Lymphangiogenesis: A new player in cancer progression
Identifieur interne : 004893 ( Pmc/Curation ); précédent : 004892; suivant : 004894Lymphangiogenesis: A new player in cancer progression
Auteurs : Masayuki Nagahashi ; Subramaniam Ramachandran ; Omar M. Rashid ; Kazuaki TakabeSource :
- World Journal of Gastroenterology : WJG [ 1007-9327 ] ; 2010.
Abstract
Lymph node metastasis is the hallmark of colon cancer progression, and is considered one of the most important prognostic factors. Recently, there has been growing evidence that tumor lymphangiogenesis (formation of new lymphatic vessels) plays an important role in this process. Here, we review the latest findings of the role of lymphangiogenesis in colorectal cancer progression, and discuss its clinical application as a biomarker and target for new therapy. Understanding the molecular pathways that regulate lymphangiogenesis is mandatory to pave the way for the development of new therapies for cancer. In the future, tailored treatments consisting of combinations of chemotherapy, other targeted therapies, and anti-lymphangiogenesis agents will hopefully improve patient outcomes. This progression to the clinic must be guided by new avenues of research, such as the identification of biomarkers that predict response to treatment.
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DOI: 10.3748/wjg.v16.i32.4003
PubMed: 20731013
PubMed Central: 2928453
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<front><journal-meta><journal-id journal-id-type="nlm-ta">World J Gastroenterol</journal-id><journal-id journal-id-type="publisher-id">WJG</journal-id><journal-title-group><journal-title>World Journal of Gastroenterology : WJG</journal-title></journal-title-group><issn pub-type="ppub">1007-9327</issn><publisher><publisher-name>Baishideng Publishing Group Co., Limited</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20731013</article-id><article-id pub-id-type="pmc">2928453</article-id><article-id pub-id-type="other">jWJG.v16.i32.pg4003</article-id><article-id pub-id-type="doi">10.3748/wjg.v16.i32.4003</article-id><article-categories><subj-group subj-group-type="heading"><subject>Frontier</subject></subj-group></article-categories><title-group><article-title>Lymphangiogenesis: A new player in cancer progression</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Nagahashi</surname><given-names>Masayuki</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ramachandran</surname><given-names>Subramaniam</given-names></name></contrib><contrib contrib-type="author"><name><surname>Rashid</surname><given-names>Omar M</given-names></name></contrib><contrib contrib-type="author"><name><surname>Takabe</surname><given-names>Kazuaki</given-names></name></contrib><aff>Masayuki Nagahashi, Subramaniam Ramachandran, Omar M Rashid, Kazuaki Takabe, Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine and Massey Cancer Center, Richmond, VA 23298-0011, United States</aff></contrib-group><author-notes><fn><p>Author contributions: Nagahashi M, Ramachandran S, Rashid OM and Takabe K all generated the ideas and contributed to the writing of this paper.</p><p>Correspondence to: Kazuaki Takabe, MD, PhD, Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine and Massey Cancer Center, PO Box 980011, West Hospital, Room 7-402, 1200 East Broad Street, Richmond, VA 23298-0011, United States. <email>ktakabe@vcu.edu</email></p><p>Telephone: +1-804-8289322 Fax: +1-804-8284808</p></fn></author-notes><pub-date pub-type="ppub"><day>28</day><month>8</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>28</day><month>8</month><year>2010</year></pub-date><volume>16</volume><issue>32</issue><fpage>4003</fpage><lpage>4012</lpage><history><date date-type="received"><day>3</day><month>5</month><year>2010</year></date><date date-type="rev-recd"><day>15</day><month>6</month><year>2010</year></date><date date-type="accepted"><day>22</day><month>6</month><year>2010</year></date></history><permissions><copyright-statement>©2010 Baishideng Publishing Group Co., Limited. All rights reserved.</copyright-statement><copyright-year>2010</copyright-year></permissions><abstract><p>Lymph node metastasis is the hallmark of colon cancer progression, and is considered one of the most important prognostic factors. Recently, there has been growing evidence that tumor lymphangiogenesis (formation of new lymphatic vessels) plays an important role in this process. Here, we review the latest findings of the role of lymphangiogenesis in colorectal cancer progression, and discuss its clinical application as a biomarker and target for new therapy. Understanding the molecular pathways that regulate lymphangiogenesis is mandatory to pave the way for the development of new therapies for cancer. In the future, tailored treatments consisting of combinations of chemotherapy, other targeted therapies, and anti-lymphangiogenesis agents will hopefully improve patient outcomes. This progression to the clinic must be guided by new avenues of research, such as the identification of biomarkers that predict response to treatment.</p></abstract><kwd-group><kwd>Colorectal neoplasms</kwd><kwd>Angiogenesis</kwd><kwd>Lymphangiogenesis</kwd><kwd>Lymphatic vessels</kwd><kwd>Lymphatic metastasis</kwd><kwd>Vascular endothelial growth factor</kwd><kwd>Monoclonal antibody D2-40</kwd><kwd>Therapy-related neoplasms</kwd><kwd>Biomarkers</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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