Growth factor therapy and lymph node graft for lymphedema.
Identifieur interne : 000E99 ( PubMed/Checkpoint ); précédent : 000E98; suivant : 000F00Growth factor therapy and lymph node graft for lymphedema.
Auteurs : Tomi V. Tervala [Finlande] ; Pauliina Hartiala [Finlande] ; Tuomas Tammela [Finlande] ; Mikko T. Visuri [Finlande] ; Seppo Yl Herttuala [Finlande] ; Kari Alitalo [Finlande] ; Anne M. Saarikko [Finlande]Source :
- The Journal of surgical research [ 1095-8673 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Facteur de croissance endothéliale vasculaire de type A (usage thérapeutique), Lymphangiogenèse, Lymphoedème (), Lymphoedème (physiopathologie), Lymphographie, Noeuds lymphatiques (transplantation), Récepteur-2 au facteur croissance endothéliale vasculaire (physiologie), Récepteur-3 au facteur croissance endothéliale vasculaire (physiologie), Souris.
- MESH :
- physiologie : Récepteur-2 au facteur croissance endothéliale vasculaire, Récepteur-3 au facteur croissance endothéliale vasculaire.
- physiopathologie : Lymphoedème.
- usage thérapeutique : Facteur de croissance endothéliale vasculaire de type A, Noeuds lymphatiques.
- Animaux, Lymphangiogenèse, Lymphoedème, Lymphographie, Souris.
English descriptors
- KwdEn :
- Animals, Lymph Nodes (transplantation), Lymphangiogenesis, Lymphedema (physiopathology), Lymphedema (therapy), Lymphography, Mice, Vascular Endothelial Growth Factor A (therapeutic use), Vascular Endothelial Growth Factor Receptor-2 (physiology), Vascular Endothelial Growth Factor Receptor-3 (physiology).
- MESH :
- chemical , physiology : Vascular Endothelial Growth Factor Receptor-2, Vascular Endothelial Growth Factor Receptor-3.
- chemical , therapeutic use : Vascular Endothelial Growth Factor A.
- physiopathology : Lymphedema.
- therapy : Lymphedema.
- transplantation : Lymph Nodes.
- Animals, Lymphangiogenesis, Lymphography, Mice.
Abstract
Lymphedema still remains an unsolved problem. Secondary lymphedema often develops after cancer operations or radiation therapy, especially in breast cancer patients. Using a mouse model, we show here that the lymphatic network can be regenerated using lymphatic vascular growth factor therapy in combination with lymph node transfer.
DOI: 10.1016/j.jss.2015.02.031
PubMed: 25777822
Affiliations:
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Tervala</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plastic Surgery, Kuopio University Hospital, Kuopio, Finland. Electronic address: tomi.tervala@kuh.fi.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Plastic Surgery, Kuopio University Hospital, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Hartiala, Pauliina" sort="Hartiala, Pauliina" uniqKey="Hartiala P" first="Pauliina" last="Hartiala">Pauliina Hartiala</name><affiliation wicri:level="3"><nlm:affiliation>Department of Plastic and General Surgery, Turku University Hospital, Turku, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Plastic and General Surgery, Turku University Hospital, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Tammela, Tuomas" sort="Tammela, Tuomas" uniqKey="Tammela T" first="Tuomas" last="Tammela">Tuomas Tammela</name><affiliation wicri:level="4"><nlm:affiliation>Wihuri Research Institute and Translational Cancer Biology Program, University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Wihuri Research Institute and Translational Cancer Biology Program, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Visuri, Mikko T" sort="Visuri, Mikko T" uniqKey="Visuri M" first="Mikko T" last="Visuri">Mikko T. 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Saarikko</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plastic and General Surgery, Turku University Hospital, Turku, Finland; Department of Plastic Surgery, Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Plastic and General Surgery, Turku University Hospital, Turku, Finland; Department of Plastic Surgery, Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Journal of surgical research</title><idno type="eISSN">1095-8673</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Lymph Nodes (transplantation)</term><term>Lymphangiogenesis</term><term>Lymphedema (physiopathology)</term><term>Lymphedema (therapy)</term><term>Lymphography</term><term>Mice</term><term>Vascular Endothelial Growth Factor A (therapeutic use)</term><term>Vascular Endothelial Growth Factor Receptor-2 (physiology)</term><term>Vascular Endothelial Growth Factor Receptor-3 (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Facteur de croissance endothéliale vasculaire de type A (usage thérapeutique)</term><term>Lymphangiogenèse</term><term>Lymphoedème ()</term><term>Lymphoedème (physiopathologie)</term><term>Lymphographie</term><term>Noeuds lymphatiques (transplantation)</term><term>Récepteur-2 au facteur croissance endothéliale vasculaire (physiologie)</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire (physiologie)</term><term>Souris</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Vascular Endothelial Growth Factor Receptor-2</term><term>Vascular Endothelial Growth Factor Receptor-3</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Vascular Endothelial Growth Factor A</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Récepteur-2 au facteur croissance endothéliale vasculaire</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Lymph Nodes</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type A</term><term>Noeuds lymphatiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Lymphangiogenesis</term><term>Lymphography</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Lymphangiogenèse</term><term>Lymphoedème</term><term>Lymphographie</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphedema still remains an unsolved problem. Secondary lymphedema often develops after cancer operations or radiation therapy, especially in breast cancer patients. Using a mouse model, we show here that the lymphatic network can be regenerated using lymphatic vascular growth factor therapy in combination with lymph node transfer.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25777822</PMID><DateCreated><Year>2015</Year><Month>05</Month><Day>13</Day></DateCreated><DateCompleted><Year>2015</Year><Month>08</Month><Day>12</Day></DateCompleted><DateRevised><Year>2015</Year><Month>05</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1095-8673</ISSN><JournalIssue CitedMedium="Internet"><Volume>196</Volume><Issue>1</Issue><PubDate><Year>2015</Year><Month>Jun</Month><Day>01</Day></PubDate></JournalIssue><Title>The Journal of surgical research</Title><ISOAbbreviation>J. Surg. Res.</ISOAbbreviation></Journal><ArticleTitle>Growth factor therapy and lymph node graft for lymphedema.</ArticleTitle><Pagination><MedlinePgn>200-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jss.2015.02.031</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0022-4804(15)00139-0</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Lymphedema still remains an unsolved problem. Secondary lymphedema often develops after cancer operations or radiation therapy, especially in breast cancer patients. Using a mouse model, we show here that the lymphatic network can be regenerated using lymphatic vascular growth factor therapy in combination with lymph node transfer.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">We have compared the therapeutic effects of different vascular endothelial growth factors (VEGF-C, VEGF-D, VEGF-C156S, and VEGF-A), in combination with lymph node transfer in mouse axilla. The lymphangiogenic effects of the growth factor therapy were examined at 3 mo postoperatively.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">VEGF therapy with VEGF-C and VEGF-D induced growth of new lymphatic vessels in the defect area, and VEGF-C also improved lymphatic vessel function compared with that of controls. VEGF-C156S induced moderate lymphangiogenesis, but the effect remained statistically nonsignificant. Prolymphangiogenic growth factors (VEGF-C, -D, and -C156S) also improved lymph node survival as compared with those of the VEGF-A and control group. VEGF-C, which activates both vascular endothelial growth factor receptor 2 and vascular endothelial growth factor receptor 3, gave the best therapeutic effect in this experimental lymphedema model.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These results support our goal to treat secondary lymphedema by combining lymph node transfer with the growth factor therapy. VEGF-C provides the preferred alternative for growth factor therapy of lymphedema when compared with other VEGF-family growth factors, due to the superior lymphangiogenic response and minor blood vascular effects.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tervala</LastName><ForeName>Tomi V</ForeName><Initials>TV</Initials><AffiliationInfo><Affiliation>Department of Plastic Surgery, Kuopio University Hospital, Kuopio, Finland. Electronic address: tomi.tervala@kuh.fi.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hartiala</LastName><ForeName>Pauliina</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Plastic and General Surgery, Turku University Hospital, Turku, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tammela</LastName><ForeName>Tuomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Wihuri Research Institute and Translational Cancer Biology Program, University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Visuri</LastName><ForeName>Mikko T</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>Department of Plastic and General Surgery, Turku University Hospital, Turku, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ylä-Herttuala</LastName><ForeName>Seppo</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alitalo</LastName><ForeName>Kari</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Wihuri Research Institute and Translational Cancer Biology Program, University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saarikko</LastName><ForeName>Anne M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Department of Plastic and General Surgery, Turku University Hospital, Turku, Finland; Department of Plastic Surgery, Helsinki University Central Hospital, Helsinki, Finland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>02</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Surg Res</MedlineTA><NlmUniqueID>0376340</NlmUniqueID><ISSNLinking>0022-4804</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D042461">Vascular Endothelial Growth Factor A</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber><NameOfSubstance UI="D040301">Vascular Endothelial Growth Factor Receptor-2</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber><NameOfSubstance UI="D040321">Vascular Endothelial Growth Factor Receptor-3</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008198" MajorTopicYN="N">Lymph Nodes</DescriptorName><QualifierName UI="Q000637" MajorTopicYN="Y">transplantation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042583" MajorTopicYN="N">Lymphangiogenesis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008220" MajorTopicYN="N">Lymphography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D042461" MajorTopicYN="N">Vascular Endothelial Growth Factor A</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D040301" MajorTopicYN="N">Vascular Endothelial Growth Factor Receptor-2</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D040321" MajorTopicYN="N">Vascular Endothelial Growth Factor Receptor-3</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Lymph node transfer</Keyword><Keyword MajorTopicYN="N">Lymphedema</Keyword><Keyword MajorTopicYN="N">Vascular endothelial growth factor</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>07</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>01</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>02</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>3</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>3</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>8</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25777822</ArticleId><ArticleId IdType="pii">S0022-4804(15)00139-0</ArticleId><ArticleId IdType="doi">10.1016/j.jss.2015.02.031</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Finlande</li></country><region><li>Finlande occidentale</li><li>Uusimaa</li></region><settlement><li>Helsinki</li><li>Turku</li></settlement><orgName><li>Université d'Helsinki</li></orgName></list><tree><country name="Finlande"><noRegion><name sortKey="Tervala, Tomi V" sort="Tervala, Tomi V" uniqKey="Tervala T" first="Tomi V" last="Tervala">Tomi V. Tervala</name></noRegion><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><name sortKey="Hartiala, Pauliina" sort="Hartiala, Pauliina" uniqKey="Hartiala P" first="Pauliina" last="Hartiala">Pauliina Hartiala</name><name sortKey="Saarikko, Anne M" sort="Saarikko, Anne M" uniqKey="Saarikko A" first="Anne M" last="Saarikko">Anne M. Saarikko</name><name sortKey="Tammela, Tuomas" sort="Tammela, Tuomas" uniqKey="Tammela T" first="Tuomas" last="Tammela">Tuomas Tammela</name><name sortKey="Visuri, Mikko T" sort="Visuri, Mikko T" uniqKey="Visuri M" first="Mikko T" last="Visuri">Mikko T. Visuri</name><name sortKey="Yl Herttuala, Seppo" sort="Yl Herttuala, Seppo" uniqKey="Yl Herttuala S" first="Seppo" last="Yl Herttuala">Seppo Yl Herttuala</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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