A recombinant human hyaluronidase sustained release gel for the treatment of post-surgical edema.
Identifieur interne : 001864 ( PubMed/Corpus ); précédent : 001863; suivant : 001865A recombinant human hyaluronidase sustained release gel for the treatment of post-surgical edema.
Auteurs : Tara Nekoroski ; Rudolph D. Paladini ; Daniel N. Sauder ; Gregory I. Frost ; Gilbert-A KellerSource :
- International journal of dermatology [ 1365-4632 ] ; 2014.
English descriptors
- KwdEn :
- Analysis of Variance, Animals, Delayed-Action Preparations (therapeutic use), Disease Models, Animal, Hyaluronoglucosaminidase (therapeutic use), Injections, Intralesional, Lymphedema (drug therapy), Lymphedema (etiology), Mice, Postoperative Care, Postoperative Complications (diagnosis), Postoperative Complications (drug therapy), Preoperative Care, Random Allocation, Recombination, Genetic, Reference Values, Time Factors, Treatment Outcome, Wound Healing (drug effects), Wound Healing (physiology).
- MESH :
- chemical , therapeutic use : Delayed-Action Preparations, Hyaluronoglucosaminidase.
- diagnosis : Postoperative Complications.
- drug effects : Wound Healing.
- drug therapy : Lymphedema, Postoperative Complications.
- etiology : Lymphedema.
- physiology : Wound Healing.
- Analysis of Variance, Animals, Disease Models, Animal, Injections, Intralesional, Mice, Postoperative Care, Preoperative Care, Random Allocation, Recombination, Genetic, Reference Values, Time Factors, Treatment Outcome.
Abstract
Edema commonly accompanies surgical procedures and when excessive, can adversely affect surgical outcomes. The skin extracellular matrix, including one of its primary components, hyaluronan (HA), is a significant barrier to effective drainage of accumulated edematous fluid. Recombinant human hyaluronidase (rHuPH20) is a human hyaluronidase that acts transiently and locally to depolymerize HA. A non-liposomal gel formulation that provides a sustained release of rHuPH20 was tested in vivo in a preclinical murine model of acquired lymphedema.
DOI: 10.1111/ijd.12304
PubMed: 24168080
Links to Exploration step
pubmed:24168080Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A recombinant human hyaluronidase sustained release gel for the treatment of post-surgical edema.</title><author><name sortKey="Nekoroski, Tara" sort="Nekoroski, Tara" uniqKey="Nekoroski T" first="Tara" last="Nekoroski">Tara Nekoroski</name><affiliation><nlm:affiliation>Halozyme Therapeutics Inc., San Diego, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Paladini, Rudolph D" sort="Paladini, Rudolph D" uniqKey="Paladini R" first="Rudolph D" last="Paladini">Rudolph D. Paladini</name></author><author><name sortKey="Sauder, Daniel N" sort="Sauder, Daniel N" uniqKey="Sauder D" first="Daniel N" last="Sauder">Daniel N. Sauder</name></author><author><name sortKey="Frost, Gregory I" sort="Frost, Gregory I" uniqKey="Frost G" first="Gregory I" last="Frost">Gregory I. Frost</name></author><author><name sortKey="Keller, Gilbert A" sort="Keller, Gilbert A" uniqKey="Keller G" first="Gilbert-A" last="Keller">Gilbert-A Keller</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24168080</idno><idno type="pmid">24168080</idno><idno type="doi">10.1111/ijd.12304</idno><idno type="wicri:Area/PubMed/Corpus">001864</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001864</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A recombinant human hyaluronidase sustained release gel for the treatment of post-surgical edema.</title><author><name sortKey="Nekoroski, Tara" sort="Nekoroski, Tara" uniqKey="Nekoroski T" first="Tara" last="Nekoroski">Tara Nekoroski</name><affiliation><nlm:affiliation>Halozyme Therapeutics Inc., San Diego, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Paladini, Rudolph D" sort="Paladini, Rudolph D" uniqKey="Paladini R" first="Rudolph D" last="Paladini">Rudolph D. Paladini</name></author><author><name sortKey="Sauder, Daniel N" sort="Sauder, Daniel N" uniqKey="Sauder D" first="Daniel N" last="Sauder">Daniel N. Sauder</name></author><author><name sortKey="Frost, Gregory I" sort="Frost, Gregory I" uniqKey="Frost G" first="Gregory I" last="Frost">Gregory I. Frost</name></author><author><name sortKey="Keller, Gilbert A" sort="Keller, Gilbert A" uniqKey="Keller G" first="Gilbert-A" last="Keller">Gilbert-A Keller</name></author></analytic><series><title level="j">International journal of dermatology</title><idno type="eISSN">1365-4632</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Delayed-Action Preparations (therapeutic use)</term><term>Disease Models, Animal</term><term>Hyaluronoglucosaminidase (therapeutic use)</term><term>Injections, Intralesional</term><term>Lymphedema (drug therapy)</term><term>Lymphedema (etiology)</term><term>Mice</term><term>Postoperative Care</term><term>Postoperative Complications (diagnosis)</term><term>Postoperative Complications (drug therapy)</term><term>Preoperative Care</term><term>Random Allocation</term><term>Recombination, Genetic</term><term>Reference Values</term><term>Time Factors</term><term>Treatment Outcome</term><term>Wound Healing (drug effects)</term><term>Wound Healing (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Delayed-Action Preparations</term><term>Hyaluronoglucosaminidase</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Postoperative Complications</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Wound Healing</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lymphedema</term><term>Postoperative