Different patterns of NF-κB and Notch1 signaling contribute to tumor-induced lymphangiogenesis of esophageal squamous cell carcinoma
Identifieur interne : 004056 ( Pmc/Curation ); précédent : 004055; suivant : 004057Different patterns of NF-κB and Notch1 signaling contribute to tumor-induced lymphangiogenesis of esophageal squamous cell carcinoma
Auteurs : Chunhua Su [République populaire de Chine] ; Zhenguang Chen [République populaire de Chine] ; Honghe Luo [République populaire de Chine] ; Yihua Su [République populaire de Chine] ; Wangkai Liu [République populaire de Chine] ; Lie Cai [République populaire de Chine] ; Tao Wang [République populaire de Chine] ; Yiyan Lei [République populaire de Chine] ; Beilong Zhong [République populaire de Chine]Source :
- Journal of Experimental & Clinical Cancer Research : CR [ 0392-9078 ] ; 2011.
Abstract
Lymph node involvement and tumor-induced lymphangiogenesis appear as the earliest features of esophageal squamous cell carcinoma (ESCC), although the molecular regulatory mechanisms involved have remained unclear. Our aim was to investigate the contribution of NF-κB and Notch1 signaling to lymph node involvement and tumor-induced lymphangiogenesis in ESCC.
NF-κB and Notch1 expression in 60 tissue samples of ESCC were assessed by immunohistochemical staining. The correlations of NF-κB and Notch1 with lymph node involvement, lymphatic vessel density (LVD), podoplanin, and vascular endothelial growth factor-C (VEGF-C) were further evaluated to determine the association of NF-κB and Notch1 expression with tumor-induced lymphangiogenesis.
Chi-square tests revealed that NF-κB and Notch1 expression in ESCC tissues were significant associated with lymph node metastasis, LVD, podoplanin, and VEGF-C expression. Strong expression of NF-κB, but weak expression of Notch1, was observed in tumor tissues with lymph nodes involvement (
These results suggest that different patterns of NF-κB and Notch1 signaling contribute to lymph nodes metastasis and tumor-induced lymphangiogenesis of ESCC, and reveal that up-regulation of NF-κB is associated with down-regulation of Notch1 in tumor tissue.
Url:
DOI: 10.1186/1756-9966-30-85
PubMed: 21939555
PubMed Central: 3215933
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Different patterns of NF-κB and Notch1 signaling contribute to tumor-induced lymphangiogenesis of esophageal squamous cell carcinoma</title><author><name sortKey="Su, Chunhua" sort="Su, Chunhua" uniqKey="Su C" first="Chunhua" last="Su">Chunhua Su</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Zhenguang" sort="Chen, Zhenguang" uniqKey="Chen Z" first="Zhenguang" last="Chen">Zhenguang Chen</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong</wicri:regionArea></affiliation></author><author><name sortKey="Luo, Honghe" sort="Luo, Honghe" uniqKey="Luo H" first="Honghe" last="Luo">Honghe Luo</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong</wicri:regionArea></affiliation></author><author><name sortKey="Su, Yihua" sort="Su, Yihua" uniqKey="Su Y" first="Yihua" last="Su">Yihua Su</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Ophthalmology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Ophthalmology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Wangkai" sort="Liu, Wangkai" uniqKey="Liu W" first="Wangkai" last="Liu">Wangkai Liu</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong</wicri:regionArea></affiliation></author><author><name sortKey="Cai, Lie" sort="Cai, Lie" uniqKey="Cai L" first="Lie" last="Cai">Lie Cai</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Rehabilitation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rehabilitation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Tao" sort="Wang, Tao" uniqKey="Wang T" first="Tao" last="Wang">Tao Wang</name><affiliation wicri:level="1"><nlm:aff id="I5">Center for Stem Cell Biology and Tissue Engineering, Sun Yat-sen University, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Guangzhou, Guangdong 510080, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center for Stem Cell Biology and Tissue Engineering, Sun Yat-sen University, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Guangzhou, Guangdong 510080</wicri:regionArea></affiliation></author><author><name