A role for tumour necrosis factor-alpha in acute lymphatic filariasis.
Identifieur interne : 005138 ( PubMed/Corpus ); précédent : 005137; suivant : 005139A role for tumour necrosis factor-alpha in acute lymphatic filariasis.
Auteurs : B K Das ; P K Sahoo ; B. RavindranSource :
- Parasite immunology [ 0141-9838 ] ; 1996.
English descriptors
- KwdEn :
- Acute Disease, Adolescent, Adult, Aged, Carrier State (immunology), Elephantiasis, Filarial (etiology), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (therapy), Humans, Inflammation Mediators (antagonists & inhibitors), Inflammation Mediators (blood), Middle Aged, Tumor Necrosis Factor-alpha (antagonists & inhibitors), Tumor Necrosis Factor-alpha (metabolism).
- MESH :
- chemical , antagonists & inhibitors : Inflammation Mediators, Tumor Necrosis Factor-alpha.
- chemical , blood : Inflammation Mediators.
- etiology : Elephantiasis, Filarial.
- immunology : Carrier State, Elephantiasis, Filarial.
- chemical , metabolism : Tumor Necrosis Factor-alpha.
- therapy : Elephantiasis, Filarial.
- Acute Disease, Adolescent, Adult, Aged, Humans, Middle Aged.
Abstract
A spectrum of clinical manifestations is a feature of human lymphatic filariasis. The acute disease is characterized by periodic and self limiting episodes of adenolymphangitis, fever and associated constitutional symptoms, while the chronic disease includes long lasting manifestations such as lymphoedema and/or hydrocoele. The microfilariae carriers are generally free of clinical symptoms. In the present study circulating Tumour Necrosis Factor (TNF-alpha) was measured in human bancroftian filariasis with different clinical manifestations. Significantly elevated levels were observed only in patients with acute disease and not in microfilariae carriers or in patients with chronic manifestations. A detailed analysis of the acute cases indicated an absence of correlation between TNF-alpha levels and duration of the episodes. However, a significant positive correlation was observed between the severity of the disease and the TNF-alpha levels. About 85% of the acute cases with severe manifestations showed raised levels of TNF-alpha while only 6.5% of mild cases showed such levels. Manifestation of fever was also significantly associated with higher levels of TNF-alpha-while 80% of acute cases with fever had significant levels only 24% of acute cases without fever had high levels of TNF-alpha. Based on these observations we propose a mediatory role for TNF-alpha in acute filariasis and the possible use of TNF-alpha inhibitors for clinical management of the disease.
PubMed: 9229396
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pubmed:9229396Le document en format XML
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Ravindran</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1996">1996</date><idno type="RBID">pubmed:9229396</idno><idno type="pmid">9229396</idno><idno type="wicri:Area/PubMed/Corpus">005138</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005138</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A role for tumour necrosis factor-alpha in acute lymphatic filariasis.</title><author><name sortKey="Das, B K" sort="Das, B K" uniqKey="Das B" first="B K" last="Das">B K Das</name><affiliation><nlm:affiliation>Division of Applied Immunology, Regional Medical Research Centre, Indian Council of Medical Research, Orissa, India.</nlm:affiliation></affiliation></author><author><name sortKey="Sahoo, P K" sort="Sahoo, P K" uniqKey="Sahoo P" first="P K" last="Sahoo">P K Sahoo</name></author><author><name sortKey="Ravindran, B" sort="Ravindran, B" uniqKey="Ravindran B" first="B" last="Ravindran">B. Ravindran</name></author></analytic><series><title level="j">Parasite immunology</title><idno type="ISSN">0141-9838</idno><imprint><date when="1996" type="published">1996</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Disease</term><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Carrier State (immunology)</term><term>Elephantiasis, Filarial (etiology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (therapy)</term><term>Humans</term><term>Inflammation Mediators (antagonists & inhibitors)</term><term>Inflammation Mediators (blood)</term><term>Middle Aged</term><term>Tumor Necrosis Factor-alpha (antagonists & inhibitors)</term><term>Tumor Necrosis Factor-alpha (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Inflammation Mediators</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Inflammation Mediators</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Carrier State</term><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acute Disease</term><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Humans</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A spectrum of clinical manifestations is a feature of human lymphatic filariasis. The acute disease is characterized by periodic