LymphedemaV1, PubMed, Checkpoint, bibRecord, 000A97

ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.

Identifieur interne : 000A97 ( PubMed/Checkpoint ); précédent : 000A96; suivant : 000A98

ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.

Auteurs : Lauriane Janssen [Belgique] ; Laura Dupont [Belgique] ; Mourad Bekhouche [Belgique] ; Agnès Noel [Belgique] ; Cédric Leduc [Belgique] ; Marianne Voz [Belgique] ; Bernard Peers [Belgique] ; Didier Cataldo [Belgique] ; Suneel S. Apte [États-Unis] ; Johanne Dubail [Belgique] ; Alain Colige [Belgique]

Source :

Angiogenesis [ 1573-7209 ] ; 2016.

RBID : pubmed:26446156

Descripteurs français

English descriptors

KwdEn :
- ADAM Proteins (deficiency), ADAM Proteins (metabolism), Animals, Blood Vessels (pathology), Cartilage (pathology), Collagen (metabolism), Edema (pathology), Embryo Loss (metabolism), Embryo Loss (pathology), Embryo, Mammalian (metabolism), Female, Gene Expression Profiling, Gene Expression Regulation, Developmental, Homozygote, Immunohistochemistry, Liver (embryology), Liver (pathology), Lymphangiogenesis, Mice, Mutation (genetics), Neovascularization, Physiologic, Oligonucleotide Array Sequence Analysis, Placenta (blood supply), Placenta (pathology), Pregnancy, Protein Processing, Post-Translational, Skin (pathology), Vascular Endothelial Growth Factor C (metabolism).
MESH :
- chemical , deficiency : ADAM Proteins.
- chemical , metabolism : ADAM Proteins, Collagen, Vascular Endothelial Growth Factor C.
- blood supply : Placenta.
- embryology : Liver.
- genetics : Mutation.
- metabolism : Embryo Loss, Embryo, Mammalian.
- pathology : Blood Vessels, Cartilage, Edema, Embryo Loss, Liver, Placenta, Skin.
- Animals, Female, Gene Expression Profiling, Gene Expression Regulation, Developmental, Homozygote, Immunohistochemistry, Lymphangiogenesis, Mice, Neovascularization, Physiologic, Oligonucleotide Array Sequence Analysis, Pregnancy, Protein Processing, Post-Translational.

Abstract

The only documented activity of a subclass of ADAMTS proteases comprising ADAMTS2, 3 and 14 is the cleavage of the aminopropeptide of fibrillar procollagens. A limited number of in vitro studies suggested that ADAMTS3 is mainly responsible for procollagen II processing in cartilage. Here, we created an ADAMTS3 knockout mouse (Adamts3(-/-)) model to determine in vivo the actual functions of ADAMTS3. Heterozygous Adamts3(+/-) mice were viable and fertile, but their intercrosses demonstrated lethality of Adamts3(-/-) embryos after 15 days of gestation. Procollagens I, II and III processing was unaffected in these embryos. However, a massive lymphedema caused by the lack of lymphatics development, an abnormal blood vessel structure in the placenta and a progressive liver destruction were observed. These phenotypes are most probably linked to dysregulation of the VEGF-C pathways. This study is the first demonstration that an aminoprocollagen peptidase is crucial for developmental processes independently of its primary role in collagen biology and has physiological functions potentially involved in several human diseases related to angiogenesis and lymphangiogenesis.

DOI: 10.1007/s10456-015-9488-z
PubMed: 26446156

Affiliations:

