ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.
Identifieur interne : 000B98 ( PubMed/Corpus ); précédent : 000B97; suivant : 000B99ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.
Auteurs : Lauriane Janssen ; Laura Dupont ; Mourad Bekhouche ; Agnès Noel ; Cédric Leduc ; Marianne Voz ; Bernard Peers ; Didier Cataldo ; Suneel S. Apte ; Johanne Dubail ; Alain ColigeSource :
- Angiogenesis [ 1573-7209 ] ; 2016.
English descriptors
- KwdEn :
- ADAM Proteins (deficiency), ADAM Proteins (metabolism), Animals, Blood Vessels (pathology), Cartilage (pathology), Collagen (metabolism), Edema (pathology), Embryo Loss (metabolism), Embryo Loss (pathology), Embryo, Mammalian (metabolism), Female, Gene Expression Profiling, Gene Expression Regulation, Developmental, Homozygote, Immunohistochemistry, Liver (embryology), Liver (pathology), Lymphangiogenesis, Mice, Mutation (genetics), Neovascularization, Physiologic, Oligonucleotide Array Sequence Analysis, Placenta (blood supply), Placenta (pathology), Pregnancy, Protein Processing, Post-Translational, Skin (pathology), Vascular Endothelial Growth Factor C (metabolism).
- MESH :
- chemical , deficiency : ADAM Proteins.
- chemical , metabolism : ADAM Proteins, Collagen, Vascular Endothelial Growth Factor C.
- blood supply : Placenta.
- embryology : Liver.
- genetics : Mutation.
- metabolism : Embryo Loss, Embryo, Mammalian.
- pathology : Blood Vessels, Cartilage, Edema, Embryo Loss, Liver, Placenta, Skin.
- Animals, Female, Gene Expression Profiling, Gene Expression Regulation, Developmental, Homozygote, Immunohistochemistry, Lymphangiogenesis, Mice, Neovascularization, Physiologic, Oligonucleotide Array Sequence Analysis, Pregnancy, Protein Processing, Post-Translational.
Abstract
The only documented activity of a subclass of ADAMTS proteases comprising ADAMTS2, 3 and 14 is the cleavage of the aminopropeptide of fibrillar procollagens. A limited number of in vitro studies suggested that ADAMTS3 is mainly responsible for procollagen II processing in cartilage. Here, we created an ADAMTS3 knockout mouse (Adamts3(-/-)) model to determine in vivo the actual functions of ADAMTS3. Heterozygous Adamts3(+/-) mice were viable and fertile, but their intercrosses demonstrated lethality of Adamts3(-/-) embryos after 15 days of gestation. Procollagens I, II and III processing was unaffected in these embryos. However, a massive lymphedema caused by the lack of lymphatics development, an abnormal blood vessel structure in the placenta and a progressive liver destruction were observed. These phenotypes are most probably linked to dysregulation of the VEGF-C pathways. This study is the first demonstration that an aminoprocollagen peptidase is crucial for developmental processes independently of its primary role in collagen biology and has physiological functions potentially involved in several human diseases related to angiogenesis and lymphangiogenesis.
