LymphedemaV1, PubMed, Corpus, bibRecord, 001555

Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis.

Identifieur interne : 001555 ( PubMed/Corpus ); précédent : 001554; suivant : 001556

Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis.

Auteurs : Taina Vuorio ; Harri Nurmi ; Karen Moulton ; Jere Kurkipuro ; Marius R. Robciuc ; Miina Ohman ; Suvi E. Heinonen ; Haritha Samaranayake ; Tommi Heikura ; Kari Alitalo ; Seppo Yl Herttuala

Source :

Arteriosclerosis, thrombosis, and vascular biology [ 1524-4636 ] ; 2014.

RBID : pubmed:24723556

English descriptors

KwdEn :
- Animals, Apolipoproteins B (physiology), Atherosclerosis (etiology), Cholesterol (metabolism), Humans, Hypercholesterolemia (complications), Lipids (blood), Lipoproteins (metabolism), Lymphatic Vessels (physiopathology), Mice, Mice, Inbred C57BL, Mice, Transgenic, Receptors, LDL (physiology), Vascular Endothelial Growth Factor Receptor-3 (physiology).
MESH :
- chemical , blood : Lipids.
- chemical , metabolism : Cholesterol, Lipoproteins.
- chemical , physiology : Apolipoproteins B, Receptors, LDL, Vascular Endothelial Growth Factor Receptor-3.
- complications : Hypercholesterolemia.
- etiology : Atherosclerosis.
- physiopathology : Lymphatic Vessels.
- Animals, Humans, Mice, Mice, Inbred C57BL, Mice, Transgenic.

Abstract

Lymphatic vessels collect extravasated fluid and proteins from tissues to blood circulation as well as play an essential role in lipid metabolism by taking up intestinal chylomicrons. Previous studies have shown that impairment of lymphatic vessel function causes lymphedema and fat accumulation, but clear connections between arterial pathologies and lymphatic vessels have not been described.

