Cloning, expression and genomic structure of a novel human GNB2L1 gene, which encodes a receptor of activated protein kinase C (RACK).
Identifieur interne : 003E15 ( PubMed/Checkpoint ); précédent : 003E14; suivant : 003E16Cloning, expression and genomic structure of a novel human GNB2L1 gene, which encodes a receptor of activated protein kinase C (RACK).
Auteurs : Shu Wang [République populaire de Chine] ; Jin-Zhong Chen ; Zhen Zhang ; Shaohua Gu ; Chaoneng Ji ; Rong Tang ; Kang Ying ; Yi Xie ; Yumin MaoSource :
- Molecular biology reports [ 0301-4851 ] ; 2003.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , biosynthesis : Receptors, Cell Surface.
- chemical , genetics : Receptors, Cell Surface.
- Chromosome Mapping, Chromosomes, Human, Pair 5, Cloning, Molecular, Evolution, Molecular, Humans, Molecular Sequence Data, Phylogeny, Sequence Analysis, DNA.
Abstract
During a large-scale screen of a human fetal brain cDNA library, a novel human gene GNB2L1 encoding a novel RACK (receptor of activated protein kinase C) protein was isolated and sequenced. The cDNA is 1142 bp long and has a predicted open reading frame encoding 316 aa. The predicted protein shows higher similarity to rat RACK1 and many RACK proteins of different organisms including Drosophila, C. elegans, mouse, rat, human, C. fasciculata, zebrafish, A. thaliana, S. cerevisiae and so on, suggesting it is conserved during evolution. The gene was mapped to human chromosome 5q35.3, the telomer position of chromosome 5q, in which the disease gene for early-onset primary congenital lymphedema was mapped. Also, 5q35.3 is a frequently reported location for cytogenetic and molecular abnormalities in renal cell carcinomas. The gene has 8 exons and 7 introns. It is expressed ubiquitously in many human tissues detected by northern blot analysis and RT-PCR.
PubMed: 12688536
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first="Zhen" last="Zhang">Zhen Zhang</name></author><author><name sortKey="Gu, Shaohua" sort="Gu, Shaohua" uniqKey="Gu S" first="Shaohua" last="Gu">Shaohua Gu</name></author><author><name sortKey="Ji, Chaoneng" sort="Ji, Chaoneng" uniqKey="Ji C" first="Chaoneng" last="Ji">Chaoneng Ji</name></author><author><name sortKey="Tang, Rong" sort="Tang, Rong" uniqKey="Tang R" first="Rong" last="Tang">Rong Tang</name></author><author><name sortKey="Ying, Kang" sort="Ying, Kang" uniqKey="Ying K" first="Kang" last="Ying">Kang Ying</name></author><author><name sortKey="Xie, Yi" sort="Xie, Yi" uniqKey="Xie Y" first="Yi" last="Xie">Yi Xie</name></author><author><name sortKey="Mao, Yumin" sort="Mao, Yumin" uniqKey="Mao Y" first="Yumin" last="Mao">Yumin Mao</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12688536</idno><idno type="pmid">12688536</idno><idno type="wicri:Area/PubMed/Corpus">004296</idno><idno 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of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433</wicri:regionArea><wicri:noRegion>Shanghai 200433</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Jin Zhong" sort="Chen, Jin Zhong" uniqKey="Chen J" first="Jin-Zhong" last="Chen">Jin-Zhong Chen</name></author><author><name sortKey="Zhang, Zhen" sort="Zhang, Zhen" uniqKey="Zhang Z" first="Zhen" last="Zhang">Zhen Zhang</name></author><author><name sortKey="Gu, Shaohua" sort="Gu, Shaohua" uniqKey="Gu S" first="Shaohua" last="Gu">Shaohua Gu</name></author><author><name sortKey="Ji, Chaoneng" sort="Ji, Chaoneng" uniqKey="Ji C" first="Chaoneng" last="Ji">Chaoneng Ji</name></author><author><name sortKey="Tang, Rong" sort="Tang, Rong" uniqKey="Tang R" first="Rong" last="Tang">Rong Tang</name></author><author><name sortKey="Ying, Kang" sort="Ying, Kang" uniqKey="Ying K" first="Kang" last="Ying">Kang Ying</name></author><author><name sortKey="Xie, Yi" sort="Xie, Yi" uniqKey="Xie Y" first="Yi" last="Xie">Yi Xie</name></author><author><name sortKey="Mao, Yumin" sort="Mao, Yumin" uniqKey="Mao Y" first="Yumin" last="Mao">Yumin Mao</name></author></analytic><series><title level="j">Molecular biology reports</title><idno type="ISSN">0301-4851</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chromosome Mapping</term><term>Chromosomes, Human, Pair 5</term><term>Cloning, Molecular</term><term>Evolution, Molecular</term><term>Humans</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Receptors, Cell Surface (biosynthesis)</term><term>Receptors, Cell Surface (genetics)</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de séquence d'ADN</term><term>Cartographie