Primary neuroendocrine carcinoma breast: our experience.
Identifieur interne : 001942 ( PubMed/Corpus ); précédent : 001941; suivant : 001943Primary neuroendocrine carcinoma breast: our experience.
Auteurs : Suhani ; Shadan Ali ; Gunjan Desai ; Shaji Thomas ; Lalit Aggarwal ; Kusum Meena ; Jitendar Kumar ; Manjula Jain ; S K TuduSource :
- Breast disease [ 1558-1551 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- chemistry : Breast Neoplasms, Carcinoma, Neuroendocrine.
- pathology : Breast Neoplasms, Carcinoma, Neuroendocrine.
- Aged, Female, Humans, Middle Aged, Neoplasm Recurrence, Local.
Abstract
This retrospective study was designed to present the clinical characteristics and histopathological features of Primary neuroendocrine carcinoma (PNEC) of breast, and to evaluate the impact on outcome following its management on the line of more common primary adenocarcinoma of breast.
DOI: 10.3233/BD-130357
PubMed: 24004513
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Primary neuroendocrine carcinoma breast: our experience.</title><author><name sortKey="Suhani" sort="Suhani" uniqKey="Suhani" last="Suhani">Suhani</name><affiliation><nlm:affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</nlm:affiliation></affiliation></author><author><name sortKey="Ali, Shadan" sort="Ali, Shadan" uniqKey="Ali S" first="Shadan" last="Ali">Shadan Ali</name><affiliation><nlm:affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</nlm:affiliation></affiliation></author><author><name sortKey="Desai, Gunjan" sort="Desai, Gunjan" uniqKey="Desai G" first="Gunjan" last="Desai">Gunjan Desai</name><affiliation><nlm:affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</nlm:affiliation></affiliation></author><author><name sortKey="Thomas, Shaji" sort="Thomas, Shaji" uniqKey="Thomas S" first="Shaji" last="Thomas">Shaji Thomas</name><affiliation><nlm:affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</nlm:affiliation></affiliation></author><author><name sortKey="Aggarwal, Lalit" sort="Aggarwal, Lalit" uniqKey="Aggarwal L" first="Lalit" last="Aggarwal">Lalit Aggarwal</name><affiliation><nlm:affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</nlm:affiliation></affiliation></author><author><name sortKey="Meena, Kusum" sort="Meena, Kusum" uniqKey="Meena K" first="Kusum" last="Meena">Kusum Meena</name><affiliation><nlm:affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</nlm:affiliation></affiliation></author><author><name sortKey="Kumar, Jitendar" sort="Kumar, Jitendar" uniqKey="Kumar J" first="Jitendar" last="Kumar">Jitendar Kumar</name><affiliation><nlm:affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</nlm:affiliation></affiliation></author><author><name sortKey="Jain, Manjula" sort="Jain, Manjula" uniqKey="Jain M" first="Manjula" last="Jain">Manjula Jain</name><affiliation><nlm:affiliation>Department of Pathology, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</nlm:affiliation></affiliation></author><author><name sortKey="Tudu, S K" sort="Tudu, S K" uniqKey="Tudu S" first="S K" last="Tudu">S K Tudu</name><affiliation><nlm:affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24004513</idno><idno type="pmid">24004513</idno><idno type="doi">10.3233/BD-130357</idno><idno type="wicri:Area/PubMed/Corpus">001942</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001942</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Primary neuroendocrine carcinoma breast: our experience.</title><author><name sortKey="Suhani" sort="Suhani" uniqKey="Suhani" last="Suhani">Suhani</name><affiliation><nlm:affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</nlm:affiliation></affiliation></author><author><name sortKey="Ali, Shadan" sort="Ali, Shadan" uniqKey="Ali S" first="Shadan" last="Ali">Shadan Ali</name><affiliation><nlm:affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</nlm:affiliation></affiliation></author><author><name sortKey="Desai, Gunjan" sort="Desai, Gunjan" uniqKey="Desai G" first="Gunjan" last="Desai">Gunjan Desai</name><affiliation><nlm:affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</nlm:affiliation></affiliation></author><author><name sortKey="Thomas, Shaji" sort="Thomas, Shaji" uniqKey="Thomas S" first="Shaji" last="Thomas">Shaji Thomas</name><affiliation><nlm:affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</nlm:affiliation></affiliation></author><author><name sortKey="Aggarwal, Lalit" sort="Aggarwal, Lalit" uniqKey="Aggarwal L" first="Lalit" last="Aggarwal">Lalit Aggarwal</name><affiliation><nlm:affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</nlm:affiliation></affiliation></author><author><name sortKey="Meena, Kusum" sort="Meena, Kusum" uniqKey="Meena K" first="Kusum" last="Meena">Kusum Meena</name><affiliation><nlm:affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</nlm:affiliation></affiliation></author><author><name sortKey="Kumar, Jitendar" sort="Kumar, Jitendar" uniqKey="Kumar J" first="Jitendar" last="Kumar">Jitendar Kumar</name><affiliation><nlm:affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</nlm:affiliation></affiliation></author><author><name sortKey="Jain, Manjula" sort="Jain, Manjula" uniqKey="Jain M" first="Manjula" last="Jain">Manjula Jain</name><affiliation><nlm:affiliation>Department of Pathology, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</nlm:affiliation></affiliation></author><author><name sortKey="Tudu, S K" sort="Tudu, S K" uniqKey="Tudu S" first="S K" last="Tudu">S K Tudu</name><affiliation><nlm:affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Breast disease</title><idno type="eISSN">1558-1551</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Breast Neoplasms (chemistry)</term><term>Breast Neoplasms (pathology)</term><term>Carcinoma, Neuroendocrine (chemistry)</term><term>Carcinoma, Neuroendocrine (pathology)</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Neoplasm Recurrence, Local</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Breast Neoplasms</term><term>Carcinoma, Neuroendocrine</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term><term>Carcinoma, Neuroendocrine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Neoplasm Recurrence, Local</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This retrospective study was designed to present the clinical characteristics and histopathological features of Primary neuroendocrine carcinoma (PNEC) of breast, and to evaluate the impact on outcome following its management on the line of more common primary adenocarcinoma of breast.