Regulatory T cells in human lymphatic filariasis: stronger functional activity in microfilaremics.
Identifieur interne : 002100 ( PubMed/Corpus ); précédent : 002099; suivant : 002101Regulatory T cells in human lymphatic filariasis: stronger functional activity in microfilaremics.
Auteurs : Linda J. Wammes ; Firdaus Hamid ; Aprilianto E. Wiria ; Heri Wibowo ; Erliyani Sartono ; Rick M. Maizels ; Hermelijn H. Smits ; Taniawati Supali ; Maria YazdanbakhshSource :
- PLoS neglected tropical diseases [ 1935-2735 ] ; 2012.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Animals, Brugia malayi (immunology), Cell Proliferation, Cytokines (secretion), Elephantiasis, Filarial (immunology), Female, Humans, Immune Tolerance, Immunophenotyping, Indonesia, Leukocytes, Mononuclear (immunology), Lymphocyte Depletion, Male, Middle Aged, T-Lymphocytes, Regulatory (chemistry), T-Lymphocytes, Regulatory (immunology), Young Adult.
- MESH :
- chemical , secretion : Cytokines.
- geographic : Indonesia.
- chemistry : T-Lymphocytes, Regulatory.
- immunology : Brugia malayi, Elephantiasis, Filarial, Leukocytes, Mononuclear, T-Lymphocytes, Regulatory.
- Adolescent, Adult, Aged, Animals, Cell Proliferation, Female, Humans, Immune Tolerance, Immunophenotyping, Lymphocyte Depletion, Male, Middle Aged, Young Adult.
Abstract
Infection with filarial parasites is associated with T cell hyporesponsiveness, which is thought to be partly mediated by their ability to induce regulatory T cells (Tregs) during human infections. This study investigates the functional capacity of Tregs from different groups of filarial patients to suppress filaria-specific immune responses during human filariasis. Microfilaremic (MF), chronic pathology (CP) and uninfected endemic normal (EN) individuals were selected in an area endemic for Brugia timori in Flores island, Indonesia. PBMC were isolated, CD4CD25(hi) cells were magnetically depleted and in vitro cytokine production and proliferation in response to B. malayi adult worm antigen (BmA) were determined in total and Treg-depleted PBMC. In MF subjects BmA-specific T and B lymphocyte proliferation as well as IFN-gamma, IL-13 and IL-17 responses were lower compared to EN and CP groups. Depletion of Tregs restored T cell as well as B cell proliferation in MF-positives, while proliferative responses in the other groups were not enhanced. BmA-induced IL-13 production was increased after Treg removal in MF-positives only. Thus, filaria-associated Tregs were demonstrated to be functional in suppressing proliferation and possibly Th2 cytokine responses to BmA. These suppressive effects were only observed in the MF group and not in EN or CP. These findings may be important when considering strategies for filarial treatment and the targeted prevention of filaria-induced lymphedema.
DOI: 10.1371/journal.pntd.0001655
PubMed: 22666510
Links to Exploration step
pubmed:22666510Le document en format XML
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Wiria</name></author><author><name sortKey="Wibowo, Heri" sort="Wibowo, Heri" uniqKey="Wibowo H" first="Heri" last="Wibowo">Heri Wibowo</name></author><author><name sortKey="Sartono, Erliyani" sort="Sartono, Erliyani" uniqKey="Sartono E" first="Erliyani" last="Sartono">Erliyani Sartono</name></author><author><name sortKey="Maizels, Rick M" sort="Maizels, Rick M" uniqKey="Maizels R" first="Rick M" last="Maizels">Rick M. Maizels</name></author><author><name sortKey="Smits, Hermelijn H" sort="Smits, Hermelijn H" uniqKey="Smits H" first="Hermelijn H" last="Smits">Hermelijn H. Smits</name></author><author><name sortKey="Supali, Taniawati" sort="Supali, Taniawati" uniqKey="Supali T" first="Taniawati" last="Supali">Taniawati Supali</name></author><author><name sortKey="Yazdanbakhsh, Maria" sort="Yazdanbakhsh, Maria" uniqKey="Yazdanbakhsh M" first="Maria" last="Yazdanbakhsh">Maria Yazdanbakhsh</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22666510</idno><idno type="pmid">22666510</idno><idno type="doi">10.1371/journal.pntd.0001655</idno><idno type="wicri:Area/PubMed/Corpus">002100</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002100</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Regulatory T cells in human lymphatic filariasis: stronger functional activity in microfilaremics.