DOI: 10.1161/ATVBAHA.114.302528
PubMed: 24723556

Links to Exploration step

pubmed:24723556

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis.</title>
<author><name sortKey="Vuorio, Taina" sort="Vuorio, Taina" uniqKey="Vuorio T" first="Taina" last="Vuorio">Taina Vuorio</name>
<affiliation><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Nurmi, Harri" sort="Nurmi, Harri" uniqKey="Nurmi H" first="Harri" last="Nurmi">Harri Nurmi</name>
<affiliation><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Moulton, Karen" sort="Moulton, Karen" uniqKey="Moulton K" first="Karen" last="Moulton">Karen Moulton</name>
<affiliation><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kurkipuro, Jere" sort="Kurkipuro, Jere" uniqKey="Kurkipuro J" first="Jere" last="Kurkipuro">Jere Kurkipuro</name>
<affiliation><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Robciuc, Marius R" sort="Robciuc, Marius R" uniqKey="Robciuc M" first="Marius R" last="Robciuc">Marius R. Robciuc</name>
<affiliation><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ohman, Miina" sort="Ohman, Miina" uniqKey="Ohman M" first="Miina" last="Ohman">Miina Ohman</name>
<affiliation><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Heinonen, Suvi E" sort="Heinonen, Suvi E" uniqKey="Heinonen S" first="Suvi E" last="Heinonen">Suvi E. Heinonen</name>
<affiliation><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Samaranayake, Haritha" sort="Samaranayake, Haritha" uniqKey="Samaranayake H" first="Haritha" last="Samaranayake">Haritha Samaranayake</name>
<affiliation><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Heikura, Tommi" sort="Heikura, Tommi" uniqKey="Heikura T" first="Tommi" last="Heikura">Tommi Heikura</name>
<affiliation><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name>
<affiliation><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yl Herttuala, Seppo" sort="Yl Herttuala, Seppo" uniqKey="Yl Herttuala S" first="Seppo" last="Yl Herttuala">Seppo Yl Herttuala</name>
<affiliation><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland. Seppo.Ylaherttuala@uef.fi.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
<idno type="RBID">pubmed:24723556</idno>
<idno type="pmid">24723556</idno>
<idno type="doi">10.1161/ATVBAHA.114.302528</idno>
<idno type="wicri:Area/PubMed/Corpus">001555</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001555</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis.</title>
<author><name sortKey="Vuorio, Taina" sort="Vuorio, Taina" uniqKey="Vuorio T" first="Taina" last="Vuorio">Taina Vuorio</name>
<affiliation><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Nurmi, Harri" sort="Nurmi, Harri" uniqKey="Nurmi H" first="Harri" last="Nurmi">Harri Nurmi</name>
<affiliation><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Moulton, Karen" sort="Moulton, Karen" uniqKey="Moulton K" first="Karen" last="Moulton">Karen Moulton</name>
<affiliation><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kurkipuro, Jere" sort="Kurkipuro, Jere" uniqKey="Kurkipuro J" first="Jere" last="Kurkipuro">Jere Kurkipuro</name>
<affiliation><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Robciuc, Marius R" sort="Robciuc, Marius R" uniqKey="Robciuc M" first="Marius R" last="Robciuc">Marius R. Robciuc</name>
<affiliation><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ohman, Miina" sort="Ohman, Miina" uniqKey="Ohman M" first="Miina" last="Ohman">Miina Ohman</name>
<affiliation><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Heinonen, Suvi E" sort="Heinonen, Suvi E" uniqKey="Heinonen S" first="Suvi E" last="Heinonen">Suvi E. Heinonen</name>
<affiliation><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Samaranayake, Haritha" sort="Samaranayake, Haritha" uniqKey="Samaranayake H" first="Haritha" last="Samaranayake">Haritha Samaranayake</name>
<affiliation><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Heikura, Tommi" sort="Heikura, Tommi" uniqKey="Heikura T" first="Tommi" last="Heikura">Tommi Heikura</name>
<affiliation><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name>
<affiliation><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yl Herttuala, Seppo" sort="Yl Herttuala, Seppo" uniqKey="Yl Herttuala S" first="Seppo" last="Yl Herttuala">Seppo Yl Herttuala</name>
<affiliation><nlm:affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland. Seppo.Ylaherttuala@uef.fi.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Arteriosclerosis, thrombosis, and vascular biology</title>
<idno type="eISSN">1524-4636</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Apolipoproteins B (physiology)</term>
<term>Atherosclerosis (etiology)</term>
<term>Cholesterol (metabolism)</term>
<term>Humans</term>
<term>Hypercholesterolemia (complications)</term>
<term>Lipids (blood)</term>
<term>Lipoproteins (metabolism)</term>
<term>Lymphatic Vessels (physiopathology)</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Transgenic</term>
<term>Receptors, LDL (physiology)</term>
<term>Vascular Endothelial Growth Factor Receptor-3 (physiology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Lipids</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cholesterol</term>
<term>Lipoproteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Apolipoproteins B</term>
<term>Receptors, LDL</term>
<term>Vascular Endothelial Growth Factor Receptor-3</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hypercholesterolemia</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Atherosclerosis</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphatic Vessels</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Transgenic</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Lymphatic vessels collect extravasated fluid and proteins from tissues to blood circulation as well as play an essential role in lipid metabolism by taking up intestinal chylomicrons. Previous studies have shown that impairment of lymphatic vessel function causes lymphedema and fat accumulation, but clear connections between arterial pathologies and lymphatic vessels have not been described.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24723556</PMID>
<DateCreated><Year>2014</Year>
<Month>05</Month>
<Day>15</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>07</Month>
<Day>10</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>02</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1524-4636</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>34</Volume>
<Issue>6</Issue>
<PubDate><Year>2014</Year>
<Month>Jun</Month>
</PubDate>
