AIDS-Kaposi Sarcoma and Classic Kaposi Sarcoma: are different ultrasound patterns related to different variants?
Identifieur interne : 004055 ( Pmc/Curation ); précédent : 004054; suivant : 004056AIDS-Kaposi Sarcoma and Classic Kaposi Sarcoma: are different ultrasound patterns related to different variants?
Auteurs : Francesco M. Solivetti ; Fulvia Elia ; Alessandra Latini ; Carlo Cota ; Paola Cordiali-Fei ; Aldo Di CarloSource :
- Journal of Experimental & Clinical Cancer Research : CR [ 0392-9078 ] ; 2011.
Abstract
Kaposi Sarcoma (KS) is a malignancy of endothelial skin cells with multifocal localization on the skin, lymph nodes and visceral organs. Although all clinical variants are associated with HHV-8 infection, specific differences in the clinical onset and in the natural history of AIDS-KS and Classic-KS have been described. The present randomised prospective-observational study aimed to investigate whether the ultrasound pattern and color Doppler flow imaging of vascularisation of skin lesions of patients with Classic KS (CKS) or AIDS-KS could provide useful information to the evaluation of clinical activity of the disease.
Cutaneous lesions of 24 patients with histologically confirmed KS were investigated using very high frequency ultrasound probes; 16 patients had CKS and 8 had AIDS-KS. HHV-8 infection was confirmed in all patients by investigating the specific humoral response to viral antigens. Immunological and virological parameters were also assessed to monitor HIV or HHV-8 viral infection. For each patient, a target skin lesion was selected on the basis of size (diameter from 0.4 to 2 cm). Each lesion was analyzed in terms of size, depth and color Doppler pattern.
The B-mode ultrasound patterns of skin lesions did not differ when comparing CKS patients to AIDS-KS patients, whereas the color Doppler signal, which is associated with vascular activity, was detected in the KS lesions of 6/8 AIDS-KS patients (75.0%) and in 2/16 CKS (16,7%); the latter two patients showed a clinically progressive and extensive disease stage (IV B).
Our preliminary results suggest that small cutaneous KS lesions - in both CKS and AIDS-KS patients- display similar B-mode ultrasound patterns ( hypoechoic, well defined, superficial lesions). However, the color Doppler signal, which is associated with endothelial activity and angiogenesis, which play a substantial role in KS progression, could constitute a useful tool for evaluating disease activity.
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DOI: 10.1186/1756-9966-30-40
PubMed: 21489270
PubMed Central: 3095540
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Francesco M. Solivetti<affiliation><nlm:aff id="I1">Radiology Department, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff><wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry></affiliation><affiliation><nlm:aff id="I1">Radiology Department, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff><wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry></affiliation><affiliation><nlm:aff id="I2">Infective Dermatology Division, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff><wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry></affiliation><affiliation><nlm:aff id="I3">Dermatopathology Division, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff><wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry></affiliation><affiliation><nlm:aff id="I4">Clinical Pathology and Microbiology Division, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff><wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry></affiliation><affiliation><nlm:aff id="I5">Scientific Director, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff><wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">AIDS-Kaposi Sarcoma and Classic Kaposi Sarcoma: are different ultrasound patterns related to different variants?</title><author><name sortKey="Solivetti, Francesco M" sort="Solivetti, Francesco M" uniqKey="Solivetti F" first="Francesco M" last="Solivetti">Francesco M. Solivetti</name><affiliation><nlm:aff id="I1">Radiology Department, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff><wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry></affiliation></author><author><name sortKey="Elia, Fulvia" sort="Elia, Fulvia" uniqKey="Elia F" first="Fulvia" last="Elia">Fulvia Elia</name><affiliation><nlm:aff id="I1">Radiology Department, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff><wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry></affiliation></author><author><name sortKey="Latini, Alessandra" sort="Latini, Alessandra" uniqKey="Latini A" first="Alessandra" last="Latini">Alessandra Latini</name><affiliation><nlm:aff id="I2">Infective Dermatology Division, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff><wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry></affiliation></author><author><name sortKey="Cota, Carlo" sort="Cota, Carlo" uniqKey="Cota C" first="Carlo" last="Cota">Carlo Cota</name><affiliation><nlm:aff id="I3">Dermatopathology Division, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff><wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry></affiliation></author><author><name sortKey="Cordiali Fei, Paola" sort="Cordiali Fei, Paola" uniqKey="Cordiali Fei