</title><author><name sortKey="Wammes, Linda J" sort="Wammes, Linda J" uniqKey="Wammes L" first="Linda J" last="Wammes">Linda J. Wammes</name><affiliation><nlm:affiliation>Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands. l.j.wammes@lumc.nl</nlm:affiliation></affiliation></author><author><name sortKey="Hamid, Firdaus" sort="Hamid, Firdaus" uniqKey="Hamid F" first="Firdaus" last="Hamid">Firdaus Hamid</name></author><author><name sortKey="Wiria, Aprilianto E" sort="Wiria, Aprilianto E" uniqKey="Wiria A" first="Aprilianto E" last="Wiria">Aprilianto E. Wiria</name></author><author><name sortKey="Wibowo, Heri" sort="Wibowo, Heri" uniqKey="Wibowo H" first="Heri" last="Wibowo">Heri Wibowo</name></author><author><name sortKey="Sartono, Erliyani" sort="Sartono, Erliyani" uniqKey="Sartono E" first="Erliyani" last="Sartono">Erliyani Sartono</name></author><author><name sortKey="Maizels, Rick M" sort="Maizels, Rick M" uniqKey="Maizels R" first="Rick M" last="Maizels">Rick M. Maizels</name></author><author><name sortKey="Smits, Hermelijn H" sort="Smits, Hermelijn H" uniqKey="Smits H" first="Hermelijn H" last="Smits">Hermelijn H. Smits</name></author><author><name sortKey="Supali, Taniawati" sort="Supali, Taniawati" uniqKey="Supali T" first="Taniawati" last="Supali">Taniawati Supali</name></author><author><name sortKey="Yazdanbakhsh, Maria" sort="Yazdanbakhsh, Maria" uniqKey="Yazdanbakhsh M" first="Maria" last="Yazdanbakhsh">Maria Yazdanbakhsh</name></author></analytic><series><title level="j">PLoS neglected tropical diseases</title><idno type="eISSN">1935-2735</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Brugia malayi (immunology)</term><term>Cell Proliferation</term><term>Cytokines (secretion)</term><term>Elephantiasis, Filarial (immunology)</term><term>Female</term><term>Humans</term><term>Immune Tolerance</term><term>Immunophenotyping</term><term>Indonesia</term><term>Leukocytes, Mononuclear (immunology)</term><term>Lymphocyte Depletion</term><term>Male</term><term>Middle Aged</term><term>T-Lymphocytes, Regulatory (chemistry)</term><term>T-Lymphocytes, Regulatory (immunology)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="secretion" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Indonesia</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>T-Lymphocytes, Regulatory</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia malayi</term><term>Elephantiasis, Filarial</term><term>Leukocytes, Mononuclear</term><term>T-Lymphocytes, Regulatory</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Cell Proliferation</term><term>Female</term><term>Humans</term><term>Immune Tolerance</term><term>Immunophenotyping</term><term>Lymphocyte Depletion</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Infection with filarial parasites is associated with T cell hyporesponsiveness, which is thought to be partly mediated by their ability to induce regulatory T cells (Tregs) during human infections. This study investigates the functional capacity of Tregs from different groups of filarial patients to suppress filaria-specific immune responses during human filariasis. Microfilaremic (MF), chronic pathology (CP) and uninfected endemic normal (EN) individuals were selected in an area endemic for Brugia timori in Flores island, Indonesia. PBMC were isolated, CD4CD25(hi) cells were magnetically depleted and in vitro cytokine production and proliferation in response to B. malayi adult worm antigen (BmA) were determined in total and Treg-depleted PBMC. In MF subjects BmA-specific T and B lymphocyte proliferation as well as IFN-gamma, IL-13 and IL-17 responses were lower compared to EN and CP groups. Depletion of Tregs restored T cell as well as B cell proliferation in MF-positives, while proliferative responses in the other groups were not enhanced. BmA-induced IL-13 production was increased after Treg removal in MF-positives only. Thus, filaria-associated Tregs were demonstrated to be functional in suppressing proliferation and possibly Th2 cytokine responses to BmA. These suppressive effects were only observed in the MF group and not in EN or CP. These findings may be important when considering strategies for filarial treatment and the targeted prevention of filaria-induced lymphedema.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22666510</PMID><DateCreated><Year>2012</Year><Month>06</Month><Day>05</Day></DateCreated><DateCompleted><Year>2012</Year><Month>08</Month><Day>30</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1935-2735</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><Issue>5</Issue><PubDate><Year>2012</Year></PubDate></JournalIssue><Title>PLoS neglected tropical diseases</Title><ISOAbbreviation>PLoS Negl Trop Dis</ISOAbbreviation></Journal><ArticleTitle>Regulatory T cells in human lymphatic filariasis: stronger functional activity in microfilaremics.