Reverse cholesterol transport: From classical view to new insights
Identifieur interne : 004894 ( Pmc/Curation ); précédent : 004893; suivant : 004895Reverse cholesterol transport: From classical view to new insights
Auteurs : Astrid E. Van Der VeldeSource :
- World Journal of Gastroenterology : WJG [ 1007-9327 ] ; 2010.
Abstract
Cholesterol is of vital importance for the human body. It is a constituent for most biological membranes, it is needed for the formation of bile salts, and it is the precursor for steroid hormones and vitamin D. However, the presence of excess cholesterol in cells, and in particular in macrophages in the arterial vessel wall, might be harmful. The accumulation of cholesterol in arteries can lead to atherosclerosis, and in turn, to other cardiovascular diseases. The route that is primarily thought to be responsible for the disposal of cholesterol is called reverse cholesterol transport (RCT). Therefore, RCT is seen as an interesting target for the development of drugs aimed at the prevention of atherosclerosis. Research on RCT has taken off in recent years. In this review, the classical concepts about RCT are discussed, together with new insights about this topic.
Url:
DOI: 10.3748/wjg.v16.i47.5908
PubMed: 21157966
PubMed Central: 3007102
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<front><journal-meta><journal-id journal-id-type="nlm-ta">World J Gastroenterol</journal-id><journal-id journal-id-type="publisher-id">WJG</journal-id><journal-title-group><journal-title>World Journal of Gastroenterology : WJG</journal-title></journal-title-group><issn pub-type="ppub">1007-9327</issn><publisher><publisher-name>Baishideng Publishing Group Co., Limited</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21157966</article-id><article-id pub-id-type="pmc">3007102</article-id><article-id pub-id-type="other">jWJG.v16.i47.pg5908</article-id><article-id pub-id-type="doi">10.3748/wjg.v16.i47.5908</article-id><article-categories><subj-group subj-group-type="heading"><subject>Topic Highlight</subject></subj-group></article-categories><title-group><article-title>Reverse cholesterol transport: From classical view to new insights</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>van der Velde</surname><given-names>Astrid E</given-names></name></contrib><aff>Astrid E van der Velde, Academic Medical Center, AMC Liver Center, Meibergdreef 69-71, 1105 BK, Amsterdam, The Netherlands</aff><aff>Astrid E van der Velde, Department of Education and Development, Gelderse Vallei Hospital, 6710 HN Ede, The Netherlands</aff></contrib-group><author-notes><fn><p>Author contributions: van der Velde AE solely contributed to this paper.</p><p>Correspondence to: Astrid E van der Velde, PhD, Department of Education and Development, Gelderse Vallei Hospital, PO Box 9025, 6710 HN Ede, The Netherlands. <email>astridvandervelde@hotmail.com</email></p><p>Telephone: +31-318-891318 Fax: +31-318-436977</p></fn></author-notes><pub-date pub-type="ppub"><day>21</day><month>12</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>21</day><month>12</month><year>2010</year></pub-date><volume>16</volume><issue>47</issue><fpage>5908</fpage><lpage>5915</lpage><history><date date-type="received"><day>12</day><month>7</month><year>2010</year></date><date date-type="rev-recd"><day>25</day><month>8</month><year>2010</year></date><date date-type="accepted"><day>1</day><month>9</month><year>2010</year></date></history><permissions><copyright-statement>©2010 Baishideng Publishing Group Co., Limited. All rights reserved.</copyright-statement><copyright-year>2010</copyright-year></permissions><abstract><p>Cholesterol is of vital importance for the human body. It is a constituent for most biological membranes, it is needed for the formation of bile salts, and it is the precursor for steroid hormones and vitamin D. However, the presence of excess cholesterol in cells, and in particular in macrophages in the arterial vessel wall, might be harmful. The accumulation of cholesterol in arteries can lead to atherosclerosis, and in turn, to other cardiovascular diseases. The route that is primarily thought to be responsible for the disposal of cholesterol is called reverse cholesterol transport (RCT). Therefore, RCT is seen as an interesting target for the development of drugs aimed at the prevention of atherosclerosis. Research on RCT has taken off in recent years. In this review, the classical concepts about RCT are discussed, together with new insights about this topic.</p></abstract><kwd-group><kwd>Cholesterol</kwd><kwd>Excretion</kwd><kwd>Transport</kwd><kwd>Intestine</kwd><kwd>Liver</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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