HLA and elephantiasis in lymphatic filariasis.
Identifieur interne : 005338 ( PubMed/Corpus ); précédent : 005337; suivant : 005339HLA and elephantiasis in lymphatic filariasis.
Auteurs : M. Yazdanbakhsh ; E. Sartono ; Y C Kruize ; A. Kurniawan ; F. Partono ; R M Maizels ; G M Schreuder ; R. Schipper ; R R De VriesSource :
- Human immunology [ 0198-8859 ] ; 1995.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (blood), Brugia malayi (immunology), Disease Susceptibility (immunology), Elephantiasis, Filarial (genetics), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Gene Frequency, Genetic Predisposition to Disease, HLA Antigens (genetics), HLA Antigens (immunology), HLA-B27 Antigen (genetics), HLA-DQ Antigens (genetics), HLA-DR3 Antigen (genetics), Humans, Immunoglobulin G (blood), Immunoglobulin Isotypes (blood), Indonesia.
- MESH :
- chemical , blood : Antibodies, Helminth, Immunoglobulin G, Immunoglobulin Isotypes.
- geographic : Indonesia.
- genetics : Elephantiasis, Filarial, HLA Antigens, HLA-B27 Antigen, HLA-DQ Antigens, HLA-DR3 Antigen.
- immunology : Brugia malayi, Disease Susceptibility, Elephantiasis, Filarial, HLA Antigens.
- parasitology : Elephantiasis, Filarial.
- Animals, Gene Frequency, Genetic Predisposition to Disease, Humans.
Abstract
Lymphatic filariasis presents a spectrum of manifestations with infection-free asymptomatics at one end and elephantiasis at the other. In order to determine if any HLA antigens are associated with the development of elephantiasis, we compared the HLA frequencies in 55 elephantiasis patients with those in 40 controls consisting of individuals older than 45 years of age without any signs of elephantiasis. The only significant difference in class I antigen frequencies was observed for B27, which was present in 11% of the patients and absent in the controls. More differences were observed in HLA class II antigen frequencies. Both DR3 and the 2B3 epitope (on DQ6, DQ8, and DQ9 molecules) were significantly decreased in patients with elephantiasis whereas the DQ5 frequency was significantly higher in patients than in controls. Analysis of specific antibody isotype profiles revealed that DQ5-positive individuals had increased levels of antifilarial IgG3, an isotype known to be involved in tissue damage. These data suggest that HLA class II genes may control the course of Brugian filariasis by influencing the T-cell-dependent antibody repertoire.
PubMed: 8522456
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">HLA and elephantiasis in lymphatic filariasis.</title><author><name sortKey="Yazdanbakhsh, M" sort="Yazdanbakhsh, M" uniqKey="Yazdanbakhsh M" first="M" last="Yazdanbakhsh">M. Yazdanbakhsh</name><affiliation><nlm:affiliation>Department of Parasitology, University Hospital Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Sartono, E" sort="Sartono, E" uniqKey="Sartono E" first="E" last="Sartono">E. Sartono</name></author><author><name sortKey="Kruize, Y C" sort="Kruize, Y C" uniqKey="Kruize Y" first="Y C" last="Kruize">Y C Kruize</name></author><author><name sortKey="Kurniawan, A" sort="Kurniawan, A" uniqKey="Kurniawan A" first="A" last="Kurniawan">A. Kurniawan</name></author><author><name sortKey="Partono, F" sort="Partono, F" uniqKey="Partono F" first="F" last="Partono">F. Partono</name></author><author><name sortKey="Maizels, R M" sort="Maizels, R M" uniqKey="Maizels R" first="R M" last="Maizels">R M Maizels</name></author><author><name sortKey="Schreuder, G M" sort="Schreuder, G M" uniqKey="Schreuder G" first="G M" last="Schreuder">G M Schreuder</name></author><author><name sortKey="Schipper, R" sort="Schipper, R" uniqKey="Schipper R" first="R" last="Schipper">R. Schipper</name></author><author><name sortKey="De Vries, R R" sort="De Vries, R R" uniqKey="De Vries R" first="R R" last="De Vries">R R De Vries</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1995">1995</date><idno type="RBID">pubmed:8522456</idno><idno type="pmid">8522456</idno><idno type="wicri:Area/PubMed/Corpus">005338</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005338</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">HLA and elephantiasis in lymphatic filariasis.</title><author><name sortKey="Yazdanbakhsh, M" sort="Yazdanbakhsh, M" uniqKey="Yazdanbakhsh M" first="M" last="Yazdanbakhsh">M. Yazdanbakhsh</name><affiliation><nlm:affiliation>Department of Parasitology, University Hospital Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Sartono, E" sort="Sartono, E" uniqKey="Sartono E" first="E" last="Sartono">E. Sartono</name></author><author><name sortKey="Kruize, Y C" sort="Kruize, Y C" uniqKey="Kruize Y" first="Y C" last="Kruize">Y C Kruize</name></author><author><name sortKey="Kurniawan, A" sort="Kurniawan, A" uniqKey="Kurniawan A" first="A" last="Kurniawan">A. Kurniawan</name></author><author><name sortKey="Partono, F" sort="Partono, F" uniqKey="Partono F" first="F" last="Partono">F. Partono</name></author><author><name sortKey="Maizels, R M" sort="Maizels, R M" uniqKey="Maizels R" first="R M" last="Maizels">R M Maizels</name></author><author><name sortKey="Schreuder, G M" sort="Schreuder, G M" uniqKey="Schreuder G" first="G M" last="Schreuder">G M Schreuder</name></author><author><name sortKey="Schipper, R" sort="Schipper, R" uniqKey="Schipper R" first="R" last="Schipper">R. Schipper</name></author><author><name sortKey="De Vries, R R" sort="De Vries, R R" uniqKey="De Vries R" first="R R" last="De Vries">R R De Vries</name></author></analytic><series><title level="j">Human immunology</title><idno type="ISSN">0198-8859</idno><imprint><date when="1995" type="published">1995</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Helminth (blood)</term><term>Brugia malayi (immunology)</term><term>Disease Susceptibility (immunology)</term><term>Elephantiasis, Filarial (genetics)</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Gene Frequency</term><term>Genetic Predisposition to Disease</term><term>HLA Antigens (genetics)</term><term>HLA Antigens (immunology)</term><term>HLA-B27 Antigen (genetics)</term><term>HLA-DQ Antigens (genetics)</term><term>HLA-DR3 Antigen (genetics)</term><term>Humans</term><term>Immunoglobulin