LymphedemaV1, PubMed, Corpus, bibRecord, 005D39

Double blind clinical trial on centperazine & DEC in bancroftian filariasis.

Identifieur interne : 005D39 ( PubMed/Corpus ); précédent : 005D38; suivant : 005D40

Double blind clinical trial on centperazine & DEC in bancroftian filariasis.

Auteurs : R N Rath ; B K Das ; M L Ali ; P K Das ; A C Mishra ; B N Mohapatra

Source :

The Indian journal of medical research [ 0971-5916 ] ; 1990.

RBID : pubmed:2228058

English descriptors

KwdEn :
- Adolescent, Adult, Animals, Diethylcarbamazine (therapeutic use), Double-Blind Method, Elephantiasis, Filarial (drug therapy), Filaricides (therapeutic use), Humans, Middle Aged, Piperazines (therapeutic use), Wuchereria bancrofti (drug effects).
MESH :
- chemical , therapeutic use : Diethylcarbamazine, Filaricides, Piperazines.
- drug effects : Wuchereria bancrofti.
- drug therapy : Elephantiasis, Filarial.
- Adolescent, Adult, Animals, Double-Blind Method, Humans, Middle Aged.

Abstract

Centperazine, an analogue of DEC, was subjected to a double blind controlled trial, to evaluate its efficacy as a newer antifilarial agent. Centperazine (300 mg/day) along with equivalent quantities of DEC and placebo were administered to different types of filariasis patients. DEC was found to be significantly effective in reducing peripheral microfilaraemia, in different weeks and months of follow-up, except at the end of 6th month, as compared to Centperazine. There was no significant difference between the placebo and Centperazine treated patients, in this respect, revealing that the drugs had no efficacy in eliminating peripheral microfilaraemia. Recurrence of acute attack within 6 months was nearly equal with both Centperazine and DEC, being 28.2 and 24 per cent respectively, whereas in the placebo group the recurrence rate was 48.9 per cent. Centperazine treated patients showed significantly less side effects (8.9%), as compared to DEC treated patients (34%). Giddiness, nausea and vomiting were the common adverse effects observed.

