A double-blind, cross-over trial of O-(beta-hydroxyethyl)-rutosides (benzo-pyrones) in the treatment of lymphoedema of the arms and legs.
Identifieur interne : 006262 ( PubMed/Corpus ); précédent : 006261; suivant : 006263A double-blind, cross-over trial of O-(beta-hydroxyethyl)-rutosides (benzo-pyrones) in the treatment of lymphoedema of the arms and legs.
Auteurs : N B Piller ; R G Morgan ; J R Casley-SmithSource :
- British journal of plastic surgery [ 0007-1226 ] ; 1988.
English descriptors
- KwdEn :
- Arm, Clinical Trials as Topic, Double-Blind Method, Female, Humans, Hydroxyethylrutoside (administration & dosage), Hydroxyethylrutoside (analogs & derivatives), Hydroxyethylrutoside (therapeutic use), Leg, Lymphedema (drug therapy), Lymphedema (physiopathology), Male, Mastectomy, Middle Aged, Postoperative Complications (drug therapy), Random Allocation, Rutin (analogs & derivatives), Skin Temperature (drug effects).
- MESH :
- chemical , administration & dosage : Hydroxyethylrutoside.
- chemical , analogs & derivatives : Hydroxyethylrutoside, Rutin.
- chemical , therapeutic use : Hydroxyethylrutoside.
- drug effects : Skin Temperature.
- drug therapy : Lymphedema, Postoperative Complications.
- physiopathology : Lymphedema.
- Arm, Clinical Trials as Topic, Double-Blind Method, Female, Humans, Leg, Male, Mastectomy, Middle Aged, Random Allocation.
Abstract
A randomised, double-blind, cross-over trial was performed on 26 patients with postmastectomy lymphoedema of the arm, and 14 with lymphoedema of the leg. For 6 months, patients took 0-(beta-hydroxyethyl)-rutosides (oxerutin; "Paroven", "Venoruton", Zyma) in doses of 3 g/day, or the placebos; then they took the reverse. Measurements (volume, circumferences, tonometry and skin temperature) were made monthly. The active drug reduced the volumes of the limbs (p less than 0.05 to 0.01) and their circumferences (p less than 0.05 to 0.001). It increased the softness of the limbs, as shown by the increases in the tonometry values (p less than 0.01 to 0.001). There was a lowering of the elevated skin temperatures (p less than 0.05 to 0.001). Patients reported increased comfort and freedom of movement, a lessening of their bursting pains, heaviness and tension (p less than 0.05 to 0.01), and an increased mobility of their limbs (p less than 0.0001). Most patients (70%) preferred the active drug (p less than 0.0001). An increase in general well-being was reported by 97% of patients when taking the active drug compared with 4% for placebo (p less than 0.0001).
PubMed: 3278764
Links to Exploration step
pubmed:3278764Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A double-blind, cross-over trial of O-(beta-hydroxyethyl)-rutosides (benzo-pyrones) in the treatment of lymphoedema of the arms and legs.</title><author><name sortKey="Piller, N B" sort="Piller, N B" uniqKey="Piller N" first="N B" last="Piller">N B Piller</name><affiliation><nlm:affiliation>Department of Surgery, Flinder's Medical Centre, Bedford Park, South Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Morgan, R G" sort="Morgan, R G" uniqKey="Morgan R" first="R G" last="Morgan">R G Morgan</name></author><author><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J R" last="Casley-Smith">J R Casley-Smith</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1988">1988</date><idno type="RBID">pubmed:3278764</idno><idno type="pmid">3278764</idno><idno type="wicri:Area/PubMed/Corpus">006262</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">006262</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A double-blind, cross-over trial of O-(beta-hydroxyethyl)-rutosides (benzo-pyrones) in the treatment of lymphoedema of the arms and legs.</title><author><name sortKey="Piller, N B" sort="Piller, N B" uniqKey="Piller N" first="N B" last="Piller">N B Piller</name><affiliation><nlm:affiliation>Department of Surgery, Flinder's Medical Centre, Bedford Park, South Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Morgan, R G" sort="Morgan, R G" uniqKey="Morgan R" first="R G" last="Morgan">R G Morgan</name></author><author><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J R" last="Casley-Smith">J R Casley-Smith</name></author></analytic><series><title level="j">British journal of plastic surgery</title><idno type="ISSN">0007-1226</idno><imprint><date when="1988" type="published">1988</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arm</term><term>Clinical Trials as Topic</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Hydroxyethylrutoside (administration & dosage)</term><term>Hydroxyethylrutoside (analogs & derivatives)</term><term>Hydroxyethylrutoside (therapeutic use)</term><term>Leg</term><term>Lymphedema (drug therapy)</term><term>Lymphedema (physiopathology)</term><term>Male</term><term>Mastectomy</term><term>Middle Aged</term><term>Postoperative Complications (drug therapy)</term><term>Random Allocation</term><term>Rutin (analogs & derivatives)</term><term>Skin Temperature (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Hydroxyethylrutoside</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Hydroxyethylrutoside</term><term>Rutin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Hydroxyethylrutoside</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Skin Temperature</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lymphedema</term><term>Postoperative Complications</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Arm</term><term>Clinical Trials as Topic</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Leg</term><term>Male</term><term>Mastectomy</term><term>Middle Aged</term><term>Random Allocation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A randomised, double-blind, cross-over trial was performed on 26 patients with postmastectomy lymphoedema of the arm, and 14 with lymphoedema of the leg. For 6 months, patients took 0-(beta-hydroxyethyl)-rutosides (oxerutin; "Paroven", "Venoruton", Zyma) in doses of 3 g/day, or the placebos; then they took the reverse. Measurements (volume, circumferences, tonometry and skin temperature) were made monthly. The active drug reduced the volumes of the limbs (p less than 0.05 to 0.01) and their circumferences (p less than 0.05 to 0.001). It increased the softness of the limbs, as shown by the increases in the tonometry values (p less than 0.01 to 0.001). There was a lowering of the elevated skin temperatures (p less than 0.05 to 0.001). Patients reported increased comfort and freedom of movement, a lessening of their bursting pains, heaviness and tension (p less than 0.05 to 0.01), and an increased mobility of their limbs (p less than 0.0001). Most patients (70%) preferred the active drug (p less than 0.0001). An increase in general well-being was reported by 97% of patients when taking the active drug compared with 4% for placebo (p less than 0.0001).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">3278764</PMID><DateCreated><Year>1988</Year><Month>04</Month><Day>14</Day></DateCreated><DateCompleted><Year>1988</Year><Month>04</Month><Day>14</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0007-1226</ISSN><JournalIssue CitedMedium="Print"><Volume>41</Volume><Issue>1</Issue><PubDate><Year>1988</Year><Month>Jan</Month></PubDate></JournalIssue><Title>British journal of plastic surgery</Title><ISOAbbreviation>Br J Plast Surg</ISOAbbreviation></Journal><ArticleTitle>A double-blind, cross-over trial of O-(beta-hydroxyethyl)-rutosides (benzo-pyrones) in the treatment of lymphoedema of the arms and legs.</ArticleTitle><Pagination><MedlinePgn>20-7</MedlinePgn></Pagination><Abstract><AbstractText>A randomised, double-blind, cross-over trial was performed on 26 patients with postmastectomy lymphoedema of the arm, and 14 with lymphoedema of the leg. For 6 months, patients took 0-(beta-hydroxyethyl)-rutosides (oxerutin; "Paroven", "Venoruton", Zyma) in doses of 3 g/day, or the placebos; then they took the reverse. Measurements (volume, circumferences, tonometry and skin temperature) were made monthly. The active drug reduced the volumes of the limbs (p less than 0.05 to 0.01) and their circumferences (p less than 0.05 to 0.001). It increased the softness of the limbs, as shown by the increases in the tonometry values (p less than 0.01 to 0.001). There was a lowering of the elevated skin temperatures (p less than 0.05 to 0.001). Patients reported increased comfort and freedom of movement, a lessening of their bursting pains, heaviness and tension (p less than 0.05 to 0.01), and an increased mobility of their limbs (p less than 0.0001). Most patients (70%) preferred the active drug (p less than 0.0001). An increase in general well-being was reported by 97% of patients when taking the active drug compared with 4% for placebo (p less than 0.0001).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Piller</LastName><ForeName>N B</ForeName><Initials>NB</Initials><AffiliationInfo><Affiliation>Department of Surgery, Flinder's Medical Centre, Bedford Park, South Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morgan</LastName><ForeName>R G</ForeName><Initials>RG</Initials></Author><Author ValidYN="Y"><LastName>Casley-Smith</LastName><ForeName>J R</ForeName><Initials>JR</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Br J Plast Surg</MedlineTA><NlmUniqueID>2984714R</NlmUniqueID><ISSNLinking>0007-1226</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006896">Hydroxyethylrutoside</NameOfSubstance></Chemical><Chemical><RegistryNumber>5G06TVY3R7</RegistryNumber><NameOfSubstance UI="D012431">Rutin</NameOfSubstance></Chemical><Chemical><RegistryNumber>7Y4N11PXO8</RegistryNumber><NameOfSubstance UI="C005865">troxerutin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001132" MajorTopicYN="N">Arm</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002986" MajorTopicYN="N">Clinical Trials as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006896" MajorTopicYN="N">Hydroxyethylrutoside</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007866" MajorTopicYN="N">Leg</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008408" MajorTopicYN="N">Mastectomy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011183" MajorTopicYN="N">Postoperative Complications</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011897" MajorTopicYN="N">Random Allocation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012431" MajorTopicYN="N">Rutin</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012881" MajorTopicYN="N">Skin Temperature</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1988</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1988</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1988</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">3278764</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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