Bancroftian filariasis in Haiti: preliminary characterization of the immunological responsiveness of microfilaremic individuals.
Identifieur interne : 006263 ( PubMed/Corpus ); précédent : 006262; suivant : 006264Bancroftian filariasis in Haiti: preliminary characterization of the immunological responsiveness of microfilaremic individuals.
Auteurs : P J Lammie ; L E Leiva ; A J Ruff ; M L Eberhard ; R C Lowrie ; S P KatzSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 1988.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (biosynthesis), Antigens, Helminth (immunology), Brugia (immunology), Elephantiasis, Filarial (immunology), Filariasis (immunology), Haiti, Humans, Immunity, Cellular, Leukocytes, Mononuclear (immunology), Lymphocyte Activation, Microfilariae (immunology), Wuchereria bancrofti (immunology).
- MESH :
- chemical , biosynthesis : Antibodies, Helminth.
- chemical , immunology : Antigens, Helminth.
- immunology : Brugia, Elephantiasis, Filarial, Filariasis, Leukocytes, Mononuclear, Microfilariae, Wuchereria bancrofti.
- Animals, Haiti, Humans, Immunity, Cellular, Lymphocyte Activation.
Abstract
Patent infections with the lymphatic filariae, Wuchereria bancrofti and Brugia malayi, are associated with suppressed in vitro cellular responsiveness to filarial antigens. In studies of bancroftian filariasis in Haiti, a significant number of microfilaremic individuals can be characterized as "responders" to filarial antigens. Cells from 37/74 untreated microfilaremic subjects responded to B. pahangi antigen (stimulation ratio greater than 2) as detected by in vitro blastogenesis. A comparison of responders to nonresponders revealed a significant difference in mean B. pahangi reactivity (15,822 vs. 4,538 cpm, P less than 0.001), but no significant differences with respect to age, microfilaremia, PPD or PHA reactivity, or B. pahangi-specific antibody levels. Subtle differences may exist between these groups with respect to recognition of specific antigens on Western blots.
PubMed: 3277457
Links to Exploration step
pubmed:3277457Le document en format XML
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<author><name sortKey="Lammie, P J" sort="Lammie, P J" uniqKey="Lammie P" first="P J" last="Lammie">P J Lammie</name>
<affiliation><nlm:affiliation>Department of Microbiology, Immunology and Parasitology, Louisiana State University Medical Center, New Orleans 70112.</nlm:affiliation>
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<author><name sortKey="Leiva, L E" sort="Leiva, L E" uniqKey="Leiva L" first="L E" last="Leiva">L E Leiva</name>
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<author><name sortKey="Ruff, A J" sort="Ruff, A J" uniqKey="Ruff A" first="A J" last="Ruff">A J Ruff</name>
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<author><name sortKey="Eberhard, M L" sort="Eberhard, M L" uniqKey="Eberhard M" first="M L" last="Eberhard">M L Eberhard</name>
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<author><name sortKey="Lowrie, R C" sort="Lowrie, R C" uniqKey="Lowrie R" first="R C" last="Lowrie">R C Lowrie</name>
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<author><name sortKey="Katz, S P" sort="Katz, S P" uniqKey="Katz S" first="S P" last="Katz">S P Katz</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Bancroftian filariasis in Haiti: preliminary characterization of the immunological responsiveness of microfilaremic individuals.</title>
<author><name sortKey="Lammie, P J" sort="Lammie, P J" uniqKey="Lammie P" first="P J" last="Lammie">P J Lammie</name>
<affiliation><nlm:affiliation>Department of Microbiology, Immunology and Parasitology, Louisiana State University Medical Center, New Orleans 70112.</nlm:affiliation>
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<author><name sortKey="Leiva, L E" sort="Leiva, L E" uniqKey="Leiva L" first="L E" last="Leiva">L E Leiva</name>
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<author><name sortKey="Ruff, A J" sort="Ruff, A J" uniqKey="Ruff A" first="A J" last="Ruff">A J Ruff</name>
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<author><name sortKey="Katz, S P" sort="Katz, S P" uniqKey="Katz S" first="S P" last="Katz">S P Katz</name>
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<series><title level="j">The American journal of tropical medicine and hygiene</title>
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<term>Antibodies, Helminth (biosynthesis)</term>
<term>Antigens, Helminth (immunology)</term>
<term>Brugia (immunology)</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Filariasis (immunology)</term>
<term>Haiti</term>
<term>Humans</term>
<term>Immunity, Cellular</term>
<term>Leukocytes, Mononuclear (immunology)</term>
<term>Lymphocyte Activation</term>
<term>Microfilariae (immunology)</term>
<term>Wuchereria bancrofti (immunology)</term>
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<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Helminth</term>
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<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia</term>
<term>Elephantiasis, Filarial</term>
<term>Filariasis</term>
<term>Leukocytes, Mononuclear</term>
<term>Microfilariae</term>
<term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Haiti</term>
<term>Humans</term>
<term>Immunity, Cellular</term>
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<front><div type="abstract" xml:lang="en">Patent infections with the lymphatic filariae, Wuchereria bancrofti and Brugia malayi, are associated with suppressed in vitro cellular responsiveness to filarial antigens. In studies of bancroftian filariasis in Haiti, a significant number of microfilaremic individuals can be characterized as "responders" to filarial antigens. Cells from 37/74 untreated microfilaremic subjects responded to B. pahangi antigen (stimulation ratio greater than 2) as detected by in vitro blastogenesis. A comparison of responders to nonresponders revealed a significant difference in mean B. pahangi reactivity (15,822 vs. 4,538 cpm, P less than 0.001), but no significant differences with respect to age, microfilaremia, PPD or PHA reactivity, or B. pahangi-specific antibody levels. Subtle differences may exist between these groups with respect to recognition of specific antigens on Western blots.</div>
</front>
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<Title>The American journal of tropical medicine and hygiene</Title>
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<ArticleTitle>Bancroftian filariasis in Haiti: preliminary characterization of the immunological responsiveness of microfilaremic individuals.</ArticleTitle>
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<Abstract><AbstractText>Patent infections with the lymphatic filariae, Wuchereria bancrofti and Brugia malayi, are associated with suppressed in vitro cellular responsiveness to filarial antigens. In studies of bancroftian filariasis in Haiti, a significant number of microfilaremic individuals can be characterized as "responders" to filarial antigens. Cells from 37/74 untreated microfilaremic subjects responded to B. pahangi antigen (stimulation ratio greater than 2) as detected by in vitro blastogenesis. A comparison of responders to nonresponders revealed a significant difference in mean B. pahangi reactivity (15,822 vs. 4,538 cpm, P less than 0.001), but no significant differences with respect to age, microfilaremia, PPD or PHA reactivity, or B. pahangi-specific antibody levels. Subtle differences may exist between these groups with respect to recognition of specific antigens on Western blots.</AbstractText>
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