P" first="Paola" last="Cordiali-Fei">Paola Cordiali-Fei</name><affiliation><nlm:aff id="I4">Clinical Pathology and Microbiology Division, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff><wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry></affiliation></author><author><name sortKey="Di Carlo, Aldo" sort="Di Carlo, Aldo" uniqKey="Di Carlo A" first="Aldo" last="Di Carlo">Aldo Di Carlo</name><affiliation><nlm:aff id="I5">Scientific Director, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff><wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21489270</idno><idno type="pmc">3095540</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095540</idno><idno type="RBID">PMC:3095540</idno><idno type="doi">10.1186/1756-9966-30-40</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">004056</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004056</idno><idno type="wicri:Area/Pmc/Curation">004055</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004055</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">AIDS-Kaposi Sarcoma and Classic Kaposi Sarcoma: are different ultrasound patterns related to different variants?</title><author><name sortKey="Solivetti, Francesco M" sort="Solivetti, Francesco M" uniqKey="Solivetti F" first="Francesco M" last="Solivetti">Francesco M. Solivetti</name><affiliation><nlm:aff id="I1">Radiology Department, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff><wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry></affiliation></author><author><name sortKey="Elia, Fulvia" sort="Elia, Fulvia" uniqKey="Elia F" first="Fulvia" last="Elia">Fulvia Elia</name><affiliation><nlm:aff id="I1">Radiology Department, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff><wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry></affiliation></author><author><name sortKey="Latini, Alessandra" sort="Latini, Alessandra" uniqKey="Latini A" first="Alessandra" last="Latini">Alessandra Latini</name><affiliation><nlm:aff id="I2">Infective Dermatology Division, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff><wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry></affiliation></author><author><name sortKey="Cota, Carlo" sort="Cota, Carlo" uniqKey="Cota C" first="Carlo" last="Cota">Carlo Cota</name><affiliation><nlm:aff id="I3">Dermatopathology Division, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff><wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry></affiliation></author><author><name sortKey="Cordiali Fei, Paola" sort="Cordiali Fei, Paola" uniqKey="Cordiali Fei P" first="Paola" last="Cordiali-Fei">Paola Cordiali-Fei</name><affiliation><nlm:aff id="I4">Clinical Pathology and Microbiology Division, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff><wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry></affiliation></author><author><name sortKey="Di Carlo, Aldo" sort="Di Carlo, Aldo" uniqKey="Di Carlo A" first="Aldo" last="Di Carlo">Aldo Di Carlo</name><affiliation><nlm:aff id="I5">Scientific Director, San Gallicano Dermatology Institute - Rome - Italy</nlm:aff><wicri:noCountry code="subfield">San Gallicano Dermatology Institute - Rome - Italy</wicri:noCountry></affiliation></author></analytic><series><title level="j">Journal of Experimental & Clinical Cancer Research : CR</title><idno type="ISSN">0392-9078</idno><idno type="eISSN">1756-9966</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Kaposi Sarcoma (KS) is a malignancy of endothelial skin cells with multifocal localization on the skin, lymph nodes and visceral organs. Although all clinical variants are associated with HHV-8 infection, specific differences in the clinical onset and in the natural history of AIDS-KS and Classic-KS have been described. The present randomised prospective-observational study aimed to investigate whether the ultrasound pattern and color Doppler flow imaging of vascularisation of skin lesions of patients with Classic KS (CKS) or AIDS-KS could provide useful information to the evaluation of clinical activity of the disease.</p></sec><sec><title>Methods</title><p>Cutaneous lesions of 24 patients with histologically confirmed KS were investigated using very high frequency ultrasound probes; 16 patients had CKS and 8 had AIDS-KS. HHV-8 infection was confirmed in all patients by investigating the specific humoral response to viral antigens. Immunological and virological parameters were also assessed to monitor HIV or HHV-8 viral infection. For each patient, a target skin lesion was selected on the basis of size (diameter from 0.4 to 2 cm). Each lesion was analyzed in terms of size, depth and color Doppler pattern.</p></sec><sec><title>Results</title><p>The B-mode ultrasound patterns of skin lesions did not differ when comparing CKS patients to AIDS-KS patients, whereas the color Doppler signal, which is associated with vascular activity, was detected in the KS lesions of 6/8 AIDS-KS patients (75.0%) and in 2/16 CKS (16,7%); the latter two patients showed a clinically progressive and extensive disease stage (IV B).</p></sec><sec><title>Conclusions</title><p>Our preliminary results suggest that small cutaneous KS lesions - in both CKS and AIDS-KS patients- display similar B-mode ultrasound patterns ( hypoechoic, well defined, superficial lesions). 