PubMed: 2228058

Links to Exploration step

pubmed:2228058

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Double blind clinical trial on centperazine & DEC in bancroftian filariasis.</title>
<author><name sortKey="Rath, R N" sort="Rath, R N" uniqKey="Rath R" first="R N" last="Rath">R N Rath</name>
<affiliation><nlm:affiliation>Department of Medicine, S.C.B. Medical College.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Das, B K" sort="Das, B K" uniqKey="Das B" first="B K" last="Das">B K Das</name>
</author>
<author><name sortKey="Ali, M L" sort="Ali, M L" uniqKey="Ali M" first="M L" last="Ali">M L Ali</name>
</author>
<author><name sortKey="Das, P K" sort="Das, P K" uniqKey="Das P" first="P K" last="Das">P K Das</name>
</author>
<author><name sortKey="Mishra, A C" sort="Mishra, A C" uniqKey="Mishra A" first="A C" last="Mishra">A C Mishra</name>
</author>
<author><name sortKey="Mohapatra, B N" sort="Mohapatra, B N" uniqKey="Mohapatra B" first="B N" last="Mohapatra">B N Mohapatra</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1990">1990</date>
<idno type="RBID">pubmed:2228058</idno>
<idno type="pmid">2228058</idno>
<idno type="wicri:Area/PubMed/Corpus">005D39</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005D39</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Double blind clinical trial on centperazine & DEC in bancroftian filariasis.</title>
<author><name sortKey="Rath, R N" sort="Rath, R N" uniqKey="Rath R" first="R N" last="Rath">R N Rath</name>
<affiliation><nlm:affiliation>Department of Medicine, S.C.B. Medical College.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Das, B K" sort="Das, B K" uniqKey="Das B" first="B K" last="Das">B K Das</name>
</author>
<author><name sortKey="Ali, M L" sort="Ali, M L" uniqKey="Ali M" first="M L" last="Ali">M L Ali</name>
</author>
<author><name sortKey="Das, P K" sort="Das, P K" uniqKey="Das P" first="P K" last="Das">P K Das</name>
</author>
<author><name sortKey="Mishra, A C" sort="Mishra, A C" uniqKey="Mishra A" first="A C" last="Mishra">A C Mishra</name>
</author>
<author><name sortKey="Mohapatra, B N" sort="Mohapatra, B N" uniqKey="Mohapatra B" first="B N" last="Mohapatra">B N Mohapatra</name>
</author>
</analytic>
<series><title level="j">The Indian journal of medical research</title>
<idno type="ISSN">0971-5916</idno>
<imprint><date when="1990" type="published">1990</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Animals</term>
<term>Diethylcarbamazine (therapeutic use)</term>
<term>Double-Blind Method</term>
<term>Elephantiasis, Filarial (drug therapy)</term>
<term>Filaricides (therapeutic use)</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Piperazines (therapeutic use)</term>
<term>Wuchereria bancrofti (drug effects)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diethylcarbamazine</term>
<term>Filaricides</term>
<term>Piperazines</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Animals</term>
<term>Double-Blind Method</term>
<term>Humans</term>
<term>Middle Aged</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Centperazine, an analogue of DEC, was subjected to a double blind controlled trial, to evaluate its efficacy as a newer antifilarial agent. Centperazine (300 mg/day) along with equivalent quantities of DEC and placebo were administered to different types of filariasis patients. DEC was found to be significantly effective in reducing peripheral microfilaraemia, in different weeks and months of follow-up, except at the end of 6th month, as compared to Centperazine. There was no significant difference between the placebo and Centperazine treated patients, in this respect, revealing that the drugs had no efficacy in eliminating peripheral microfilaraemia. Recurrence of acute attack within 6 months was nearly equal with both Centperazine and DEC, being 28.2 and 24 per cent respectively, whereas in the placebo group the recurrence rate was 48.9 per cent. Centperazine treated patients showed significantly less side effects (8.9%), as compared to DEC treated patients (34%). Giddiness, nausea and vomiting were the common adverse effects observed.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">2228058</PMID>
<DateCreated><Year>1990</Year>
<Month>12</Month>
<Day>12</Day>
</DateCreated>
<DateCompleted><Year>1990</Year>
<Month>12</Month>
<Day>12</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0971-5916</ISSN>
<JournalIssue CitedMedium="Print"><Volume>91</Volume>
<PubDate><Year>1990</Year>
<Month>Jul</Month>
</PubDate>
</JournalIssue>
<Title>The Indian journal of medical research</Title>
<ISOAbbreviation>Indian J. Med. Res.</ISOAbbreviation>
</Journal>
<ArticleTitle>Double blind clinical trial on centperazine & DEC in bancroftian filariasis.</ArticleTitle>
<Pagination><MedlinePgn>277-81</MedlinePgn>
</Pagination>
<Abstract><AbstractText>Centperazine, an analogue of DEC, was subjected to a double blind controlled trial, to evaluate its efficacy as a newer antifilarial agent. Centperazine (300 mg/day) along with equivalent quantities of DEC and placebo were administered to different types of filariasis patients. DEC was found to be significantly effective in reducing peripheral microfilaraemia, in different weeks and months of follow-up, except at the end of 6th month, as compared to Centperazine. There was no significant difference between the placebo and Centperazine treated patients, in this respect, revealing that the drugs had no efficacy in eliminating peripheral microfilaraemia. Recurrence of acute attack within 6 months was nearly equal with both Centperazine and DEC, being 28.2 and 24 per cent respectively, whereas in the placebo group the recurrence rate was 48.9 per cent. Centperazine treated patients showed significantly less side effects (8.9%), as compared to DEC treated patients (34%). Giddiness, nausea and vomiting were the common adverse effects observed.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rath</LastName>
<ForeName>R N</ForeName>
<Initials>RN</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, S.C.B. Medical College.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Das</LastName>
<ForeName>B K</ForeName>
<Initials>BK</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ali</LastName>
<ForeName>M L</ForeName>
<Initials>ML</Initials>
</Author>
<Author ValidYN="Y"><LastName>Das</LastName>
<ForeName>P K</ForeName>
<Initials>PK</Initials>
</Author>
<Author ValidYN="Y"><LastName>Mishra</LastName>
<ForeName>A C</ForeName>
<Initials>AC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Mohapatra</LastName>
<ForeName>B N</ForeName>
<Initials>BN</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType>
<PublicationType UI="D018848">Controlled Clinical Trial</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>India</Country>
<MedlineTA>Indian J Med Res</MedlineTA>
<NlmUniqueID>0374701</NlmUniqueID>
<ISSNLinking>0971-5916</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D005369">Filaricides</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010879">Piperazines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>25143-13-9</RegistryNumber>
<NameOfSubstance UI="C033224">centperazine</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>V867Q8X3ZD</RegistryNumber>
<NameOfSubstance UI="D004049">Diethylcarbamazine</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004049" MajorTopicYN="N">Diethylcarbamazine</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005369" MajorTopicYN="N">Filaricides</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010879" MajorTopicYN="N">Piperazines</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014958" MajorTopicYN="N">Wuchereria bancrofti</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1990</Year>
<Month>7</Month>
<Day>1</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>1990</Year>
<Month>7</Month>
<Day>1</Day>
<Hour>0</Hour>
<Minute>1</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>1990</Year>
<Month>7</Month>
<Day>1</Day>
<Hour>0</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">2228058</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005D39 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 005D39 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    PubMed
   |étape=   Corpus
   |type=    RBID
   |clé=     pubmed:2228058
   |texte=   Double blind clinical trial on centperazine & DEC in bancroftian filariasis.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i   -Sk "pubmed:2228058" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le lymphœdème

Double blind clinical trial on centperazine & DEC in bancroftian filariasis.

Double blind clinical trial on centperazine & DEC in bancroftian filariasis.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki