Lack of IgG4 antibody response to carbohydrate antigens in patients with lymphatic filariasis.
Identifieur interne : 005A70 ( PubMed/Curation ); précédent : 005A69; suivant : 005A71Lack of IgG4 antibody response to carbohydrate antigens in patients with lymphatic filariasis.
Auteurs : R B Lal [États-Unis] ; R R Dhawan ; J J Tarrand ; E M Ayoub ; E A OttesenSource :
- Immunology [ 0019-2805 ] ; 1991.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Anticorps antibactériens (biosynthèse), Anticorps antihelminthe (immunologie), Antigènes bactériens (immunologie), Désoxyribonucléases (immunologie), Femelle, Filariose lymphatique (immunologie), Humains, Immunoglobuline G (biosynthèse), Mâle, Polyosides bactériens (immunologie), Protéines bactériennes, Streptococcus pyogenes (immunologie), Streptolysines (immunologie), Sujet âgé, Wuchereria bancrofti (immunologie).
- MESH :
- biosynthèse : Anticorps antibactériens, Immunoglobuline G.
- immunologie : Anticorps antihelminthe, Antigènes bactériens, Désoxyribonucléases, Filariose lymphatique, Polyosides bactériens, Streptococcus pyogenes, Streptolysines, Wuchereria bancrofti.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Femelle, Humains, Mâle, Protéines bactériennes, Sujet âgé.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Animals, Antibodies, Bacterial (biosynthesis), Antibodies, Helminth (immunology), Antigens, Bacterial (immunology), Bacterial Proteins, Deoxyribonucleases (immunology), Elephantiasis, Filarial (immunology), Female, Humans, Immunoglobulin G (biosynthesis), Male, Middle Aged, Polysaccharides, Bacterial (immunology), Streptococcus pyogenes (immunology), Streptolysins (immunology), Wuchereria bancrofti (immunology).
- MESH :
- chemical , biosynthesis : Antibodies, Bacterial, Immunoglobulin G.
- chemical , immunology : Antibodies, Helminth, Antigens, Bacterial, Deoxyribonucleases, Polysaccharides, Bacterial, Streptolysins.
- immunology : Elephantiasis, Filarial, Streptococcus pyogenes, Wuchereria bancrofti.
- Adolescent, Adult, Aged, Animals, Bacterial Proteins, Female, Humans, Male, Middle Aged.
Abstract
It has been suggested that humans are genetically restricted from making IgG4 antibody responses to carbohydrate antigens. To test this hypothesis we examined sera from 35 patients with bancroftian filariasis (an infection known to induce very high levels of IgG4 antibodies to the parasite and known to be associated with repeated streptococcal infections) as well as from 15 normal individuals for their IgG and IgG subclass responses to streptococcal protein [streptolysin-O (SO), deoxyribonuclease B (DB)] and carbohydrate [group A carbohydrate (GAC)] antigens. Levels of IgG antibodies to all three antigens were found to be significantly higher in the filariasis patients compared to normals (P less than 0.01), and the subclass composition of these antibodies proved heterogenous. Although responses to all three antigens included IgG1, IgG2 and IgG3 antibodies and although IgG4 responses to the proteins SO and DB were significantly higher in the filariasis patients than in normals (P less than 0.001), more importantly there were no detectable anti-GAC IgG4 antibodies in either study group. These observations, coupled with our earlier finding of the absence of IgG4 responses to phosphocholine (PC) in patients with lymphatic filariasis, suggest that even the chronic antigenic stimulation of filarial helminth infection, which leads to very prominent IgG4 responses to protein antigens, cannot overcome the genetic restriction in humans for making IgG4 antibodies to carbohydrate antigens, whether of parasite or non-parasite origin.