DOI: 10.1007/s10456-015-9488-z
PubMed: 26446156
Links to Exploration step
pubmed:26446156Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.</title><author><name sortKey="Janssen, Lauriane" sort="Janssen, Lauriane" uniqKey="Janssen L" first="Lauriane" last="Janssen">Lauriane Janssen</name><affiliation><nlm:affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Dupont, Laura" sort="Dupont, Laura" uniqKey="Dupont L" first="Laura" last="Dupont">Laura Dupont</name><affiliation><nlm:affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Bekhouche, Mourad" sort="Bekhouche, Mourad" uniqKey="Bekhouche M" first="Mourad" last="Bekhouche">Mourad Bekhouche</name><affiliation><nlm:affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Noel, Agnes" sort="Noel, Agnes" uniqKey="Noel A" first="Agnès" last="Noel">Agnès Noel</name><affiliation><nlm:affiliation>Laboratory of Tumor and Developmental Biology, GIGA-R, University of Liege, 4000, Sart Tilman, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Leduc, Cedric" sort="Leduc, Cedric" uniqKey="Leduc C" first="Cédric" last="Leduc">Cédric Leduc</name><affiliation><nlm:affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Voz, Marianne" sort="Voz, Marianne" uniqKey="Voz M" first="Marianne" last="Voz">Marianne Voz</name><affiliation><nlm:affiliation>Laboratory of Zebrafish Development and Disease Models, GIGA-R, University of Liege, 4000, Sart Tilman, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Peers, Bernard" sort="Peers, Bernard" uniqKey="Peers B" first="Bernard" last="Peers">Bernard Peers</name><affiliation><nlm:affiliation>Laboratory of Zebrafish Development and Disease Models, GIGA-R, University of Liege, 4000, Sart Tilman, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Cataldo, Didier" sort="Cataldo, Didier" uniqKey="Cataldo D" first="Didier" last="Cataldo">Didier Cataldo</name><affiliation><nlm:affiliation>Laboratory of Tumor and Developmental Biology, GIGA-R, University of Liege, 4000, Sart Tilman, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Apte, Suneel S" sort="Apte, Suneel S" uniqKey="Apte S" first="Suneel S" last="Apte">Suneel S. Apte</name><affiliation><nlm:affiliation>Department of Biomedical Engineering, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, 44195, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Dubail, Johanne" sort="Dubail, Johanne" uniqKey="Dubail J" first="Johanne" last="Dubail">Johanne Dubail</name><affiliation><nlm:affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Colige, Alain" sort="Colige, Alain" uniqKey="Colige A" first="Alain" last="Colige">Alain Colige</name><affiliation><nlm:affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium. acolige@ulg.ac.be.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26446156</idno><idno type="pmid">26446156</idno><idno type="doi">10.1007/s10456-015-9488-z</idno><idno type="wicri:Area/PubMed/Corpus">000B98</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B98</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.</title><author><name sortKey="Janssen, Lauriane" sort="Janssen, Lauriane" uniqKey="Janssen L" first="Lauriane" last="Janssen">Lauriane Janssen</name><affiliation><nlm:affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Dupont, Laura" sort="Dupont, Laura" uniqKey="Dupont L" first="Laura" last="Dupont">Laura Dupont</name><affiliation><nlm:affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Bekhouche, Mourad" sort="Bekhouche, Mourad" uniqKey="Bekhouche M" first="Mourad" last="Bekhouche">Mourad Bekhouche</name><affiliation><nlm:affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Noel, Agnes" sort="Noel, Agnes" uniqKey="Noel A" first="Agnès" last="Noel">Agnès Noel</name><affiliation><nlm:affiliation>Laboratory of Tumor and Developmental Biology, GIGA-R, University of Liege, 4000, Sart Tilman, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Leduc, Cedric" sort="Leduc, Cedric" uniqKey="Leduc C" first="Cédric" last="Leduc">Cédric Leduc</name><affiliation><nlm:affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Voz, Marianne" sort="Voz, Marianne" uniqKey="Voz M" first="Marianne" last="Voz">Marianne Voz</name><affiliation><nlm:affiliation>Laboratory of Zebrafish Development and Disease Models, GIGA-R, University of Liege, 4000, Sart Tilman, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Peers, Bernard" sort="Peers, Bernard" uniqKey="Peers B" first="Bernard" last="Peers">Bernard Peers</name><affiliation><nlm:affiliation>Laboratory of Zebrafish Development and Disease Models, GIGA-R, University of Liege, 4000, Sart Tilman, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Cataldo, Didier" sort="Cataldo, Didier" uniqKey="Cataldo D" first="Didier" last="Cataldo">Didier Cataldo</name><affiliation><nlm:affiliation>Laboratory of Tumor and Developmental Biology, GIGA-R, University of Liege, 4000, Sart Tilman, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Apte, Suneel S" sort="Apte, Suneel S" uniqKey="Apte S" first="Suneel S" last="Apte">Suneel S. Apte</name><affiliation><nlm:affiliation>Department of Biomedical Engineering, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, 44195, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Dubail, Johanne" sort="Dubail, Johanne" uniqKey="Dubail J" first="Johanne" last="Dubail">Johanne Dubail</name><affiliation><nlm:affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Colige, Alain" sort="Colige, Alain" uniqKey="Colige A" first="Alain" last="Colige">Alain Colige</name><affiliation><nlm:affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium. acolige@ulg.ac.be.