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24004513</PMID><DateCreated><Year>2014</Year><Month>07</Month><Day>03</Day></DateCreated><DateCompleted><Year>2015</Year><Month>03</Month><Day>30</Day></DateCompleted><DateRevised><Year>2014</Year><Month>07</Month><Day>03</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1558-1551</ISSN><JournalIssue CitedMedium="Internet"><Volume>34</Volume><Issue>3</Issue><PubDate><Year>2014</Year></PubDate></JournalIssue><Title>Breast disease</Title><ISOAbbreviation>Breast Dis</ISOAbbreviation></Journal><ArticleTitle>Primary neuroendocrine carcinoma breast: our experience.</ArticleTitle><Pagination><MedlinePgn>95-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3233/BD-130357</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">This retrospective study was designed to present the clinical characteristics and histopathological features of Primary neuroendocrine carcinoma (PNEC) of breast, and to evaluate the impact on outcome following its management on the line of more common primary adenocarcinoma of breast.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Records of four patients diagnosed with PNEC of breast were retrospectively reviewed. Data were obtained from medical record from January 2008 to December 2012. Diagnosis of PNEC was confirmed by histopathological examination (HPE) and immunohistochemical (IHC) staining of tissue obtained from Trucut biopsy of the breast lump in all four patients. PNEC of breast was defined by the presence of more than 50% of invasive tumor cells with cytoplasmic immunoreaction for neuroendocrine (NE) markers synaptophysin, chromogranin or neuron specific enolase as per WHO classification. All patients were treated with Modified Radical Mastectomy (MRM), six cycle of Cyclophosphamide, Adriamycin and 5-Flurouracil (CAF) based adjuvant chemotherapy, radiotherapy and hormonal therapy.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">There were four female patients. The mean age was 58~years (50-65 years). Breast lump was the presenting complaint in all patients. The result of HPE showed tumor size ranging from 4 to 6.5 cm in diameter. Axillary lymph node metastasis was detected in three (75%) patients. ER and PR expression was positive in four (100%) and three patients (75%) respectively. None of the patients expressed Her-2-neu. IHC staining was positive for NE markers chromogranin in three (75%) patients, synoptophysin in two patients (50%) and Neuron specific enolase three (75%) patients. The mean follow-up time was 27.7 months (range 48-9). All four patients survived without any loco-regional or metastatic recurrence with one patient developing lymphedema of arm.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Breast lump is the most common presentation of PNEC of the breast with characteristic expression of NE markers by the tumor. Management of this rare tumor may include surgery, chemotherapy, radiotherapy and hormonal therapy depending on the size of the tumor, lymph node and hormone receptor status. However, most appropriate treatment plan has yet to be established.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Suhani</LastName><AffiliationInfo><Affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ali</LastName><ForeName>Shadan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Desai</LastName><ForeName>Gunjan</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thomas</LastName><ForeName>Shaji</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aggarwal</LastName><ForeName>Lalit</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meena</LastName><ForeName>Kusum</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kumar</LastName><ForeName>Jitendar</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jain</LastName><ForeName>Manjula</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pathology, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tudu</LastName><ForeName>S K</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>Department of General Surgery, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Breast Dis</MedlineTA><NlmUniqueID>8801277</NlmUniqueID><ISSNLinking>0888-6008</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018278" MajorTopicYN="N">Carcinoma, Neuroendocrine</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009364" MajorTopicYN="N">Neoplasm Recurrence, Local</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Primary neuroendocrine carcinoma breast</Keyword><Keyword MajorTopicYN="N">breast lump</Keyword><Keyword MajorTopicYN="N">modified radical mastectomy</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>9</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>9</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>3</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24004513</ArticleId><ArticleId IdType="pii">MG388XV136945421</ArticleId><ArticleId IdType="doi">10.3233/BD-130357</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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