Phenotypic modulation of smooth muscle cells in lymphoedema.
Identifieur interne : 001253 ( PubMed/Corpus ); précédent : 001252; suivant : 001254Phenotypic modulation of smooth muscle cells in lymphoedema.
Auteurs : F. Ogata ; K. Fujiu ; I. Koshima ; R. Nagai ; I. ManabeSource :
- The British journal of dermatology [ 1365-2133 ] ; 2015.
English descriptors
- KwdEn :
- Actins (metabolism), Adult, Aged, Aged, 80 and over, Chronic Disease, Female, Fibrosis (pathology), Humans, Immunohistochemistry, Lymphatic Vessels (metabolism), Lymphatic Vessels (pathology), Lymphedema (metabolism), Lymphedema (pathology), Male, Microscopy, Electron, Transmission, Middle Aged, Myocytes, Smooth Muscle (metabolism), Myocytes, Smooth Muscle (physiology), Myosin Heavy Chains (metabolism), Phenotype, Smooth Muscle Myosins (metabolism).
- MESH :
- chemical , metabolism : Actins, Myosin Heavy Chains, Smooth Muscle Myosins.
- metabolism : Lymphatic Vessels, Lymphedema, Myocytes, Smooth Muscle.
- pathology : Fibrosis, Lymphatic Vessels, Lymphedema.
- physiology : Myocytes, Smooth Muscle.
- Adult, Aged, Aged, 80 and over, Chronic Disease, Female, Humans, Immunohistochemistry, Male, Microscopy, Electron, Transmission, Middle Aged, Phenotype.
Abstract
Lymphoedema is a debilitating progressive condition that is frequently observed following cancer surgery and severely restricts quality of life. Although it is known that lymphatic dysfunction and obstruction underlie lymphoedema, the pathogenic mechanism is poorly understood. Smooth muscle cells (SMCs) play pivotal roles in the pathogenesis of various vascular diseases, including atherosclerosis.
DOI: 10.1111/bjd.13482
PubMed: 25319851
Links to Exploration step
pubmed:25319851Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Phenotypic modulation of smooth muscle cells in lymphoedema.</title>
<author><name sortKey="Ogata, F" sort="Ogata, F" uniqKey="Ogata F" first="F" last="Ogata">F. Ogata</name>
<affiliation><nlm:affiliation>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Fujiu, K" sort="Fujiu, K" uniqKey="Fujiu K" first="K" last="Fujiu">K. Fujiu</name>
<affiliation><nlm:affiliation>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Koshima, I" sort="Koshima, I" uniqKey="Koshima I" first="I" last="Koshima">I. Koshima</name>
<affiliation><nlm:affiliation>Department of Plastic, Reconstructive and Aesthetic Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Nagai, R" sort="Nagai, R" uniqKey="Nagai R" first="R" last="Nagai">R. Nagai</name>
<affiliation><nlm:affiliation>Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-0498, Japan.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Manabe, I" sort="Manabe, I" uniqKey="Manabe I" first="I" last="Manabe">I. Manabe</name>
<affiliation><nlm:affiliation>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Phenotypic modulation of smooth muscle cells in lymphoedema.</title>
<author><name sortKey="Ogata, F" sort="Ogata, F" uniqKey="Ogata F" first="F" last="Ogata">F. Ogata</name>
<affiliation><nlm:affiliation>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</nlm:affiliation>
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<author><name sortKey="Fujiu, K" sort="Fujiu, K" uniqKey="Fujiu K" first="K" last="Fujiu">K. Fujiu</name>
<affiliation><nlm:affiliation>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</nlm:affiliation>
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<author><name sortKey="Koshima, I" sort="Koshima, I" uniqKey="Koshima I" first="I" last="Koshima">I. Koshima</name>
<affiliation><nlm:affiliation>Department of Plastic, Reconstructive and Aesthetic Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Nagai, R" sort="Nagai, R" uniqKey="Nagai R" first="R" last="Nagai">R. Nagai</name>
<affiliation><nlm:affiliation>Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-0498, Japan.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Manabe, I" sort="Manabe, I" uniqKey="Manabe I" first="I" last="Manabe">I. Manabe</name>
<affiliation><nlm:affiliation>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</nlm:affiliation>
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<series><title level="j">The British journal of dermatology</title>
<idno type="eISSN">1365-2133</idno>
<imprint><date when="2015" type="published">2015</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Actins (metabolism)</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Chronic Disease</term>
<term>Female</term>
<term>Fibrosis (pathology)</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Lymphatic Vessels (metabolism)</term>
<term>Lymphatic Vessels (pathology)</term>
<term>Lymphedema (metabolism)</term>
<term>Lymphedema (pathology)</term>
<term>Male</term>
<term>Microscopy, Electron, Transmission</term>
<term>Middle Aged</term>
<term>Myocytes, Smooth Muscle (metabolism)</term>
<term>Myocytes, Smooth Muscle (physiology)</term>
<term>Myosin Heavy Chains (metabolism)</term>
<term>Phenotype</term>
<term>Smooth Muscle Myosins (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Actins</term>
<term>Myosin Heavy Chains</term>
<term>Smooth Muscle Myosins</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymphatic Vessels</term>
<term>Lymphedema</term>
<term>Myocytes, Smooth Muscle</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Fibrosis</term>
<term>Lymphatic Vessels</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Myocytes, Smooth Muscle</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Chronic Disease</term>
