AIDS-Kaposi Sarcoma and Classic Kaposi Sarcoma: are different ultrasound patterns related to different variants?
Identifieur interne : 004055 ( Pmc/Curation ); précédent : 004054; suivant : 004056AIDS-Kaposi Sarcoma and Classic Kaposi Sarcoma: are different ultrasound patterns related to different variants?
Auteurs : Francesco M. Solivetti ; Fulvia Elia ; Alessandra Latini ; Carlo Cota ; Paola Cordiali-Fei ; Aldo Di CarloSource :
- Journal of Experimental & Clinical Cancer Research : CR [ 0392-9078 ] ; 2011.
Abstract
Kaposi Sarcoma (KS) is a malignancy of endothelial skin cells with multifocal localization on the skin, lymph nodes and visceral organs. Although all clinical variants are associated with HHV-8 infection, specific differences in the clinical onset and in the natural history of AIDS-KS and Classic-KS have been described. The present randomised prospective-observational study aimed to investigate whether the ultrasound pattern and color Doppler flow imaging of vascularisation of skin lesions of patients with Classic KS (CKS) or AIDS-KS could provide useful information to the evaluation of clinical activity of the disease.
Cutaneous lesions of 24 patients with histologically confirmed KS were investigated using very high frequency ultrasound probes; 16 patients had CKS and 8 had AIDS-KS. HHV-8 infection was confirmed in all patients by investigating the specific humoral response to viral antigens. Immunological and virological parameters were also assessed to monitor HIV or HHV-8 viral infection. For each patient, a target skin lesion was selected on the basis of size (diameter from 0.4 to 2 cm). Each lesion was analyzed in terms of size, depth and color Doppler pattern.
The B-mode ultrasound patterns of skin lesions did not differ when comparing CKS patients to AIDS-KS patients, whereas the color Doppler signal, which is associated with vascular activity, was detected in the KS lesions of 6/8 AIDS-KS patients (75.0%) and in 2/16 CKS (16,7%); the latter two patients showed a clinically progressive and extensive disease stage (IV B).
Our preliminary results suggest that small cutaneous KS lesions - in both CKS and AIDS-KS patients- display similar B-mode ultrasound patterns ( hypoechoic, well defined, superficial lesions). However, the color Doppler signal, which is associated with endothelial activity and angiogenesis, which play a substantial role in KS progression, could constitute a useful tool for evaluating disease activity.
Url:
DOI: 10.1186/1756-9966-30-40
PubMed: 21489270
PubMed Central: 3095540
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Francesco M. Solivetti<affiliation><nlm:aff id="I1">Radiology Department, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff>
<wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="I1">Radiology Department, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff>
<wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="I2">Infective Dermatology Division, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff>
<wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="I3">Dermatopathology Division, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff>
<wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="I4">Clinical Pathology and Microbiology Division, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff>
<wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="I5">Scientific Director, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff>
<wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry>
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">AIDS-Kaposi Sarcoma and Classic Kaposi Sarcoma: are different ultrasound patterns related to different variants?</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Kaposi Sarcoma (KS) is a malignancy of endothelial skin cells with multifocal localization on the skin, lymph nodes and visceral organs. Although all clinical variants are associated with HHV-8 infection, specific differences in the clinical onset and in the natural history of AIDS-KS and Classic-KS have been described. The present randomised prospective-observational study aimed to investigate whether the ultrasound pattern and color Doppler flow imaging of vascularisation of skin lesions of patients with Classic KS (CKS) or AIDS-KS could provide useful information to the evaluation of clinical activity of the disease.</p>
</sec>
<sec><title>Methods</title>
<p>Cutaneous lesions of 24 patients with histologically confirmed KS were investigated using very high frequency ultrasound probes; 16 patients had CKS and 8 had AIDS-KS. HHV-8 infection was confirmed in all patients by investigating the specific humoral response to viral antigens. Immunological and virological parameters were also assessed to monitor HIV or HHV-8 viral infection. For each patient, a target skin lesion was selected on the basis of size (diameter from 0.4 to 2 cm). Each lesion was analyzed in terms of size, depth and color Doppler pattern.</p>
</sec>
<sec><title>Results</title>
<p>The B-mode ultrasound patterns of skin lesions did not differ when comparing CKS patients to AIDS-KS patients, whereas the color Doppler signal, which is associated with vascular activity, was detected in the KS lesions of 6/8 AIDS-KS patients (75.0%) and in 2/16 CKS (16,7%); the latter two patients showed a clinically progressive and extensive disease stage (IV B).</p>
</sec>
<sec><title>Conclusions</title>
<p>Our preliminary results suggest that small cutaneous KS lesions - in both CKS and AIDS-KS patients- display similar B-mode ultrasound patterns ( hypoechoic, well defined, superficial lesions). However, the color Doppler signal, which is associated with endothelial activity and angiogenesis, which play a substantial role in KS progression, could constitute a useful tool for evaluating disease activity.</p>
</sec>
</div>
</front>
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<author><name sortKey="Ensoli, B" uniqKey="Ensoli B">B Ensoli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cammarota, T" uniqKey="Cammarota T">T Cammarota</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barillari, G" uniqKey="Barillari G">G Barillari</name>