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<author><name sortKey="Cataldo, Didier" sort="Cataldo, Didier" uniqKey="Cataldo D" first="Didier" last="Cataldo">Didier Cataldo</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.</title>
<author><name sortKey="Janssen, Lauriane" sort="Janssen, Lauriane" uniqKey="Janssen L" first="Lauriane" last="Janssen">Lauriane Janssen</name>
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<country xml:lang="fr">Belgique</country>
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<author><name sortKey="Dupont, Laura" sort="Dupont, Laura" uniqKey="Dupont L" first="Laura" last="Dupont">Laura Dupont</name>
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<country xml:lang="fr">Belgique</country>
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<author><name sortKey="Bekhouche, Mourad" sort="Bekhouche, Mourad" uniqKey="Bekhouche M" first="Mourad" last="Bekhouche">Mourad Bekhouche</name>
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<author><name sortKey="Noel, Agnes" sort="Noel, Agnes" uniqKey="Noel A" first="Agnès" last="Noel">Agnès Noel</name>
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<country xml:lang="fr">Belgique</country>
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<orgName type="university">Université de Liège</orgName>
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<author><name sortKey="Leduc, Cedric" sort="Leduc, Cedric" uniqKey="Leduc C" first="Cédric" last="Leduc">Cédric Leduc</name>
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<country xml:lang="fr">Belgique</country>
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<placeName><settlement type="city">Liège</settlement>
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<author><name sortKey="Voz, Marianne" sort="Voz, Marianne" uniqKey="Voz M" first="Marianne" last="Voz">Marianne Voz</name>
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<country xml:lang="fr">Belgique</country>
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<orgName type="university">Université de Liège</orgName>
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<region type="province" nuts="1">Province de Liège</region>
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<author><name sortKey="Peers, Bernard" sort="Peers, Bernard" uniqKey="Peers B" first="Bernard" last="Peers">Bernard Peers</name>
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<country xml:lang="fr">Belgique</country>
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<author><name sortKey="Cataldo, Didier" sort="Cataldo, Didier" uniqKey="Cataldo D" first="Didier" last="Cataldo">Didier Cataldo</name>
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<placeName><settlement type="city">Liège</settlement>
<region type="region" nuts="1">Région wallonne</region>
<region type="province" nuts="1">Province de Liège</region>
</placeName>
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<author><name sortKey="Apte, Suneel S" sort="Apte, Suneel S" uniqKey="Apte S" first="Suneel S" last="Apte">Suneel S. Apte</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Engineering, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, 44195, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biomedical Engineering, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, 44195</wicri:regionArea>
<wicri:noRegion>44195</wicri:noRegion>
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<author><name sortKey="Dubail, Johanne" sort="Dubail, Johanne" uniqKey="Dubail J" first="Johanne" last="Dubail">Johanne Dubail</name>
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<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman</wicri:regionArea>
<orgName type="university">Université de Liège</orgName>
<placeName><settlement type="city">Liège</settlement>
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<region type="province" nuts="1">Province de Liège</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Colige, Alain" sort="Colige, Alain" uniqKey="Colige A" first="Alain" last="Colige">Alain Colige</name>
<affiliation wicri:level="4"><nlm:affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium. acolige@ulg.ac.be.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
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<placeName><settlement type="city">Liège</settlement>
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<region type="province" nuts="1">Province de Liège</region>
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<series><title level="j">Angiogenesis</title>
<idno type="eISSN">1573-7209</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
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</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ADAM Proteins (deficiency)</term>
<term>ADAM Proteins (metabolism)</term>
<term>Animals</term>
<term>Blood Vessels (pathology)</term>
<term>Cartilage (pathology)</term>
<term>Collagen (metabolism)</term>
<term>Edema (pathology)</term>
<term>Embryo Loss (metabolism)</term>
<term>Embryo Loss (pathology)</term>
<term>Embryo, Mammalian (metabolism)</term>
