[A preliminary study on vascular endothelial growth factor C gene modified lymph node transplantation in promoting proliferation of lymphatic endothelial cells].
Identifieur interne : 001A04 ( PubMed/Curation ); précédent : 001A03; suivant : 001A05[A preliminary study on vascular endothelial growth factor C gene modified lymph node transplantation in promoting proliferation of lymphatic endothelial cells].
Auteurs : Nanhang Lu [République populaire de Chine] ; Yong Zhang ; Zihao Feng ; Fazhi QiSource :
- Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery [ 1002-1892 ] ; 2013.
Descripteurs français
- KwdFr :
- Adenoviridae (génétique), Animaux, Attribution aléatoire, Cellules endothéliales (cytologie), Cellules endothéliales (métabolisme), Facteur de croissance endothéliale vasculaire de type C (génétique), Injections lymphatiques, Lymphoedème (), Modèles animaux de maladie humaine, Mâle, Noeuds lymphatiques (anatomopathologie), Noeuds lymphatiques (métabolisme), Noeuds lymphatiques (transplantation), Prolifération cellulaire, Protéines suppresseurs de tumeurs (métabolisme), Protéines à homéodomaine (métabolisme), Rat Sprague-Dawley, Rats, Techniques de transfert de gènes, Transplantation autologue, Vecteurs génétiques (génétique).
- MESH :
- anatomopathologie : Noeuds lymphatiques.
- cytologie : Cellules endothéliales.
- génétique : Adenoviridae, Facteur de croissance endothéliale vasculaire de type C, Vecteurs génétiques.
- métabolisme : Cellules endothéliales, Noeuds lymphatiques, Protéines suppresseurs de tumeurs, Protéines à homéodomaine.
- Animaux, Attribution aléatoire, Injections lymphatiques, Lymphoedème, Modèles animaux de maladie humaine, Mâle, Noeuds lymphatiques, Prolifération cellulaire, Rat Sprague-Dawley, Rats, Techniques de transfert de gènes, Transplantation autologue.
English descriptors
- KwdEn :
- Adenoviridae (genetics), Animals, Cell Proliferation, Disease Models, Animal, Endothelial Cells (cytology), Endothelial Cells (metabolism), Gene Transfer Techniques, Genetic Vectors (genetics), Homeodomain Proteins (metabolism), Injections, Intralymphatic, Lymph Nodes (metabolism), Lymph Nodes (pathology), Lymph Nodes (transplantation), Lymphedema (therapy), Male, Random Allocation, Rats, Rats, Sprague-Dawley, Transplantation, Autologous, Tumor Suppressor Proteins (metabolism), Vascular Endothelial Growth Factor C (genetics).
- MESH :
- chemical , genetics : Vascular Endothelial Growth Factor C.
- chemical , metabolism : Homeodomain Proteins, Tumor Suppressor Proteins.
- cytology : Endothelial Cells.
- genetics : Adenoviridae, Genetic Vectors.
- metabolism : Endothelial Cells, Lymph Nodes.
- pathology : Lymph Nodes.
- therapy : Lymphedema.
- transplantation : Lymph Nodes.
- Animals, Cell Proliferation, Disease Models, Animal, Gene Transfer Techniques, Injections, Intralymphatic, Male, Random Allocation, Rats, Rats, Sprague-Dawley, Transplantation, Autologous.
Abstract
To investigate the effects of vascular endothelial growth factor C (VEGF-C) gene modified lymph nodes on promoting proliferation of lymphatic endothelial cells in the surrounding tissues.