PubMed: 1748481
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M" uniqKey="Ayoub E" first="E M" last="Ayoub">E M Ayoub</name></author><author><name sortKey="Ottesen, E A" sort="Ottesen, E A" uniqKey="Ottesen E" first="E A" last="Ottesen">E A Ottesen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1991">1991</date><idno type="RBID">pubmed:1748481</idno><idno type="pmid">1748481</idno><idno type="wicri:Area/PubMed/Corpus">005A70</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005A70</idno><idno type="wicri:Area/PubMed/Curation">005A70</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005A70</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Lack of IgG4 antibody response to carbohydrate antigens in patients with lymphatic filariasis.</title><author><name sortKey="Lal, R B" sort="Lal, R B" uniqKey="Lal R" first="R B" last="Lal">R B Lal</name><affiliation wicri:level="2"><nlm:affiliation>Division of Tropical Public Health, Uniformed Services University of Health Services, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Tropical Public Health, Uniformed Services University of Health Services, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Dhawan, R R" sort="Dhawan, R R" uniqKey="Dhawan R" first="R R" last="Dhawan">R R Dhawan</name></author><author><name sortKey="Tarrand, J J" sort="Tarrand, J J" uniqKey="Tarrand J" first="J J" last="Tarrand">J J Tarrand</name></author><author><name sortKey="Ayoub, E M" sort="Ayoub, E M" uniqKey="Ayoub E" first="E M" last="Ayoub">E M Ayoub</name></author><author><name sortKey="Ottesen, E A" sort="Ottesen, E A" uniqKey="Ottesen E" first="E A" last="Ottesen">E A Ottesen</name></author></analytic><series><title level="j">Immunology</title><idno type="ISSN">0019-2805</idno><imprint><date when="1991" type="published">1991</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Antibodies, Bacterial (biosynthesis)</term><term>Antibodies, Helminth (immunology)</term><term>Antigens, Bacterial (immunology)</term><term>Bacterial Proteins</term><term>Deoxyribonucleases (immunology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Female</term><term>Humans</term><term>Immunoglobulin G (biosynthesis)</term><term>Male</term><term>Middle Aged</term><term>Polysaccharides, Bacterial (immunology)</term><term>Streptococcus pyogenes (immunology)</term><term>Streptolysins (immunology)</term><term>Wuchereria bancrofti (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Anticorps antibactériens (biosynthèse)</term><term>Anticorps antihelminthe (immunologie)</term><term>Antigènes bactériens (immunologie)</term><term>Désoxyribonucléases (immunologie)</term><term>Femelle</term><term>Filariose lymphatique (immunologie)</term><term>Humains</term><term>Immunoglobuline G (biosynthèse)</term><term>Mâle</term><term>Polyosides bactériens (immunologie)</term><term>Protéines bactériennes</term><term>Streptococcus pyogenes (immunologie)</term><term>Streptolysines (immunologie)</term><term>Sujet âgé</term><term>Wuchereria bancrofti (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Bacterial</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Helminth</term><term>Antigens, Bacterial</term><term>Deoxyribonucleases</term><term>Polysaccharides, Bacterial</term><term>Streptolysins</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antibactériens</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Antigènes bactériens</term><term>Désoxyribonucléases</term><term>Filariose lymphatique</term><term>Polyosides bactériens</term><term>Streptococcus pyogenes</term><term>Streptolysines</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Streptococcus pyogenes</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Bacterial Proteins</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Protéines bactériennes</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">It has been suggested that humans are genetically restricted from making IgG4 antibody responses to carbohydrate antigens. To test this hypothesis we examined sera from 35 patients with bancroftian filariasis (an infection known to induce very high levels of IgG4 antibodies to the parasite and known to be associated with repeated streptococcal infections) as well as from 15 normal individuals for their IgG and IgG subclass responses to streptococcal protein [streptolysin-O (SO), deoxyribonuclease B (DB)] and carbohydrate [group A carbohydrate (GAC)] antigens. Levels of IgG antibodies to all three antigens were found to be significantly higher in the filariasis patients compared to normals (P less than 0.01), and the subclass composition of these antibodies proved heterogenous. Although responses to all three antigens included IgG1, IgG2 and IgG3 antibodies and although IgG4 responses to the proteins SO and DB were significantly higher in the filariasis patients than in normals (P less than 0.001), more importantly there were no detectable anti-GAC IgG4 antibodies in either study group. These observations, coupled with our earlier finding of the absence of IgG4 responses to phosphocholine (PC) in patients with lymphatic filariasis, suggest that even the chronic antigenic stimulation of filarial helminth infection, which leads to very prominent IgG4 responses to protein antigens, cannot overcome the genetic restriction in humans for making IgG4 antibodies to carbohydrate antigens, whether of parasite or non-parasite origin.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1748481</PMID><DateCreated><Year>1992</Year><Month>01</Month><Day>21</Day></DateCreated><DateCompleted><Year>1992</Year><Month>01</Month><Day>21</Day></DateCompleted><DateRevised><Year>2009</Year><Month>11</Month><Day>18</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0019-2805</ISSN><JournalIssue CitedMedium="Print"><Volume>74</Volume><Issue>2</Issue><PubDate><Year>1991</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Immunology</Title><ISOAbbreviation>Immunology</ISOAbbreviation></Journal><ArticleTitle>Lack of IgG4 antibody response to carbohydrate antigens in patients with lymphatic filariasis.