Changes of tissue fluid hyaluronan (hyaluronic acid) in peripheral lymphedema.
Identifieur interne : 004865 ( PubMed/Checkpoint ); précédent : 004864; suivant : 004866Changes of tissue fluid hyaluronan (hyaluronic acid) in peripheral lymphedema.
Auteurs : N F Liu [République populaire de Chine] ; L R ZhangSource :
- Lymphology [ 0024-7766 ] ; 1998.
Descripteurs français
- KwdFr :
- Acide hyaluronique (métabolisme), Acide hyaluronique (sang), Bras, Dosage radioimmunologique, Espace extracellulaire (métabolisme), Femelle, Humains, Jambe, Lymphe (métabolisme), Lymphoedème (métabolisme), Lymphoedème (étiologie), Mastectomie (effets indésirables), Mâle, Oedème (métabolisme), Oedème (étiologie), Thrombose veineuse (), Tumeurs du sein (), Études cas-témoins.
- MESH :
- effets indésirables : Mastectomie.
- métabolisme : Acide hyaluronique, Espace extracellulaire, Lymphe, Lymphoedème, Oedème.
- sang : Acide hyaluronique.
- étiologie : Lymphoedème, Oedème.
- Bras, Dosage radioimmunologique, Femelle, Humains, Jambe, Mâle, Thrombose veineuse, Tumeurs du sein, Études cas-témoins.
English descriptors
- KwdEn :
- Arm, Breast Neoplasms (complications), Breast Neoplasms (surgery), Case-Control Studies, Edema (etiology), Edema (metabolism), Extracellular Space (metabolism), Female, Humans, Hyaluronic Acid (blood), Hyaluronic Acid (metabolism), Leg, Lymph (metabolism), Lymphedema (etiology), Lymphedema (metabolism), Male, Mastectomy (adverse effects), Radioimmunoassay, Venous Thrombosis (complications).
- MESH :
- chemical , blood : Hyaluronic Acid.
- adverse effects : Mastectomy.
- complications : Breast Neoplasms, Venous Thrombosis.
- etiology : Edema, Lymphedema.
- metabolism : Edema, Extracellular Space, Hyaluronic Acid, Lymph, Lymphedema.
- surgery : Breast Neoplasms.
- Arm, Case-Control Studies, Female, Humans, Leg, Male, Radioimmunoassay.
Abstract
Hyaluronan (hyaluronic acid or HA) is an important component of the extracellular matrix which is synthesized in the tissue, transported in lymph and catabolized mainly in lymph nodes and the liver. In 39 patients with chronic peripheral lymphedema, the HA content in lymphedematous interstitial fluid was measured using radioimmunoassay. For comparison, the concentration of HA in serum and normal tissue fluid were also determined. These samples were also tested for protein concentration. The results showed that the HA concentration in interstitial fluid of a lymphedema limb was 22 x 10(3) +/- 10(3) (aspiration) and 30 x 10(3) +/- 4 x 10(3) (wick) ng/ml which were significantly higher than that in interstitial fluid, serum and lymph of normal limbs (control) and interstitial fluid of limbs with venous edema (p < 0.001). The protein concentration in these fluids did not show significant differences between lymphedema and those with normal limbs. The findings suggest that HA stagnates in the limb with impaired lymph drainage which may exert a deleterious effect on the interstitium.
PubMed: 9949388
Affiliations:
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pubmed:9949388Le document en format XML
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<author><name sortKey="Liu, N F" sort="Liu, N F" uniqKey="Liu N" first="N F" last="Liu">N F Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plastic Surgery, Chang Zheng Hospital, Second Military Medical University, Shanghai, China.</nlm:affiliation>
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<wicri:regionArea>Department of Plastic Surgery, Chang Zheng Hospital, Second Military Medical University, Shanghai</wicri:regionArea>
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<author><name sortKey="Zhang, L R" sort="Zhang, L R" uniqKey="Zhang L" first="L R" last="Zhang">L R Zhang</name>
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<term>Breast Neoplasms (complications)</term>
<term>Breast Neoplasms (surgery)</term>
<term>Case-Control Studies</term>
<term>Edema (etiology)</term>
<term>Edema (metabolism)</term>
<term>Extracellular Space (metabolism)</term>
<term>Female</term>
<term>Humans</term>
<term>Hyaluronic Acid (blood)</term>
<term>Hyaluronic Acid (metabolism)</term>
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<term>Lymph (metabolism)</term>
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<term>Lymphedema (metabolism)</term>
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<term>Dosage radioimmunologique</term>
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<term>Humains</term>
<term>Jambe</term>
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<term>Lymphoedème (étiologie)</term>
<term>Mastectomie (effets indésirables)</term>
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<term>Oedème (métabolisme)</term>
<term>Oedème (étiologie)</term>
<term>Thrombose veineuse ()</term>
<term>Tumeurs du sein ()</term>
<term>Études cas-témoins</term>
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<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Hyaluronic Acid</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Mastectomy</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Breast Neoplasms</term>
<term>Venous Thrombosis</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Mastectomie</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Edema</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Edema</term>
<term>Extracellular Space</term>
<term>Hyaluronic Acid</term>
<term>Lymph</term>
<term>Lymphedema</term>
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<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Acide hyaluronique</term>
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<term>Lymphoedème</term>
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<term>Case-Control Studies</term>
<term>Female</term>
<term>Humans</term>
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<term>Male</term>
<term>Radioimmunoassay</term>
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<term>Dosage radioimmunologique</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jambe</term>
<term>Mâle</term>
<term>Thrombose veineuse</term>
<term>Tumeurs du sein</term>
<term>Études cas-témoins</term>
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<front><div type="abstract" xml:lang="en">Hyaluronan (hyaluronic acid or HA) is an important component of the extracellular matrix which is synthesized in the tissue, transported in lymph and catabolized mainly in lymph nodes and the liver. In 39 patients with chronic peripheral lymphedema, the HA content in lymphedematous interstitial fluid was measured using radioimmunoassay. For comparison, the concentration of HA in serum and normal tissue fluid were also determined. These samples were also tested for protein concentration. The results showed that the HA concentration in interstitial fluid of a lymphedema limb was 22 x 10(3) +/- 10(3) (aspiration) and 30 x 10(3) +/- 4 x 10(3) (wick) ng/ml which were significantly higher than that in interstitial fluid, serum and lymph of normal limbs (control) and interstitial fluid of limbs with venous edema (p < 0.001). The protein concentration in these fluids did not show significant differences between lymphedema and those with normal limbs. The findings suggest that HA stagnates in the limb with impaired lymph drainage which may exert a deleterious effect on the interstitium.</div>
</front>
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<Abstract><AbstractText>Hyaluronan (hyaluronic acid or HA) is an important component of the extracellular matrix which is synthesized in the tissue, transported in lymph and catabolized mainly in lymph nodes and the liver. In 39 patients with chronic peripheral lymphedema, the HA content in lymphedematous interstitial fluid was measured using radioimmunoassay. For comparison, the concentration of HA in serum and normal tissue fluid were also determined. These samples were also tested for protein concentration. The results showed that the HA concentration in interstitial fluid of a lymphedema limb was 22 x 10(3) +/- 10(3) (aspiration) and 30 x 10(3) +/- 4 x 10(3) (wick) ng/ml which were significantly higher than that in interstitial fluid, serum and lymph of normal limbs (control) and interstitial fluid of limbs with venous edema (p < 0.001). The protein concentration in these fluids did not show significant differences between lymphedema and those with normal limbs. The findings suggest that HA stagnates in the limb with impaired lymph drainage which may exert a deleterious effect on the interstitium.</AbstractText>
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