Allergic reactivity and IgG subclasses to a proteinase fraction of Setaria digitata in filariasis.
Identifieur interne : 005337 ( PubMed/Corpus ); précédent : 005336; suivant : 005338Allergic reactivity and IgG subclasses to a proteinase fraction of Setaria digitata in filariasis.
Auteurs : M K Beuria ; M. Bal ; M K DasSource :
- Journal of helminthology [ 0022-149X ] ; 1995.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (blood), Antigens, Helminth (immunology), Antigens, Helminth (metabolism), Carrier State, Cattle, Cysteine Endopeptidases (immunology), Cysteine Endopeptidases (metabolism), Cysteine Proteinase Inhibitors, Elephantiasis, Filarial (immunology), Humans, Hydrogen-Ion Concentration, Hypersensitivity, Immediate, Immunoglobulin G (blood), India, Intradermal Tests, Setaria Nematode (enzymology), Setaria Nematode (immunology), Setariasis (immunology), Zinc (physiology).
- MESH :
- chemical , blood : Antibodies, Helminth, Immunoglobulin G.
- chemical , immunology : Antigens, Helminth, Cysteine Endopeptidases.
- chemical , metabolism : Antigens, Helminth, Cysteine Endopeptidases.
- chemical , physiology : Zinc.
- geographic : India.
- enzymology : Setaria Nematode.
- immunology : Elephantiasis, Filarial, Setaria Nematode, Setariasis.
- Animals, Carrier State, Cattle, Cysteine Proteinase Inhibitors, Humans, Hydrogen-Ion Concentration, Hypersensitivity, Immediate, Intradermal Tests.
Abstract
A low molecular weight fraction (30 KDa) of the cattle filarial parasite Setaria digitata that was earlier demonstrated to have allergenic activity was characterized to be a zinc-dependent cysteine proteinase. Immediate type hypersensitivity (ITH) reaction to the proteinase was evaluated in lymphatic filariasis patients and in endemic controls from Orissa, India. The extent of ITH positivity to the proteinase in infected individuals ranged from 20% in chronic filariasis (CP) patients group to 56% in asymptomatic microfilaraemic carriers (AS). About 62% of endemic normals (EN) were also ITH positive. The serum levels of IgG subclasses were compared in ITH positive and ITH negative filarial patients (AS and CP) as well as in endemic normals (EN) respectively. IgG4 levels were found to be inversely dependent on ITH reaction only in AS groups. Asymptomatic patients (AS) with positive ITH reactivity had lower IgG4 than ITH negative individuals from the same group. The serum levels of other IgG subclasses except IgG2, did not correlate with ITH reactivity. IgG2 levels were higher in ITH negative EN and CP patients but not in the AS group.
PubMed: 8522762
Links to Exploration step
pubmed:8522762Le document en format XML
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Bal</name></author><author><name sortKey="Das, M K" sort="Das, M K" uniqKey="Das M" first="M K" last="Das">M K Das</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1995">1995</date><idno type="RBID">pubmed:8522762</idno><idno type="pmid">8522762</idno><idno type="wicri:Area/PubMed/Corpus">005337</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005337</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Allergic reactivity and IgG subclasses to a proteinase fraction of Setaria digitata in filariasis.</title><author><name sortKey="Beuria, M K" sort="Beuria, M K" uniqKey="Beuria M" first="M K" last="Beuria">M K Beuria</name><affiliation><nlm:affiliation>Parasite Immunology Division, Regional Medical Centre (ICMR), Bhubaneswar, India.</nlm:affiliation></affiliation></author><author><name sortKey="Bal, M" sort="Bal, M" uniqKey="Bal M" first="M" last="Bal">M. Bal</name></author><author><name sortKey="Das, M K" sort="Das, M K" uniqKey="Das M" first="M K" last="Das">M K Das</name></author></analytic><series><title level="j">Journal of helminthology</title><idno type="ISSN">0022-149X</idno><imprint><date when="1995" type="published">1995</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Helminth (blood)</term><term>Antigens, Helminth (immunology)</term><term>Antigens, Helminth (metabolism)</term><term>Carrier State</term><term>Cattle</term><term>Cysteine Endopeptidases (immunology)</term><term>Cysteine Endopeptidases (metabolism)</term><term>Cysteine Proteinase Inhibitors</term><term>Elephantiasis, Filarial (immunology)</term><term>Humans</term><term>Hydrogen-Ion Concentration</term><term>Hypersensitivity, Immediate</term><term>Immunoglobulin G (blood)</term><term>India</term><term>Intradermal Tests</term><term>Setaria Nematode (enzymology)</term><term>Setaria Nematode (immunology)</term><term>Setariasis (immunology)</term><term>Zinc (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Helminth</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term><term>Cysteine Endopeptidases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, Helminth</term><term>Cysteine Endopeptidases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Zinc</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>India</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Setaria Nematode</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Setaria Nematode</term><term>Setariasis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Carrier State</term><term>Cattle</term><term>Cysteine Proteinase Inhibitors</term><term>Humans</term><term>Hydrogen-Ion Concentration</term><term>Hypersensitivity, Immediate</term><term>Intradermal Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A low molecular weight fraction (30 KDa) of the cattle filarial parasite Setaria digitata that was earlier