Tumor cell expression of podoplanin correlates with nodal metastasis in esophageal squamous cell carcinoma.
Identifieur interne : 002E20 ( PubMed/Corpus ); précédent : 002E19; suivant : 002E21Tumor cell expression of podoplanin correlates with nodal metastasis in esophageal squamous cell carcinoma.
Auteurs : Wen-Yu Chuang ; Chi-Ju Yeh ; Yi-Chin Wu ; Yin-Kai Chao ; Yun-Hen Liu ; Chen-Kan Tseng ; Hsien-Kun Chang ; Hui-Ping Liu ; Chuen HsuehSource :
- Histology and histopathology [ 1699-5848 ] ; 2009.
English descriptors
- KwdEn :
- Aged, Biomarkers, Tumor (metabolism), Carcinoma, Squamous Cell (metabolism), Carcinoma, Squamous Cell (pathology), Esophageal Neoplasms (metabolism), Esophageal Neoplasms (pathology), Female, Follow-Up Studies, Humans, Immunohistochemistry, Lymphatic Metastasis (pathology), Lymphatic Vessels (pathology), Male, Membrane Glycoproteins (metabolism), Middle Aged, Survival Analysis, Time Factors.
- MESH :
- chemical , metabolism : Biomarkers, Tumor, Membrane Glycoproteins.
- metabolism : Carcinoma, Squamous Cell, Esophageal Neoplasms.
- pathology : Carcinoma, Squamous Cell, Esophageal Neoplasms, Lymphatic Metastasis, Lymphatic Vessels.
- Aged, Female, Follow-Up Studies, Humans, Immunohistochemistry, Male, Middle Aged, Survival Analysis, Time Factors.
Abstract
Podoplanin is a mucin-like glycoprotein expressed in the lymphatic endothelium. It has been suggested to play a role in lymphangiogenesis, since podoplanin deficient mice were found to have dilated malfunctioning lymphatic vessels and lymphedema. High podoplanin expression in tumor cells was found to correlate with lymph node metastasis and poor clinical outcome in patients with oral squamous cell carcinoma (SCC). However, the prognostic significance of podoplanin expression in esophageal SCC remains unexplored. Herein, we studied podoplanin expression in 59 patients who underwent surgical resection of esophageal SCC, with 43 of them preceded by preoperative concurrent chemoradiotherapy (CCRT). We found that high podoplanin expression strongly correlated with clinical nodal metastasis (cN1; p=0.0063), which was associated with short survival (p=0.012). However, there was no direct association between high podoplanin expression and short survival. We also found that lymphatic vessel invasion in the resected esophagus was strongly associated with pathological nodal metastasis (pN1; p=0.00092). Our results suggest that podoplanin could also play a role in tumor aggressiveness in esophageal SCC, as well as in oral SCC.
DOI: 10.14670/HH-24.1021
PubMed: 19554509
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Liu</name></author><author><name sortKey="Tseng, Chen Kan" sort="Tseng, Chen Kan" uniqKey="Tseng C" first="Chen-Kan" last="Tseng">Chen-Kan Tseng</name></author><author><name sortKey="Chang, Hsien Kun" sort="Chang, Hsien Kun" uniqKey="Chang H" first="Hsien-Kun" last="Chang">Hsien-Kun Chang</name></author><author><name sortKey="Liu, Hui Ping" sort="Liu, Hui Ping" uniqKey="Liu H" first="Hui-Ping" last="Liu">Hui-Ping Liu</name></author><author><name sortKey="Hsueh, Chuen" sort="Hsueh, Chuen" uniqKey="Hsueh C" first="Chuen" last="Hsueh">Chuen Hsueh</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19554509</idno><idno type="pmid">19554509</idno><idno type="doi">10.14670/HH-24.1021</idno><idno type="wicri:Area/PubMed/Corpus">002E20</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002E20</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Tumor cell expression of podoplanin correlates with nodal metastasis in esophageal squamous cell carcinoma.</title><author><name sortKey="Chuang, Wen Yu" sort="Chuang, Wen Yu" uniqKey="Chuang W" first="Wen-Yu" last="Chuang">Wen-Yu Chuang</name><affiliation><nlm:affiliation>Department of Pathology, Chang Gung Memorial Hospital, Linko, Chang Gung University College of Medicine, Taoyuan, Taiwan.</nlm:affiliation></affiliation></author><author><name sortKey="Yeh, Chi Ju" sort="Yeh, Chi Ju" uniqKey="Yeh C" first="Chi-Ju" last="Yeh">Chi-Ju Yeh</name></author><author><name sortKey="Wu, Yi Chin" sort="Wu, Yi Chin" uniqKey="Wu Y" first="Yi-Chin" last="Wu">Yi-Chin Wu</name></author><author><name sortKey="Chao, Yin Kai" sort="Chao, Yin Kai" uniqKey="Chao Y" first="Yin-Kai" last="Chao">Yin-Kai Chao</name></author><author><name sortKey="Liu, Yun Hen" sort="Liu, Yun Hen" uniqKey="Liu Y" first="Yun-Hen" last="Liu">Yun-Hen Liu</name></author><author><name sortKey="Tseng, Chen Kan" sort="Tseng, Chen Kan" uniqKey="Tseng C" first="Chen-Kan" last="Tseng">Chen-Kan Tseng</name></author><author><name sortKey="Chang, Hsien Kun" sort="Chang, Hsien Kun" uniqKey="Chang H" first="Hsien-Kun" last="Chang">Hsien-Kun Chang</name></author><author><name sortKey="Liu, Hui Ping" sort="Liu, Hui Ping" uniqKey="Liu H" first="Hui-Ping" last="Liu">Hui-Ping Liu</name></author><author><name sortKey="Hsueh, Chuen" sort="Hsueh, Chuen" uniqKey="Hsueh C" first="Chuen" last="Hsueh">Chuen Hsueh</name></author></analytic><series><title level="j">Histology and histopathology</title><idno type="eISSN">1699-5848</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Biomarkers, Tumor (metabolism)</term><term>Carcinoma, Squamous Cell (metabolism)</term><term>Carcinoma, Squamous Cell (pathology)</term><term>Esophageal Neoplasms (metabolism)</term><term>Esophageal Neoplasms (pathology)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Immunohistochemistry</term><term>Lymphatic Metastasis (pathology)</term><term>Lymphatic Vessels (pathology)</term><term>Male</term><term>Membrane Glycoproteins (metabolism)</term><term>Middle