Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis.
Identifieur interne : 001555 ( PubMed/Curation ); précédent : 001554; suivant : 001556Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis.
Auteurs : Taina Vuorio [Finlande] ; Harri Nurmi [Finlande] ; Karen Moulton [Finlande] ; Jere Kurkipuro [Finlande] ; Marius R. Robciuc [Finlande] ; Miina Ohman [Finlande] ; Suvi E. Heinonen [Finlande] ; Haritha Samaranayake [Finlande] ; Tommi Heikura [Finlande] ; Kari Alitalo [Finlande] ; Seppo Yl Herttuala [Finlande]Source :
- Arteriosclerosis, thrombosis, and vascular biology [ 1524-4636 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Apolipoprotéines B (physiologie), Athérosclérose (étiologie), Cholestérol (métabolisme), Humains, Hypercholestérolémie (), Lipides (sang), Lipoprotéines (métabolisme), Récepteur-3 au facteur croissance endothéliale vasculaire (physiologie), Récepteurs aux lipoprotéines LDL (physiologie), Souris, Souris de lignée C57BL, Souris transgéniques, Vaisseaux lymphatiques (physiopathologie).
- MESH :
- métabolisme : Cholestérol, Lipoprotéines.
- physiologie : Apolipoprotéines B, Récepteur-3 au facteur croissance endothéliale vasculaire, Récepteurs aux lipoprotéines LDL.
- physiopathologie : Vaisseaux lymphatiques.
- sang : Lipides.
- étiologie : Athérosclérose.
- Animaux, Humains, Hypercholestérolémie, Souris, Souris de lignée C57BL, Souris transgéniques.
English descriptors
- KwdEn :
- Animals, Apolipoproteins B (physiology), Atherosclerosis (etiology), Cholesterol (metabolism), Humans, Hypercholesterolemia (complications), Lipids (blood), Lipoproteins (metabolism), Lymphatic Vessels (physiopathology), Mice, Mice, Inbred C57BL, Mice, Transgenic, Receptors, LDL (physiology), Vascular Endothelial Growth Factor Receptor-3 (physiology).
- MESH :
- chemical , blood : Lipids.
- chemical , metabolism : Cholesterol, Lipoproteins.
- chemical , physiology : Apolipoproteins B, Receptors, LDL, Vascular Endothelial Growth Factor Receptor-3.
- complications : Hypercholesterolemia.
- etiology : Atherosclerosis.
- physiopathology : Lymphatic Vessels.
- Animals, Humans, Mice, Mice, Inbred C57BL, Mice, Transgenic.
Abstract
Lymphatic vessels collect extravasated fluid and proteins from tissues to blood circulation as well as play an essential role in lipid metabolism by taking up intestinal chylomicrons. Previous studies have shown that impairment of lymphatic vessel function causes lymphedema and fat accumulation, but clear connections between arterial pathologies and lymphatic vessels have not been described.
DOI: 10.1161/ATVBAHA.114.302528
PubMed: 24723556
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pubmed:24723556Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis.</title>
<author><name sortKey="Vuorio, Taina" sort="Vuorio, Taina" uniqKey="Vuorio T" first="Taina" last="Vuorio">Taina Vuorio</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio</wicri:regionArea>
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<author><name sortKey="Nurmi, Harri" sort="Nurmi, Harri" uniqKey="Nurmi H" first="Harri" last="Nurmi">Harri Nurmi</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio</wicri:regionArea>
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<author><name sortKey="Moulton, Karen" sort="Moulton, Karen" uniqKey="Moulton K" first="Karen" last="Moulton">Karen Moulton</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
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<author><name sortKey="Kurkipuro, Jere" sort="Kurkipuro, Jere" uniqKey="Kurkipuro J" first="Jere" last="Kurkipuro">Jere Kurkipuro</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Robciuc, Marius R" sort="Robciuc, Marius R" uniqKey="Robciuc M" first="Marius R" last="Robciuc">Marius R. Robciuc</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
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<author><name sortKey="Ohman, Miina" sort="Ohman, Miina" uniqKey="Ohman M" first="Miina" last="Ohman">Miina Ohman</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heinonen, Suvi E" sort="Heinonen, Suvi E" uniqKey="Heinonen S" first="Suvi E" last="Heinonen">Suvi E. Heinonen</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Samaranayake, Haritha" sort="Samaranayake, Haritha" uniqKey="Samaranayake H" first="Haritha" last="Samaranayake">Haritha Samaranayake</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heikura, Tommi" sort="Heikura, Tommi" uniqKey="Heikura T" first="Tommi" last="Heikura">Tommi Heikura</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yl Herttuala, Seppo" sort="Yl Herttuala, Seppo" uniqKey="Yl Herttuala S" first="Seppo" last="Yl Herttuala">Seppo Yl Herttuala</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland. Seppo.Ylaherttuala@uef.fi.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis.</title>