</JournalIssue>
<Title>Arteriosclerosis, thrombosis, and vascular biology</Title>
<ISOAbbreviation>Arterioscler. Thromb. Vasc. Biol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis.</ArticleTitle>
<Pagination><MedlinePgn>1162-70</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1161/ATVBAHA.114.302528</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Lymphatic vessels collect extravasated fluid and proteins from tissues to blood circulation as well as play an essential role in lipid metabolism by taking up intestinal chylomicrons. Previous studies have shown that impairment of lymphatic vessel function causes lymphedema and fat accumulation, but clear connections between arterial pathologies and lymphatic vessels have not been described.</AbstractText>
<AbstractText Label="APPROACH AND RESULTS" NlmCategory="RESULTS">Two transgenic mouse strains with lymphatic insufficiency (soluble vascular endothelial growth factor 3 [sVEGFR3] and Chy) were crossed with atherosclerotic mice deficient of low-density lipoprotein receptor and apolipoprotein B48 (LDLR(-/-)/ApoB(100/100)) to study the effects of insufficient lymphatic vessel transport on lipoprotein metabolism and atherosclerosis. Both sVEGFR3×LDLR(-/-)/ApoB(100/100) mice and Chy×LDLR(-/-)/ApoB(100/100) mice had higher plasma cholesterol levels compared with LDLR(-/-)/ApoB(100/100) control mice during both normal chow diet (16.3 and 13.7 versus 8.2 mmol/L, respectively) and Western-type high-fat diet (eg, after 2 weeks of fat diet, 45.9 and 42.6 versus 30.2 mmol/L, respectively). Cholesterol and triglyceride levels in very-low-density lipoprotein and low-density lipoprotein fractions were increased. Atherosclerotic lesions in young and intermediate cohorts of sVEGFR3×LDLR(-/-)/ApoB(100/100) mice progressed faster than in control mice (eg, intermediate cohort mice at 6 weeks, 18.3% versus 7.7% of the whole aorta, respectively). In addition, lesions in sVEGFR3×LDLR(-/-)/ApoB(100/100) mice and Chy×LDLR(-/-)/ApoB(100/100) mice had much less lymphatic vessels than lesions in control mice (0.33% and 1.07% versus 7.45% of podoplanin-positive vessels, respectively).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">We show a novel finding linking impaired lymphatic vessels to lipoprotein metabolism, increased plasma cholesterol levels, and enhanced atherogenesis.</AbstractText>
<CopyrightInformation>© 2014 American Heart Association, Inc.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vuorio</LastName>
<ForeName>Taina</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nurmi</LastName>
<ForeName>Harri</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moulton</LastName>
<ForeName>Karen</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kurkipuro</LastName>
<ForeName>Jere</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Robciuc</LastName>
<ForeName>Marius R</ForeName>
<Initials>MR</Initials>
<AffiliationInfo><Affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ohman</LastName>
<ForeName>Miina</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Heinonen</LastName>
<ForeName>Suvi E</ForeName>
<Initials>SE</Initials>
<AffiliationInfo><Affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Samaranayake</LastName>
<ForeName>Haritha</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Heikura</LastName>
<ForeName>Tommi</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alitalo</LastName>
<ForeName>Kari</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ylä-Herttuala</LastName>
<ForeName>Seppo</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland. Seppo.Ylaherttuala@uef.fi.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R21 HL108177</GrantID>
<Acronym>HL</Acronym>
<Agency>NHLBI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>UL1 RR025780</GrantID>
<Acronym>RR</Acronym>
<Agency>NCRR NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>ERC_250050</GrantID>
<Agency>European Research Council</Agency>
<Country>International</Country>
</Grant>
<Grant><GrantID>ERC_268804</GrantID>
<Agency>European Research Council</Agency>
<Country>International</Country>
</Grant>
<Grant><GrantID>UL1 TR001082</GrantID>
<Acronym>TR</Acronym>
<Agency>NCATS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>04</Month>
<Day>10</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Arterioscler Thromb Vasc Biol</MedlineTA>
<NlmUniqueID>9505803</NlmUniqueID>
<ISSNLinking>1079-5642</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D001055">Apolipoproteins B</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008055">Lipids</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008074">Lipoproteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011973">Receptors, LDL</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>97C5T2UQ7J</RegistryNumber>
<NameOfSubstance UI="D002784">Cholesterol</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber>
<NameOfSubstance UI="D040321">Vascular Endothelial Growth Factor Receptor-3</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Cardiovasc Res. 2006 Sep 1;71(4):774-84</RefSource>
<PMID Version="1">16887107</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2008 Nov 10;26(32):5213-9</RefSource>
<PMID Version="1">18838709</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Atherosclerosis. 1994 Feb;105(2):117-29</RefSource>
<PMID Version="1">8003088</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cardiovasc Res. 2003 Oct 1;59(4):971-9</RefSource>
<PMID Version="1">14553837</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Trends Endocrinol Metab. 2010 Aug;21(8):480-7</RefSource>
<PMID Version="1">20541951</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell Metab. 2013 May 7;17(5):671-84</RefSource>
<PMID Version="1">23663736</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 1984 Jan 19;310(3):175-7</RefSource>
<PMID Version="1">6197652</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2009 Jan 16;206(1):233-48</RefSource>
<PMID Version="1">19139167</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2011;17(11):1371-80</RefSource>
<PMID Version="1">22064427</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2005 Oct;37(10):1072-81</RefSource>
<PMID Version="1">16170315</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann N Y Acad Sci. 2010 Oct;1207 Suppl 1:E52-7</RefSource>
<PMID Version="1">20961306</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2013 Mar;123(3):1323-34</RefSource>
<PMID Version="1">23426179</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Lipid Res. 1987 Mar;28(3):225-37</RefSource>