</ArticleTitle><Pagination><MedlinePgn>e1655</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pntd.0001655</ELocationID><Abstract><AbstractText>Infection with filarial parasites is associated with T cell hyporesponsiveness, which is thought to be partly mediated by their ability to induce regulatory T cells (Tregs) during human infections. This study investigates the functional capacity of Tregs from different groups of filarial patients to suppress filaria-specific immune responses during human filariasis. Microfilaremic (MF), chronic pathology (CP) and uninfected endemic normal (EN) individuals were selected in an area endemic for Brugia timori in Flores island, Indonesia. PBMC were isolated, CD4CD25(hi) cells were magnetically depleted and in vitro cytokine production and proliferation in response to B. malayi adult worm antigen (BmA) were determined in total and Treg-depleted PBMC. In MF subjects BmA-specific T and B lymphocyte proliferation as well as IFN-gamma, IL-13 and IL-17 responses were lower compared to EN and CP groups. Depletion of Tregs restored T cell as well as B cell proliferation in MF-positives, while proliferative responses in the other groups were not enhanced. BmA-induced IL-13 production was increased after Treg removal in MF-positives only. Thus, filaria-associated Tregs were demonstrated to be functional in suppressing proliferation and possibly Th2 cytokine responses to BmA. These suppressive effects were only observed in the MF group and not in EN or CP. These findings may be important when considering strategies for filarial treatment and the targeted prevention of filaria-induced lymphedema.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wammes</LastName><ForeName>Linda J</ForeName><Initials>LJ</Initials><AffiliationInfo><Affiliation>Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands. l.j.wammes@lumc.nl</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hamid</LastName><ForeName>Firdaus</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Wiria</LastName><ForeName>Aprilianto E</ForeName><Initials>AE</Initials></Author><Author ValidYN="Y"><LastName>Wibowo</LastName><ForeName>Heri</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Sartono</LastName><ForeName>Erliyani</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Maizels</LastName><ForeName>Rick M</ForeName><Initials>RM</Initials></Author><Author ValidYN="Y"><LastName>Smits</LastName><ForeName>Hermelijn H</ForeName><Initials>HH</Initials></Author><Author ValidYN="Y"><LastName>Supali</LastName><ForeName>Taniawati</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Yazdanbakhsh</LastName><ForeName>Maria</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>WT095831</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>05</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS Negl Trop Dis</MedlineTA><NlmUniqueID>101291488</NlmUniqueID><ISSNLinking>1935-2727</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>PLoS Negl Trop Dis. 2009;3(4):e420</RefSource><PMID Version="1">19381284</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Parasitol. 2003 Dec;19(12):565-70</RefSource><PMID Version="1">14642766</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Trop Med Hyg. 1988 Jan;38(1):125-9</RefSource><PMID Version="1">3277457</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2003 Dec 15;171(12):6723-32</RefSource><PMID Version="1">14662876</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 2001 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Version="1">12949497</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017178" MajorTopicYN="N">Brugia malayi</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000557" MajorTopicYN="N">secretion</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007108" MajorTopicYN="Y">Immune Tolerance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016130" MajorTopicYN="N">Immunophenotyping</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007214" MajorTopicYN="N" Type="Geographic">Indonesia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007963" MajorTopicYN="N">Leukocytes, Mononuclear</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008212" MajorTopicYN="N">Lymphocyte Depletion</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D050378" MajorTopicYN="N">T-Lymphocytes, Regulatory</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC3362610</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>10</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>03</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>6</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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