<author><name sortKey="Vuorio, Taina" sort="Vuorio, Taina" uniqKey="Vuorio T" first="Taina" last="Vuorio">Taina Vuorio</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nurmi, Harri" sort="Nurmi, Harri" uniqKey="Nurmi H" first="Harri" last="Nurmi">Harri Nurmi</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Moulton, Karen" sort="Moulton, Karen" uniqKey="Moulton K" first="Karen" last="Moulton">Karen Moulton</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kurkipuro, Jere" sort="Kurkipuro, Jere" uniqKey="Kurkipuro J" first="Jere" last="Kurkipuro">Jere Kurkipuro</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Robciuc, Marius R" sort="Robciuc, Marius R" uniqKey="Robciuc M" first="Marius R" last="Robciuc">Marius R. Robciuc</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ohman, Miina" sort="Ohman, Miina" uniqKey="Ohman M" first="Miina" last="Ohman">Miina Ohman</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heinonen, Suvi E" sort="Heinonen, Suvi E" uniqKey="Heinonen S" first="Suvi E" last="Heinonen">Suvi E. Heinonen</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Samaranayake, Haritha" sort="Samaranayake, Haritha" uniqKey="Samaranayake H" first="Haritha" last="Samaranayake">Haritha Samaranayake</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heikura, Tommi" sort="Heikura, Tommi" uniqKey="Heikura T" first="Tommi" last="Heikura">Tommi Heikura</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yl Herttuala, Seppo" sort="Yl Herttuala, Seppo" uniqKey="Yl Herttuala S" first="Seppo" last="Yl Herttuala">Seppo Yl Herttuala</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland. Seppo.Ylaherttuala@uef.fi.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Arteriosclerosis, thrombosis, and vascular biology</title>
<idno type="eISSN">1524-4636</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Apolipoproteins B (physiology)</term>
<term>Atherosclerosis (etiology)</term>
<term>Cholesterol (metabolism)</term>
<term>Humans</term>
<term>Hypercholesterolemia (complications)</term>
<term>Lipids (blood)</term>
<term>Lipoproteins (metabolism)</term>
<term>Lymphatic Vessels (physiopathology)</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Transgenic</term>
<term>Receptors, LDL (physiology)</term>
<term>Vascular Endothelial Growth Factor Receptor-3 (physiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Apolipoprotéines B (physiologie)</term>
<term>Athérosclérose (étiologie)</term>
<term>Cholestérol (métabolisme)</term>
<term>Humains</term>
<term>Hypercholestérolémie ()</term>
<term>Lipides (sang)</term>
<term>Lipoprotéines (métabolisme)</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire (physiologie)</term>
<term>Récepteurs aux lipoprotéines LDL (physiologie)</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Souris transgéniques</term>
<term>Vaisseaux lymphatiques (physiopathologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Lipids</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cholesterol</term>
<term>Lipoproteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Apolipoproteins B</term>
<term>Receptors, LDL</term>
<term>Vascular Endothelial Growth Factor Receptor-3</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hypercholesterolemia</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Atherosclerosis</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cholestérol</term>
<term>Lipoprotéines</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Apolipoprotéines B</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire</term>
<term>Récepteurs aux lipoprotéines LDL</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Vaisseaux lymphatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphatic Vessels</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Lipides</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Athérosclérose</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Transgenic</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Humains</term>
<term>Hypercholestérolémie</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
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<front><div type="abstract" xml:lang="en">Lymphatic vessels collect extravasated fluid and proteins from tissues to blood circulation as well as play an essential role in lipid metabolism by taking up intestinal chylomicrons. Previous studies have shown that impairment of lymphatic vessel function causes lymphedema and fat accumulation, but clear connections between arterial pathologies and lymphatic vessels have not been described.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24723556</PMID>
<DateCreated><Year>2014</Year>
<Month>05</Month>
<Day>15</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>07</Month>
<Day>10</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>02</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1524-4636</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>34</Volume>
<Issue>6</Issue>
<PubDate><Year>2014</Year>
<Month>Jun</Month>
</PubDate>
</JournalIssue>
<Title>Arteriosclerosis, thrombosis, and vascular biology</Title>
<ISOAbbreviation>Arterioscler. Thromb. Vasc. Biol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis.</ArticleTitle>