</ArticleTitle><Pagination><MedlinePgn>333-7</MedlinePgn></Pagination><Abstract><AbstractText>It has been suggested that humans are genetically restricted from making IgG4 antibody responses to carbohydrate antigens. To test this hypothesis we examined sera from 35 patients with bancroftian filariasis (an infection known to induce very high levels of IgG4 antibodies to the parasite and known to be associated with repeated streptococcal infections) as well as from 15 normal individuals for their IgG and IgG subclass responses to streptococcal protein [streptolysin-O (SO), deoxyribonuclease B (DB)] and carbohydrate [group A carbohydrate (GAC)] antigens. Levels of IgG antibodies to all three antigens were found to be significantly higher in the filariasis patients compared to normals (P less than 0.01), and the subclass composition of these antibodies proved heterogenous. Although responses to all three antigens included IgG1, IgG2 and IgG3 antibodies and although IgG4 responses to the proteins SO and DB were significantly higher in the filariasis patients than in normals (P less than 0.001), more importantly there were no detectable anti-GAC IgG4 antibodies in either study group. These observations, coupled with our earlier finding of the absence of IgG4 responses to phosphocholine (PC) in patients with lymphatic filariasis, suggest that even the chronic antigenic stimulation of filarial helminth infection, which leads to very prominent IgG4 responses to protein antigens, cannot overcome the genetic restriction in humans for making IgG4 antibodies to carbohydrate antigens, whether of parasite or non-parasite origin.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lal</LastName><ForeName>R B</ForeName><Initials>RB</Initials><AffiliationInfo><Affiliation>Division of Tropical Public Health, Uniformed Services University of Health Services, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dhawan</LastName><ForeName>R R</ForeName><Initials>RR</Initials></Author><Author ValidYN="Y"><LastName>Tarrand</LastName><ForeName>J J</ForeName><Initials>JJ</Initials></Author><Author ValidYN="Y"><LastName>Ayoub</LastName><ForeName>E M</ForeName><Initials>EM</Initials></Author><Author ValidYN="Y"><LastName>Ottesen</LastName><ForeName>E A</ForeName><Initials>EA</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Immunology</MedlineTA><NlmUniqueID>0374672</NlmUniqueID><ISSNLinking>0019-2805</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000907">Antibodies, Bacterial</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000909">Antibodies, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000942">Antigens, Bacterial</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001426">Bacterial Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011135">Polysaccharides, Bacterial</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013301">Streptolysins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C044260">streptococcal group A cell wall carbohydrate</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C025964">streptolysin O</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.1.-</RegistryNumber><NameOfSubstance UI="D003851">Deoxyribonucleases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.1.4.-</RegistryNumber><NameOfSubstance UI="C020069">deoxyribonuclease B</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1985 Apr;134(4):2707-12</RefSource><PMID Version="1">2579154</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1987 May 15;138(10):3454-60</RefSource><PMID Version="1">2437195</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Crit Rev Clin Lab Sci. 1989;27(1):27-58</RefSource><PMID Version="1">2647414</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1989 Apr 1;142(7):2495-500</RefSource><PMID Version="1">2647851</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1988 May 1;140(9):3200-5</RefSource><PMID Version="1">3283244</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Diagn Clin Immunol. 1988;5(5):241-8</RefSource><PMID 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Version="1">2494261</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000907" MajorTopicYN="N">Antibodies, Bacterial</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000909" MajorTopicYN="N">Antibodies, Helminth</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000942" MajorTopicYN="N">Antigens, Bacterial</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001426" MajorTopicYN="N">Bacterial Proteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003851" MajorTopicYN="N">Deoxyribonucleases</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011135" MajorTopicYN="N">Polysaccharides, Bacterial</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013297" MajorTopicYN="N">Streptococcus pyogenes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013301" MajorTopicYN="N">Streptolysins</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014958" MajorTopicYN="Y">Wuchereria bancrofti</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC1384614</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1991</Year><Month>10</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1991</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1991</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1748481</ArticleId><ArticleId IdType="pmc">PMC1384614</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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