Radiotherapy for node positive penile cancer: experience of the Leeds teaching hospitals.
Identifieur interne : 002322 ( PubMed/Checkpoint ); précédent : 002321; suivant : 002323Radiotherapy for node positive penile cancer: experience of the Leeds teaching hospitals.
Auteurs : Kevin N. Franks [Royaume-Uni] ; Kiran Kancherla ; Brinda Sethugavalar ; Peter Whelan ; Ian Eardley ; Anne E. KiltieSource :
- The Journal of urology [ 1527-3792 ] ; 2011.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Angleterre, Carcinome épidermoïde (), Carcinome épidermoïde (anatomopathologie), Carcinome épidermoïde (radiothérapie), Humains, Hôpitaux d'enseignement, Lymphadénectomie, Mâle, Métastase lymphatique, Radiothérapie adjuvante, Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute, Tumeurs du pénis (), Tumeurs du pénis (anatomopathologie), Tumeurs du pénis (radiothérapie), Études rétrospectives.
- MESH :
- anatomopathologie : Carcinome épidermoïde, Tumeurs du pénis.
- radiothérapie : Carcinome épidermoïde, Tumeurs du pénis.
- Adulte, Adulte d'âge moyen, Angleterre, Carcinome épidermoïde, Humains, Hôpitaux d'enseignement, Lymphadénectomie, Mâle, Métastase lymphatique, Radiothérapie adjuvante, Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute, Tumeurs du pénis, Études rétrospectives.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell (pathology), Carcinoma, Squamous Cell (radiotherapy), Carcinoma, Squamous Cell (surgery), Disease-Free Survival, England, Hospitals, Teaching, Humans, Lymph Node Excision, Lymphatic Metastasis, Male, Middle Aged, Penile Neoplasms (pathology), Penile Neoplasms (radiotherapy), Penile Neoplasms (surgery), Radiotherapy, Adjuvant, Retrospective Studies.
- MESH :
- geographic : England.
- pathology : Carcinoma, Squamous Cell, Penile Neoplasms.
- radiotherapy : Carcinoma, Squamous Cell, Penile Neoplasms.
- surgery : Carcinoma, Squamous Cell, Penile Neoplasms.
- Adult, Aged, Aged, 80 and over, Disease-Free Survival, Hospitals, Teaching, Humans, Lymph Node Excision, Lymphatic Metastasis, Male, Middle Aged, Radiotherapy, Adjuvant, Retrospective Studies.
Abstract
We studied the outcomes in patients with node positive penile cancer who received radiotherapy to inguinal and pelvic nodes. Although half of node positive cases are cured by lymphadenectomy, little data are available on the potential further benefits and toxicities of postoperative radiotherapy.
DOI: 10.1016/j.juro.2011.03.117
PubMed: 21700296
Affiliations:
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Franks</name><affiliation wicri:level="3"><nlm:affiliation>St. James's Institute of Oncology, Department of Urology, St. James's University Hospital, Leeds, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>St. James's Institute of Oncology, Department of Urology, St. James's University Hospital, Leeds, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Kancherla, Kiran" sort="Kancherla, Kiran" uniqKey="Kancherla K" first="Kiran" last="Kancherla">Kiran Kancherla</name></author><author><name sortKey="Sethugavalar, Brinda" sort="Sethugavalar, Brinda" uniqKey="Sethugavalar B" first="Brinda" last="Sethugavalar">Brinda Sethugavalar</name></author><author><name sortKey="Whelan, Peter" sort="Whelan, Peter" uniqKey="Whelan P" first="Peter" last="Whelan">Peter Whelan</name></author><author><name sortKey="Eardley, Ian" sort="Eardley, Ian" uniqKey="Eardley I" first="Ian" last="Eardley">Ian Eardley</name></author><author><name sortKey="Kiltie, Anne E" sort="Kiltie, Anne E" uniqKey="Kiltie A" first="Anne E" last="Kiltie">Anne E. 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Franks</name><affiliation wicri:level="3"><nlm:affiliation>St. James's Institute of Oncology, Department of Urology, St. James's University Hospital, Leeds, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>St. James's Institute of Oncology, Department of Urology, St. James's University Hospital, Leeds, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Kancherla, Kiran" sort="Kancherla, Kiran" uniqKey="Kancherla K" first="Kiran" last="Kancherla">Kiran Kancherla</name></author><author><name sortKey="Sethugavalar, Brinda" sort="Sethugavalar, Brinda" uniqKey="Sethugavalar B" first="Brinda" last="Sethugavalar">Brinda Sethugavalar</name></author><author><name sortKey="Whelan, Peter" sort="Whelan, Peter" uniqKey="Whelan P" first="Peter" last="Whelan">Peter Whelan</name></author><author><name sortKey="Eardley, Ian" sort="Eardley, Ian" uniqKey="Eardley I" first="Ian" last="Eardley">Ian Eardley</name></author><author><name