<PMID Version="1">3553402</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2013 Apr;123(4):1571-9</RefSource>
<PMID Version="1">23524964</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12677-82</RefSource>
<PMID Version="1">11592985</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cardiovasc Res. 2013 Sep 1;99(4):716-23</RefSource>
<PMID Version="1">23756254</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 1998 Oct 30;282(5390):946-9</RefSource>
<PMID Version="1">9794766</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2000 Sep 14;407(6801):233-41</RefSource>
<PMID Version="1">11001066</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2013 May 1;190(9):4608-20</RefSource>
<PMID Version="1">23530147</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Cardiovasc Dis Res. 2011 Jul;2(3):141-52</RefSource>
<PMID Version="1">22022141</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>EMBO J. 1996 Apr 1;15(7):1751</RefSource>
<PMID Version="1">8612600</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2005 Feb;115(2):247-57</RefSource>
<PMID Version="1">15668734</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell. 2001 Feb 23;104(4):503-16</RefSource>
<PMID Version="1">11239408</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Hum Pathol. 2005 Apr;36(4):330-40</RefSource>
<PMID Version="1">15891993</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Pathol. 2009 Sep;175(3):1328-37</RefSource>
<PMID Version="1">19679879</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Hepatology. 2010 Nov;52(5):1836-46</RefSource>
<PMID Version="1">21038418</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Lipid Res. 2000 Aug;41(8):1317-27</RefSource>
<PMID Version="1">10946020</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lymphology. 2006 Jun;39(2):76-83</RefSource>
<PMID Version="1">16910098</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lymphology. 1990 Sep;23(3):135-9</RefSource>
<PMID Version="1">2250482</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lymphat Res Biol. 2009;7(1):29-45</RefSource>
<PMID Version="1">19302022</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Invest Dermatol. 2006 Oct;126(10):2167-77</RefSource>
<PMID Version="1">16983326</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2004 Apr;113(7):1040-50</RefSource>
<PMID Version="1">15057311</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2001 Feb;7(2):199-205</RefSource>
<PMID Version="1">11175851</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 1998 Oct 15;102(8):1559-68</RefSource>
<PMID Version="1">9788969</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2003 Dec 11;349(24):2316-25</RefSource>
<PMID Version="1">14668457</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 1993 Apr 29;362(6423):801-9</RefSource>
<PMID Version="1">8479518</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3566-70</RefSource>
<PMID Version="1">7724599</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2010 Apr 8;464(7290):917-21</RefSource>
<PMID Version="1">20228789</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2012 Sep 1;189(5):2181-90</RefSource>
<PMID Version="1">22844119</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Circulation. 2005 Sep 20;112(12):1813-24</RefSource>
<PMID Version="1">16172288</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Circulation. 2004 Sep 7;110(10):1330-6</RefSource>
<PMID Version="1">15313955</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):548-53</RefSource>
<PMID Version="1">9435229</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr Opin Lipidol. 2006 Oct;17(5):548-55</RefSource>
<PMID Version="1">16960504</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Thromb Haemost. 2011 Jul;106(1):1-19</RefSource>
<PMID Version="1">21670845</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Atherosclerosis. 2009 Oct;206(2):343-5</RefSource>
<PMID Version="1">19339011</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Eur J Clin Invest. 2011 May;41(5):487-97</RefSource>
<PMID Version="1">21128936</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Circulation. 2011 Nov 8;124(19):2129-38</RefSource>
<PMID Version="1">21986280</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001055" MajorTopicYN="N">Apolipoproteins B</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050197" MajorTopicYN="N">Atherosclerosis</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002784" MajorTopicYN="N">Cholesterol</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006937" MajorTopicYN="N">Hypercholesterolemia</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008055" MajorTopicYN="N">Lipids</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008074" MajorTopicYN="N">Lipoproteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D042601" MajorTopicYN="N">Lymphatic Vessels</DescriptorName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008822" MajorTopicYN="N">Mice, Transgenic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011973" MajorTopicYN="N">Receptors, LDL</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D040321" MajorTopicYN="N">Vascular Endothelial Growth Factor Receptor-3</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<OtherID Source="NLM">NIHMS581451</OtherID>
<OtherID Source="NLM">PMC4031366</OtherID>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">atherosclerosis</Keyword>
<Keyword MajorTopicYN="N">lipoproteins</Keyword>
<Keyword MajorTopicYN="N">lymphatic vessels</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year>
<Month>4</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2014</Year>
<Month>4</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2014</Year>
<Month>7</Month>
<Day>11</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">24723556</ArticleId>
<ArticleId IdType="pii">ATVBAHA.114.302528</ArticleId>
<ArticleId IdType="doi">10.1161/ATVBAHA.114.302528</ArticleId>
<ArticleId IdType="pmc">PMC4031366</ArticleId>
<ArticleId IdType="mid">NIHMS581451</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001555 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 001555 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    PubMed
   |étape=   Corpus
   |type=    RBID
   |clé=     pubmed:24723556
   |texte=   Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i   -Sk "pubmed:24723556" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le lymphœdème

Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis.

Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki