ref-type="bibr" rid="CR7">7</xref>], the special collection of the meeting proceedings and abstracts from the 4th COMET meeting in Rome in November 2014, and the report of the first meeting to discuss Trial Forge [<xref ref-type="bibr" rid="CR8">8</xref>]. The 5th COMET meeting was jointly hosted with Cochrane Canada in Calgary in May 2015, hence the large number of referrals from Cochrane Canada, and the more than doubling in the annual number of visits from Canada, from 624 in 2014 to 1449 in 2015 (Table <xref rid="Tab3" ref-type="table">3</xref>). The referrals from SPIRIT reflect that initiative’s encouragement of trial investigators to consider measuring the outcomes in a COS in their trial as part of their effort to improve the quality of clinical trial protocols by defining an evidence-based set of items to address in a protocol.<table-wrap id="Tab3"><label>Table 3</label><caption><p>Countries with the most visits to the Core Outcome Measure in Effectiveness Trials (COMET) website in 2012 to 2015</p></caption><table frame="hsides" rules="groups"><thead><tr><th colspan="2">2012</th><th colspan="2">2013</th><th colspan="2">2014</th><th colspan="2">2015</th></tr></thead><tbody><tr><td>United Kingdom</td><td>5577</td><td>United Kingdom</td><td>7526</td><td>United Kingdom</td><td>8203</td><td>United Kingdom</td><td>9862</td></tr><tr><td>United States</td><td>431</td><td>United States</td><td>1022</td><td>United States</td><td>2038</td><td>United States</td><td>2444</td></tr><tr><td>Canada</td><td>326</td><td>Canada</td><td>501</td><td>Italy</td><td>1115</td><td>Canada</td><td>1449</td></tr><tr><td>Australia</td><td>201</td><td>Australia</td><td>321</td><td>Canada</td><td>624</td><td>Australia</td><td>654</td></tr><tr><td>Germany</td><td>186</td><td>Italy</td><td>315</td><td>Germany</td><td>581</td><td>France</td><td>593</td></tr><tr><td>Netherlands</td><td>166</td><td>Netherlands</td><td>308</td><td>Netherlands</td><td>510</td><td>Netherlands</td><td>570</td></tr><tr><td>Italy</td><td>161</td><td>Germany</td><td>285</td><td>Australia</td><td>494</td><td>Germany</td><td>553</td></tr><tr><td>France</td><td>125</td><td>Japan</td><td>228</td><td>France</td><td>374</td><td>India</td><td>477</td></tr><tr><td>Ireland</td><td>113</td><td>France</td><td>227</td><td>India</td><td>306</td><td>Italy</td><td>439</td></tr><tr><td>Norway</td><td>62</td><td>Ireland</td><td>159</td><td>Ireland</td><td>239</td><td>Ireland</td><td>415</td></tr></tbody></table></table-wrap></p><p>In 2015, there were a total 80,799 page views, a 10% increase from 73,617 in 2014. Analyses of the COMET website data show that 56% of visitors went beyond the page on which they landed in 2015, similar to 2014 and, as in previous years, the most common first interaction was to search the COMET database. Other first interactions included moving to the overview of the COMET Initiative, accessing the database without completing a search, and checking the resources page. This Core Resource Pack is once again the second most highly accessed resource on the website (after the database), with 1372 page views in 2015, compared to 1064 in 2014 (29% increase).</p><p>The total number of visits increased by 25% in 2015 compared to 2014.The number of unique visitors also increased by 25%, and the number of new visitors increased by 33%. Full details are provided in Table <xref rid="Tab1" ref-type="table">1</xref>. Visitors came from 127 countries, with 53% of visits now coming from outside the UK, an increase of 2% from 8565/16,768 in 2014 to 11,090/20,952 in 2015 (Table <xref rid="Tab3" ref-type="table">3</xref>).</p><p>By the end of December 2015 in the time zone of the COMET website, a total of 9999 searches had been undertaken in the COMET database, with 3411 in 2015 alone (a 43% increase from 2014). The most frequently used search criteria were consistent with previous years with the most frequently searched category being Disease Category. The ‘top 10’ searched for terms are shown in Table <xref rid="Tab4" ref-type="table">4</xref>. In 2014, the most commonly searched term was ‘cancer’ (<italic>n</italic> = 129) and although this increased to 137 searches in 2015, it was superseded in 2015 by ‘pregnancy and childbirth’ (<italic>n</italic> = 193).