PubMed: 23879104
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pubmed:23879104Le document en format XML
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Feng</name></author><author><name sortKey="Qi, Fazhi" sort="Qi, Fazhi" uniqKey="Qi F" first="Fazhi" last="Qi">Fazhi Qi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23879104</idno><idno type="pmid">23879104</idno><idno type="wicri:Area/PubMed/Corpus">001A04</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001A04</idno><idno type="wicri:Area/PubMed/Curation">001A04</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001A04</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[A preliminary study on vascular endothelial growth factor C gene modified lymph node transplantation in promoting proliferation of lymphatic endothelial cells].</title><author><name sortKey="Lu, Nanhang" sort="Lu, Nanhang" uniqKey="Lu N" first="Nanhang" last="Lu">Nanhang Lu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plastic & Reconstructive Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plastic & Reconstructive Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Yong" sort="Zhang, Yong" uniqKey="Zhang Y" first="Yong" last="Zhang">Yong Zhang</name></author><author><name sortKey="Feng, Zihao" sort="Feng, Zihao" uniqKey="Feng Z" first="Zihao" last="Feng">Zihao Feng</name></author><author><name sortKey="Qi, Fazhi" sort="Qi, Fazhi" uniqKey="Qi F" first="Fazhi" last="Qi">Fazhi Qi</name></author></analytic><series><title level="j">Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery</title><idno type="ISSN">1002-1892</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviridae (genetics)</term><term>Animals</term><term>Cell Proliferation</term><term>Disease Models, Animal</term><term>Endothelial Cells (cytology)</term><term>Endothelial Cells (metabolism)</term><term>Gene Transfer Techniques</term><term>Genetic Vectors (genetics)</term><term>Homeodomain Proteins (metabolism)</term><term>Injections, Intralymphatic</term><term>Lymph Nodes (metabolism)</term><term>Lymph Nodes (pathology)</term><term>Lymph Nodes (transplantation)</term><term>Lymphedema (therapy)</term><term>Male</term><term>Random Allocation</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Transplantation, Autologous</term><term>Tumor Suppressor Proteins (metabolism)</term><term>Vascular Endothelial Growth Factor C (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adenoviridae (génétique)</term><term>Animaux</term><term>Attribution aléatoire</term><term>Cellules endothéliales (cytologie)</term><term>Cellules endothéliales (métabolisme)</term><term>Facteur de croissance endothéliale vasculaire de type C (génétique)</term><term>Injections lymphatiques</term><term>Lymphoedème ()</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Noeuds lymphatiques (anatomopathologie)</term><term>Noeuds lymphatiques (métabolisme)</term><term>Noeuds lymphatiques (transplantation)</term><term>Prolifération cellulaire</term><term>Protéines suppresseurs de tumeurs (métabolisme)</term><term>Protéines à homéodomaine (métabolisme)</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Techniques de transfert de gènes</term><term>Transplantation autologue</term><term>Vecteurs génétiques (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Vascular Endothelial Growth Factor C</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Homeodomain Proteins</term><term>Tumor Suppressor Proteins</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Noeuds lymphatiques</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules endothéliales</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Endothelial Cells</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenoviridae</term><term>Genetic Vectors</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adenoviridae</term><term>Facteur de croissance endothéliale vasculaire de type C</term><term>Vecteurs génétiques</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Endothelial Cells</term><term>Lymph Nodes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules endothéliales</term><term>Noeuds lymphatiques</term><term>Protéines suppresseurs de tumeurs</term><term>Protéines à homéodomaine</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymph Nodes</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Lymph Nodes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Proliferation</term><term>Disease Models, Animal</term><term>Gene Transfer Techniques</term><term>Injections, Intralymphatic</term><term>Male</term><term>Random Allocation</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Transplantation, Autologous</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Attribution aléatoire</term><term>Injections lymphatiques</term><term>Lymphoedème</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Noeuds lymphatiques</term><term>Prolifération cellulaire</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Techniques de transfert de gènes</term><term>Transplantation autologue</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate the effects of vascular endothelial growth factor C (VEGF-C) gene modified lymph nodes on promoting proliferation of lymphatic endothelial cells in the surrounding tissues.