Understanding the relationship between prevalence of microfilariae and antigenaemia using a model of lymphatic filariasis infection.
Identifieur interne : 000A29 ( PubMed/Corpus ); précédent : 000A28; suivant : 000A30Understanding the relationship between prevalence of microfilariae and antigenaemia using a model of lymphatic filariasis infection.
Auteurs : Michael A. Irvine ; Sammy M. Njenga ; Shamini Gunawardena ; Claire Njeri Wamae ; Jorge Cano ; Simon J. Brooker ; T. Deirdre HollingsworthSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 1878-3503 ] ; 2016.
English descriptors
- KwdEn :
- Animals, Antigens, Helminth (blood), Antigens, Helminth (isolation & purification), Carrier State (parasitology), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (immunology), Filaricides (therapeutic use), Humans, Immunochromatography, Microfilariae (isolation & purification), Models, Theoretical, Prevalence, Public Health Surveillance, Wuchereria bancrofti (isolation & purification).
- MESH :
- chemical , blood : Antigens, Helminth.
- chemical , isolation & purification : Antigens, Helminth.
- epidemiology : Elephantiasis, Filarial.
- immunology : Elephantiasis, Filarial.
- isolation & purification : Microfilariae, Wuchereria bancrofti.
- parasitology : Carrier State.
- chemical , therapeutic use : Filaricides.
- Animals, Humans, Immunochromatography, Models, Theoretical, Prevalence, Public Health Surveillance.
Abstract
Lymphatic filariasis is a debilitating neglected tropical disease that affects impoverished communities. Rapid diagnostic tests of antigenaemia are a practical alternative to parasitological tests of microfilaraemia for mapping and surveillance. However the relationship between these two methods of measuring burden has previously been difficult to interpret.
DOI: 10.1093/trstmh/trv096
PubMed: 26822604
Links to Exploration step
pubmed:26822604Le document en format XML
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Box 54840, Post Code 00200, Nairobi, Kenya.</nlm:affiliation></affiliation></author><author><name sortKey="Gunawardena, Shamini" sort="Gunawardena, Shamini" uniqKey="Gunawardena S" first="Shamini" last="Gunawardena">Shamini Gunawardena</name><affiliation><nlm:affiliation>School of Health Sciences, Mount Kenya University, P.O. Box 342-01000, Thika, Kenya.</nlm:affiliation></affiliation></author><author><name sortKey="Njeri Wamae, Claire" sort="Njeri Wamae, Claire" uniqKey="Njeri Wamae C" first="Claire" last="Njeri Wamae">Claire Njeri Wamae</name><affiliation><nlm:affiliation>School of Health Sciences, Mount Kenya University, P.O. Box 342-01000, Thika, Kenya.</nlm:affiliation></affiliation></author><author><name sortKey="Cano, Jorge" sort="Cano, Jorge" uniqKey="Cano J" first="Jorge" last="Cano">Jorge Cano</name><affiliation><nlm:affiliation>London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Brooker, Simon J" sort="Brooker, Simon J" uniqKey="Brooker S" first="Simon J" last="Brooker">Simon J. Brooker</name><affiliation><nlm:affiliation>London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Deirdre Hollingsworth, T" sort="Deirdre Hollingsworth, T" uniqKey="Deirdre Hollingsworth T" first="T" last="Deirdre Hollingsworth">T. Deirdre Hollingsworth</name><affiliation><nlm:affiliation>School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK Mathematics Institute, University of Warwick, Coventry, CV4 7AL, UK.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26822604</idno><idno type="pmid">26822604</idno><idno type="doi">10.1093/trstmh/trv096</idno><idno type="wicri:Area/PubMed/Corpus">000A29</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A29</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Understanding the relationship between prevalence of microfilariae and antigenaemia using a model of lymphatic filariasis infection.</title><author><name sortKey="Irvine, Michael A" sort="Irvine, Michael A" uniqKey="Irvine M" first="Michael A" last="Irvine">Michael A. Irvine</name><affiliation><nlm:affiliation>School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK m.irvine.1@warwick.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Njenga, Sammy M" sort="Njenga, Sammy M" uniqKey="Njenga S" first="Sammy M" last="Njenga">Sammy M. Njenga</name><affiliation><nlm:affiliation>Kenya Medical Research Institute (KEMRI), P.O. Box 54840, Post Code 00200, Nairobi, Kenya.</nlm:affiliation></affiliation></author><author><name sortKey="Gunawardena, Shamini" sort="Gunawardena, Shamini" uniqKey="Gunawardena S" first="Shamini" last="Gunawardena">Shamini Gunawardena</name><affiliation><nlm:affiliation>School of Health Sciences, Mount Kenya University, P.O. Box 342-01000, Thika, Kenya.</nlm:affiliation></affiliation></author><author><name sortKey="Njeri Wamae, Claire" sort="Njeri Wamae, Claire" uniqKey="Njeri Wamae C" first="Claire" last="Njeri Wamae">Claire Njeri Wamae</name><affiliation><nlm:affiliation>School of Health Sciences, Mount Kenya University, P.O. Box 342-01000, Thika, Kenya.</nlm:affiliation></affiliation></author><author><name sortKey="Cano, Jorge" sort="Cano, Jorge" uniqKey="Cano J" first="Jorge" last="Cano">Jorge Cano</name><affiliation><nlm:affiliation>London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Brooker, Simon J" sort="Brooker, Simon J" uniqKey="Brooker S" first="Simon J" last="Brooker">Simon J. Brooker</name><affiliation><nlm:affiliation>London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Deirdre Hollingsworth, T" sort="Deirdre Hollingsworth, T" uniqKey="Deirdre Hollingsworth T" first="T" last="Deirdre Hollingsworth">T. Deirdre Hollingsworth</name><affiliation><nlm:affiliation>School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK Mathematics Institute, University of Warwick, Coventry, CV4 7AL, UK.