sortKey="Lei, Yiyan" sort="Lei, Yiyan" uniqKey="Lei Y" first="Yiyan" last="Lei">Yiyan Lei</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong</wicri:regionArea></affiliation></author><author><name sortKey="Zhong, Beilong" sort="Zhong, Beilong" uniqKey="Zhong B" first="Beilong" last="Zhong">Beilong Zhong</name><affiliation wicri:level="1"><nlm:aff id="I6">Department of Thoracic Surgery, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai (519000), Guangdong, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai (519000), Guangdong</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21939555</idno><idno type="pmc">3215933</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215933</idno><idno type="RBID">PMC:3215933</idno><idno type="doi">10.1186/1756-9966-30-85</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">004057</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004057</idno><idno type="wicri:Area/Pmc/Curation">004056</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004056</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Different patterns of NF-κB and Notch1 signaling contribute to tumor-induced lymphangiogenesis of esophageal squamous cell carcinoma</title><author><name sortKey="Su, Chunhua" sort="Su, Chunhua" uniqKey="Su C" first="Chunhua" last="Su">Chunhua Su</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Zhenguang" sort="Chen, Zhenguang" uniqKey="Chen Z" first="Zhenguang" last="Chen">Zhenguang Chen</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong</wicri:regionArea></affiliation></author><author><name sortKey="Luo, Honghe" sort="Luo, Honghe" uniqKey="Luo H" first="Honghe" last="Luo">Honghe Luo</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong</wicri:regionArea></affiliation></author><author><name sortKey="Su, Yihua" sort="Su, Yihua" uniqKey="Su Y" first="Yihua" last="Su">Yihua Su</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Ophthalmology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Ophthalmology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Wangkai" sort="Liu, Wangkai" uniqKey="Liu W" first="Wangkai" last="Liu">Wangkai Liu</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong</wicri:regionArea></affiliation></author><author><name sortKey="Cai, Lie" sort="Cai, Lie" uniqKey="Cai L" first="Lie" last="Cai">Lie Cai</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Rehabilitation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rehabilitation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Tao" sort="Wang, Tao" uniqKey="Wang T" first="Tao" last="Wang">Tao Wang</name><affiliation wicri:level="1"><nlm:aff id="I5">Center for Stem Cell Biology and Tissue Engineering, Sun Yat-sen University, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Guangzhou, Guangdong 510080, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center for Stem Cell Biology and Tissue Engineering, Sun Yat-sen University, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Guangzhou, Guangdong 510080</wicri:regionArea></affiliation></author><author><name sortKey="Lei, Yiyan" sort="Lei, Yiyan" uniqKey="Lei Y" first="Yiyan" last="Lei">Yiyan Lei</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong</wicri:regionArea></affiliation></author><author><name sortKey="Zhong, Beilong" sort="Zhong, Beilong" uniqKey="Zhong B" first="Beilong" last="Zhong">Beilong Zhong</name><affiliation wicri:level="1"><nlm:aff id="I6">Department of Thoracic Surgery, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai (519000), Guangdong, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai (519000), Guangdong</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Experimental & Clinical Cancer Research : CR</title><idno type="ISSN">0392-9078</idno><idno type="eISSN">1756-9966</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Lymph node involvement and tumor-induced lymphangiogenesis appear as the earliest features of esophageal squamous cell carcinoma (ESCC), although the molecular regulatory mechanisms involved have remained unclear. Our aim was to investigate the contribution of NF-κB and Notch1 signaling to lymph node involvement and tumor-induced lymphangiogenesis in ESCC.