Aged</term><term>Survival Analysis</term><term>Time Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers, Tumor</term><term>Membrane Glycoproteins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Esophageal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Esophageal Neoplasms</term><term>Lymphatic Metastasis</term><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Middle Aged</term><term>Survival Analysis</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Podoplanin is a mucin-like glycoprotein expressed in the lymphatic endothelium. It has been suggested to play a role in lymphangiogenesis, since podoplanin deficient mice were found to have dilated malfunctioning lymphatic vessels and lymphedema. High podoplanin expression in tumor cells was found to correlate with lymph node metastasis and poor clinical outcome in patients with oral squamous cell carcinoma (SCC). However, the prognostic significance of podoplanin expression in esophageal SCC remains unexplored. Herein, we studied podoplanin expression in 59 patients who underwent surgical resection of esophageal SCC, with 43 of them preceded by preoperative concurrent chemoradiotherapy (CCRT). We found that high podoplanin expression strongly correlated with clinical nodal metastasis (cN1; p=0.0063), which was associated with short survival (p=0.012). However, there was no direct association between high podoplanin expression and short survival. We also found that lymphatic vessel invasion in the resected esophagus was strongly associated with pathological nodal metastasis (pN1; p=0.00092). Our results suggest that podoplanin could also play a role in tumor aggressiveness in esophageal SCC, as well as in oral SCC.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19554509</PMID><DateCreated><Year>2009</Year><Month>06</Month><Day>25</Day></DateCreated><DateCompleted><Year>2009</Year><Month>08</Month><Day>25</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1699-5848</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>8</Issue><PubDate><Year>2009</Year><Month>08</Month></PubDate></JournalIssue><Title>Histology and histopathology</Title><ISOAbbreviation>Histol. Histopathol.</ISOAbbreviation></Journal><ArticleTitle>Tumor cell expression of podoplanin correlates with nodal metastasis in esophageal squamous cell carcinoma.</ArticleTitle><Pagination><MedlinePgn>1021-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.14670/HH-24.1021</ELocationID><Abstract><AbstractText>Podoplanin is a mucin-like glycoprotein expressed in the lymphatic endothelium. It has been suggested to play a role in lymphangiogenesis, since podoplanin deficient mice were found to have dilated malfunctioning lymphatic vessels and lymphedema. High podoplanin expression in tumor cells was found to correlate with lymph node metastasis and poor clinical outcome in patients with oral squamous cell carcinoma (SCC). However, the prognostic significance of podoplanin expression in esophageal SCC remains unexplored. Herein, we studied podoplanin expression in 59 patients who underwent surgical resection of esophageal SCC, with 43 of them preceded by preoperative concurrent chemoradiotherapy (CCRT). We found that high podoplanin expression strongly correlated with clinical nodal metastasis (cN1; p=0.0063), which was associated with short survival (p=0.012). However, there was no direct association between high podoplanin expression and short survival. We also found that lymphatic vessel invasion in the resected esophagus was strongly associated with pathological nodal metastasis (pN1; p=0.00092). Our results suggest that podoplanin could also play a role in tumor aggressiveness in esophageal SCC, as well as in oral SCC.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chuang</LastName><ForeName>Wen-Yu</ForeName><Initials>WY</Initials><AffiliationInfo><Affiliation>Department of Pathology, Chang Gung Memorial Hospital, Linko, Chang Gung University College of Medicine, Taoyuan, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yeh</LastName><ForeName>Chi-Ju</ForeName><Initials>CJ</Initials></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Yi-Chin</ForeName><Initials>YC</Initials></Author><Author ValidYN="Y"><LastName>Chao</LastName><ForeName>Yin-Kai</ForeName><Initials>YK</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Yun-Hen</ForeName><Initials>YH</Initials></Author><Author ValidYN="Y"><LastName>Tseng</LastName><ForeName>Chen-Kan</ForeName><Initials>CK</Initials></Author><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Hsien-Kun</ForeName><Initials>HK</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Hui-Ping</ForeName><Initials>HP</Initials></Author><Author ValidYN="Y"><LastName>Hsueh</LastName><ForeName>Chuen</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Spain</Country><MedlineTA>Histol Histopathol</MedlineTA><NlmUniqueID>8609357</NlmUniqueID><ISSNLinking>0213-3911</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014408">Biomarkers, Tumor</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008562">Membrane Glycoproteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C117468">PDPN protein, human</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014408" MajorTopicYN="N">Biomarkers, Tumor</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002294" MajorTopicYN="N">Carcinoma, Squamous Cell</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004938" MajorTopicYN="N">Esophageal Neoplasms</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" 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