<term>Female</term>
<term>Gene Expression Profiling</term>
<term>Gene Expression Regulation, Developmental</term>
<term>Homozygote</term>
<term>Immunohistochemistry</term>
<term>Liver (embryology)</term>
<term>Liver (pathology)</term>
<term>Lymphangiogenesis</term>
<term>Mice</term>
<term>Mutation (genetics)</term>
<term>Neovascularization, Physiologic</term>
<term>Oligonucleotide Array Sequence Analysis</term>
<term>Placenta (blood supply)</term>
<term>Placenta (pathology)</term>
<term>Pregnancy</term>
<term>Protein Processing, Post-Translational</term>
<term>Skin (pathology)</term>
<term>Vascular Endothelial Growth Factor C (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term>
<term>Animaux</term>
<term>Cartilage (anatomopathologie)</term>
<term>Collagène (métabolisme)</term>
<term>Embryon de mammifère (métabolisme)</term>
<term>Facteur de croissance endothéliale vasculaire de type C (métabolisme)</term>
<term>Femelle</term>
<term>Foie (anatomopathologie)</term>
<term>Foie (embryologie)</term>
<term>Grossesse</term>
<term>Homozygote</term>
<term>Immunohistochimie</term>
<term>Lymphangiogenèse</term>
<term>Maturation post-traductionnelle des protéines</term>
<term>Mutation (génétique)</term>
<term>Néovascularisation physiologique</term>
<term>Oedème (anatomopathologie)</term>
<term>Peau (anatomopathologie)</term>
<term>Perte de l'embryon (anatomopathologie)</term>
<term>Perte de l'embryon (métabolisme)</term>
<term>Placenta ()</term>
<term>Placenta (anatomopathologie)</term>
<term>Protéines ADAM (déficit)</term>
<term>Protéines ADAM (métabolisme)</term>
<term>Régulation de l'expression des gènes au cours du développement</term>
<term>Souris</term>
<term>Séquençage par oligonucléotides en batterie</term>
<term>Vaisseaux sanguins (anatomopathologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>ADAM Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>ADAM Proteins</term>
<term>Collagen</term>
<term>Vascular Endothelial Growth Factor C</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cartilage</term>
<term>Foie</term>
<term>Oedème</term>
<term>Peau</term>
<term>Perte de l'embryon</term>
<term>Placenta</term>
<term>Vaisseaux sanguins</term>
</keywords>
<keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Placenta</term>
</keywords>
<keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Protéines ADAM</term>
</keywords>
<keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Foie</term>
</keywords>
<keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Liver</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mutation</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Mutation</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Embryo Loss</term>
<term>Embryo, Mammalian</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Collagène</term>
<term>Embryon de mammifère</term>
<term>Facteur de croissance endothéliale vasculaire de type C</term>
<term>Perte de l'embryon</term>
<term>Protéines ADAM</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Blood Vessels</term>
<term>Cartilage</term>
<term>Edema</term>
<term>Embryo Loss</term>
<term>Liver</term>
<term>Placenta</term>
<term>Skin</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Gene Expression Profiling</term>
<term>Gene Expression Regulation, Developmental</term>
<term>Homozygote</term>
<term>Immunohistochemistry</term>
<term>Lymphangiogenesis</term>
<term>Mice</term>
<term>Neovascularization, Physiologic</term>
<term>Oligonucleotide Array Sequence Analysis</term>
<term>Pregnancy</term>
<term>Protein Processing, Post-Translational</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term>
<term>Animaux</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Homozygote</term>
<term>Immunohistochimie</term>
<term>Lymphangiogenèse</term>
<term>Maturation post-traductionnelle des protéines</term>
<term>Néovascularisation physiologique</term>
<term>Placenta</term>
<term>Régulation de l'expression des gènes au cours du développement</term>
<term>Souris</term>
<term>Séquençage par oligonucléotides en batterie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The only documented activity of a subclass of ADAMTS proteases comprising ADAMTS2, 3 and 14 is the cleavage of the aminopropeptide of fibrillar procollagens. A limited number of in vitro studies suggested that ADAMTS3 is mainly responsible for procollagen II processing in cartilage. Here, we created an ADAMTS3 knockout mouse (Adamts3(-/-)) model to determine in vivo the actual functions of ADAMTS3. Heterozygous Adamts3(+/-) mice were viable and fertile, but their intercrosses demonstrated lethality of Adamts3(-/-) embryos after 15 days of gestation. Procollagens I, II and III processing was unaffected in these embryos. However, a massive lymphedema caused by the lack of lymphatics development, an abnormal blood vessel structure in the placenta and a progressive liver destruction were observed. These phenotypes are most probably linked to dysregulation of the VEGF-C pathways. This study is the first demonstration that an aminoprocollagen peptidase is crucial for developmental processes independently of its primary role in collagen biology and has physiological functions potentially involved in several human diseases related to angiogenesis and lymphangiogenesis.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26446156</PMID>