demonstrated to have allergenic activity was characterized to be a zinc-dependent cysteine proteinase. Immediate type hypersensitivity (ITH) reaction to the proteinase was evaluated in lymphatic filariasis patients and in endemic controls from Orissa, India. The extent of ITH positivity to the proteinase in infected individuals ranged from 20% in chronic filariasis (CP) patients group to 56% in asymptomatic microfilaraemic carriers (AS). About 62% of endemic normals (EN) were also ITH positive. The serum levels of IgG subclasses were compared in ITH positive and ITH negative filarial patients (AS and CP) as well as in endemic normals (EN) respectively. IgG4 levels were found to be inversely dependent on ITH reaction only in AS groups. Asymptomatic patients (AS) with positive ITH reactivity had lower IgG4 than ITH negative individuals from the same group. The serum levels of other IgG subclasses except IgG2, did not correlate with ITH reactivity. IgG2 levels were higher in ITH negative EN and CP patients but not in the AS group.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8522762</PMID><DateCreated><Year>1996</Year><Month>01</Month><Day>24</Day></DateCreated><DateCompleted><Year>1996</Year><Month>01</Month><Day>24</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-149X</ISSN><JournalIssue CitedMedium="Print"><Volume>69</Volume><Issue>3</Issue><PubDate><Year>1995</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Journal of helminthology</Title><ISOAbbreviation>J. Helminthol.</ISOAbbreviation></Journal><ArticleTitle>Allergic reactivity and IgG subclasses to a proteinase fraction of Setaria digitata in filariasis.</ArticleTitle><Pagination><MedlinePgn>181-5</MedlinePgn></Pagination><Abstract><AbstractText>A low molecular weight fraction (30 KDa) of the cattle filarial parasite Setaria digitata that was earlier demonstrated to have allergenic activity was characterized to be a zinc-dependent cysteine proteinase. Immediate type hypersensitivity (ITH) reaction to the proteinase was evaluated in lymphatic filariasis patients and in endemic controls from Orissa, India. The extent of ITH positivity to the proteinase in infected individuals ranged from 20% in chronic filariasis (CP) patients group to 56% in asymptomatic microfilaraemic carriers (AS). About 62% of endemic normals (EN) were also ITH positive. The serum levels of IgG subclasses were compared in ITH positive and ITH negative filarial patients (AS and CP) as well as in endemic normals (EN) respectively. IgG4 levels were found to be inversely dependent on ITH reaction only in AS groups. Asymptomatic patients (AS) with positive ITH reactivity had lower IgG4 than ITH negative individuals from the same group. The serum levels of other IgG subclasses except IgG2, did not correlate with ITH reactivity. IgG2 levels were higher in ITH negative EN and CP patients but not in the AS group.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Beuria</LastName><ForeName>M K</ForeName><Initials>MK</Initials><AffiliationInfo><Affiliation>Parasite Immunology Division, Regional Medical Centre (ICMR), Bhubaneswar, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bal</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Das</LastName><ForeName>M K</ForeName><Initials>MK</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Helminthol</MedlineTA><NlmUniqueID>2985115R</NlmUniqueID><ISSNLinking>0022-149X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000909">Antibodies, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000947">Antigens, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015853">Cysteine Proteinase Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.22.-</RegistryNumber><NameOfSubstance UI="D003546">Cysteine Endopeptidases</NameOfSubstance></Chemical><Chemical><RegistryNumber>J41CSQ7QDS</RegistryNumber><NameOfSubstance UI="D015032">Zinc</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000909" MajorTopicYN="N">Antibodies, Helminth</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000947" MajorTopicYN="N">Antigens, Helminth</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002353" MajorTopicYN="N">Carrier State</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002417" MajorTopicYN="N">Cattle</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003546" MajorTopicYN="N">Cysteine Endopeptidases</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015853" MajorTopicYN="N">Cysteine Proteinase Inhibitors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006863" MajorTopicYN="N">Hydrogen-Ion Concentration</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006969" MajorTopicYN="Y">Hypersensitivity, Immediate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007194" MajorTopicYN="N" Type="Geographic">India</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007428" MajorTopicYN="N">Intradermal Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017182" MajorTopicYN="N">Setaria Nematode</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012719" MajorTopicYN="N">Setariasis</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015032" MajorTopicYN="N">Zinc</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1995</Year><Month>9</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1995</Year><Month>9</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1995</Year><Month>9</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8522762</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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