</author>
<author><name sortKey="Ensoli, B" uniqKey="Ensoli B">B Ensoli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pyakurel, P" uniqKey="Pyakurel P">P Pyakurel</name>
</author>
<author><name sortKey="Pak, F" uniqKey="Pak F">F Pak</name>
</author>
<author><name sortKey="Mwakigonja, Ar" uniqKey="Mwakigonja A">AR Mwakigonja</name>
</author>
<author><name sortKey="Kaaya, E" uniqKey="Kaaya E">E Kaaya</name>
</author>
<author><name sortKey="Biberfeld, P" uniqKey="Biberfeld P">P Biberfeld</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Exp Clin Cancer Res</journal-id>
<journal-title-group><journal-title>Journal of Experimental & Clinical Cancer Research : CR</journal-title>
</journal-title-group>
<issn pub-type="ppub">0392-9078</issn>
<issn pub-type="epub">1756-9966</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21489270</article-id>
<article-id pub-id-type="pmc">3095540</article-id>
<article-id pub-id-type="publisher-id">1756-9966-30-40</article-id>
<article-id pub-id-type="doi">10.1186/1756-9966-30-40</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research</subject>
</subj-group>
</article-categories>
<title-group><article-title>AIDS-Kaposi Sarcoma and Classic Kaposi Sarcoma: are different ultrasound patterns related to different variants?</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes" id="A1"><name><surname>Solivetti</surname>
<given-names>Francesco M</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>solivetti@ifo.it</email>
</contrib>
<contrib contrib-type="author" id="A2"><name><surname>Elia</surname>
<given-names>Fulvia</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>elia@ifo.it</email>
</contrib>
<contrib contrib-type="author" id="A3"><name><surname>Latini</surname>
<given-names>Alessandra</given-names>
</name>
<xref ref-type="aff" rid="I2">2</xref>
<email>a.latini@ifo.it</email>
</contrib>
<contrib contrib-type="author" id="A4"><name><surname>Cota</surname>
<given-names>Carlo</given-names>
</name>
<xref ref-type="aff" rid="I3">3</xref>
<email>cota@ifo.it</email>
</contrib>
<contrib contrib-type="author" id="A5"><name><surname>Cordiali-Fei</surname>
<given-names>Paola</given-names>
</name>
<xref ref-type="aff" rid="I4">4</xref>
<email>cordiali-fei@ifo.it</email>
</contrib>
<contrib contrib-type="author" id="A6"><name><surname>Di Carlo</surname>
<given-names>Aldo</given-names>
</name>
<xref ref-type="aff" rid="I5">5</xref>
<email>dicarlo@ifo.it</email>
</contrib>
</contrib-group>
<aff id="I1"><label>1</label>
Radiology Department, San Gallicano Dermatology Institute - Rome - Italy</aff>
<aff id="I2"><label>2</label>
Infective Dermatology Division, San Gallicano Dermatology Institute - Rome - Italy</aff>
<aff id="I3"><label>3</label>
Dermatopathology Division, San Gallicano Dermatology Institute - Rome - Italy</aff>
<aff id="I4"><label>4</label>
Clinical Pathology and Microbiology Division, San Gallicano Dermatology Institute - Rome - Italy</aff>
<aff id="I5"><label>5</label>
Scientific Director, San Gallicano Dermatology Institute - Rome - Italy</aff>
<pub-date pub-type="collection"><year>2011</year>
</pub-date>
<pub-date pub-type="epub"><day>13</day>
<month>4</month>
<year>2011</year>
</pub-date>
<volume>30</volume>
<issue>1</issue>
<fpage>40</fpage>
<lpage>40</lpage>
<history><date date-type="received"><day>16</day>
<month>2</month>
<year>2011</year>
</date>
<date date-type="accepted"><day>13</day>
<month>4</month>
<year>2011</year>
</date>
</history>
<permissions><copyright-statement>Copyright ©2011 Solivetti et al; licensee BioMed Central Ltd.</copyright-statement>
<copyright-year>2011</copyright-year>
<copyright-holder>Solivetti et al; licensee BioMed Central Ltd.</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<self-uri xlink:href="http://www.jeccr.com/content/30/1/40"></self-uri>
<abstract><sec><title>Background</title>
<p>Kaposi Sarcoma (KS) is a malignancy of endothelial skin cells with multifocal localization on the skin, lymph nodes and visceral organs. Although all clinical variants are associated with HHV-8 infection, specific differences in the clinical onset and in the natural history of AIDS-KS and Classic-KS have been described. The present randomised prospective-observational study aimed to investigate whether the ultrasound pattern and color Doppler flow imaging of vascularisation of skin lesions of patients with Classic KS (CKS) or AIDS-KS could provide useful information to the evaluation of clinical activity of the disease.</p>
</sec>
<sec><title>Methods</title>
<p>Cutaneous lesions of 24 patients with histologically confirmed KS were investigated using very high frequency ultrasound probes; 16 patients had CKS and 8 had AIDS-KS. HHV-8 infection was confirmed in all patients by investigating the specific humoral response to viral antigens. Immunological and virological parameters were also assessed to monitor HIV or HHV-8 viral infection. For each patient, a target skin lesion was selected on the basis of size (diameter from 0.4 to 2 cm). Each lesion was analyzed in terms of size, depth and color Doppler pattern.</p>
</sec>
<sec><title>Results</title>
<p>The B-mode ultrasound patterns of skin lesions did not differ when comparing CKS patients to AIDS-KS patients, whereas the color Doppler signal, which is associated with vascular activity, was detected in the KS lesions of 6/8 AIDS-KS patients (75.0%) and in 2/16 CKS (16,7%); the latter two patients showed a clinically progressive and extensive disease stage (IV B).</p>
</sec>
<sec><title>Conclusions</title>
<p>Our preliminary results suggest that small cutaneous KS lesions - in both CKS and AIDS-KS patients- display similar B-mode ultrasound patterns ( hypoechoic, well defined, superficial lesions). However, the color Doppler signal, which is associated with endothelial activity and angiogenesis, which play a substantial role in KS progression, could constitute a useful tool for evaluating disease activity.</p>
</sec>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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