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Angiogenesis</title><idno type="eISSN">1573-7209</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ADAM Proteins (deficiency)</term><term>ADAM Proteins (metabolism)</term><term>Animals</term><term>Blood Vessels (pathology)</term><term>Cartilage (pathology)</term><term>Collagen (metabolism)</term><term>Edema (pathology)</term><term>Embryo Loss (metabolism)</term><term>Embryo Loss (pathology)</term><term>Embryo, Mammalian (metabolism)</term><term>Female</term><term>Gene Expression Profiling</term><term>Gene Expression Regulation, Developmental</term><term>Homozygote</term><term>Immunohistochemistry</term><term>Liver (embryology)</term><term>Liver (pathology)</term><term>Lymphangiogenesis</term><term>Mice</term><term>Mutation (genetics)</term><term>Neovascularization, Physiologic</term><term>Oligonucleotide Array Sequence Analysis</term><term>Placenta (blood supply)</term><term>Placenta (pathology)</term><term>Pregnancy</term><term>Protein Processing, Post-Translational</term><term>Skin (pathology)</term><term>Vascular Endothelial Growth Factor C (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>ADAM Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>ADAM Proteins</term><term>Collagen</term><term>Vascular Endothelial Growth Factor C</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Placenta</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Liver</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mutation</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Embryo Loss</term><term>Embryo, Mammalian</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Blood Vessels</term><term>Cartilage</term><term>Edema</term><term>Embryo Loss</term><term>Liver</term><term>Placenta</term><term>Skin</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Gene Expression Profiling</term><term>Gene Expression Regulation, Developmental</term><term>Homozygote</term><term>Immunohistochemistry</term><term>Lymphangiogenesis</term><term>Mice</term><term>Neovascularization, Physiologic</term><term>Oligonucleotide Array Sequence Analysis</term><term>Pregnancy</term><term>Protein Processing, Post-Translational</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The only documented activity of a subclass of ADAMTS proteases comprising ADAMTS2, 3 and 14 is the cleavage of the aminopropeptide of fibrillar procollagens. A limited number of in vitro studies suggested that ADAMTS3 is mainly responsible for procollagen II processing in cartilage. Here, we created an ADAMTS3 knockout mouse (Adamts3(-/-)) model to determine in vivo the actual functions of ADAMTS3. Heterozygous Adamts3(+/-) mice were viable and fertile, but their intercrosses demonstrated lethality of Adamts3(-/-) embryos after 15 days of gestation. Procollagens I, II and III processing was unaffected in these embryos. However, a massive lymphedema caused by the lack of lymphatics development, an abnormal blood vessel structure in the placenta and a progressive liver destruction were observed. These phenotypes are most probably linked to dysregulation of the VEGF-C pathways. This study is the first demonstration that an aminoprocollagen peptidase is crucial for developmental processes independently of its primary role in collagen biology and has physiological functions potentially involved in several human diseases related to angiogenesis and lymphangiogenesis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26446156</PMID><DateCreated><Year>2016</Year><Month>01</Month><Day>05</Day></DateCreated><DateCompleted><Year>2016</Year><Month>09</Month><Day>30</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1573-7209</ISSN><JournalIssue CitedMedium="Internet"><Volume>19</Volume><Issue>1</Issue><PubDate><Year>2016</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Angiogenesis</Title><ISOAbbreviation>Angiogenesis</ISOAbbreviation></Journal><ArticleTitle>ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.