<Pagination><MedlinePgn>1162-70</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1161/ATVBAHA.114.302528</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Lymphatic vessels collect extravasated fluid and proteins from tissues to blood circulation as well as play an essential role in lipid metabolism by taking up intestinal chylomicrons. Previous studies have shown that impairment of lymphatic vessel function causes lymphedema and fat accumulation, but clear connections between arterial pathologies and lymphatic vessels have not been described.</AbstractText>
<AbstractText Label="APPROACH AND RESULTS" NlmCategory="RESULTS">Two transgenic mouse strains with lymphatic insufficiency (soluble vascular endothelial growth factor 3 [sVEGFR3] and Chy) were crossed with atherosclerotic mice deficient of low-density lipoprotein receptor and apolipoprotein B48 (LDLR(-/-)/ApoB(100/100)) to study the effects of insufficient lymphatic vessel transport on lipoprotein metabolism and atherosclerosis. Both sVEGFR3×LDLR(-/-)/ApoB(100/100) mice and Chy×LDLR(-/-)/ApoB(100/100) mice had higher plasma cholesterol levels compared with LDLR(-/-)/ApoB(100/100) control mice during both normal chow diet (16.3 and 13.7 versus 8.2 mmol/L, respectively) and Western-type high-fat diet (eg, after 2 weeks of fat diet, 45.9 and 42.6 versus 30.2 mmol/L, respectively). Cholesterol and triglyceride levels in very-low-density lipoprotein and low-density lipoprotein fractions were increased. Atherosclerotic lesions in young and intermediate cohorts of sVEGFR3×LDLR(-/-)/ApoB(100/100) mice progressed faster than in control mice (eg, intermediate cohort mice at 6 weeks, 18.3% versus 7.7% of the whole aorta, respectively). In addition, lesions in sVEGFR3×LDLR(-/-)/ApoB(100/100) mice and Chy×LDLR(-/-)/ApoB(100/100) mice had much less lymphatic vessels than lesions in control mice (0.33% and 1.07% versus 7.45% of podoplanin-positive vessels, respectively).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">We show a novel finding linking impaired lymphatic vessels to lipoprotein metabolism, increased plasma cholesterol levels, and enhanced atherogenesis.</AbstractText>
<CopyrightInformation>© 2014 American Heart Association, Inc.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vuorio</LastName>
<ForeName>Taina</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nurmi</LastName>
<ForeName>Harri</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moulton</LastName>
<ForeName>Karen</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kurkipuro</LastName>
<ForeName>Jere</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Robciuc</LastName>
<ForeName>Marius R</ForeName>
<Initials>MR</Initials>
<AffiliationInfo><Affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ohman</LastName>
<ForeName>Miina</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Heinonen</LastName>
<ForeName>Suvi E</ForeName>
<Initials>SE</Initials>
<AffiliationInfo><Affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Samaranayake</LastName>
<ForeName>Haritha</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Heikura</LastName>
<ForeName>Tommi</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alitalo</LastName>
<ForeName>Kari</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ylä-Herttuala</LastName>
<ForeName>Seppo</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland. Seppo.Ylaherttuala@uef.fi.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R21 HL108177</GrantID>
<Acronym>HL</Acronym>
<Agency>NHLBI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>UL1 RR025780</GrantID>
<Acronym>RR</Acronym>
<Agency>NCRR NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>ERC_250050</GrantID>
<Agency>European Research Council</Agency>
<Country>International</Country>
</Grant>
<Grant><GrantID>ERC_268804</GrantID>
<Agency>European Research Council</Agency>
<Country>International</Country>
</Grant>
<Grant><GrantID>UL1 TR001082</GrantID>
<Acronym>TR</Acronym>
<Agency>NCATS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>04</Month>
<Day>10</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Arterioscler Thromb Vasc Biol</MedlineTA>
<NlmUniqueID>9505803</NlmUniqueID>
<ISSNLinking>1079-5642</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D001055">Apolipoproteins B</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008055">Lipids</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008074">Lipoproteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011973">Receptors, LDL</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>97C5T2UQ7J</RegistryNumber>
<NameOfSubstance UI="D002784">Cholesterol</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber>
<NameOfSubstance UI="D040321">Vascular Endothelial Growth Factor Receptor-3</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Cardiovasc Res. 2006 Sep 1;71(4):774-84</RefSource>
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