<DateCreated><Year>2016</Year>
<Month>01</Month>
<Day>05</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>09</Month>
<Day>30</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>10</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1573-7209</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>19</Volume>
<Issue>1</Issue>
<PubDate><Year>2016</Year>
<Month>Jan</Month>
</PubDate>
</JournalIssue>
<Title>Angiogenesis</Title>
<ISOAbbreviation>Angiogenesis</ISOAbbreviation>
</Journal>
<ArticleTitle>ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.</ArticleTitle>
<Pagination><MedlinePgn>53-65</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s10456-015-9488-z</ELocationID>
<Abstract><AbstractText>The only documented activity of a subclass of ADAMTS proteases comprising ADAMTS2, 3 and 14 is the cleavage of the aminopropeptide of fibrillar procollagens. A limited number of in vitro studies suggested that ADAMTS3 is mainly responsible for procollagen II processing in cartilage. Here, we created an ADAMTS3 knockout mouse (Adamts3(-/-)) model to determine in vivo the actual functions of ADAMTS3. Heterozygous Adamts3(+/-) mice were viable and fertile, but their intercrosses demonstrated lethality of Adamts3(-/-) embryos after 15 days of gestation. Procollagens I, II and III processing was unaffected in these embryos. However, a massive lymphedema caused by the lack of lymphatics development, an abnormal blood vessel structure in the placenta and a progressive liver destruction were observed. These phenotypes are most probably linked to dysregulation of the VEGF-C pathways. This study is the first demonstration that an aminoprocollagen peptidase is crucial for developmental processes independently of its primary role in collagen biology and has physiological functions potentially involved in several human diseases related to angiogenesis and lymphangiogenesis.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Janssen</LastName>
<ForeName>Lauriane</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dupont</LastName>
<ForeName>Laura</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bekhouche</LastName>
<ForeName>Mourad</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Noel</LastName>
<ForeName>Agnès</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Laboratory of Tumor and Developmental Biology, GIGA-R, University of Liege, 4000, Sart Tilman, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Leduc</LastName>
<ForeName>Cédric</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Voz</LastName>
<ForeName>Marianne</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Laboratory of Zebrafish Development and Disease Models, GIGA-R, University of Liege, 4000, Sart Tilman, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Peers</LastName>
<ForeName>Bernard</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Laboratory of Zebrafish Development and Disease Models, GIGA-R, University of Liege, 4000, Sart Tilman, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cataldo</LastName>
<ForeName>Didier</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Laboratory of Tumor and Developmental Biology, GIGA-R, University of Liege, 4000, Sart Tilman, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Apte</LastName>
<ForeName>Suneel S</ForeName>
<Initials>SS</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Engineering, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, 44195, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dubail</LastName>
<ForeName>Johanne</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Biomedical Engineering, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, 44195, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Colige</LastName>
<ForeName>Alain</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium. acolige@ulg.ac.be.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>P01 HL107147</GrantID>
<Acronym>HL</Acronym>
<Agency>NHLBI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>10</Month>
<Day>07</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Germany</Country>
<MedlineTA>Angiogenesis</MedlineTA>
<NlmUniqueID>9814575</NlmUniqueID>
<ISSNLinking>0969-6970</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D042582">Vascular Endothelial Growth Factor C</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>9007-34-5</RegistryNumber>
<NameOfSubstance UI="D003094">Collagen</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.4.24.-</RegistryNumber>
<NameOfSubstance UI="D051722">ADAM Proteins</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D051722" MajorTopicYN="N">ADAM Proteins</DescriptorName>