<term>Female</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Male</term>
<term>Microscopy, Electron, Transmission</term>
<term>Middle Aged</term>
<term>Phenotype</term>
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<front><div type="abstract" xml:lang="en">Lymphoedema is a debilitating progressive condition that is frequently observed following cancer surgery and severely restricts quality of life. Although it is known that lymphatic dysfunction and obstruction underlie lymphoedema, the pathogenic mechanism is poorly understood. Smooth muscle cells (SMCs) play pivotal roles in the pathogenesis of various vascular diseases, including atherosclerosis.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25319851</PMID>
<DateCreated><Year>2015</Year>
<Month>05</Month>
<Day>12</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>02</Month>
<Day>01</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>05</Month>
<Day>12</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1365-2133</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>172</Volume>
<Issue>5</Issue>
<PubDate><Year>2015</Year>
</PubDate>
</JournalIssue>
<Title>The British journal of dermatology</Title>
<ISOAbbreviation>Br. J. Dermatol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Phenotypic modulation of smooth muscle cells in lymphoedema.</ArticleTitle>
<Pagination><MedlinePgn>1286-93</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1111/bjd.13482</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Lymphoedema is a debilitating progressive condition that is frequently observed following cancer surgery and severely restricts quality of life. Although it is known that lymphatic dysfunction and obstruction underlie lymphoedema, the pathogenic mechanism is poorly understood. Smooth muscle cells (SMCs) play pivotal roles in the pathogenesis of various vascular diseases, including atherosclerosis.</AbstractText>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">We analysed SMCs in lymphatic vessels from the lymphoedematous legs of 29 patients.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Expression of smooth muscle α-actin (SMαA) and smooth muscle myosin heavy chain (SM-MHC) isoforms SM1 and SM2 was investigated using immunohistochemistry.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Compared with normal lymphatic vessels, all affected lymphatic vessels in chronic lymphoedema showed marked wall thickening. In addition to increases in the numbers of rows of SMαA(+) SM1(+) SMCs in the tunica media, SMCs were also observed in the subendothelial region (tunica intima). While most intimal and medial cells were positive for SMαA and SM1, staining for SM1 and particularly SM2, a marker of mature SMCs, progressively declined in lymphatic vessels in increasingly severe lymphoedema lesions. Consequently, the SM1(+) and SM2(+) cell fractions were significantly reduced in the tunica media and intima of lymphatic vessels.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These observations indicate that the lymphatic tunica media and tunica intima consist mainly of phenotypically modulated SMCs, and that SMCs play a key role in the development of lymphoedema.</AbstractText>
<CopyrightInformation>© 2014 British Association of Dermatologists.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ogata</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Plastic, Reconstructive and Aesthetic Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fujiu</LastName>
<ForeName>K</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Translational Systems Biology and Medicine Initiative, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Koshima</LastName>
<ForeName>I</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Department of Plastic, Reconstructive and Aesthetic Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nagai</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-0498, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Manabe</LastName>
<ForeName>I</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>03</Month>
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<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Br J Dermatol</MedlineTA>
<NlmUniqueID>0004041</NlmUniqueID>
<ISSNLinking>0007-0963</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000199">Actins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.6.1.-</RegistryNumber>
<NameOfSubstance UI="D024745">Smooth Muscle Myosins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.6.4.1</RegistryNumber>
<NameOfSubstance UI="D018995">Myosin Heavy Chains</NameOfSubstance>
</Chemical>
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<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Br J Dermatol. 2015 May;172(5):1184-5</RefSource>
<PMID Version="1">25963208</PMID>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D042601" MajorTopicYN="N">Lymphatic Vessels</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D032389" MajorTopicYN="N">Myocytes, Smooth Muscle</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018995" MajorTopicYN="N">Myosin Heavy Chains</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010641" MajorTopicYN="N">Phenotype</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D024745" MajorTopicYN="N">Smooth Muscle Myosins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
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