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Transactions of the Royal Society of Tropical Medicine and Hygiene</title><idno type="eISSN">1878-3503</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigens, Helminth (blood)</term><term>Antigens, Helminth (isolation & purification)</term><term>Carrier State (parasitology)</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Filaricides (therapeutic use)</term><term>Humans</term><term>Immunochromatography</term><term>Microfilariae (isolation & purification)</term><term>Models, Theoretical</term><term>Prevalence</term><term>Public Health Surveillance</term><term>Wuchereria bancrofti (isolation & purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Microfilariae</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Carrier State</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Filaricides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Immunochromatography</term><term>Models, Theoretical</term><term>Prevalence</term><term>Public Health Surveillance</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphatic filariasis is a debilitating neglected tropical disease that affects impoverished communities. Rapid diagnostic tests of antigenaemia are a practical alternative to parasitological tests of microfilaraemia for mapping and surveillance. However the relationship between these two methods of measuring burden has previously been difficult to interpret.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26822604</PMID><DateCreated><Year>2016</Year><Month>01</Month><Day>29</Day></DateCreated><DateCompleted><Year>2016</Year><Month>11</Month><Day>07</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1878-3503</ISSN><JournalIssue CitedMedium="Internet"><Volume>110</Volume><Issue>2</Issue><PubDate><Year>2016</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Transactions of the Royal Society of Tropical Medicine and Hygiene</Title><ISOAbbreviation>Trans. R. Soc. Trop. Med. Hyg.</ISOAbbreviation></Journal><ArticleTitle>Understanding the relationship between prevalence of microfilariae and antigenaemia using a model of lymphatic filariasis infection.</ArticleTitle><Pagination><MedlinePgn>118-24</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/trstmh/trv096</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Lymphatic filariasis is a debilitating neglected tropical disease that affects impoverished communities. Rapid diagnostic tests of antigenaemia are a practical alternative to parasitological tests of microfilaraemia for mapping and surveillance. However the relationship between these two methods of measuring burden has previously been difficult to interpret.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A statistical model of the distribution of worm burden and microfilariae (mf) and resulting antigenaemic and mf prevalence was developed and fitted to surveys of two contrasting sentinel sites undergoing interventions. The fitted model was then used to explore the relationship in various pre- and post-intervention scenarios.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The model had good quantitative agreement with the data and provided estimates of the reduction in mf output due to treatment. When extrapolating the results to a range of prevalences there was good qualitative agreement with published data.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The observed relationship between antigenamic and mf prevalence is a natural consequence of the relationship between prevalence and intensity of adult worms and mf production. The method described here allows the estimation of key epidemiological parameters and consequently gives insight into the efficacy of an intervention programme.</AbstractText><CopyrightInformation>© The Author 2015. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Irvine</LastName><ForeName>Michael A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK m.irvine.1@warwick.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Njenga</LastName><ForeName>Sammy M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Kenya Medical Research Institute (KEMRI), P.O. Box 54840, Post Code 00200, Nairobi, Kenya.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gunawardena</LastName><ForeName>Shamini</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>School of Health Sciences, Mount Kenya University, P.O. Box 342-01000, Thika, Kenya.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Njeri Wamae</LastName><ForeName>Claire</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>School of Health Sciences, Mount Kenya University, P.O. Box 342-01000, Thika, Kenya.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cano</LastName><ForeName>Jorge</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brooker</LastName><ForeName>Simon J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deirdre Hollingsworth</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK Mathematics Institute, University of Warwick, Coventry, CV4 7AL, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>098045</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Trans R Soc Trop Med Hyg</MedlineTA><NlmUniqueID>7506129</NlmUniqueID><ISSNLinking>0035-9203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000947">Antigens, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005369">Filaricides</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="ErratumIn"><RefSource>Trans R Soc Trop Med Hyg. 2016 May;110(5):317</RefSource><PMID Version="1">27198217</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Negl Trop 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Helminth</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002353" MajorTopicYN="N">Carrier State</DescriptorName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005369" MajorTopicYN="N">Filaricides</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059665" MajorTopicYN="N">Immunochromatography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008842" MajorTopicYN="N">Microfilariae</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008962" MajorTopicYN="N">Models, Theoretical</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D062486" MajorTopicYN="N">Public Health Surveillance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014958" MajorTopicYN="N">Wuchereria bancrofti</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4731003</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antigenaemia</Keyword><Keyword MajorTopicYN="N">Elimination programme</Keyword><Keyword 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