chromosomique</term><term>Chromosomes humains de la paire 5</term><term>Clonage moléculaire</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Phylogénie</term><term>Récepteurs de surface cellulaire (biosynthèse)</term><term>Récepteurs de surface cellulaire (génétique)</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Receptors, Cell Surface</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptors, Cell Surface</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Récepteurs de surface cellulaire</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Récepteurs de surface cellulaire</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Chromosome Mapping</term><term>Chromosomes, Human, Pair 5</term><term>Cloning, Molecular</term><term>Evolution, Molecular</term><term>Humans</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de séquence d'ADN</term><term>Cartographie chromosomique</term><term>Chromosomes humains de la paire 5</term><term>Clonage moléculaire</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Phylogénie</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During a large-scale screen of a human fetal brain cDNA library, a novel human gene GNB2L1 encoding a novel RACK (receptor of activated protein kinase C) protein was isolated and sequenced. The cDNA is 1142 bp long and has a predicted open reading frame encoding 316 aa. The predicted protein shows higher similarity to rat RACK1 and many RACK proteins of different organisms including Drosophila, C. elegans, mouse, rat, human, C. fasciculata, zebrafish, A. thaliana, S. cerevisiae and so on, suggesting it is conserved during evolution. The gene was mapped to human chromosome 5q35.3, the telomer position of chromosome 5q, in which the disease gene for early-onset primary congenital lymphedema was mapped. Also, 5q35.3 is a frequently reported location for cytogenetic and molecular abnormalities in renal cell carcinomas. The gene has 8 exons and 7 introns. It is expressed ubiquitously in many human tissues detected by northern blot analysis and RT-PCR.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12688536</PMID><DateCreated><Year>2003</Year><Month>04</Month><Day>11</Day></DateCreated><DateCompleted><Year>2003</Year><Month>11</Month><Day>04</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0301-4851</ISSN><JournalIssue CitedMedium="Print"><Volume>30</Volume><Issue>1</Issue><PubDate><Year>2003</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Molecular biology reports</Title><ISOAbbreviation>Mol. Biol. 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Also, 5q35.3 is a frequently reported location for cytogenetic and molecular abnormalities in renal cell carcinomas. The gene has 8 exons and 7 introns. 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ValidYN="Y"><LastName>Ying</LastName><ForeName>Kang</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Xie</LastName><ForeName>Yi</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Mao</LastName><ForeName>Yumin</ForeName><Initials>Y</Initials></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>GENBANK</DataBankName><AccessionNumberList><AccessionNumber>AY028802</AccessionNumber><AccessionNumber>BC021993</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Mol Biol 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PubStatus="entrez"><Year>2003</Year><Month>4</Month><Day>12</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12688536</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Chen, Jin Zhong" sort="Chen, Jin Zhong" uniqKey="Chen J" first="Jin-Zhong" last="Chen">Jin-Zhong Chen</name><name sortKey="Gu, Shaohua" sort="Gu, Shaohua" uniqKey="Gu S" first="Shaohua" last="Gu">Shaohua Gu</name><name sortKey="Ji, Chaoneng" sort="Ji, Chaoneng" uniqKey="Ji C" first="Chaoneng" last="Ji">Chaoneng Ji</name><name sortKey="Mao, Yumin" sort="Mao, Yumin" uniqKey="Mao Y" first="Yumin" last="Mao">Yumin Mao</name><name sortKey="Tang, Rong" sort="Tang, Rong" uniqKey="Tang R" first="Rong" last="Tang">Rong Tang</name><name sortKey="Xie, Yi" sort="Xie, Yi" uniqKey="Xie Y" first="Yi" last="Xie">Yi Xie</name><name sortKey="Ying, Kang" sort="Ying, Kang" uniqKey="Ying K" first="Kang" last="Ying">Kang Ying</name><name sortKey="Zhang, Zhen" sort="Zhang, Zhen" uniqKey="Zhang Z" first="Zhen" last="Zhang">Zhen Zhang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Shu" sort="Wang, Shu" uniqKey="Wang S" first="Shu" last="Wang">Shu Wang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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