<table-wrap id="Tab4"><label>Table 4</label><caption><p>‘Top 10’ search terms in 2015</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Category</th><th>Number</th></tr></thead><tbody><tr><td>Pregnancy and childbirth</td><td>193</td></tr><tr><td>Cancer</td><td>137</td></tr><tr><td>Neurology</td><td>88</td></tr><tr><td>Mental health</td><td>79</td></tr><tr><td>Gynaecology</td><td>77</td></tr><tr><td>Skin</td><td>76</td></tr><tr><td>Heart and circulation</td><td>69</td></tr><tr><td>Anaesthesia and pain control</td><td>68</td></tr><tr><td>Dentistry and oral health</td><td>65</td></tr><tr><td>Orthopaedics and trauma</td><td>65</td></tr></tbody></table></table-wrap></p><p>In 2015, we conducted a pop-up survey to find out why people were searching in the COMET database. The survey appeared at the beginning of each search during a 1-month period, asking people to select single response to give their reason for searching in the COMET database. Full details of the survey have been published [<xref ref-type="bibr" rid="CR2">2</xref>] but, in summary, it showed that the most common reasons for searching the database were to inform decision-making about developing a COS, or to inform the outcomes in planning a clinical trial. The pop-up survey also confirmed the importance of keeping the contents of the database up to date, if it is to help researchers to avoid unnecessary duplication of effort and minimise waste [<xref ref-type="bibr" rid="CR9">9</xref>].</p><p>The sustained growth in use of the website and database suggests that COMET is continuing to gain interest and prominence, and that the resources are useful to people interested in COS development. To help ensure that the content is kept up to date a second update of the systematic review of COS [<xref ref-type="bibr" rid="CR1">1</xref>, <xref ref-type="bibr" rid="CR2">2</xref>] is underway and the COMET website and database usage figures will continue to be monitored and assessed annually.</p></sec></sec></body><back><glossary><title>Abbreviations</title><def-list><def-item><term>COMET</term><def><p>Core Outcome Measures in Effectiveness Trials</p></def></def-item><def-item><term>COS</term><def><p>Core outcome set(s)</p></def></def-item><def-item><term>CROWN</term><def><p>Core Outcomes in Women’s Health</p></def></def-item><def-item><term>NSCLC</term><def><p>Non-small-cell lung cancer</p></def></def-item><def-item><term>SPIRIT</term><def><p>Standard Protocol Items: Recommendations for Interventional Trials</p></def></def-item></def-list></glossary><ack><title>Acknowledgements</title><p>Ms. Mel Major, Associate Professor Marike vander Schaaf and Professor Dale Needham consent for their Twitter profiles and tweets to be used in this manuscript.</p><sec id="FPar1"><title>Funding</title><p>This work was supported by the MRC North West Hub for Trials Methodology Research (MR/K025635/1), and the NIHR Senior Investigators Award (NF-SI_0513-10025).</p></sec><sec id="FPar2"><title>Availability of data and materials</title><p>Not applicable (but data used to prepare the tables is available from the authors).</p></sec><sec id="FPar3"><title>Authors’ contributions</title><p>EG and MC conceived the idea for these periodic reports. EG performed the analysis. EG, PW, MC, JB, ST and DA interpreted data. EG wrote the manuscript. All authors read and approved the final manuscript.</p></sec><sec id="FPar4"><title>Competing interests</title><p>DA, JB, MC, ST and PW are members of the COMET Management Group and coapplicants on grants to support COMET and related work. EG is a member of the COMET Management Group and is the COMET project coordinator.</p></sec><sec id="FPar5"><title>Consent for publication</title><p>Not applicable.</p></sec><sec id="FPar6"><title>Ethics approval and consent to participate</title><p>Not applicable.</p></sec></ack><ref-list id="Bib1"><title>References</title><ref id="CR1"><label>1.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gargon</surname><given-names>E</given-names></name><etal></etal></person-group><article-title>Choosing important health outcomes for comparative effectiveness research: a systematic review</article-title><source>PLoS One</source><year>2014</year><volume>9</volume><issue>6</issue><fpage>e99111</fpage><pub-id pub-id-type="doi">10.1371/journal.pone.0099111</pub-id><pub-id pub-id-type="pmid">24932522</pub-id></element-citation></ref><ref id="CR2"><label>2.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gorst</surname><given-names>SL</given-names></name><etal></etal></person-group><article-title>Choosing important health outcomes for comparative effectiveness research: an updated review and user survey</article-title><source>PLoS One</source><year>2016</year><volume>11</volume><issue>1</issue><fpage>e0146444</fpage><pub-id pub-id-type="doi">10.1371/journal.pone.0146444</pub-id><pub-id pub-id-type="pmid">26785121</pub-id></element-citation></ref><ref id="CR3"><label>3.</label><mixed-citation publication-type="other">COMET. 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