Growth factor therapy and lymph node graft for lymphedema.
Identifieur interne : 000F81 ( PubMed/Curation ); précédent : 000F80; suivant : 000F82Growth factor therapy and lymph node graft for lymphedema.
Auteurs : Tomi V. Tervala [Finlande] ; Pauliina Hartiala [Finlande] ; Tuomas Tammela [Finlande] ; Mikko T. Visuri [Finlande] ; Seppo Yl Herttuala [Finlande] ; Kari Alitalo [Finlande] ; Anne M. Saarikko [Finlande]Source :
- The Journal of surgical research [ 1095-8673 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Facteur de croissance endothéliale vasculaire de type A (usage thérapeutique), Lymphangiogenèse, Lymphoedème (), Lymphoedème (physiopathologie), Lymphographie, Noeuds lymphatiques (transplantation), Récepteur-2 au facteur croissance endothéliale vasculaire (physiologie), Récepteur-3 au facteur croissance endothéliale vasculaire (physiologie), Souris.
- MESH :
- physiologie : Récepteur-2 au facteur croissance endothéliale vasculaire, Récepteur-3 au facteur croissance endothéliale vasculaire.
- physiopathologie : Lymphoedème.
- usage thérapeutique : Facteur de croissance endothéliale vasculaire de type A, Noeuds lymphatiques.
- Animaux, Lymphangiogenèse, Lymphoedème, Lymphographie, Souris.
English descriptors
- KwdEn :
- Animals, Lymph Nodes (transplantation), Lymphangiogenesis, Lymphedema (physiopathology), Lymphedema (therapy), Lymphography, Mice, Vascular Endothelial Growth Factor A (therapeutic use), Vascular Endothelial Growth Factor Receptor-2 (physiology), Vascular Endothelial Growth Factor Receptor-3 (physiology).
- MESH :
- chemical , physiology : Vascular Endothelial Growth Factor Receptor-2, Vascular Endothelial Growth Factor Receptor-3.
- chemical , therapeutic use : Vascular Endothelial Growth Factor A.
- physiopathology : Lymphedema.
- therapy : Lymphedema.
- transplantation : Lymph Nodes.
- Animals, Lymphangiogenesis, Lymphography, Mice.
Abstract
Lymphedema still remains an unsolved problem. Secondary lymphedema often develops after cancer operations or radiation therapy, especially in breast cancer patients. Using a mouse model, we show here that the lymphatic network can be regenerated using lymphatic vascular growth factor therapy in combination with lymph node transfer.
DOI: 10.1016/j.jss.2015.02.031
PubMed: 25777822
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- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000F81
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pubmed:25777822Le document en format XML
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<term>Lymph Nodes (transplantation)</term>
<term>Lymphangiogenesis</term>
<term>Lymphedema (physiopathology)</term>
<term>Lymphedema (therapy)</term>
<term>Lymphography</term>
<term>Mice</term>
<term>Vascular Endothelial Growth Factor A (therapeutic use)</term>
<term>Vascular Endothelial Growth Factor Receptor-2 (physiology)</term>
<term>Vascular Endothelial Growth Factor Receptor-3 (physiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Facteur de croissance endothéliale vasculaire de type A (usage thérapeutique)</term>
<term>Lymphangiogenèse</term>
<term>Lymphoedème ()</term>
<term>Lymphoedème (physiopathologie)</term>
<term>Lymphographie</term>
<term>Noeuds lymphatiques (transplantation)</term>
<term>Récepteur-2 au facteur croissance endothéliale vasculaire (physiologie)</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire (physiologie)</term>
<term>Souris</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Vascular Endothelial Growth Factor Receptor-2</term>
<term>Vascular Endothelial Growth Factor Receptor-3</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Vascular Endothelial Growth Factor A</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Récepteur-2 au facteur croissance endothéliale vasculaire</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Lymphoedème</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Lymphedema</term>
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<term>Noeuds lymphatiques</term>
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<term>Lymphangiogenesis</term>
<term>Lymphography</term>
<term>Mice</term>
</keywords>
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<term>Lymphangiogenèse</term>
<term>Lymphoedème</term>
<term>Lymphographie</term>
<term>Souris</term>
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<front><div type="abstract" xml:lang="en">Lymphedema still remains an unsolved problem. Secondary lymphedema often develops after cancer operations or radiation therapy, especially in breast cancer patients. Using a mouse model, we show here that the lymphatic network can be regenerated using lymphatic vascular growth factor therapy in combination with lymph node transfer.</div>
</front>
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<DateCreated><Year>2015</Year>
<Month>05</Month>
<Day>13</Day>
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<DateCompleted><Year>2015</Year>
<Month>08</Month>
<Day>12</Day>
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<Month>05</Month>