</p></sec><sec><title>Material and methods</title><p>NF-κB and Notch1 expression in 60 tissue samples of ESCC were assessed by immunohistochemical staining. The correlations of NF-κB and Notch1 with lymph node involvement, lymphatic vessel density (LVD), podoplanin, and vascular endothelial growth factor-C (VEGF-C) were further evaluated to determine the association of NF-κB and Notch1 expression with tumor-induced lymphangiogenesis.</p></sec><sec><title>Results</title><p>Chi-square tests revealed that NF-κB and Notch1 expression in ESCC tissues were significant associated with lymph node metastasis, LVD, podoplanin, and VEGF-C expression. Strong expression of NF-κB, but weak expression of Notch1, was observed in tumor tissues with lymph nodes involvement (<italic>P </italic>< 0.05 for both). The mean histoscores of LVD, podoplanin, and VEGF-C staining were higher in high-NF-κB-expressing tissue than in low-expressing tissue (<italic>P </italic>< 0.05 for each). In contrast, the mean histoscores of LVD and VEGF-C staining were lower in high-Notch1-expressing tissue than in low-expressing tissue (<italic>P </italic>< 0.05 for both). A multiple factors analysis of LVD and VEGF-C further demonstrated that LVD and VEGF-C status were significantly correlated with NF-κB and Notch1 expression in tumors. NF-κB and Notch1 expression were also significantly inversely correlated (<italic>P </italic>< 0.05).</p></sec><sec><title>Conclusion</title><p>These results suggest that different patterns of NF-κB and Notch1 signaling contribute to lymph nodes metastasis and tumor-induced lymphangiogenesis of ESCC, and reveal that up-regulation of NF-κB is associated with down-regulation of Notch1 in tumor tissue.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Jemal, A" uniqKey="Jemal A">A Jemal</name></author><author><name sortKey="Murray, T" uniqKey="Murray T">T Murray</name></author><author><name sortKey="Ward, E" uniqKey="Ward E">E Ward</name></author><author><name sortKey="Samuels, A" uniqKey="Samuels A">A Samuels</name></author><author><name sortKey="Tiwari, Rc" uniqKey="Tiwari R">RC Tiwari</name></author><author><name sortKey="Ghafoor, A" uniqKey="Ghafoor A">A Ghafoor</name></author><author><name sortKey="Feuer, Ej" uniqKey="Feuer 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Exp Clin Cancer Res</journal-id><journal-title-group><journal-title>Journal of Experimental & Clinical Cancer Research : CR</journal-title></journal-title-group><issn pub-type="ppub">0392-9078</issn><issn pub-type="epub">1756-9966</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21939555</article-id><article-id pub-id-type="pmc">3215933</article-id><article-id pub-id-type="publisher-id">1756-9966-30-85</article-id><article-id pub-id-type="doi">10.1186/1756-9966-30-85</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group></article-categories><title-group><article-title>Different patterns of NF-κB and Notch1 signaling contribute to tumor-induced lymphangiogenesis of esophageal squamous cell carcinoma</article-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes" id="A1"><name><surname>Su</surname><given-names>Chunhua</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>Kitten_sch@163.com</email></contrib><contrib contrib-type="author" corresp="yes" equal-contrib="yes" id="A2"><name><surname>Chen</surname><given-names>Zhenguang</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>chenzhenguang@yahoo.com</email></contrib><contrib contrib-type="author" equal-contrib="yes" id="A3"><name><surname>Luo</surname><given-names>Honghe</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>luohhzm@163.com</email></contrib><contrib contrib-type="author" id="A4"><name><surname>Su</surname><given-names>Yihua</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>13822288800@139.com</email></contrib><contrib contrib-type="author" id="A5"><name><surname>Liu</surname><given-names>Wangkai</given-names></name><xref ref-type="aff" rid="I3">3</xref><email>kaidoctor@126.com</email></contrib><contrib contrib-type="author" id="A6"><name><surname>Cai</surname><given-names>Lie</given-names></name><xref ref-type="aff" rid="I4">4</xref><email>Cai-lie@tom.com</email></contrib><contrib contrib-type="author" id="A7"><name><surname>Wang</surname><given-names>Tao</given-names></name><xref ref-type="aff" rid="I5">5</xref><email>rabbit.tao@163.com</email></contrib><contrib