Tumor cell expression of podoplanin correlates with nodal metastasis in esophageal squamous cell carcinoma.
Identifieur interne : 002A41 ( PubMed/Checkpoint ); précédent : 002A40; suivant : 002A42Tumor cell expression of podoplanin correlates with nodal metastasis in esophageal squamous cell carcinoma.
Auteurs : Wen-Yu Chuang [Taïwan] ; Chi-Ju Yeh ; Yi-Chin Wu ; Yin-Kai Chao ; Yun-Hen Liu ; Chen-Kan Tseng ; Hsien-Kun Chang ; Hui-Ping Liu ; Chuen HsuehSource :
- Histology and histopathology [ 1699-5848 ] ; 2009.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Analyse de survie, Carcinome épidermoïde (anatomopathologie), Carcinome épidermoïde (métabolisme), Facteurs temps, Femelle, Glycoprotéines membranaires (métabolisme), Humains, Immunohistochimie, Marqueurs biologiques tumoraux (métabolisme), Mâle, Métastase lymphatique (anatomopathologie), Sujet âgé, Tumeurs de l'oesophage (anatomopathologie), Tumeurs de l'oesophage (métabolisme), Vaisseaux lymphatiques (anatomopathologie), Études de suivi.
- MESH :
- anatomopathologie : Carcinome épidermoïde, Métastase lymphatique, Tumeurs de l'oesophage, Vaisseaux lymphatiques.
- métabolisme : Carcinome épidermoïde, Glycoprotéines membranaires, Marqueurs biologiques tumoraux, Tumeurs de l'oesophage.
- Adulte d'âge moyen, Analyse de survie, Facteurs temps, Femelle, Humains, Immunohistochimie, Mâle, Sujet âgé, Études de suivi.
English descriptors
- KwdEn :
- Aged, Biomarkers, Tumor (metabolism), Carcinoma, Squamous Cell (metabolism), Carcinoma, Squamous Cell (pathology), Esophageal Neoplasms (metabolism), Esophageal Neoplasms (pathology), Female, Follow-Up Studies, Humans, Immunohistochemistry, Lymphatic Metastasis (pathology), Lymphatic Vessels (pathology), Male, Membrane Glycoproteins (metabolism), Middle Aged, Survival Analysis, Time Factors.
- MESH :
- chemical , metabolism : Biomarkers, Tumor, Membrane Glycoproteins.
- metabolism : Carcinoma, Squamous Cell, Esophageal Neoplasms.
- pathology : Carcinoma, Squamous Cell, Esophageal Neoplasms, Lymphatic Metastasis, Lymphatic Vessels.
- Aged, Female, Follow-Up Studies, Humans, Immunohistochemistry, Male, Middle Aged, Survival Analysis, Time Factors.
Abstract
Podoplanin is a mucin-like glycoprotein expressed in the lymphatic endothelium. It has been suggested to play a role in lymphangiogenesis, since podoplanin deficient mice were found to have dilated malfunctioning lymphatic vessels and lymphedema. High podoplanin expression in tumor cells was found to correlate with lymph node metastasis and poor clinical outcome in patients with oral squamous cell carcinoma (SCC). However, the prognostic significance of podoplanin expression in esophageal SCC remains unexplored. Herein, we studied podoplanin expression in 59 patients who underwent surgical resection of esophageal SCC, with 43 of them preceded by preoperative concurrent chemoradiotherapy (CCRT). We found that high podoplanin expression strongly correlated with clinical nodal metastasis (cN1; p=0.0063), which was associated with short survival (p=0.012). However, there was no direct association between high podoplanin expression and short survival. We also found that lymphatic vessel invasion in the resected esophagus was strongly associated with pathological nodal metastasis (pN1; p=0.00092). Our results suggest that podoplanin could also play a role in tumor aggressiveness in esophageal SCC, as well as in oral SCC.
DOI: 10.14670/HH-24.1021
PubMed: 19554509
Affiliations:
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Links to Exploration step
pubmed:19554509Le document en format XML
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<front><div type="abstract" xml:lang="en">Podoplanin is a mucin-like glycoprotein expressed in the lymphatic endothelium. It has been suggested to play a role in lymphangiogenesis, since podoplanin deficient mice were found to have dilated malfunctioning lymphatic vessels and lymphedema. High podoplanin expression in tumor cells was found to correlate with lymph node metastasis and poor clinical outcome in patients with oral squamous cell carcinoma (SCC). However, the prognostic significance of podoplanin expression in esophageal SCC remains unexplored. Herein, we studied podoplanin expression in 59 patients who underwent surgical resection of esophageal SCC, with 43 of them preceded by preoperative concurrent chemoradiotherapy (CCRT). We found that high podoplanin expression strongly correlated with clinical nodal metastasis (cN1; p=0.0063), which was associated with short survival (p=0.012). However, there was no direct association between high podoplanin expression and short survival. We also found that lymphatic vessel invasion in the resected esophagus was strongly associated with pathological nodal metastasis (pN1; p=0.00092). Our results suggest that podoplanin could also play a role in tumor aggressiveness in esophageal SCC, as well as in oral SCC.</div>
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