Phenotypic modulation of smooth muscle cells in lymphoedema.
Identifieur interne : 001253 ( PubMed/Curation ); précédent : 001252; suivant : 001254Phenotypic modulation of smooth muscle cells in lymphoedema.
Auteurs : F. Ogata [Japon] ; K. Fujiu [Japon] ; I. Koshima [Japon] ; R. Nagai [Japon] ; I. Manabe [Japon]Source :
- The British journal of dermatology [ 1365-2133 ] ; 2015.
Descripteurs français
- KwdFr :
- Actines (métabolisme), Adulte, Adulte d'âge moyen, Chaînes lourdes de myosine (métabolisme), Femelle, Fibrose (anatomopathologie), Humains, Immunohistochimie, Lymphoedème (anatomopathologie), Lymphoedème (métabolisme), Maladie chronique, Microscopie électronique à transmission, Myocytes du muscle lisse (métabolisme), Myocytes du muscle lisse (physiologie), Myosines du muscle lisse (métabolisme), Mâle, Phénotype, Sujet âgé, Sujet âgé de 80 ans ou plus, Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (métabolisme).
- MESH :
- anatomopathologie : Fibrose, Lymphoedème, Vaisseaux lymphatiques.
- métabolisme : Actines, Chaînes lourdes de myosine, Lymphoedème, Myocytes du muscle lisse, Myosines du muscle lisse, Vaisseaux lymphatiques.
- physiologie : Myocytes du muscle lisse.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Immunohistochimie, Maladie chronique, Microscopie électronique à transmission, Mâle, Phénotype, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Actins (metabolism), Adult, Aged, Aged, 80 and over, Chronic Disease, Female, Fibrosis (pathology), Humans, Immunohistochemistry, Lymphatic Vessels (metabolism), Lymphatic Vessels (pathology), Lymphedema (metabolism), Lymphedema (pathology), Male, Microscopy, Electron, Transmission, Middle Aged, Myocytes, Smooth Muscle (metabolism), Myocytes, Smooth Muscle (physiology), Myosin Heavy Chains (metabolism), Phenotype, Smooth Muscle Myosins (metabolism).
- MESH :
- chemical , metabolism : Actins, Myosin Heavy Chains, Smooth Muscle Myosins.
- metabolism : Lymphatic Vessels, Lymphedema, Myocytes, Smooth Muscle.
- pathology : Fibrosis, Lymphatic Vessels, Lymphedema.
- physiology : Myocytes, Smooth Muscle.
- Adult, Aged, Aged, 80 and over, Chronic Disease, Female, Humans, Immunohistochemistry, Male, Microscopy, Electron, Transmission, Middle Aged, Phenotype.
Abstract
Lymphoedema is a debilitating progressive condition that is frequently observed following cancer surgery and severely restricts quality of life. Although it is known that lymphatic dysfunction and obstruction underlie lymphoedema, the pathogenic mechanism is poorly understood. Smooth muscle cells (SMCs) play pivotal roles in the pathogenesis of various vascular diseases, including atherosclerosis.