sortKey="Kiltie, Anne E" sort="Kiltie, Anne E" uniqKey="Kiltie A" first="Anne E" last="Kiltie">Anne E. Kiltie</name></author></analytic><series><title level="j">The Journal of urology</title><idno type="eISSN">1527-3792</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Carcinoma, Squamous Cell (pathology)</term><term>Carcinoma, Squamous Cell (radiotherapy)</term><term>Carcinoma, Squamous Cell (surgery)</term><term>Disease-Free Survival</term><term>England</term><term>Hospitals, Teaching</term><term>Humans</term><term>Lymph Node Excision</term><term>Lymphatic Metastasis</term><term>Male</term><term>Middle Aged</term><term>Penile Neoplasms (pathology)</term><term>Penile Neoplasms (radiotherapy)</term><term>Penile Neoplasms (surgery)</term><term>Radiotherapy, Adjuvant</term><term>Retrospective Studies</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Angleterre</term><term>Carcinome épidermoïde ()</term><term>Carcinome épidermoïde (anatomopathologie)</term><term>Carcinome épidermoïde (radiothérapie)</term><term>Humains</term><term>Hôpitaux d'enseignement</term><term>Lymphadénectomie</term><term>Mâle</term><term>Métastase lymphatique</term><term>Radiothérapie adjuvante</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Survie sans rechute</term><term>Tumeurs du pénis ()</term><term>Tumeurs du pénis (anatomopathologie)</term><term>Tumeurs du pénis (radiothérapie)</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>England</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome épidermoïde</term><term>Tumeurs du pénis</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Penile Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Penile Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Carcinome épidermoïde</term><term>Tumeurs du pénis</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Penile Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Disease-Free Survival</term><term>Hospitals, Teaching</term><term>Humans</term><term>Lymph Node Excision</term><term>Lymphatic Metastasis</term><term>Male</term><term>Middle Aged</term><term>Radiotherapy, Adjuvant</term><term>Retrospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Angleterre</term><term>Carcinome épidermoïde</term><term>Humains</term><term>Hôpitaux d'enseignement</term><term>Lymphadénectomie</term><term>Mâle</term><term>Métastase lymphatique</term><term>Radiothérapie adjuvante</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Survie sans rechute</term><term>Tumeurs du pénis</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied the outcomes in patients with node positive penile cancer who received radiotherapy to inguinal and pelvic nodes. Although half of node positive cases are cured by lymphadenectomy, little data are available on the potential further benefits and toxicities of postoperative radiotherapy.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21700296</PMID><DateCreated><Year>2011</Year><Month>07</Month><Day>11</Day></DateCreated><DateCompleted><Year>2011</Year><Month>09</Month><Day>15</Day></DateCompleted><DateRevised><Year>2015</Year><Month>07</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1527-3792</ISSN><JournalIssue CitedMedium="Internet"><Volume>186</Volume><Issue>2</Issue><PubDate><Year>2011</Year><Month>Aug</Month></PubDate></JournalIssue><Title>The Journal of urology</Title><ISOAbbreviation>J. Urol.</ISOAbbreviation></Journal><ArticleTitle>Radiotherapy for node positive penile cancer: experience of the Leeds teaching hospitals.</ArticleTitle><Pagination><MedlinePgn>524-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.juro.2011.03.117</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">We studied the outcomes in patients with node positive penile cancer who received radiotherapy to inguinal and pelvic nodes. Although half of node positive cases are cured by lymphadenectomy, little data are available on the potential further benefits and toxicities of postoperative radiotherapy.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">We retrospectively audited the clinical notes and electronic records of 23 patients referred to a specialist center from 2002 to 2008 who received radiotherapy to the inguinal/pelvic nodes as adjuvant treatment after lymphadenectomy (14), or as high grade palliation for extensive/fixed nodes (8) or extensive local tumor (1). The primary outcome measure was overall survival. Secondary end points were locoregional recurrence-free survival and toxicity.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">All 13 deaths were due to penile cancer. Patients with adjuvant therapy had better overall survival (66% vs 11%, p<0.001) and locoregional relapse-free survival (56% vs 22%, p=0.03) than those with high grade palliation. Six of 14 adjuvant cases and 7 of 9 with high grade palliation relapsed locoregionally. Of patients with adjuvant therapy and extracapsular spread 1 of 6 with N1, 1 of 4 with N2 and 3 of 4 with N3 disease relapsed (p=0.31). No life threatening toxicity was observed. It was difficult to determine the relative contributions of radiotherapy and surgery to leg/scrotal lymphedema. The study was limited by its small size, which reflects the rarity of this tumor.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Adjuvant radiotherapy appears to have a role after inguinal lymphadenectomy, particularly in patients with extracapsular nodal spread, in whom historically survival rates have been poor. Our findings warrant further investigation in larger series of patients.</AbstractText><CopyrightInformation>Copyright © 2011 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Franks</LastName><ForeName>Kevin N</ForeName><Initials>KN</Initials><AffiliationInfo><Affiliation>St. James's Institute of Oncology, Department of Urology, St. James's University Hospital, Leeds, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kancherla</LastName><ForeName>Kiran</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Sethugavalar</LastName><ForeName>Brinda</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Whelan</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Eardley</LastName><ForeName>Ian</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Kiltie</LastName><ForeName>Anne E</ForeName><Initials>AE</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>C5255/A12678</GrantID><Agency>Cancer Research UK</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>06</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Urol</MedlineTA><NlmUniqueID>0376374</NlmUniqueID><ISSNLinking>0022-5347</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>J Urol. 2011 Aug;186(2):529</RefSource><PMID Version="1">21700297</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002294" MajorTopicYN="N">Carcinoma, Squamous Cell</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000532" MajorTopicYN="Y">radiotherapy</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018572" MajorTopicYN="N">Disease-Free Survival</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004739" MajorTopicYN="N" Type="Geographic">England</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006784" MajorTopicYN="N">Hospitals, Teaching</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008197" MajorTopicYN="N">Lymph Node Excision</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008207" MajorTopicYN="N">Lymphatic Metastasis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010412" MajorTopicYN="N">Penile Neoplasms</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000532" MajorTopicYN="Y">radiotherapy</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018714" MajorTopicYN="N">Radiotherapy, Adjuvant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year><Month>11</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>6</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>6</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>9</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21700296</ArticleId><ArticleId IdType="pii">S0022-5347(11)03521-X</ArticleId><ArticleId IdType="doi">10.1016/j.juro.2011.03.117</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Oxfordshire</li></region><settlement><li>Oxford</li></settlement></list><tree><noCountry><name sortKey="Eardley, Ian" sort="Eardley, Ian" uniqKey="Eardley I" first="Ian" last="Eardley">Ian Eardley</name><name sortKey="Kancherla, Kiran" sort="Kancherla, Kiran" uniqKey="Kancherla K" first="Kiran" last="Kancherla">Kiran Kancherla</name><name sortKey="Kiltie, Anne E" sort="Kiltie, Anne E" uniqKey="Kiltie A" first="Anne E" last="Kiltie">Anne E. Kiltie</name><name sortKey="Sethugavalar, Brinda" sort="Sethugavalar, Brinda" uniqKey="Sethugavalar B" first="Brinda" last="Sethugavalar">Brinda Sethugavalar</name><name sortKey="Whelan, Peter" sort="Whelan, Peter" uniqKey="Whelan P" first="Peter" last="Whelan">Peter Whelan</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Franks, Kevin N" sort="Franks, Kevin N" uniqKey="Franks K" first="Kevin N" last="Franks">Kevin N. Franks</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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