Changes of tissue fluid hyaluronan (hyaluronic acid) in peripheral lymphedema.
Identifieur interne : 004D28 ( PubMed/Corpus ); précédent : 004D27; suivant : 004D29Changes of tissue fluid hyaluronan (hyaluronic acid) in peripheral lymphedema.
Auteurs : N F Liu ; L R ZhangSource :
- Lymphology [ 0024-7766 ] ; 1998.
English descriptors
- KwdEn :
- Arm, Breast Neoplasms (complications), Breast Neoplasms (surgery), Case-Control Studies, Edema (etiology), Edema (metabolism), Extracellular Space (metabolism), Female, Humans, Hyaluronic Acid (blood), Hyaluronic Acid (metabolism), Leg, Lymph (metabolism), Lymphedema (etiology), Lymphedema (metabolism), Male, Mastectomy (adverse effects), Radioimmunoassay, Venous Thrombosis (complications).
- MESH :
- chemical , blood : Hyaluronic Acid.
- adverse effects : Mastectomy.
- complications : Breast Neoplasms, Venous Thrombosis.
- etiology : Edema, Lymphedema.
- metabolism : Edema, Extracellular Space, Hyaluronic Acid, Lymph, Lymphedema.
- surgery : Breast Neoplasms.
- Arm, Case-Control Studies, Female, Humans, Leg, Male, Radioimmunoassay.
Abstract
Hyaluronan (hyaluronic acid or HA) is an important component of the extracellular matrix which is synthesized in the tissue, transported in lymph and catabolized mainly in lymph nodes and the liver. In 39 patients with chronic peripheral lymphedema, the HA content in lymphedematous interstitial fluid was measured using radioimmunoassay. For comparison, the concentration of HA in serum and normal tissue fluid were also determined. These samples were also tested for protein concentration. The results showed that the HA concentration in interstitial fluid of a lymphedema limb was 22 x 10(3) +/- 10(3) (aspiration) and 30 x 10(3) +/- 4 x 10(3) (wick) ng/ml which were significantly higher than that in interstitial fluid, serum and lymph of normal limbs (control) and interstitial fluid of limbs with venous edema (p < 0.001). The protein concentration in these fluids did not show significant differences between lymphedema and those with normal limbs. The findings suggest that HA stagnates in the limb with impaired lymph drainage which may exert a deleterious effect on the interstitium.
PubMed: 9949388
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Changes of tissue fluid hyaluronan (hyaluronic acid) in peripheral lymphedema.</title><author><name sortKey="Liu, N F" sort="Liu, N F" uniqKey="Liu N" first="N F" last="Liu">N F Liu</name><affiliation><nlm:affiliation>Department of Plastic Surgery, Chang Zheng Hospital, Second Military Medical University, Shanghai, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, L R" sort="Zhang, L R" uniqKey="Zhang L" first="L R" last="Zhang">L R Zhang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1998">1998</date><idno type="RBID">pubmed:9949388</idno><idno type="pmid">9949388</idno><idno type="wicri:Area/PubMed/Corpus">004D28</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004D28</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Changes of tissue fluid hyaluronan (hyaluronic acid) in peripheral lymphedema.</title><author><name sortKey="Liu, N F" sort="Liu, N F" uniqKey="Liu N" first="N F" last="Liu">N F Liu</name><affiliation><nlm:affiliation>Department of Plastic Surgery, Chang Zheng Hospital, Second Military Medical University, Shanghai, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, L R" sort="Zhang, L R" uniqKey="Zhang L" first="L R" last="Zhang">L R Zhang</name></author></analytic><series><title level="j">Lymphology</title><idno type="ISSN">0024-7766</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arm</term><term>Breast Neoplasms (complications)</term><term>Breast Neoplasms (surgery)</term><term>Case-Control Studies</term><term>Edema (etiology)</term><term>Edema (metabolism)</term><term>Extracellular Space (metabolism)</term><term>Female</term><term>Humans</term><term>Hyaluronic Acid (blood)</term><term>Hyaluronic Acid (metabolism)</term><term>Leg</term><term>Lymph (metabolism)</term><term>Lymphedema (etiology)</term><term>Lymphedema (metabolism)</term><term>Male</term><term>Mastectomy (adverse effects)</term><term>Radioimmunoassay</term><term>Venous Thrombosis (complications)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Hyaluronic Acid</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Mastectomy</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Breast Neoplasms</term><term>Venous Thrombosis</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Edema</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Edema</term><term>Extracellular Space</term><term>Hyaluronic Acid</term><term>Lymph</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Arm</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Leg</term><term>Male</term><term>Radioimmunoassay</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hyaluronan (hyaluronic acid or HA) is an important component of the extracellular matrix which is synthesized in the tissue, transported in lymph and catabolized mainly in lymph nodes and the liver. In 39 patients with chronic peripheral lymphedema, the HA content in lymphedematous interstitial fluid was measured using radioimmunoassay. For comparison, the concentration of HA in serum and normal tissue fluid were also determined. These samples were also tested for protein concentration. The results showed that the HA concentration in interstitial fluid of a lymphedema limb was 22 x 10(3) +/- 10(3) (aspiration) and 30 x 10(3) +/- 4 x 10(3) (wick) ng/ml which were significantly higher than that in interstitial fluid, serum and lymph of normal limbs (control) and interstitial fluid of limbs with venous edema (p < 0.001). The protein concentration in these fluids did not show significant differences between lymphedema and those with normal limbs. The findings suggest that HA stagnates in the limb with impaired lymph drainage which may exert a deleterious effect on the interstitium.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9949388</PMID><DateCreated><Year>1999</Year><Month>04</Month><Day>19</Day></DateCreated><DateCompleted><Year>1999</Year><Month>04</Month><Day>19</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>03</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0024-7766</ISSN><JournalIssue CitedMedium="Print"><Volume>31</Volume><Issue>4</Issue><PubDate><Year>1998</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Lymphology</Title><ISOAbbreviation>Lymphology</ISOAbbreviation></Journal><ArticleTitle>Changes of tissue fluid hyaluronan (hyaluronic acid) in peripheral lymphedema.</ArticleTitle><Pagination><MedlinePgn>173-9</MedlinePgn></Pagination><Abstract><AbstractText>Hyaluronan (hyaluronic acid or HA) is an important component of the extracellular matrix which is synthesized in the tissue, transported in lymph and catabolized mainly in lymph nodes and the liver. In 39 patients with chronic peripheral lymphedema, the HA content in lymphedematous interstitial fluid was measured using radioimmunoassay. For comparison, the concentration of HA in serum and normal tissue fluid were also determined. These samples were also tested for protein concentration. The results showed that the HA concentration in interstitial fluid of a lymphedema limb was 22 x 10(3) +/- 10(3) (aspiration) and 30 x 10(3) +/- 4 x 10(3) (wick) ng/ml which were significantly higher than that in interstitial fluid, serum and lymph of normal limbs (control) and interstitial fluid of limbs with venous edema (p < 0.001). The protein concentration in these fluids did not show significant differences between lymphedema and those with normal limbs. The findings suggest that HA stagnates in the limb with impaired lymph drainage which may exert a deleterious effect on the interstitium.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>N F</ForeName><Initials>NF</Initials><AffiliationInfo><Affiliation>Department of Plastic Surgery, Chang Zheng Hospital, Second Military Medical University, Shanghai, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>L R</ForeName><Initials>LR</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Lymphology</MedlineTA><NlmUniqueID>0155112</NlmUniqueID><ISSNLinking>0024-7766</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>9004-61-9</RegistryNumber><NameOfSubstance UI="D006820">Hyaluronic Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001132" MajorTopicYN="N">Arm</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004487" MajorTopicYN="N">Edema</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005110" MajorTopicYN="N">Extracellular Space</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006820" MajorTopicYN="N">Hyaluronic Acid</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007866" MajorTopicYN="N">Leg</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008196" MajorTopicYN="N">Lymph</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008408" MajorTopicYN="N">Mastectomy</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011863" MajorTopicYN="N">Radioimmunoassay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020246" MajorTopicYN="N">Venous Thrombosis</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year><Month>2</Month><Day>9</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1999</Year><Month>2</Month><Day>9</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1999</Year><Month>2</Month><Day>9</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9949388</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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