DOI: 10.1111/bjd.13482
PubMed: 25319851
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001253
Links to Exploration step
pubmed:25319851Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Phenotypic modulation of smooth muscle cells in lymphoedema.</title><author><name sortKey="Ogata, F" sort="Ogata, F" uniqKey="Ogata F" first="F" last="Ogata">F. Ogata</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655</wicri:regionArea></affiliation></author><author><name sortKey="Fujiu, K" sort="Fujiu, K" uniqKey="Fujiu K" first="K" last="Fujiu">K. Fujiu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655</wicri:regionArea></affiliation></author><author><name sortKey="Koshima, I" sort="Koshima, I" uniqKey="Koshima I" first="I" last="Koshima">I. Koshima</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plastic, Reconstructive and Aesthetic Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Plastic, Reconstructive and Aesthetic Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655</wicri:regionArea></affiliation></author><author><name sortKey="Nagai, R" sort="Nagai, R" uniqKey="Nagai R" first="R" last="Nagai">R. Nagai</name><affiliation wicri:level="1"><nlm:affiliation>Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-0498, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-0498</wicri:regionArea></affiliation></author><author><name sortKey="Manabe, I" sort="Manabe, I" uniqKey="Manabe I" first="I" last="Manabe">I. Manabe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25319851</idno><idno type="pmid">25319851</idno><idno type="doi">10.1111/bjd.13482</idno><idno type="wicri:Area/PubMed/Corpus">001253</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001253</idno><idno type="wicri:Area/PubMed/Curation">001253</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001253</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Phenotypic modulation of smooth muscle cells in lymphoedema.</title><author><name sortKey="Ogata, F" sort="Ogata, F" uniqKey="Ogata F" first="F" last="Ogata">F. Ogata</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655</wicri:regionArea></affiliation></author><author><name sortKey="Fujiu, K" sort="Fujiu, K" uniqKey="Fujiu K" first="K" last="Fujiu">K. Fujiu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655</wicri:regionArea></affiliation></author><author><name sortKey="Koshima, I" sort="Koshima, I" uniqKey="Koshima I" first="I" last="Koshima">I. Koshima</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plastic, Reconstructive and Aesthetic Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Plastic, Reconstructive and Aesthetic Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655</wicri:regionArea></affiliation></author><author><name sortKey="Nagai, R" sort="Nagai, R" uniqKey="Nagai R" first="R" last="Nagai">R. Nagai</name><affiliation wicri:level="1"><nlm:affiliation>Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-0498, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-0498</wicri:regionArea></affiliation></author><author><name sortKey="Manabe, I" sort="Manabe, I" uniqKey="Manabe I" first="I" last="Manabe">I. Manabe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655</wicri:regionArea></affiliation></author></analytic><series><title level="j">The British journal of dermatology</title><idno type="eISSN">1365-2133</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Actins (metabolism)</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Chronic Disease</term><term>Female</term><term>Fibrosis (pathology)</term><term>Humans</term><term>Immunohistochemistry</term><term>Lymphatic Vessels (metabolism)</term><term>Lymphatic Vessels (pathology)</term><term>Lymphedema (metabolism)</term><term>Lymphedema (pathology)</term><term>Male</term><term>Microscopy, Electron, Transmission</term><term>Middle Aged</term><term>Myocytes, Smooth Muscle (metabolism)</term><term>Myocytes, Smooth Muscle (physiology)</term><term>Myosin Heavy Chains (metabolism)</term><term>Phenotype</term><term>Smooth Muscle Myosins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Actines (métabolisme)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Chaînes lourdes de myosine (métabolisme)</term><term>Femelle</term><term>Fibrose (anatomopathologie)</term><term>Humains</term><term>Immunohistochimie</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (métabolisme)</term><term>Maladie chronique</term><term>Microscopie électronique à transmission</term><term>Myocytes du muscle lisse (métabolisme)</term><term>Myocytes du muscle lisse (physiologie)</term><term>Myosines du muscle lisse (métabolisme)</term><term>Mâle</term><term>Phénotype</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Vaisseaux lymphatiques (anatomopathologie)</term><term>Vaisseaux lymphatiques (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Actins</term><term>Myosin Heavy Chains</term><term>Smooth Muscle Myosins</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Fibrose</term><term>Lymphoedème</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Myocytes, Smooth Muscle</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Actines</term><term>Chaînes lourdes de myosine</term><term>Lymphoedème</term><term>Myocytes du muscle lisse</term><term>Myosines du muscle lisse</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Fibrosis</term><term>Lymphatic Vessels</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Myocytes du muscle lisse</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Myocytes, Smooth Muscle</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Chronic Disease</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Microscopy, Electron, Transmission</term><term>Middle Aged</term><term>Phenotype</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Immunohistochimie</term><term>Maladie chronique</term><term>Microscopie électronique à