and self limiting episodes of adenolymphangitis, fever and associated constitutional symptoms, while the chronic disease includes long lasting manifestations such as lymphoedema and/or hydrocoele. The microfilariae carriers are generally free of clinical symptoms. In the present study circulating Tumour Necrosis Factor (TNF-alpha) was measured in human bancroftian filariasis with different clinical manifestations. Significantly elevated levels were observed only in patients with acute disease and not in microfilariae carriers or in patients with chronic manifestations. A detailed analysis of the acute cases indicated an absence of correlation between TNF-alpha levels and duration of the episodes. However, a significant positive correlation was observed between the severity of the disease and the TNF-alpha levels. About 85% of the acute cases with severe manifestations showed raised levels of TNF-alpha while only 6.5% of mild cases showed such levels. Manifestation of fever was also significantly associated with higher levels of TNF-alpha-while 80% of acute cases with fever had significant levels only 24% of acute cases without fever had high levels of TNF-alpha. Based on these observations we propose a mediatory role for TNF-alpha in acute filariasis and the possible use of TNF-alpha inhibitors for clinical management of the disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9229396</PMID><DateCreated><Year>1997</Year><Month>09</Month><Day>22</Day></DateCreated><DateCompleted><Year>1997</Year><Month>09</Month><Day>22</Day></DateCompleted><DateRevised><Year>2004</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0141-9838</ISSN><JournalIssue CitedMedium="Print"><Volume>18</Volume><Issue>8</Issue><PubDate><Year>1996</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Parasite immunology</Title><ISOAbbreviation>Parasite Immunol.</ISOAbbreviation></Journal><ArticleTitle>A role for tumour necrosis factor-alpha in acute lymphatic filariasis.</ArticleTitle><Pagination><MedlinePgn>421-4</MedlinePgn></Pagination><Abstract><AbstractText>A spectrum of clinical manifestations is a feature of human lymphatic filariasis. The acute disease is characterized by periodic and self limiting episodes of adenolymphangitis, fever and associated constitutional symptoms, while the chronic disease includes long lasting manifestations such as lymphoedema and/or hydrocoele. The microfilariae carriers are generally free of clinical symptoms. In the present study circulating Tumour Necrosis Factor (TNF-alpha) was measured in human bancroftian filariasis with different clinical manifestations. Significantly elevated levels were observed only in patients with acute disease and not in microfilariae carriers or in patients with chronic manifestations. A detailed analysis of the acute cases indicated an absence of correlation between TNF-alpha levels and duration of the episodes. However, a significant positive correlation was observed between the severity of the disease and the TNF-alpha levels. About 85% of the acute cases with severe manifestations showed raised levels of TNF-alpha while only 6.5% of mild cases showed such levels. Manifestation of fever was also significantly associated with higher levels of TNF-alpha-while 80% of acute cases with fever had significant levels only 24% of acute cases without fever had high levels of TNF-alpha. Based on these observations we propose a mediatory role for TNF-alpha in acute filariasis and the possible use of TNF-alpha inhibitors for clinical management of the disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Das</LastName><ForeName>B K</ForeName><Initials>BK</Initials><AffiliationInfo><Affiliation>Division of Applied Immunology, Regional Medical Research Centre, Indian Council of Medical Research, Orissa, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sahoo</LastName><ForeName>P K</ForeName><Initials>PK</Initials></Author><Author ValidYN="Y"><LastName>Ravindran</LastName><ForeName>B</ForeName><Initials>B</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Parasite Immunol</MedlineTA><NlmUniqueID>7910948</NlmUniqueID><ISSNLinking>0141-9838</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018836">Inflammation Mediators</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000208" MajorTopicYN="N">Acute Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002353" MajorTopicYN="N">Carrier State</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018836" MajorTopicYN="N">Inflammation Mediators</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1996</Year><Month>8</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1996</Year><Month>8</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1996</Year><Month>8</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9229396</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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