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23879104</PMID><DateCreated><Year>2013</Year><Month>07</Month><Day>24</Day></DateCreated><DateCompleted><Year>2013</Year><Month>12</Month><Day>12</Day></DateCompleted><DateRevised><Year>2013</Year><Month>07</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1002-1892</ISSN><JournalIssue CitedMedium="Print"><Volume>27</Volume><Issue>5</Issue><PubDate><Year>2013</Year><Month>May</Month></PubDate></JournalIssue><Title>Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery</Title><ISOAbbreviation>Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi</ISOAbbreviation></Journal><ArticleTitle>[A preliminary study on vascular endothelial growth factor C gene modified lymph node transplantation in promoting proliferation of lymphatic endothelial cells].</ArticleTitle><Pagination><MedlinePgn>619-23</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To investigate the effects of vascular endothelial growth factor C (VEGF-C) gene modified lymph nodes on promoting proliferation of lymphatic endothelial cells in the surrounding tissues.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Thirty-six Sprague Dawley rats, weighing 200.1-271.5 g, were randomly divided into 2 groups (n=18). After the in situ axillary lymph nodes transplantation models were established in both groups, 1.5 x 10(8) PFU Ad-VEGF-C-Flag and Ad-Flag were injected into the transplanted lymph nodes in experimental group and control group, respectively. At 3 days after injection, the axillary lymph nodes were harvested to observe the expression of Flag; at 1, 2, and 4 weeks after injection, the axillary lymph nodes and the surrounding tissues were harvested to observe the expression of Prxo-1 protein and to calculate the fluorescence density; at 2 and 4 weeks after injection, the absorbance (A) value of treated blood at 620 nm was calculated to observe lymphatic backflow function improvement; the rats without treatment served as normal control group, and the rats with in situ axillary lymph</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">At 3 days after injection, the expression of Flag could be nodes transplantation model served as blank control group. detected in experimental group and control group. The fluorescence density of Prox-1 protein in experimental group increased at 1, 2, and 4 weeks, and it was significantly higher than that in control group (P < 0.05). The A values of normal control group and blank control group were 0.539 +/-0.020 and 0.151 +/- 0.007, respectively. The A values of experimental group and control group were 0.170 +/- 0.011 and 0.168 +/- 0.010 at 2 weeks, and 0.212 +/- 0.016 and 0.197 +/- 0.006 at 4 weeks, which were significantly lower than those of normal control group (P < 0.05), but no significant difference was found when compared with blank control group, and between the experimental group and control group (P > 0.05).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The VEGF-C gene modified lymph nodes can stimulate the proliferation of lymphatic endothelial cells in the surrounding tissues. However, it has no improved effect on lymphatic back-flovi function in the affected limb.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Nanhang</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Plastic & Reconstructive Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yong</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Feng</LastName><ForeName>Zihao</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Qi</LastName><ForeName>Fazhi</ForeName><Initials>F</Initials></Author></AuthorList><Language>chi</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi</MedlineTA><NlmUniqueID>9425194</NlmUniqueID><ISSNLinking>1002-1892</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018398">Homeodomain Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D025521">Tumor Suppressor Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D042582">Vascular Endothelial Growth Factor C</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C102225">prospero-related homeobox 1 protein</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000256" MajorTopicYN="N">Adenoviridae</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D042783" MajorTopicYN="N">Endothelial Cells</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018014" MajorTopicYN="N">Gene Transfer Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005822" MajorTopicYN="N">Genetic Vectors</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018398" MajorTopicYN="N">Homeodomain Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007272" MajorTopicYN="N">Injections, Intralymphatic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008198" MajorTopicYN="N">Lymph Nodes</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000637" MajorTopicYN="Y">transplantation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011897" MajorTopicYN="N">Random Allocation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014182" MajorTopicYN="N">Transplantation, Autologous</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D025521" MajorTopicYN="N">Tumor Suppressor Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042582" MajorTopicYN="N">Vascular Endothelial Growth Factor C</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>7</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>7</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>12</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23879104</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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