<Day>13</Day>
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<Month>Jun</Month>
<Day>01</Day>
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<Title>The Journal of surgical research</Title>
<ISOAbbreviation>J. Surg. Res.</ISOAbbreviation>
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<ArticleTitle>Growth factor therapy and lymph node graft for lymphedema.</ArticleTitle>
<Pagination><MedlinePgn>200-7</MedlinePgn>
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<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jss.2015.02.031</ELocationID>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Lymphedema still remains an unsolved problem. Secondary lymphedema often develops after cancer operations or radiation therapy, especially in breast cancer patients. Using a mouse model, we show here that the lymphatic network can be regenerated using lymphatic vascular growth factor therapy in combination with lymph node transfer.</AbstractText>
<AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">We have compared the therapeutic effects of different vascular endothelial growth factors (VEGF-C, VEGF-D, VEGF-C156S, and VEGF-A), in combination with lymph node transfer in mouse axilla. The lymphangiogenic effects of the growth factor therapy were examined at 3 mo postoperatively.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">VEGF therapy with VEGF-C and VEGF-D induced growth of new lymphatic vessels in the defect area, and VEGF-C also improved lymphatic vessel function compared with that of controls. VEGF-C156S induced moderate lymphangiogenesis, but the effect remained statistically nonsignificant. Prolymphangiogenic growth factors (VEGF-C, -D, and -C156S) also improved lymph node survival as compared with those of the VEGF-A and control group. VEGF-C, which activates both vascular endothelial growth factor receptor 2 and vascular endothelial growth factor receptor 3, gave the best therapeutic effect in this experimental lymphedema model.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These results support our goal to treat secondary lymphedema by combining lymph node transfer with the growth factor therapy. VEGF-C provides the preferred alternative for growth factor therapy of lymphedema when compared with other VEGF-family growth factors, due to the superior lymphangiogenic response and minor blood vascular effects.</AbstractText>
<CopyrightInformation>Copyright © 2015 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tervala</LastName>
<ForeName>Tomi V</ForeName>
<Initials>TV</Initials>
<AffiliationInfo><Affiliation>Department of Plastic Surgery, Kuopio University Hospital, Kuopio, Finland. Electronic address: tomi.tervala@kuh.fi.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Hartiala</LastName>
<ForeName>Pauliina</ForeName>
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<AffiliationInfo><Affiliation>Department of Plastic and General Surgery, Turku University Hospital, Turku, Finland.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Tammela</LastName>
<ForeName>Tuomas</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Wihuri Research Institute and Translational Cancer Biology Program, University of Helsinki, Helsinki, Finland.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Visuri</LastName>
<ForeName>Mikko T</ForeName>
<Initials>MT</Initials>
<AffiliationInfo><Affiliation>Department of Plastic and General Surgery, Turku University Hospital, Turku, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ylä-Herttuala</LastName>
<ForeName>Seppo</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Alitalo</LastName>
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<Initials>K</Initials>
<AffiliationInfo><Affiliation>Wihuri Research Institute and Translational Cancer Biology Program, University of Helsinki, Helsinki, Finland.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Saarikko</LastName>
<ForeName>Anne M</ForeName>
<Initials>AM</Initials>
<AffiliationInfo><Affiliation>Department of Plastic and General Surgery, Turku University Hospital, Turku, Finland; Department of Plastic Surgery, Helsinki University Central Hospital, Helsinki, Finland.</Affiliation>
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<NameOfSubstance UI="D042461">Vascular Endothelial Growth Factor A</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
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<MeshHeading><DescriptorName UI="D008198" MajorTopicYN="N">Lymph Nodes</DescriptorName>
<QualifierName UI="Q000637" MajorTopicYN="Y">transplantation</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D042583" MajorTopicYN="N">Lymphangiogenesis</DescriptorName>
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<MeshHeading><DescriptorName UI="D040301" MajorTopicYN="N">Vascular Endothelial Growth Factor Receptor-2</DescriptorName>
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<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Lymph node transfer</Keyword>
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