contrib-type="author" id="A8"><name><surname>Lei</surname><given-names>Yiyan</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>leiyiyan@21cn.com</email></contrib><contrib contrib-type="author" id="A9"><name><surname>Zhong</surname><given-names>Beilong</given-names></name><xref ref-type="aff" rid="I6">6</xref><email>beilongzhuhai@hotmail.com</email></contrib></contrib-group><aff id="I1"><label>1</label>Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong, People's Republic of China</aff><aff id="I2"><label>2</label>Department of Ophthalmology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong, People's Republic of China</aff><aff id="I3"><label>3</label>Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong, People's Republic of China</aff><aff id="I4"><label>4</label>Department of Rehabilitation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou (510080), Guangdong, People's Republic of China</aff><aff id="I5"><label>5</label>Center for Stem Cell Biology and Tissue Engineering, Sun Yat-sen University, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Guangzhou, Guangdong 510080, China</aff><aff id="I6"><label>6</label>Department of Thoracic Surgery, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai (519000), Guangdong, People's Republic of China</aff><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>22</day><month>9</month><year>2011</year></pub-date><volume>30</volume><issue>1</issue><fpage>85</fpage><lpage>85</lpage><history><date date-type="received"><day>16</day><month>6</month><year>2011</year></date><date date-type="accepted"><day>22</day><month>9</month><year>2011</year></date></history><permissions><copyright-statement>Copyright ©2011 Su et al; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2011</copyright-year><copyright-holder>Su et al; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri xlink:href="http://www.jeccr.com/content/30/1/85"></self-uri><abstract><sec><title>Background</title><p>Lymph node involvement and tumor-induced lymphangiogenesis appear as the earliest features of esophageal squamous cell carcinoma (ESCC), although the molecular regulatory mechanisms involved have remained unclear. Our aim was to investigate the contribution of NF-κB and Notch1 signaling to lymph node involvement and tumor-induced lymphangiogenesis in ESCC.</p></sec><sec><title>Material and methods</title><p>NF-κB and Notch1 expression in 60 tissue samples of ESCC were assessed by immunohistochemical staining. The correlations of NF-κB and Notch1 with lymph node involvement, lymphatic vessel density (LVD), podoplanin, and vascular endothelial growth factor-C (VEGF-C) were further evaluated to determine the association of NF-κB and Notch1 expression with tumor-induced lymphangiogenesis.</p></sec><sec><title>Results</title><p>Chi-square tests revealed that NF-κB and Notch1 expression in ESCC tissues were significant associated with lymph node metastasis, LVD, podoplanin, and VEGF-C expression. Strong expression of NF-κB, but weak expression of Notch1, was observed in tumor tissues with lymph nodes involvement (<italic>P </italic>< 0.05 for both). The mean histoscores of LVD, podoplanin, and VEGF-C staining were higher in high-NF-κB-expressing tissue than in low-expressing tissue (<italic>P </italic>< 0.05 for each). In contrast, the mean histoscores of LVD and VEGF-C staining were lower in high-Notch1-expressing tissue than in low-expressing tissue (<italic>P </italic>< 0.05 for both). A multiple factors analysis of LVD and VEGF-C further demonstrated that LVD and VEGF-C status were significantly correlated with NF-κB and Notch1 expression in tumors. NF-κB and Notch1 expression were also significantly inversely correlated (<italic>P </italic>< 0.05).</p></sec><sec><title>Conclusion</title><p>These results suggest that different patterns of NF-κB and Notch1 signaling contribute to lymph nodes metastasis and tumor-induced lymphangiogenesis of ESCC, and reveal that up-regulation of NF-κB is associated with down-regulation of Notch1 in tumor tissue.</p></sec></abstract><kwd-group><kwd>esophageal squamous cell carcinoma</kwd><kwd>Notch</kwd><kwd>NF-κB</kwd><kwd>angiogenesis</kwd><kwd>lymphangiogenesis</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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