Complications</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Wound Healing</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Disease Models, Animal</term><term>Injections, Intralesional</term><term>Mice</term><term>Postoperative Care</term><term>Preoperative Care</term><term>Random Allocation</term><term>Recombination, Genetic</term><term>Reference Values</term><term>Time Factors</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Edema commonly accompanies surgical procedures and when excessive, can adversely affect surgical outcomes. The skin extracellular matrix, including one of its primary components, hyaluronan (HA), is a significant barrier to effective drainage of accumulated edematous fluid. Recombinant human hyaluronidase (rHuPH20) is a human hyaluronidase that acts transiently and locally to depolymerize HA. A non-liposomal gel formulation that provides a sustained release of rHuPH20 was tested in vivo in a preclinical murine model of acquired lymphedema.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24168080</PMID><DateCreated><Year>2014</Year><Month>05</Month><Day>19</Day></DateCreated><DateCompleted><Year>2015</Year><Month>01</Month><Day>07</Day></DateCompleted><DateRevised><Year>2014</Year><Month>05</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1365-4632</ISSN><JournalIssue CitedMedium="Internet"><Volume>53</Volume><Issue>6</Issue><PubDate><Year>2014</Year><Month>Jun</Month></PubDate></JournalIssue><Title>International journal of dermatology</Title><ISOAbbreviation>Int. J. Dermatol.</ISOAbbreviation></Journal><ArticleTitle>A recombinant human hyaluronidase sustained release gel for the treatment of post-surgical edema.</ArticleTitle><Pagination><MedlinePgn>777-85</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/ijd.12304</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Edema commonly accompanies surgical procedures and when excessive, can adversely affect surgical outcomes. The skin extracellular matrix, including one of its primary components, hyaluronan (HA), is a significant barrier to effective drainage of accumulated edematous fluid. Recombinant human hyaluronidase (rHuPH20) is a human hyaluronidase that acts transiently and locally to depolymerize HA. A non-liposomal gel formulation that provides a sustained release of rHuPH20 was tested in vivo in a preclinical murine model of acquired lymphedema.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Lymphedemic mice were injected 24 hours before surgery, and at 2 and 12 days following surgery with rHuPH20 sustained release gel (PH20 SR gel). Quantitative assessment of treatment response indicated that a single dose of PH20 SR gel resulted in accelerated resolution and reduced severity of post-surgical edema as compared to the gel vehicle (control).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Statistically significant enzymatic degradation of HA was demonstrated up to 5 mm from the injection site, and histological analysis confirmed removal of HA up to 72 hours following PH20 SR gel administration.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These results demonstrate sustained hyaluronidase enzymatic activity that promotes diffusion of accumulated post-surgical edematous fluid, suggesting that PH20 SR gel may be a useful adjuvant in promoting postoperative edema resolution.</AbstractText><CopyrightInformation>© 2013 The International Society of Dermatology.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nekoroski</LastName><ForeName>Tara</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Halozyme Therapeutics Inc., San Diego, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Paladini</LastName><ForeName>Rudolph D</ForeName><Initials>RD</Initials></Author><Author ValidYN="Y"><LastName>Sauder</LastName><ForeName>Daniel N</ForeName><Initials>DN</Initials></Author><Author ValidYN="Y"><LastName>Frost</LastName><ForeName>Gregory I</ForeName><Initials>GI</Initials></Author><Author ValidYN="Y"><LastName>Keller</LastName><ForeName>Gilbert-A</ForeName><Initials>GA</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>10</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Int J Dermatol</MedlineTA><NlmUniqueID>0243704</NlmUniqueID><ISSNLinking>0011-9059</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003692">Delayed-Action Preparations</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.2.1.35</RegistryNumber><NameOfSubstance UI="D006821">Hyaluronoglucosaminidase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003692" MajorTopicYN="N">Delayed-Action Preparations</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006821" MajorTopicYN="N">Hyaluronoglucosaminidase</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015552" MajorTopicYN="N">Injections, Intralesional</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011182" MajorTopicYN="N">Postoperative Care</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011183" MajorTopicYN="N">Postoperative Complications</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011300" MajorTopicYN="N">Preoperative Care</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011897" MajorTopicYN="N">Random Allocation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011995" MajorTopicYN="N">Recombination, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012016" MajorTopicYN="N">Reference Values</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014945" MajorTopicYN="N">Wound Healing</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate 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