Evidence for protective immunity to bancroftian filariasis in the Cook Islands.
Identifieur interne : 005137 ( PubMed/Corpus ); précédent : 005136; suivant : 005138Evidence for protective immunity to bancroftian filariasis in the Cook Islands.
Auteurs : C. Steel ; A. Guinea ; E A OttesenSource :
- The Journal of infectious diseases [ 0022-1899 ] ; 1996.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Animals, Antibodies, Helminth (analysis), Antigens, Helminth (immunology), Brugia malayi (chemistry), Child, Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (immunology), Female, Granulocyte-Macrophage Colony-Stimulating Factor (analysis), Humans, Immunity, Cellular, Immunoglobulin E (analysis), Immunoglobulin E (blood), Immunoglobulin G (analysis), Immunoglobulin G (blood), Interferon-gamma (analysis), Interleukin-10 (analysis), Interleukin-2 (analysis), Interleukin-5 (analysis), Lymphocyte Activation, Male, Middle Aged, Polynesia, Time Factors, Wuchereria bancrofti (immunology).
- MESH :
- chemical , analysis : Antibodies, Helminth, Granulocyte-Macrophage Colony-Stimulating Factor, Immunoglobulin E, Immunoglobulin G, Interferon-gamma, Interleukin-10, Interleukin-2, Interleukin-5.
- chemical , blood : Immunoglobulin E, Immunoglobulin G.
- chemical , immunology : Antigens, Helminth.
- geographic : Polynesia.
- chemistry : Brugia malayi.
- diagnosis : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial.
- immunology : Elephantiasis, Filarial, Wuchereria bancrofti.
- Adolescent, Adult, Aged, Animals, Child, Female, Humans, Immunity, Cellular, Lymphocyte Activation, Male, Middle Aged, Time Factors.
Abstract
To challenge the concept of protective immunity in lymphatic filariasis, 19 adult residents of a Wuchereria bancrofti-endemic island who had been diagnosed 17 years earlier as putatively immune endemic normals (PI/EN) were reexamined. Even with continued exposure to infection, all 19 had maintained their apparent infection-free status. Studies to define the mechanisms underlying this putative immunity revealed that cellular immune responses (including proliferation; generation of interleukin [IL]-2, IL-5, IL-10, interferon-gamma, and granulocyte-macrophage colony-stimulating factor) to adult- and microfilarial-stage antigens, but not antibody responses, were markedly greater than those of 20 age-matched, infected patients. Furthermore, the PI/EN group was comprised of high- and low-responding persons who were clinically indistinguishable. These findings provide evidence that protective immunity to lymphatic filariasis does occur and that it is probably T cell-mediated.
PubMed: 8769619
Links to Exploration step
pubmed:8769619Le document en format XML
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<author><name sortKey="Steel, C" sort="Steel, C" uniqKey="Steel C" first="C" last="Steel">C. Steel</name>
<affiliation><nlm:affiliation>Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland 20892-0425, USA.</nlm:affiliation>
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<author><name sortKey="Guinea, A" sort="Guinea, A" uniqKey="Guinea A" first="A" last="Guinea">A. Guinea</name>
</author>
<author><name sortKey="Ottesen, E A" sort="Ottesen, E A" uniqKey="Ottesen E" first="E A" last="Ottesen">E A Ottesen</name>
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<author><name sortKey="Guinea, A" sort="Guinea, A" uniqKey="Guinea A" first="A" last="Guinea">A. Guinea</name>
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<author><name sortKey="Ottesen, E A" sort="Ottesen, E A" uniqKey="Ottesen E" first="E A" last="Ottesen">E A Ottesen</name>
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<term>Antigens, Helminth (immunology)</term>
<term>Brugia malayi (chemistry)</term>
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<term>Elephantiasis, Filarial (diagnosis)</term>
<term>Elephantiasis, Filarial (epidemiology)</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Female</term>
<term>Granulocyte-Macrophage Colony-Stimulating Factor (analysis)</term>
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<term>Immunoglobulin E (analysis)</term>
<term>Immunoglobulin E (blood)</term>
<term>Immunoglobulin G (analysis)</term>
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<term>Interferon-gamma (analysis)</term>
<term>Interleukin-10 (analysis)</term>
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<term>Lymphocyte Activation</term>
<term>Male</term>
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<term>Polynesia</term>
<term>Time Factors</term>
<term>Wuchereria bancrofti (immunology)</term>
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<front><div type="abstract" xml:lang="en">To challenge the concept of protective immunity in lymphatic filariasis, 19 adult residents of a Wuchereria bancrofti-endemic island who had been diagnosed 17 years earlier as putatively immune endemic normals (PI/EN) were reexamined. Even with continued exposure to infection, all 19 had maintained their apparent infection-free status. Studies to define the mechanisms underlying this putative immunity revealed that cellular immune responses (including proliferation; generation of interleukin [IL]-2, IL-5, IL-10, interferon-gamma, and granulocyte-macrophage colony-stimulating factor) to adult- and microfilarial-stage antigens, but not antibody responses, were markedly greater than those of 20 age-matched, infected patients. Furthermore, the PI/EN group was comprised of high- and low-responding persons who were clinically indistinguishable. These findings provide evidence that protective immunity to lymphatic filariasis does occur and that it is probably T cell-mediated.</div>
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<Abstract><AbstractText>To challenge the concept of protective immunity in lymphatic filariasis, 19 adult residents of a Wuchereria bancrofti-endemic island who had been diagnosed 17 years earlier as putatively immune endemic normals (PI/EN) were reexamined. Even with continued exposure to infection, all 19 had maintained their apparent infection-free status. Studies to define the mechanisms underlying this putative immunity revealed that cellular immune responses (including proliferation; generation of interleukin [IL]-2, IL-5, IL-10, interferon-gamma, and granulocyte-macrophage colony-stimulating factor) to adult- and microfilarial-stage antigens, but not antibody responses, were markedly greater than those of 20 age-matched, infected patients. Furthermore, the PI/EN group was comprised of high- and low-responding persons who were clinically indistinguishable. These findings provide evidence that protective immunity to lymphatic filariasis does occur and that it is probably T cell-mediated.</AbstractText>
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