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Exp Clin Cancer Res</journal-id><journal-title-group><journal-title>Journal of Experimental & Clinical Cancer Research : CR</journal-title></journal-title-group><issn pub-type="ppub">0392-9078</issn><issn pub-type="epub">1756-9966</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21489270</article-id><article-id pub-id-type="pmc">3095540</article-id><article-id pub-id-type="publisher-id">1756-9966-30-40</article-id><article-id pub-id-type="doi">10.1186/1756-9966-30-40</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group></article-categories><title-group><article-title>AIDS-Kaposi Sarcoma and Classic Kaposi Sarcoma: are different ultrasound patterns related to different variants?</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes" id="A1"><name><surname>Solivetti</surname><given-names>Francesco M</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>solivetti@ifo.it</email></contrib><contrib contrib-type="author" id="A2"><name><surname>Elia</surname><given-names>Fulvia</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>elia@ifo.it</email></contrib><contrib contrib-type="author" id="A3"><name><surname>Latini</surname><given-names>Alessandra</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>a.latini@ifo.it</email></contrib><contrib contrib-type="author" id="A4"><name><surname>Cota</surname><given-names>Carlo</given-names></name><xref ref-type="aff" rid="I3">3</xref><email>cota@ifo.it</email></contrib><contrib contrib-type="author" id="A5"><name><surname>Cordiali-Fei</surname><given-names>Paola</given-names></name><xref ref-type="aff" rid="I4">4</xref><email>cordiali-fei@ifo.it</email></contrib><contrib contrib-type="author" id="A6"><name><surname>Di Carlo</surname><given-names>Aldo</given-names></name><xref ref-type="aff" rid="I5">5</xref><email>dicarlo@ifo.it</email></contrib></contrib-group><aff id="I1"><label>1</label>Radiology Department, San Gallicano Dermatology Institute - Rome - Italy</aff><aff id="I2"><label>2</label>Infective Dermatology Division, San Gallicano Dermatology Institute - Rome - Italy</aff><aff id="I3"><label>3</label>Dermatopathology Division, San Gallicano Dermatology Institute - Rome - Italy</aff><aff id="I4"><label>4</label>Clinical Pathology and Microbiology Division, San Gallicano Dermatology Institute - Rome - Italy</aff><aff id="I5"><label>5</label>Scientific Director, San Gallicano Dermatology Institute - Rome - Italy</aff><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>13</day><month>4</month><year>2011</year></pub-date><volume>30</volume><issue>1</issue><fpage>40</fpage><lpage>40</lpage><history><date date-type="received"><day>16</day><month>2</month><year>2011</year></date><date date-type="accepted"><day>13</day><month>4</month><year>2011</year></date></history><permissions><copyright-statement>Copyright ©2011 Solivetti et al; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2011</copyright-year><copyright-holder>Solivetti et al; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri xlink:href="http://www.jeccr.com/content/30/1/40"></self-uri><abstract><sec><title>Background</title><p>Kaposi Sarcoma (KS) is a malignancy of endothelial skin cells with multifocal localization on the skin, lymph nodes and visceral organs. Although all clinical variants are associated with HHV-8 infection, specific differences in the clinical onset and in the natural history of AIDS-KS and Classic-KS have been described. The present randomised prospective-observational study aimed to investigate whether the ultrasound pattern and color Doppler flow imaging of vascularisation of skin lesions of patients with Classic KS (CKS) or AIDS-KS could provide useful information to the evaluation of clinical activity of the disease.</p></sec><sec><title>Methods</title><p>Cutaneous lesions of 24 patients with histologically confirmed KS were investigated using very high frequency ultrasound probes; 16 patients had CKS and 8 had AIDS-KS. HHV-8 infection was confirmed in all patients by investigating the specific humoral response to viral antigens. Immunological and virological parameters were also assessed to monitor HIV or HHV-8 viral infection. For each patient, a target skin lesion was selected on the basis of size (diameter from 0.4 to 2 cm). Each lesion was analyzed in terms of size, depth and color Doppler pattern.</p></sec><sec><title>Results</title><p>The B-mode ultrasound patterns of skin lesions did not differ when comparing CKS patients to AIDS-KS patients, whereas the color Doppler signal, which is associated with vascular activity, was detected in the KS lesions of 6/8 AIDS-KS patients (75.0%) and in 2/16 CKS (16,7%); the latter two patients showed a clinically progressive and extensive disease stage (IV B).</p></sec><sec><title>Conclusions</title><p>Our preliminary results suggest that small cutaneous KS lesions - in both CKS and AIDS-KS patients- display similar B-mode ultrasound patterns ( hypoechoic, well defined, superficial lesions). However, the color Doppler signal, which is associated with endothelial activity and angiogenesis, which play a substantial role in KS progression, could constitute a useful tool for evaluating disease activity.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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