</ArticleTitle><Pagination><MedlinePgn>53-65</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s10456-015-9488-z</ELocationID><Abstract><AbstractText>The only documented activity of a subclass of ADAMTS proteases comprising ADAMTS2, 3 and 14 is the cleavage of the aminopropeptide of fibrillar procollagens. A limited number of in vitro studies suggested that ADAMTS3 is mainly responsible for procollagen II processing in cartilage. Here, we created an ADAMTS3 knockout mouse (Adamts3(-/-)) model to determine in vivo the actual functions of ADAMTS3. Heterozygous Adamts3(+/-) mice were viable and fertile, but their intercrosses demonstrated lethality of Adamts3(-/-) embryos after 15 days of gestation. Procollagens I, II and III processing was unaffected in these embryos. However, a massive lymphedema caused by the lack of lymphatics development, an abnormal blood vessel structure in the placenta and a progressive liver destruction were observed. These phenotypes are most probably linked to dysregulation of the VEGF-C pathways. This study is the first demonstration that an aminoprocollagen peptidase is crucial for developmental processes independently of its primary role in collagen biology and has physiological functions potentially involved in several human diseases related to angiogenesis and lymphangiogenesis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Janssen</LastName><ForeName>Lauriane</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dupont</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bekhouche</LastName><ForeName>Mourad</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Noel</LastName><ForeName>Agnès</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratory of Tumor and Developmental Biology, GIGA-R, University of Liege, 4000, Sart Tilman, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leduc</LastName><ForeName>Cédric</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Voz</LastName><ForeName>Marianne</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratory of Zebrafish Development and Disease Models, GIGA-R, University of Liege, 4000, Sart Tilman, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peers</LastName><ForeName>Bernard</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Laboratory of Zebrafish Development and Disease Models, GIGA-R, University of Liege, 4000, Sart Tilman, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cataldo</LastName><ForeName>Didier</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Laboratory of Tumor and Developmental Biology, GIGA-R, University of Liege, 4000, Sart Tilman, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Apte</LastName><ForeName>Suneel S</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>Department of Biomedical Engineering, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, 44195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dubail</LastName><ForeName>Johanne</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biomedical Engineering, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, 44195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Colige</LastName><ForeName>Alain</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium. acolige@ulg.ac.be.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P01 HL107147</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>10</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Angiogenesis</MedlineTA><NlmUniqueID>9814575</NlmUniqueID><ISSNLinking>0969-6970</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D042582">Vascular Endothelial Growth Factor C</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-34-5</RegistryNumber><NameOfSubstance UI="D003094">Collagen</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.24.-</RegistryNumber><NameOfSubstance UI="D051722">ADAM Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Circ Res. 2011 Aug 19;109(5):486-91</RefSource><PMID Version="1">21778431</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cell Sci. 2011 Oct 1;124(Pt 19):3235-46</RefSource><PMID Version="1">21896644</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochim Biophys Acta. 2011 Dec;1812(12):1616-29</RefSource><PMID Version="1">21914474</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Pathol. 2013 Jan;229(2):286-97</RefSource><PMID Version="1">23132749</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2012 Dec 20;120(26):5231-6</RefSource><PMID Version="1">22990015</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2013 Apr 18;121(16):3228-36</RefSource><PMID Version="1">23426945</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Development. 2014 Mar;141(6):1239-49</RefSource><PMID Version="1">24523457</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Circulation. 2014 May 13;129(19):1962-71</RefSource><PMID Version="1">24552833</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genes Dev. 2000 Jan 15;14(2):152-7</RefSource><PMID Version="1">10652269</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochem J. 2001 Apr 15;355(Pt 2):271-8</RefSource><PMID Version="1">11284712</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4611-6</RefSource><PMID Version="1">11287661</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2001 Aug 24;276(34):31502-9</RefSource><PMID Version="1">11408482</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2001 Sep 15;98(6):1662-6</RefSource><PMID Version="1">11535495</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2001 Oct 4;413(6855):488-94</RefSource><PMID Version="1">11586351</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2001 Nov 2;276(44):41059-63</RefSource><PMID Version="1">11557746</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2002 Feb 22;277(8):5756-66</RefSource><PMID Version="1">11741898</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Cell Biol. 2003 Jun;23(12):4371-85</RefSource><PMID Version="1">12773577</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Invest Dermatol. 