<QualifierName UI="Q000172" MajorTopicYN="N">deficiency</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001808" MajorTopicYN="N">Blood Vessels</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002356" MajorTopicYN="N">Cartilage</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003094" MajorTopicYN="N">Collagen</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004487" MajorTopicYN="N">Edema</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020964" MajorTopicYN="N">Embryo Loss</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004622" MajorTopicYN="N">Embryo, Mammalian</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020869" MajorTopicYN="N">Gene Expression Profiling</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018507" MajorTopicYN="N">Gene Expression Regulation, Developmental</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006720" MajorTopicYN="N">Homozygote</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName>
<QualifierName UI="Q000196" MajorTopicYN="N">embryology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D042583" MajorTopicYN="Y">Lymphangiogenesis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018919" MajorTopicYN="Y">Neovascularization, Physiologic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020411" MajorTopicYN="N">Oligonucleotide Array Sequence Analysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010920" MajorTopicYN="N">Placenta</DescriptorName>
<QualifierName UI="Q000098" MajorTopicYN="Y">blood supply</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011499" MajorTopicYN="N">Protein Processing, Post-Translational</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012867" MajorTopicYN="N">Skin</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D042582" MajorTopicYN="N">Vascular Endothelial Growth Factor C</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<OtherID Source="NLM">PMC4700087</OtherID>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">ADAMTS</Keyword>
<Keyword MajorTopicYN="N">Angiogenesis</Keyword>
<Keyword MajorTopicYN="N">Collagen</Keyword>
<Keyword MajorTopicYN="N">Development</Keyword>
<Keyword MajorTopicYN="N">Lymphangiogenesis</Keyword>
<Keyword MajorTopicYN="N">Placenta</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year>
<Month>05</Month>
<Day>07</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2015</Year>
<Month>09</Month>
<Day>28</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2015</Year>
<Month>10</Month>
<Day>9</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="pubmed"><Year>2015</Year>
<Month>10</Month>
<Day>9</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>10</Month>
<Day>1</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">26446156</ArticleId>
<ArticleId IdType="doi">10.1007/s10456-015-9488-z</ArticleId>
<ArticleId IdType="pii">10.1007/s10456-015-9488-z</ArticleId>
<ArticleId IdType="pmc">PMC4700087</ArticleId>
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</pubmed>
<affiliations><list><country><li>Belgique</li>
<li>États-Unis</li>
</country>
<region><li>Province de Liège</li>
<li>Région wallonne</li>
</region>
<settlement><li>Liège</li>
</settlement>
<orgName><li>Université de Liège</li>
</orgName>
</list>
<tree><country name="Belgique"><region name="Région wallonne"><name sortKey="Janssen, Lauriane" sort="Janssen, Lauriane" uniqKey="Janssen L" first="Lauriane" last="Janssen">Lauriane Janssen</name>
</region>
<name sortKey="Bekhouche, Mourad" sort="Bekhouche, Mourad" uniqKey="Bekhouche M" first="Mourad" last="Bekhouche">Mourad Bekhouche</name>
<name sortKey="Cataldo, Didier" sort="Cataldo, Didier" uniqKey="Cataldo D" first="Didier" last="Cataldo">Didier Cataldo</name>
<name sortKey="Colige, Alain" sort="Colige, Alain" uniqKey="Colige A" first="Alain" last="Colige">Alain Colige</name>
<name sortKey="Dubail, Johanne" sort="Dubail, Johanne" uniqKey="Dubail J" first="Johanne" last="Dubail">Johanne Dubail</name>
<name sortKey="Dupont, Laura" sort="Dupont, Laura" uniqKey="Dupont L" first="Laura" last="Dupont">Laura Dupont</name>
<name sortKey="Leduc, Cedric" sort="Leduc, Cedric" uniqKey="Leduc C" first="Cédric" last="Leduc">Cédric Leduc</name>
<name sortKey="Noel, Agnes" sort="Noel, Agnes" uniqKey="Noel A" first="Agnès" last="Noel">Agnès Noel</name>
<name sortKey="Peers, Bernard" sort="Peers, Bernard" uniqKey="Peers B" first="Bernard" last="Peers">Bernard Peers</name>
<name sortKey="Voz, Marianne" sort="Voz, Marianne" uniqKey="Voz M" first="Marianne" last="Voz">Marianne Voz</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Apte, Suneel S" sort="Apte, Suneel S" uniqKey="Apte S" first="Suneel S" last="Apte">Suneel S. Apte</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A97 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000A97 | SxmlIndent | more

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{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:26446156
   |texte=   ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:26446156" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le lymphœdème

ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.

ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.

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Pour générer des pages wiki