G (blood)</term><term>Immunoglobulin Isotypes (blood)</term><term>Indonesia</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Helminth</term><term>Immunoglobulin G</term><term>Immunoglobulin Isotypes</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Indonesia</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Elephantiasis, Filarial</term><term>HLA Antigens</term><term>HLA-B27 Antigen</term><term>HLA-DQ Antigens</term><term>HLA-DR3 Antigen</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia malayi</term><term>Disease Susceptibility</term><term>Elephantiasis, Filarial</term><term>HLA Antigens</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Gene Frequency</term><term>Genetic Predisposition to Disease</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphatic filariasis presents a spectrum of manifestations with infection-free asymptomatics at one end and elephantiasis at the other. In order to determine if any HLA antigens are associated with the development of elephantiasis, we compared the HLA frequencies in 55 elephantiasis patients with those in 40 controls consisting of individuals older than 45 years of age without any signs of elephantiasis. The only significant difference in class I antigen frequencies was observed for B27, which was present in 11% of the patients and absent in the controls. More differences were observed in HLA class II antigen frequencies. Both DR3 and the 2B3 epitope (on DQ6, DQ8, and DQ9 molecules) were significantly decreased in patients with elephantiasis whereas the DQ5 frequency was significantly higher in patients than in controls. Analysis of specific antibody isotype profiles revealed that DQ5-positive individuals had increased levels of antifilarial IgG3, an isotype known to be involved in tissue damage. These data suggest that HLA class II genes may control the course of Brugian filariasis by influencing the T-cell-dependent antibody repertoire.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8522456</PMID><DateCreated><Year>1996</Year><Month>01</Month><Day>25</Day></DateCreated><DateCompleted><Year>1996</Year><Month>01</Month><Day>25</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0198-8859</ISSN><JournalIssue CitedMedium="Print"><Volume>44</Volume><Issue>1</Issue><PubDate><Year>1995</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Human immunology</Title><ISOAbbreviation>Hum. Immunol.</ISOAbbreviation></Journal><ArticleTitle>HLA and elephantiasis in lymphatic filariasis.</ArticleTitle><Pagination><MedlinePgn>58-61</MedlinePgn></Pagination><Abstract><AbstractText>Lymphatic filariasis presents a spectrum of manifestations with infection-free asymptomatics at one end and elephantiasis at the other. In order to determine if any HLA antigens are associated with the development of elephantiasis, we compared the HLA frequencies in 55 elephantiasis patients with those in 40 controls consisting of individuals older than 45 years of age without any signs of elephantiasis. The only significant difference in class I antigen frequencies was observed for B27, which was present in 11% of the patients and absent in the controls. More differences were observed in HLA class II antigen frequencies. Both DR3 and the 2B3 epitope (on DQ6, DQ8, and DQ9 molecules) were significantly decreased in patients with elephantiasis whereas the DQ5 frequency was significantly higher in patients than in controls. Analysis of specific antibody isotype profiles revealed that DQ5-positive individuals had increased levels of antifilarial IgG3, an isotype known to be involved in tissue damage. These data suggest that HLA class II genes may control the course of Brugian filariasis by influencing the T-cell-dependent antibody repertoire.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yazdanbakhsh</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Parasitology, University Hospital Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sartono</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Kruize</LastName><ForeName>Y C</ForeName><Initials>YC</Initials></Author><Author ValidYN="Y"><LastName>Kurniawan</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Partono</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Maizels</LastName><ForeName>R M</ForeName><Initials>RM</Initials></Author><Author ValidYN="Y"><LastName>Schreuder</LastName><ForeName>G M</ForeName><Initials>GM</Initials></Author><Author ValidYN="Y"><LastName>Schipper</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>de Vries</LastName><ForeName>R R</ForeName><Initials>RR</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Hum Immunol</MedlineTA><NlmUniqueID>8010936</NlmUniqueID><ISSNLinking>0198-8859</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000909">Antibodies, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006680">HLA Antigens</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015796">HLA-B27 Antigen</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006683">HLA-DQ Antigens</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015803">HLA-DR3 Antigen</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007132">Immunoglobulin Isotypes</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000909" MajorTopicYN="N">Antibodies, Helminth</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017178" MajorTopicYN="Y">Brugia malayi</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004198" MajorTopicYN="N">Disease Susceptibility</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005787" MajorTopicYN="N">Gene Frequency</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020022" MajorTopicYN="N">Genetic Predisposition to Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006680" MajorTopicYN="N">HLA Antigens</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015796" MajorTopicYN="N">HLA-B27 Antigen</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006683" MajorTopicYN="N">HLA-DQ Antigens</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015803" MajorTopicYN="N">HLA-DR3 Antigen</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000097" 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