2004 Oct;123(4):656-63</RefSource><PMID Version="1">15373769</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 1995 Feb 23;373(6516):699-702</RefSource><PMID Version="1">7854452</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 1995 Feb 23;373(6516):702-5</RefSource><PMID Version="1">7854453</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>EMBO J. 1998 May 15;17(10):2846-54</RefSource><PMID Version="1">9582278</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Hum Genet. 1999 Aug;65(2):308-17</RefSource><PMID Version="1">10417273</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2005 Dec 15;438(7070):946-53</RefSource><PMID Version="1">16355212</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Development. 2006 Apr;133(8):1587-96</RefSource><PMID Version="1">16556917</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hepatology. 2007 Nov;46(5):1620-31</RefSource><PMID Version="1">17929299</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Mol Med (Berl). 2008 Mar;86(3):323-32</RefSource><PMID Version="1">18084737</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Dev Biol. 2008 Apr 1;316(1):149-59</RefSource><PMID Version="1">18304521</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Protoc. 2009;4(1):44-57</RefSource><PMID Version="1">19131956</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2009 Nov 13;284(46):31493-7</RefSource><PMID Version="1">19734141</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2009 Dec;41(12):1272-4</RefSource><PMID Version="1">19935664</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):207-9</RefSource><PMID Version="1">19910638</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Mol Life Sci. 2010 Dec;67(24):4213-32</RefSource><PMID Version="1">20574651</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Rep. 2015 Feb 24;10(7):1158-72</RefSource><PMID Version="1">25704818</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D051722" MajorTopicYN="N">ADAM Proteins</DescriptorName><QualifierName UI="Q000172" MajorTopicYN="N">deficiency</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001808" MajorTopicYN="N">Blood Vessels</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002356" MajorTopicYN="N">Cartilage</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003094" MajorTopicYN="N">Collagen</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004487" MajorTopicYN="N">Edema</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020964" MajorTopicYN="N">Embryo Loss</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004622" MajorTopicYN="N">Embryo, Mammalian</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020869" MajorTopicYN="N">Gene Expression Profiling</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018507" MajorTopicYN="N">Gene Expression Regulation, Developmental</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006720" 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Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010920" MajorTopicYN="N">Placenta</DescriptorName><QualifierName UI="Q000098" MajorTopicYN="Y">blood supply</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011499" MajorTopicYN="N">Protein Processing, Post-Translational</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012867" MajorTopicYN="N">Skin</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042582" MajorTopicYN="N">Vascular Endothelial Growth Factor C</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4700087</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">ADAMTS</Keyword><Keyword MajorTopicYN="N">Angiogenesis</Keyword><Keyword MajorTopicYN="N">Collagen</Keyword><Keyword MajorTopicYN="N">Development</Keyword><Keyword MajorTopicYN="N">Lymphangiogenesis</Keyword><Keyword MajorTopicYN="N">Placenta</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>05</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>09</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>10</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>10</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>10</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26446156</ArticleId><ArticleId IdType="doi">10.1007/s10456-015-9488-z</ArticleId><ArticleId IdType="pii">10.1007/s10456-015-9488-z</ArticleId><ArticleId IdType="pmc">PMC4700087</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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