transmission</term><term>Mâle</term><term>Phénotype</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphoedema is a debilitating progressive condition that is frequently observed following cancer surgery and severely restricts quality of life. Although it is known that lymphatic dysfunction and obstruction underlie lymphoedema, the pathogenic mechanism is poorly understood. Smooth muscle cells (SMCs) play pivotal roles in the pathogenesis of various vascular diseases, including atherosclerosis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25319851</PMID><DateCreated><Year>2015</Year><Month>05</Month><Day>12</Day></DateCreated><DateCompleted><Year>2016</Year><Month>02</Month><Day>01</Day></DateCompleted><DateRevised><Year>2015</Year><Month>05</Month><Day>12</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1365-2133</ISSN><JournalIssue CitedMedium="Internet"><Volume>172</Volume><Issue>5</Issue><PubDate><Year>2015</Year></PubDate></JournalIssue><Title>The British journal of dermatology</Title><ISOAbbreviation>Br. J. Dermatol.</ISOAbbreviation></Journal><ArticleTitle>Phenotypic modulation of smooth muscle cells in lymphoedema.</ArticleTitle><Pagination><MedlinePgn>1286-93</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/bjd.13482</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Lymphoedema is a debilitating progressive condition that is frequently observed following cancer surgery and severely restricts quality of life. Although it is known that lymphatic dysfunction and obstruction underlie lymphoedema, the pathogenic mechanism is poorly understood. Smooth muscle cells (SMCs) play pivotal roles in the pathogenesis of various vascular diseases, including atherosclerosis.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">We analysed SMCs in lymphatic vessels from the lymphoedematous legs of 29 patients.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Expression of smooth muscle α-actin (SMαA) and smooth muscle myosin heavy chain (SM-MHC) isoforms SM1 and SM2 was investigated using immunohistochemistry.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Compared with normal lymphatic vessels, all affected lymphatic vessels in chronic lymphoedema showed marked wall thickening. In addition to increases in the numbers of rows of SMαA(+) SM1(+) SMCs in the tunica media, SMCs were also observed in the subendothelial region (tunica intima). While most intimal and medial cells were positive for SMαA and SM1, staining for SM1 and particularly SM2, a marker of mature SMCs, progressively declined in lymphatic vessels in increasingly severe lymphoedema lesions. Consequently, the SM1(+) and SM2(+) cell fractions were significantly reduced in the tunica media and intima of lymphatic vessels.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These observations indicate that the lymphatic tunica media and tunica intima consist mainly of phenotypically modulated SMCs, and that SMCs play a key role in the development of lymphoedema.</AbstractText><CopyrightInformation>© 2014 British Association of Dermatologists.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ogata</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Plastic, Reconstructive and Aesthetic Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fujiu</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Translational Systems Biology and Medicine Initiative, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koshima</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Plastic, Reconstructive and Aesthetic Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nagai</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-0498, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manabe</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>03</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Br J Dermatol</MedlineTA><NlmUniqueID>0004041</NlmUniqueID><ISSNLinking>0007-0963</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000199">Actins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.1.-</RegistryNumber><NameOfSubstance UI="D024745">Smooth Muscle Myosins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.4.1</RegistryNumber><NameOfSubstance UI="D018995">Myosin Heavy Chains</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Br J Dermatol. 2015 May;172(5):1184-5</RefSource><PMID Version="1">25963208</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000199" MajorTopicYN="N">Actins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002908" MajorTopicYN="N">Chronic Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005355" MajorTopicYN="N">Fibrosis</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D042601" MajorTopicYN="N">Lymphatic Vessels</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D046529" MajorTopicYN="N">Microscopy, Electron, Transmission</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032389" MajorTopicYN="N">Myocytes, Smooth Muscle</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018995" MajorTopicYN="N">Myosin Heavy Chains</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010641" MajorTopicYN="N">Phenotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D024745" MajorTopicYN="N">Smooth Muscle Myosins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>10</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>10</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>10</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>2</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25319851</ArticleId><ArticleId IdType="doi">10.1111/bjd.13482</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001253 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 001253 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:25319851
|texte= Phenotypic modulation of smooth muscle cells in lymphoedema.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:25319851" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |